Acta Paediatrica最新文献

Maternal Oncological Disease and Congenital Pneumonia Are New Independent Risk Factors for Surfactant Requirements in Late Preterm Infants. 母亲肿瘤疾病和先天性肺炎是晚期早产儿表面活性剂需求的新独立危险因素。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-24 DOI: 10.1111/apa.70250

Simonetta Costa, Simona Fattore, Milena Tana, Giorgia Di Brina, Nicoletta Menzella, Paola Catalano, Benedetta De Santis, Chiara Barone, Giovanni Vento

{"title":"Maternal Oncological Disease and Congenital Pneumonia Are New Independent Risk Factors for Surfactant Requirements in Late Preterm Infants.","authors":"Simonetta Costa, Simona Fattore, Milena Tana, Giorgia Di Brina, Nicoletta Menzella, Paola Catalano, Benedetta De Santis, Chiara Barone, Giovanni Vento","doi":"10.1111/apa.70250","DOIUrl":"https://doi.org/10.1111/apa.70250","url":null,"abstract":"Aim: The purpose of this study was to evaluate the incidence of respiratory distress syndrome (RDS) in late preterm (LPT) infants. We also aimed to identify the risk factors associated with surfactant requirement and the clinical outcomes associated with surfactant therapy.Methods: We retrospectively analysed data from a single-centre neonatology unit at the Fondazione Policlinico Universitario Agostino Gemelli, IRCCS in Rome, Italy over a 4 year period. For each risk factor, the odds ratio (OR) and the 95% confidence interval (95% CI) were reported.Results: The incidence of RDS among 1335 LPT infants was 7.8%. The percentage of infants who required the surfactant was 3.4%. Gestational age (OR 0.541, 95% CI 0.367-0.796, p = 0.002), birth weight (OR 1.001, 95% CI 1.000-1.003; p = 0.037), 1 min Apgar score (OR 0.631, 95% CI 0.440-0.905, p = 0.012) and congenital pneumonia (OR 28.931, 95% CI 9.139-91.597, p < 0.001) were the neonatal risk factors associated with surfactant requirement. Oncological disease (OR 4.116, 95% CI 1.081-15.672, p = 0.038) was the maternal risk factor associated with surfactant requirement.Conclusions: Maternal oncological disease and congenital pneumonia emerged as new risk factors for surfactant requirement in LPT infants. These findings expanded the understanding of the mechanisms underlying RDS in LPT infants, moving beyond the known risk factors.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mobile Health Is a Cost-Effective Strategy for Managing Obesity in Adolescents: A Randomised Controlled Trial. 移动医疗是管理青少年肥胖的一种具有成本效益的策略：一项随机对照试验。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-24 DOI: 10.1111/apa.70248

Frantz Foissac, Géraldine Lepage, Nelly Briand, Marion Cosnefroy, Adrien Charrat, Myriam Dabbas

{"title":"Mobile Health Is a Cost-Effective Strategy for Managing Obesity in Adolescents: A Randomised Controlled Trial.","authors":"Frantz Foissac, Géraldine Lepage, Nelly Briand, Marion Cosnefroy, Adrien Charrat, Myriam Dabbas","doi":"10.1111/apa.70248","DOIUrl":"https://doi.org/10.1111/apa.70248","url":null,"abstract":"Aim: To compare the efficacy of remote monitoring versus traditional monitoring in reducing body mass index (BMI) in adolescents with obesity.Methods: Adolescents with obesity attending Necker Children's Hospital in Paris for the first time were enrolled in a randomised trial. After completing the three-month intervention, patients were randomised into two groups for the maintenance phase: a remote and a traditional monitoring group. The primary outcome was the proportion of participants achieving a BMI Z-score reduction > 0.5 standard deviation at 15 months. Secondary outcomes included attrition rate, child quality of life, and lifestyle factors.Results: Adolescents with severe obesity, a median age of 12 years, and a BMI Z-score of 3.95, were enrolled. No significant difference in the success rate was observed between remote (n = 38) and traditional (n = 40) groups (31.6% vs. 25.0%, p = 0.69). Failure was more likely in adolescents under 14 years and those with lower social quality of life scores. The remote group had significantly lower follow-up visits during the study (p < 0.0001).Conclusion: Mobile health interventions may be an effective alternative to traditional monitoring for reducing weight in adolescents with obesity during the maintenance phase while reducing the burden of clinic visits for parents and caregivers.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reported Experience of Family Violence in the New Zealand SUDI Case-Control Study. 新西兰SUDI病例对照研究中报告的家庭暴力经历。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-24 DOI: 10.1111/apa.70239

Dawn E Elder, John M D Thompson, Jess Wilson, Edwin A Mitchell

{"title":"Reported Experience of Family Violence in the New Zealand SUDI Case-Control Study.","authors":"Dawn E Elder, John M D Thompson, Jess Wilson, Edwin A Mitchell","doi":"10.1111/apa.70239","DOIUrl":"https://doi.org/10.1111/apa.70239","url":null,"abstract":"Aim: This study aimed to investigate the prevalence of family violence (FV) in sudden Unexpected Death in Infancy (SUDI) cases in New Zealand.Methods: A case-control study was implemented from March 2012 to February 2015. Cases comprised all SUDI deaths referred to the coroner. Controls were selected randomly, based on characteristics of previous SUDI deaths. The primary risk factor assessed was exposure to \"family violence ever\".Results: Of 258 controls, 248 (96.1%) had FV data and 73 (29.4%) had ever experienced FV. Among 132 SUDI cases, 58 (43.9%) had FV data and 35 (60.3%) had ever experienced FV. Adjusted risk factors associated with FV in controls included being in a de facto relationship, being single, mother's current partner not being the baby's biological father, maternal depression during pregnancy, and the number of previous pregnancies. In the multivariable model, FV was significantly associated with an increased risk of SUDI (OR 2.57 (95% CI 1.14, 5.81)).Conclusion: In this study, a history of FV was a significant risk factor for SUDI. Routine screening for FV exposure during perinatal and postnatal care is crucial, with appropriate support and referrals offered to affected families to potentially reduce SUDI risk.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to "Comment on 'High Body Fat Level in Normal Weight Girls Is Related to Inflammation and Cardiometabolic Risk'". 回复“关于‘正常体重女孩的高体脂水平与炎症和心脏代谢风险有关’的评论”。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-24 DOI: 10.1111/apa.70249

Ariane Ribeiro de Freitas Rocha, Silvia Eloiza Priore

引用次数: 0

EBNEO Commentary: Review of the 'Norepinephrine Versus Dopamine for Septic Shock in Neonates: A Randomised Controlled Trial'. EBNEO评论：“去甲肾上腺素与多巴胺治疗新生儿感染性休克：一项随机对照试验”综述。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-23 DOI: 10.1111/apa.70241

Gabriel Altit

引用次数: 0

Infant Acid-Suppressant Medication, C. difficile Colonisation, and Childhood Body Mass Index in a Canadian Cohort. 加拿大队列中婴儿抑酸药物、艰难梭菌定植和儿童体重指数。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-22 DOI: 10.1111/apa.70243

Sarah L Bridgman, Kelsea M Drall, Amanda A Lau, Hein M Tun, Nadia P Morales-Lizcano, Hien Q Huynh, Piushkumar J Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, James A Scott, Anita L Kozyrskyj

{"title":"Infant Acid-Suppressant Medication, C. difficile Colonisation, and Childhood Body Mass Index in a Canadian Cohort.","authors":"Sarah L Bridgman, Kelsea M Drall, Amanda A Lau, Hein M Tun, Nadia P Morales-Lizcano, Hien Q Huynh, Piushkumar J Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, James A Scott, Anita L Kozyrskyj","doi":"10.1111/apa.70243","DOIUrl":"https://doi.org/10.1111/apa.70243","url":null,"abstract":"Aim: To determine relationships between paediatric use of acid-suppressive medications (ASMs) (proton pump inhibitors (PPI) and histamine-2 receptor antagonists (H2RA)) and preschool body mass index (BMI) and mediation by C. difficile colonisation.Methods: ASMs were parent-reported at age 3, 6 and 12 months in 1025 infants from the CHILD Cohort Study. Targeted qPCR for C. difficile was conducted in stool collected at 3 months, and age/sex adjusted BMI-z scores were calculated at age 5 years. ASM use and BMI-z score associations were assessed by regression, and mediation analyses were conducted.Results: Approximately 4% of infants received H2RAs, most before age 3 months. C. difficile colonisation was twice as likely in 3-month-old infants receiving H2RAs (OR: 2.27, 95% CI: 1.13-4.51) and was associated with higher BMI-z scores at age 5 years (β: 0.31, 95% CI: 0.16, 0.46). Mediation models showed an indirect positive effect of H2RA use on 5-year BMI-z scores, mediated through C. difficile colonisation (β: 0.065, 95% CI: 0.01, 0.13).Conclusions: We found evidence of increased preschool BMI following H2RA use in infants that was mediated through C. difficile colonisation. Further study on ASM use in infancy, the gut microbiome, and pathways to body weight health outcomes is warranted.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Limiting Sternal Tumour of Childhood: Recognition Prevents Unnecessary Diagnostics and Treatment. 儿童自限性胸骨肿瘤：识别防止不必要的诊断和治疗。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-21 DOI: 10.1111/apa.70231

Thomas Mol, Astrid Leus, Nathan Demeyere, Jaques van Heerden, Machiel van den Akker

{"title":"Self-Limiting Sternal Tumour of Childhood: Recognition Prevents Unnecessary Diagnostics and Treatment.","authors":"Thomas Mol, Astrid Leus, Nathan Demeyere, Jaques van Heerden, Machiel van den Akker","doi":"10.1111/apa.70231","DOIUrl":"https://doi.org/10.1111/apa.70231","url":null,"abstract":"Aim: Self-limiting sternal tumour of childhood (SELSTOC) is a rare, benign tumour, characterised by a rapidly growing pre- or parasternal mass in children up to 2 years of age. This review aimed to improve awareness among physicians and summarise the clinical features and outcomes of SELSTOC.Methods: We conducted PubMed and Google Scholar searches to collect data on children diagnosed with SELSTOC from the earliest records until July 2024. Three new cases from two Belgian paediatric hospitals (ZAS Queen Paola Children's Hospital and University Hospital Brussels) were included. Data on demographics, clinical presentation, diagnostics, treatment and outcomes were analysed.Results: Forty-one children were included (3 new cases) with a mean age of 14.0 ± 8.3 months and with a male predominance (25 males, 16 females). Fever occurred in 33% (13/39), pain or tenderness in 55% (21/38), discolouration in 33% (11/33) and warmth in 4% (1/23). Ultrasound was used in 90% (37/41), typically showing a hypoechoic, heterogeneous, avascular mass with pre-, para- and retrosternal components ('dumbbell' shape). All lesions resolved spontaneously within weeks to months.Conclusion: Greater clinical awareness of SELSTOC is essential to prevent unnecessary investigations and treatments, given its benign, self-limiting course.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBNEO Commentary: Reevaluating Dopamine for Hypotension in Extremely Preterm Infants: Insights From the HIP Trial Follow-Up. EBNEO评论：重新评估多巴胺对极早产儿低血压的作用：来自HIP试验随访的见解。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-21 DOI: 10.1111/apa.70236

N Rao, H Gowda

引用次数: 0

Trends in Birth Prevalence of Congenital Heart Defects in Norway-A Population Study 1994-2014. 挪威先天性心脏缺陷出生流行趋势——1994-2014年人口研究

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-21 DOI: 10.1111/apa.70235

Elisabeth Leirgul, Tatiana Fomina, Gottfried Greve, Grethe S Tell, Marit Sandberg, Nina Øyen

{"title":"Trends in Birth Prevalence of Congenital Heart Defects in Norway-A Population Study 1994-2014.","authors":"Elisabeth Leirgul, Tatiana Fomina, Gottfried Greve, Grethe S Tell, Marit Sandberg, Nina Øyen","doi":"10.1111/apa.70235","DOIUrl":"https://doi.org/10.1111/apa.70235","url":null,"abstract":"Aim: The prevalence of severe congenital heart defects (CHDs) has been declining in Europe, possibly because pregnancies with foetal anomalies are often terminated. We present trends in the prevalence of CHD among live births, stillbirths and terminated pregnancies over a 21-year period in Norway.Method: All births and terminated pregnancies registered in Norway's Medical Birth Registry from 1994-2014 were linked to information on CHDs and extracardiac birth defects or chromosomal aberrations found in national administrative and clinical registries.Results: We identified 18 838 individuals with CHD among the 1 261 952 live births, stillbirths and terminated pregnancies, which was 149.3 per 10 000. In live births, the CHD prevalence was 144.6 per 10 000. The prevalence of severe CHD increased from 27.1 in 1994 to 36.1 in 2004, then declined to 27.8 in 2014, with an overall prevalence of 32.1 per 10 000. In live births, the prevalence was 29.0 per 10 000. The prevalence of severe CHD in nonsyndromic births was 20.4 per 10 000, with no time trend. Septal defects increased continuously after 1994.Conclusion: From 2004-2014, the prevalence of severe CHD declined, primarily due to a decrease in syndromic CHD. This could likely be explained by pregnancy terminations. Septal defects increased over the entire study period.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmittance Mode of Time-Resolved Near-Infrared Spectroscopy for Monitoring Deeper Cerebral Tissues in Extremely Low-Birth-Weight Infants. 时间分辨近红外光谱透射模式监测极低出生体重儿深部脑组织。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-21 DOI: 10.1111/apa.70245

Toshiyuki Imanishi, Wakako Sumiya, Chika Kanno, Masayuki Kanno, Ken Kawabata, Masaki Shimizu

{"title":"Transmittance Mode of Time-Resolved Near-Infrared Spectroscopy for Monitoring Deeper Cerebral Tissues in Extremely Low-Birth-Weight Infants.","authors":"Toshiyuki Imanishi, Wakako Sumiya, Chika Kanno, Masayuki Kanno, Ken Kawabata, Masaki Shimizu","doi":"10.1111/apa.70245","DOIUrl":"https://doi.org/10.1111/apa.70245","url":null,"abstract":"Aim: To investigate the potential of the transmittance mode of time-resolved near-infrared spectroscopy, in which the source and detector probes are placed on the bilateral temporal region of the head, compared with the conventional reflectance mode in extremely low-birth-weight (ELBW) infants.Methods: Differences in cerebral tissue oxygen saturation (StO2) and cerebral blood volume (CBV) between the two modes were evaluated. Linear regression was performed to investigate contributing factors to StO2 and CBV.Results: Forty-nine ELBW infants (median gestational age, 24.9 weeks; mean birthweight, 672 g), including nine intraventricular haemorrhage (IVH) cases, were evaluated at a median of 14.0 days of age. StO2 and CBV values were significantly lower in the transmittance mode than in the reflectance mode. IVH was a significant contributor to StO2 and CBV. Two out of four cases with IVH grade 3 had larger ventricular dilations and showed outliers towards low StO2.Conclusion: The transmittance mode detected lower StO2 in ELBW infants as compared to the reflectance mode, especially in IVH cases. This was either due to the optical effects of the IVH itself and/or large dilated ventricles.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0