Acta Paediatrica最新文献

Understanding the Epidemiology of Pertussis in Denmark. 了解丹麦百日咳的流行病学。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-30 DOI: 10.1111/apa.70159

Tine Dalby, Aoife Ronayne, Peter Henrik Andersen

引用次数: 0

Feasibility of a Digitalised Cognitive Training Programme in Children Treated for Brain Tumours. 儿童脑肿瘤治疗中数字化认知训练方案的可行性。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-29 DOI: 10.1111/apa.70149

P Boström, R Lovio, H Forslin, I Vanʼt Hooft

{"title":"Feasibility of a Digitalised Cognitive Training Programme in Children Treated for Brain Tumours.","authors":"P Boström, R Lovio, H Forslin, I Vanʼt Hooft","doi":"10.1111/apa.70149","DOIUrl":"https://doi.org/10.1111/apa.70149","url":null,"abstract":"Aim: Few evidence-based methods are available in cognitive neurorehabilitation for children. The aim of this study was to evaluate the feasibility of a digitalised version of the Swedish Memory and Attention Re-training in children treated for brain tumours.Methods: Children referred to neurorehabilitation after brain tumour treatment in Stockholm, and their parents, were invited to participate and train for 4 weeks with the programme. Evaluation considering time consumption, motivation and overall experience of the programme was made in weekly meetings with a supervisor and through questionnaires.Results: Three children aged 10-14 and their parents participated. The amount of daily training was considered acceptable, the digitalised format was viewed as appealing, and strategies learned were considered applicable to everyday life. However, the programme was perceived as too short and needed more levels of difficulty.Conclusion: We consider the programme feasible for children with attention and memory problems after brain tumour treatment. Further accommodations should include a wider range of difficulty levels in exercises and further promote far-transfer effects.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Multiresistant Catheter-Associated Urinary Tract Infection in the Paediatric Critical Patient. 儿科危重患者多耐药导尿管相关尿路感染的危险因素分析。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-28 DOI: 10.1111/apa.70150

Cristina González-Anleo, Mònica Girona-Alarcón, Sara Bobillo-Perez, Elena Fresán-Ruiz, Anna Solé-Ribalta, Maria Ciutad-Celdrán, Eneritz Velasco-Arnaiz, Mireia Urrea, Iolanda Jordan

{"title":"Risk Factors for Multiresistant Catheter-Associated Urinary Tract Infection in the Paediatric Critical Patient.","authors":"Cristina González-Anleo, Mònica Girona-Alarcón, Sara Bobillo-Perez, Elena Fresán-Ruiz, Anna Solé-Ribalta, Maria Ciutad-Celdrán, Eneritz Velasco-Arnaiz, Mireia Urrea, Iolanda Jordan","doi":"10.1111/apa.70150","DOIUrl":"https://doi.org/10.1111/apa.70150","url":null,"abstract":"Aim: Catheter-associated urinary tract infections (CAUTIs) are common hospital-acquired infections in the paediatric intensive care unit (PICU), with high rates of multidrug resistance (MDR), conditioning worse outcomes. The aim of the study was to identify specific MDR-CAUTI risk factors and to compare outcomes between MDR and non-MDR infections.Methods: Single centre, prospective, observational study, conducted between 2015 and 2022, including PICU patients with a microbiologically confirmed CAUTI. Demographical, clinical, and microbiological data and outcomes were compared among patients with and without MDR-CAUTI.Results: Ninety-one CAUTI episodes were included, 32 (35.2%) caused by MDR microorganisms. In the univariate analysis, comorbidity (p = 0.010), previous antibiotic therapy (p = 0.003), first 48 h antibiotic exposure (p = 0.005), PICU stay before CAUTI (p = 0.017), previous MDR colonisation (p < 0.001), and previous MDR infection (p = 0.002) were associated with MDR-CAUTI. In the multivariate analysis, previous colonisation (OR 6.056), previous MDR infection (OR 9.153), and first 48 h antibiotic exposure (OR 3.029) were independently associated with MDR-CAUTI. Higher empirical treatment inappropriateness (39.3% vs. 7.1%, p < 0.001) and longer stays were observed for MDR-CAUTI, without differences in mortality.Conclusions: MDR rates among CAUTI in PICU are concerning and can jeopardise empirical treatment success. Acknowledging risk factors for MDR-CAUTI is crucial to guide empirical antibiotic therapy.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabinoids for Medical Purposes in Children: A Living Systematic Review. 大麻素用于儿童的医疗目的：一个活的系统评价。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-28 DOI: 10.1111/apa.70140

Manik Chhabra, Arun Paul, Omaymah Abulannaz, Mê-Linh Lê, Holly Mansell, Yaron Finkelstein, Richard J Huntsman, Lauren E Kelly

{"title":"Cannabinoids for Medical Purposes in Children: A Living Systematic Review.","authors":"Manik Chhabra, Arun Paul, Omaymah Abulannaz, Mê-Linh Lê, Holly Mansell, Yaron Finkelstein, Richard J Huntsman, Lauren E Kelly","doi":"10.1111/apa.70140","DOIUrl":"https://doi.org/10.1111/apa.70140","url":null,"abstract":"Aim: We developed a living systematic review (LSR) that will continuously map the safety and reported benefit data related to cannabinoid use for medical purposes in children.Methods: MEDLINE, Embase, PsycInfo, and the Cochrane Library were searched from inception to April 2023. Studies involving at least one child < 18 years who was administered plant-derived or pharmaceutical cannabinoids as an intervention or treatment for medical conditions were included.Results: Of 37 189 identified citations, 276 studies were included: 84 interventional, 131 observational, 54 surveys, and 7 qualitative studies. Among interventional and observational studies, common indications for cannabinoids in children were refractory epilepsy (n = 146 studies, 188 726 participants), cancer and cancer symptoms (n = 30 studies, 208 753 participants), and autism spectrum disorder (n = 18 studies, 1285 participants). Common cannabinoids identified in interventional studies were purified cannabidiol (CBD) (78.6%, n = 66 studies, 5235 participants) with dose range of 2-50 mg/kg/day, tetrahydrocannabinol (6%, n = 5 studies, 148 participants) with dose range of 2.5-10 mg/day (max dose of tetrahydrocannabinol in nabiximols 32.4 mg) and nabilone (6%, n = 5 studies, 267 participants) with dose range of 0.5-2 mg/day. In randomised controlled trials, purified cannabidiol was reported to reduce seizure frequency ranging between 30% and 50%. Common adverse events (> 20% studies) in studies enrolling children were somnolence, diarrhoea, vomiting, and decreased appetite.Conclusion: These findings will continue to be updated to inform practice and reveal knowledge gaps for future research.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory Function Monitoring and Visual Attention in Resuscitating Term Infants: A Manikin-Based Randomised Crossover Trial. 复苏中的足月婴儿呼吸功能监测和视觉注意：一项基于人体模型的随机交叉试验。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-28 DOI: 10.1111/apa.70141

Robert T Joyce, Dalal Alhassan, Anne L Murray, Aisling Fanning, Vicki Livingstone, Mmoloki Kenosi, Eugene M Dempsey

{"title":"Respiratory Function Monitoring and Visual Attention in Resuscitating Term Infants: A Manikin-Based Randomised Crossover Trial.","authors":"Robert T Joyce, Dalal Alhassan, Anne L Murray, Aisling Fanning, Vicki Livingstone, Mmoloki Kenosi, Eugene M Dempsey","doi":"10.1111/apa.70141","DOIUrl":"https://doi.org/10.1111/apa.70141","url":null,"abstract":"Aim: Determine the effect of Respiratory Function Monitor (RFM) use on the time taken to provide 30 s of effective positive pressure ventilation (PPV) in a simulated newborn-term resuscitation.Methods: Randomised crossover trial conducted at Cork University Maternity Hospital (Ireland). Participants performed two simulated manikin resuscitations with and without a RFM visible. Visual attention (VA) of the participants was assessed for each arm.Results: Thirty clinicians were enrolled (n = 30). Data was incomplete for two participants in the RFM visible (RFMv) arm, and one participant did not complete the task when the RFM was not visible (RFMnv).The median time taken to provide 30 s of effective PPV when RFMnv was 73.1 (IQR 53.9-106.1) seconds compared to 71.9 (IQR 46.4-116.1) seconds (p = 0.294) with RFMv. There was no significant difference in mean tidal volume (RFMnv 4.1 mL/kg to RFMv 4.6 mL/kg, p = 0.773). There was no statistically significant reduction in mask leak when RFMv (71.5% to 59.5%, p = 0.053). The median percentage VA spent on the manikin decreased from 81.3% when RFMnv to 59.5% with RFMv (p < 0.001).Conclusion: Using an RFM in a simulated term manikin resuscitation did not decrease the time taken to provide 30 s of effective PPV.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal Ultrasound Findings After a Urinary Tract Infection in Children. 儿童尿路感染后超声异常表现。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-27 DOI: 10.1111/apa.70152

Mikael Hakkola, Ida Tervo, Oskari Pieviläinen, Johan Heiskanen, Minna Honkila, Tytti Pokka, Niko Paalanne, Mika Venhola, Marja Perhomaa, Terhi Ruuska-Loewald

{"title":"Abnormal Ultrasound Findings After a Urinary Tract Infection in Children.","authors":"Mikael Hakkola, Ida Tervo, Oskari Pieviläinen, Johan Heiskanen, Minna Honkila, Tytti Pokka, Niko Paalanne, Mika Venhola, Marja Perhomaa, Terhi Ruuska-Loewald","doi":"10.1111/apa.70152","DOIUrl":"https://doi.org/10.1111/apa.70152","url":null,"abstract":"Aim: This study aimed to investigate the occurrence of urinary tract abnormalities detected in the ultrasound screening of children after a urinary tract infection episode, regardless of their age.Methods: This cohort study included children aged 0-16 years who underwent urinary tract ultrasound screening after a urinary tract infection between January 1, 2004, and December 31, 2015 in a paediatric university hospital in Finland. We excluded children with previously diagnosed pathologies of the urinary tract.Results: A total of 2050 children were included in this study. Among these, 116 (5.7%, 95% confidence interval 4.7%-6.7%) children had an abnormal ultrasound. In children with pyelonephritis, 70% of the abnormal ultrasounds were found in children younger than 2 years old. Age younger than 2 years was not associated with an increased risk of abnormality (odds ratio: 0.99, 95% confidence interval 0.65-1.52). Boys and children with non-Escherichia coli urinary tract infection or recurrent urinary tract infection were associated with a higher risk of having a urinary tract abnormality.Conclusion: Limiting ultrasound screening after pyelonephritis to children under 2 years of age, as recommended in many current treatment guidelines, may miss a significant proportion (30%) of children with urinary tract abnormalities.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adolescents With Severe Obesity Had an Increased Risk of Reporting Symptoms That Indicated They Had Major Depression. 严重肥胖的青少年报告出现严重抑郁症状的风险增加。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-26 DOI: 10.1111/apa.70147

Geoffrey Chek-Fei Yu, Ka-Man Yip, Wilfred Hing-Sang Wong, Queenie Wing-Shan See

{"title":"Adolescents With Severe Obesity Had an Increased Risk of Reporting Symptoms That Indicated They Had Major Depression.","authors":"Geoffrey Chek-Fei Yu, Ka-Man Yip, Wilfred Hing-Sang Wong, Queenie Wing-Shan See","doi":"10.1111/apa.70147","DOIUrl":"https://doi.org/10.1111/apa.70147","url":null,"abstract":"Aim: This study aimed to compare the severity of depressive symptoms of Hong Kong adolescents with and without obesity and to explore the correlates of depressive symptoms using Patient Health Questionnaire-9 (PHQ-9).Methods: Participants were recruited from the Paediatric Weight Control Clinic of Queen Mary Hospital or mainstream secondary schools in Hong Kong during the period of June 2023 and December 2023. This was a cross-sectional study comparing depression risk among adolescents with and without obesity. Subgroup analysis was conducted to examine the risk factors.Results: A total of 612 adolescents were included for analysis. No significant difference in PHQ-9 scores ≥ 10 was found between normal weight and obesity groups after socio-economic status (SES) adjustment. A positive correlation between BMI z-score and PHQ-9 was observed in adolescents with obesity, especially beyond the 99.6th percentile BMI. BMI ≥ 99.6% was identified as a significant risk factor for depression, without collinearity.Conclusion: Using the BMI ≥ 95th percentile to define obesity, no link was found between obesity and depression risk in Hong Kong adolescents. However, our study showed that adolescents with severe obesity (BMI ≥ 99.6th percentile) have a significantly higher risk of depressive symptoms. We recommend routine depression screening for adolescents with severe obesity.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prone Positioning Was Associated With Less Hypoxemic Events and Improved Feeding Tolerance in Preterm Infants. 俯卧位与早产儿低氧血症事件减少和喂养耐受性提高有关。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-26 DOI: 10.1111/apa.70153

Bettina Bohnhorst, Eva Lutz, Sabine Pirr, Corinna Peter, Carolin Böhne

{"title":"Prone Positioning Was Associated With Less Hypoxemic Events and Improved Feeding Tolerance in Preterm Infants.","authors":"Bettina Bohnhorst, Eva Lutz, Sabine Pirr, Corinna Peter, Carolin Böhne","doi":"10.1111/apa.70153","DOIUrl":"https://doi.org/10.1111/apa.70153","url":null,"abstract":"Aim: Cardiorespiratory events such as apnea, bradycardia and hypoxemia are common in preterm infants and may contribute to an impaired neurodevelopmental outcome. We hypothesised a significant reduction in the incidence of hypoxemia, bradycardia and gastric residuals in the prone position.Methods: In this monocentric, prospective, randomised, two-arm crossover trial, at a tertiary university hospital, 48 preterm infants with a gestational age of < 32 weeks and a postmenstrual age of < 34 weeks were randomised to either a prone-supine or a supine-prone sequence of cardiorespiratory monitoring over a period of 24 h. The primary outcome parameter was the cumulative frequency of hypoxemias and bradycardias; secondary parameters comprised evaluation of basal parameters, hypoxemias, bradycardias and the amount of gastric residuals.Results: The cumulative frequency of hypoxemias and bradycardias and the number of severe hypoxemias (peripheral oxygen saturation [SpO2] < 80%) were halved in the prone position (p = 0.03). Median basal SpO2 was significantly higher (p = 0.01) and gastric residuals were significantly lower (p = 0.0002) in the prone position. The frequency of apneas (> 10 s) was significantly increased in the prone position (p = 0.01).Conclusion: Prone positioning of preterm infants significantly reduces the cumulative frequency of hypoxemias and bradycardias, severe hypoxemias and gastric residuals while increasing basal SpO2.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic Review Suggests Nutraceuticals Containing Vitamin B2 Could Provide an Alternative Treatment for Paediatric Migraines. 系统评价表明含有维生素B2的营养品可以为儿科偏头痛提供替代治疗。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-24 DOI: 10.1111/apa.70157

Elisa Martello, Fatimah Aiyelabegan, Jemma Orr, Emma Wilson, Joanne R Morling, Maria Kinali, Titus Joseph, Dirontsho Koboto, Surakshya Dhungana, Prudence Ikechukwu, Princella Seripenah, Heidi Emery, James Stewart-Evans, Jo Leonardi-Bee

{"title":"Systematic Review Suggests Nutraceuticals Containing Vitamin B2 Could Provide an Alternative Treatment for Paediatric Migraines.","authors":"Elisa Martello, Fatimah Aiyelabegan, Jemma Orr, Emma Wilson, Joanne R Morling, Maria Kinali, Titus Joseph, Dirontsho Koboto, Surakshya Dhungana, Prudence Ikechukwu, Princella Seripenah, Heidi Emery, James Stewart-Evans, Jo Leonardi-Bee","doi":"10.1111/apa.70157","DOIUrl":"https://doi.org/10.1111/apa.70157","url":null,"abstract":"Aim: The aim of this review is to systematically summarise the evidence on the effectiveness of riboflavin (vitamin B2) or supplements containing riboflavin in preventing paediatric migraines.Methods: This systematic review followed the Joanna Briggs Institute methodology and is reported to adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched multiple electronic databases on 25 October 2023 to identify potentially relevant studies. Studies were screened, critically appraised and data extracted by two reviewers. Data underwent a narrative synthesis using vote counting based on direction of effect and was presented using harvest plots.Results: Seventeen studies of varying quality were included in the review. Riboflavin or its combination with other natural ingredients was significantly effective in reducing migraine frequency (7/10 comparisons), migraine days (3/4 studies) and use of analgesics (3/4 studies). Mixed findings were found on headache duration in hours (3/5 studies), pain intensity (4/6 studies) and disability (3/5 studies). No negative outcomes and few side effects were reported (five studies).Conclusion: Our findings suggest that using riboflavin at different dosages and treatment lengths offers a promising alternative to common medications for paediatric migraine prevention. Future research should explore mechanisms of action, optimal dosing and treatment duration using robust evidence.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic Review on the Increase in Body Mass Index Percentiles in Girls With Central Precocious Puberty Receiving Gonadotropin-Releasing Hormone Analogues. 接受促性腺激素释放激素类似物治疗的中枢性性早熟女孩体重指数百分位数增加的系统评价。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-05-23 DOI: 10.1111/apa.70145

Natasha Yixuan Ong, Zera Yingrui Te, Seth En Teoh, Sarvesha K, Kah Yin Loke, Yung Seng Lee, Nicholas Beng Hui Ng

{"title":"Systematic Review on the Increase in Body Mass Index Percentiles in Girls With Central Precocious Puberty Receiving Gonadotropin-Releasing Hormone Analogues.","authors":"Natasha Yixuan Ong, Zera Yingrui Te, Seth En Teoh, Sarvesha K, Kah Yin Loke, Yung Seng Lee, Nicholas Beng Hui Ng","doi":"10.1111/apa.70145","DOIUrl":"https://doi.org/10.1111/apa.70145","url":null,"abstract":"Aim: To evaluate the association between gonadotropin-releasing hormone (GnRH)-analogue use and adiposity change in girls with idiopathic central precocious puberty (CPP) or early puberty (EP).Method: A systematic review was performed using PubMed, Embase, Scopus, PsycInfo and Cochrane. Primary studies reporting quantitative measures of adiposity in girls with idiopathic CPP-EP who received GnRH-analogues were included. A meta-analysis was performed, with subgroup analyses based on baseline body mass index (BMI) and GnRH-analogue type.Results: There were 46 studies with 3606 girls who received GnRH-analogues. BMI-standard deviation scores (SDS) increased significantly within 2 years (0.17, 95% CI 0.12-0.23) but not beyond 2 years of therapy. Between the start and end of therapy, girls with normal BMI at baseline experienced a significant increase in BMI-SDS (0.32, 95% CI 0.22-0.42) compared to those with overweight or obesity (BMI-SDS -0.03, 95% CI -0.09 to 0.02). Leuprorelin use was associated with an increase in BMI-SDS during therapy.Conclusion: GnRH-analogue use in girls with CPP-EP was associated with a transient increase in BMI-SDS during, but not beyond therapy. Girls with normal BMI at baseline had a higher risk of experiencing significant increases in BMI-SDS during therapy. BMI monitoring and anticipatory guidance for weight are recommended for those receiving GnRH-analogues.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0