Acta Paediatrica最新文献

German Hypothermia Registry Improves Clinician Confidence and Harmonises Decentralised Neonatal Hypoxic-Ischaemic Encephalopathy Care in Germany. 德国低温登记提高临床医生的信心和协调分散的新生儿缺氧缺血性脑病护理在德国。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-08 DOI: 10.1111/apa.70579

Till Dresbach, Khaled Abdelrahman, Sebiha Demir, Anne Groteklaes, Alexandra Boeckenhoff, Andreas Mueller, Hemmen Sabir

{"title":"German Hypothermia Registry Improves Clinician Confidence and Harmonises Decentralised Neonatal Hypoxic-Ischaemic Encephalopathy Care in Germany.","authors":"Till Dresbach, Khaled Abdelrahman, Sebiha Demir, Anne Groteklaes, Alexandra Boeckenhoff, Andreas Mueller, Hemmen Sabir","doi":"10.1111/apa.70579","DOIUrl":"https://doi.org/10.1111/apa.70579","url":null,"abstract":"Aim: Decentralised implementation of therapeutic hypothermia (TH) for neonatal hypoxic-ischaemic encephalopathy (HIE) in Germany historically caused heterogeneous clinical practices. The aim of this study was to assess the impact of the German Hypothermia Registry on clinical standardisation and confidence in neonatal HIE care since its initiation in 2022.Methods: We conducted a nationwide, two-phase, web-based survey in 2022 (n = 66) and 2025 (n = 222). A longitudinal subgroup analysis included physicians participating in both surveys (n = 30). Outcomes included guideline adherence, subjective diagnostic and therapeutic confidence, and perceived needs for further standardisation.Results: From 2022 to 2025, clinician confidence improved across most domains. Complete confidence in diagnosing HIE increased from 42.4% to 80.0% in the longitudinal subgroup, while confidence in performing TH rose from 53.0% to 86.7%. Clarity regarding inclusion criteria reached 100% among longitudinal participants. In contrast, complete confidence in neurological assessment (36.7%) and amplitude-integrated electroencephalography (aEEG) interpretation (60.0%) remained comparatively lower in 2025.Conclusion: The German Hypothermia Registry markedly improved standardisation and clinician confidence in neonatal HIE care. However, neurological assessment and aEEG interpretation remain key areas requiring targeted educational support.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Monitoring of Adverse Reactions During Paediatric Food Oral Immunotherapy in a Real-World Cohort. 真实世界队列中儿科食品口服免疫治疗不良反应的数字监测。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-08 DOI: 10.1111/apa.70586

Tiina Kauppila, Heidi Sandström, Anna Kaarina Kukkonen, Kati Palosuo, Mika J Mäkelä

引用次数: 0

Response to the Critique by Bragazzi et al. of Ruuska et al. 对Bragazzi等人对Ruuska等人的批评的回应。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-08 DOI: 10.1111/apa.70584

Sami-Matti Ruuska, Katinka Tuisku, Timo Holttinen, Riittakerttu Kaltiala

引用次数: 0

Interpreting Psychiatric Needs After Gender Reassignment: Methodological Considerations From a Nationwide Register Study. 解释性别重置后的精神病学需求：一项全国性登记研究的方法学考虑。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-08 DOI: 10.1111/apa.70585

Nicola Luigi Bragazzi, Manlio Converti, Rola Khamisy-Farah

引用次数: 0

Thirty Years of Pneumococcal Conjugate Vaccines in Children: Achievements, Challenges and Lessons From a Moving Target. 儿童肺炎球菌结合疫苗的三十年：成就、挑战和来自移动目标的教训。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-06 DOI: 10.1111/apa.70574

Robert Cohen, Corinne Levy, André Birgy, Emmanuelle Varon

{"title":"Thirty Years of Pneumococcal Conjugate Vaccines in Children: Achievements, Challenges and Lessons From a Moving Target.","authors":"Robert Cohen, Corinne Levy, André Birgy, Emmanuelle Varon","doi":"10.1111/apa.70574","DOIUrl":"https://doi.org/10.1111/apa.70574","url":null,"abstract":"Aim: To review the long-term epidemiological and immunological impact of pneumococcal conjugate vaccines (PCVs) in the context of serotype replacement and the development of higher-valency formulations.Methods: Brief literature overview of current evidence on pneumococcal biology, natural and vaccine-induced immunity, population-level effects of PCVs and the epidemiological dynamics of serotype distribution.Results: PCVs have profoundly reshaped the landscape of paediatric infectious diseases, leading to a dramatic decline in Streptococcus pneumoniae infections in children and, through herd protection, in adults. The decline in vaccine-type infections has been partially offset by the gradual emergence of non-vaccine serotypes. However, despite this serotype replacement, PCVs remain among the most powerful paediatric vaccines ever developed. The diversity of pneumococcal biology, the interplay between natural and vaccine-induced immunity and the dynamic process of serotype replacement create a constantly moving target. The introduction of higher-valency vaccines, now including up to 15 or 20 serotypes, seeks to address this adaptation but faces intrinsic immunological limits.Conclusion: Three decades after the first clinical trials, our understanding of their long-term epidemiological and immunological impact is still evolving. Future vaccine strategies must optimize the balance between expanded serotype coverage and durable immune protection at both the individual and population levels.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to 'Adverse neonatal outcomes following planned vaginal birth compared to planned caesarean birth: A population-based study'. “计划阴道分娩与计划剖宫产的不良新生儿结局比较：一项基于人群的研究”的更正。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-06 DOI: 10.1111/apa.70580

引用次数: 0

Early Transepidermal Water Loss in Term Neonates and Its Perinatal Influences Using a Closed-Chamber System. 闭室系统对足月新生儿早期经皮失水及其围产期影响的研究。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-05 DOI: 10.1111/apa.70583

Colin P McGrath, Michael A Boyle

{"title":"Early Transepidermal Water Loss in Term Neonates and Its Perinatal Influences Using a Closed-Chamber System.","authors":"Colin P McGrath, Michael A Boyle","doi":"10.1111/apa.70583","DOIUrl":"https://doi.org/10.1111/apa.70583","url":null,"abstract":"Aims: To establish transepidermal water loss values on the first postnatal day in healthy term neonates and associations with perinatal factors utilising a closed-chamber system.Methods: A cross-sectional single-centre study was conducted over a 7-month period. Healthy infants ≥ 37-week gestation and 2-24 h old were recruited. Transepidermal water loss was measured at a single time-point, non-invasively under typical ambient conditions using a standardised approach. Anthropometric and perinatal variables were collated. Outcomes assessed included device validity and reliability, transepidermal water loss values, and interactions with maternal and infant variables.Results: A total of 120 term infants were recruited. The intra-class correlation coefficient of three consecutive readings was 0.735, indicating good reliability. There was no interaction between transepidermal water loss and ambient conditions. Mean values were 13.9 ± 3.28 g/m2/h. The 5th and 95th percentiles were 9.7 and 20.3 g/m2/h, respectively. Each additional postnatal hour conferred a reduction in transepidermal water loss of 0.11 g/m2/h. Caesarean section increased transepidermal losses by 1.4 g/m2/h. No other associations were significant.Conclusion: Early postnatal transepidermal water loss in the term infant is low but variable. Physiological variability is not attributable to typical ambient conditions or common perinatal factors, indicating a uniformly competent skin barrier at term.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrospective Analysis of Point-of-Care Ultrasound Results in the Follow-Up of Paediatric Functional Constipation. 小儿功能性便秘即时超声随访结果的回顾性分析。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-04 DOI: 10.1111/apa.70581

Martyna Laskowska, Agata Chobot, Marta Drabik, Katarzyna Głuszko, Piotr Adamczyk, Katarzyna Bąk-Drabik

{"title":"Retrospective Analysis of Point-of-Care Ultrasound Results in the Follow-Up of Paediatric Functional Constipation.","authors":"Martyna Laskowska, Agata Chobot, Marta Drabik, Katarzyna Głuszko, Piotr Adamczyk, Katarzyna Bąk-Drabik","doi":"10.1111/apa.70581","DOIUrl":"https://doi.org/10.1111/apa.70581","url":null,"abstract":"Aim: This study aimed to evaluate point-of-care ultrasound (POCUS) findings in children with functional constipation who achieved complete clinical improvement following standard treatment in accordance with international guidelines.Material and methods: The study included 58 children (31 boys) aged 0.9-16.1 (mean age 5.22 ± 3.24), diagnosed with functional constipation, who attended two visits: First due to constipation-related symptoms and second to evaluate the treatment response. Each patient underwent a complete abdominal ultrasound examination before or during the first visit and a POCUS assessment at follow-up.Results: The median time to follow-up was 3.7 months (IQR: 2.5-7.4), with a range of 0.9-29.2 months. The mean rectal diameter decreased from 38.93 ± 10.7 mm at baseline to 24.46 ± 11.54 mm after treatment. Initially, hard stool predominated in the rectal ampulla (96.6%) and sigmoid colon (93.1%). At follow-up, hard stool decreased to 63.7% in the rectum and 45.5% in the sigmoid colon. Although symptom resolution and physical examination would suggest continuing the current treatment, it was intensified in 51.7% of patients based on POCUS findings.Conclusion: In the studied children with functional constipation, POCUS findings provided additional, clinically meaningful information for evaluating treatment response.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gestational Age-Specific Prevalence of Retinopathy of Prematurity in Very Preterm Infants: An Exploratory Meta-Analysis. 极早产儿视网膜病变的胎龄特异性患病率：一项探索性meta分析。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-04 DOI: 10.1111/apa.70570

Paige Scudder, Shiyu Zhang, Tora Sund Morken, Christiane E L Dammann, Olaf Dammann

引用次数: 0

The Expanding Spectrum of Fuel Toxicity: A Migration-Related Toxic Syndrome. 燃料毒性的扩展谱：一种与迁徙有关的毒性综合症。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2026-05-04 DOI: 10.1111/apa.70576

Antonio Corsello, Simone Maria Calogero Gramaglia, Giuseppe Gramaglia, Gerlando Verruso, Giusy Ranucci

引用次数: 0