Acta Paediatrica最新文献

Signs of Cross-Reactivity Between SARS-CoV-2 and Other Coronaviruses in a Pre-Vaccine Swedish School Setting. 在未接种疫苗的瑞典学校环境中，SARS-CoV-2和其他冠状病毒之间交叉反应的迹象。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-04-04 DOI: 10.1111/apa.70532

Lina Schollin Ask, Sharon Kühlmann Berenzon, Ulrika Marking, Sara Nouiser, Andreas Bråve, Sören Andersson, Charlotta Nordenhäll, Tobias Alfvén, Teghesti Tecleab, Olof Hertting, Tyler Sandberg, Wanda Christ, Jonas Klingström, Kim Blom, Charlotta Nilsson

{"title":"Signs of Cross-Reactivity Between SARS-CoV-2 and Other Coronaviruses in a Pre-Vaccine Swedish School Setting.","authors":"Lina Schollin Ask, Sharon Kühlmann Berenzon, Ulrika Marking, Sara Nouiser, Andreas Bråve, Sören Andersson, Charlotta Nordenhäll, Tobias Alfvén, Teghesti Tecleab, Olof Hertting, Tyler Sandberg, Wanda Christ, Jonas Klingström, Kim Blom, Charlotta Nilsson","doi":"10.1111/apa.70532","DOIUrl":"10.1111/apa.70532","url":null,"abstract":"Aim: This pilot study explored signs of immunological cross-reactivity between SARS-CoV-2 and human coronaviruses (HCoVs) in a Swedish school setting.Methods: A cross-sectional, hypothesis-generating study was conducted late 2020 before vaccines against COVID-19 were available. Forty-seven 7-8-year-old children, seventy-five 14-year-old adolescents, fifty-four 17-year-old adolescents, and 52 adult school staff were included, and immune responses to SARS-CoV-2 and HCoVs were assessed.Results: The SARS-CoV-2 seroprevalence was high in the older age groups (33%-41%). Seropositive individuals had significantly higher levels of antibodies against betacorona virus compared to seronegative individuals. SARS-CoV-2 seropositivity was rare among the 7-8-year-old children despite the high endemic context. SARS-CoV-2-specific T-cell responses in the absence of SARS-CoV-2-specific antibodies were seen in all age groups.Conclusion: The data support a role for cross-reactive immune responses induced by recent HCoV infections, with cross-reactive T-cell responses providing protection against COVID-19 in young children.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2616-2624"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socioeconomic Risk Factors for Incomplete Vaccination in Swedish Two-Year-Olds-A Nationwide, Population-Based Cohort Study. 瑞典两岁儿童不完全疫苗接种的社会经济风险因素——一项全国性、基于人群的队列研究

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-05-14 DOI: 10.1111/apa.70582

Cecilia Chrapkowska Almqvist, Ilias Galanis, Tiia Lepp, Malin Kark, Sharon Kühlmann-Berenzon, Anna Nilsson

{"title":"Socioeconomic Risk Factors for Incomplete Vaccination in Swedish Two-Year-Olds-A Nationwide, Population-Based Cohort Study.","authors":"Cecilia Chrapkowska Almqvist, Ilias Galanis, Tiia Lepp, Malin Kark, Sharon Kühlmann-Berenzon, Anna Nilsson","doi":"10.1111/apa.70582","DOIUrl":"10.1111/apa.70582","url":null,"abstract":"Aim: To analyse the association between specific socioeconomic measures and the risk of incomplete vaccination for diphtheria-tetanus-pertussis (DTP) and measles-containing vaccine (MCV) in Swedish two-year-olds.Methods: This nationwide, population-based cohort study included 227 457 children born in Sweden during 2014-2015. Data were obtained from the National Vaccination Register (NVR) and linked to socioeconomic data from Statistics Sweden. Multivariable logistic regression was used to estimate the associations between family characteristics-including income, education, employment, and family structure-and incomplete DTP and MCV vaccination at 24 months of age.Results: Incomplete vaccination was found in 13.1% of children for DTP3 (three doses) and 8.7% for MCV1 (one dose). Low family income, single parenthood, parental unemployment, frequent residential mobility, and parental immigration were risk factors for incomplete vaccination. A previously unreported risk factor was having a sibling with a disability or chronic disease, which increased the risk of incomplete DTP3 (aOR 1.15, 95% CI 1.05-1.27) and MCV1 (aOR 1.27, 95% CI 1.14-1.41).Conclusion: Despite a tax-funded national immunisation programme, socioeconomic disparities in vaccination coverage exist in Sweden. Children in socially vulnerable families, and those with siblings requiring disability support, need targeted interventions to ensure full immunisation.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2555-2565"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustained Vaccine Coverage During the Transition From 2-Dose to 3-Dose of Rota Virus Vaccines in Jönköping, Sweden. 瑞典Jönköping从2剂到3剂轮状病毒疫苗过渡期间的持续疫苗覆盖率

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-02-02 DOI: 10.1111/apa.70458

Carin Oldin, Marie Golsäter, Johanna Rubin, Maria Ekelund

引用次数: 0

A Global Perspective of Childhood Vaccinations: Past, Present, and Future-From Smallpox to mRNA. 儿童疫苗接种的全球视角：过去、现在和未来——从天花到mRNA。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-07-15 DOI: 10.1111/apa.70677

Tobias Alfvén, Tania Reza, Alieu Sowe

引用次数: 0

Normalising Vaccinations During Pregnancy Provides Benefits for Neonates and Infants. 怀孕期间疫苗接种正常化有利于新生儿和婴儿。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2025-07-10 DOI: 10.1111/apa.70225

Pauline F MacDonald

引用次数: 0

Perspectives on Pertussis Prevention. 百日咳预防的观点。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2025-11-19 DOI: 10.1111/apa.70377

Ulrich Heininger

引用次数: 0

A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors. 基于儿童癌症幸存者免疫重建的个性化疫苗接种计划。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-04-25 DOI: 10.1111/apa.70559

Menucha Jurkowicz, Raz Somech, Dan Dominissini, Nathan Keller, Efrat Dresner, Michal Paret, Gilad Sherman, Guy Katzenellenbogen, Elina Gelman, Keren Asraf, Ram Doolman, Atar Lev, Amos J Simon, Helly Vernitsky, Assaf Barg, Hana Golan, Amos Toren, Michal Stein

{"title":"A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors.","authors":"Menucha Jurkowicz, Raz Somech, Dan Dominissini, Nathan Keller, Efrat Dresner, Michal Paret, Gilad Sherman, Guy Katzenellenbogen, Elina Gelman, Keren Asraf, Ram Doolman, Atar Lev, Amos J Simon, Helly Vernitsky, Assaf Barg, Hana Golan, Amos Toren, Michal Stein","doi":"10.1111/apa.70559","DOIUrl":"10.1111/apa.70559","url":null,"abstract":"Aims: Paediatric cancer survivors often experience treatment-induced immunosuppression, requiring post-treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute-lymphoblastic-leukaemia (ALL), may not be applicable across all paediatric malignancies. This study evaluated a personalised revaccination approach based on immune recovery.Methods: Immune recovery was evaluated using antibody titers to common childhood vaccines, immunoglobulin levels, B- and T-cell subpopulations, and T-cell receptor excision circles (TREC) and kappa-deleting recombination excision circles (KREC) markers. The recommended revaccination window was defined as 3-6 months post-treatment. Patients completing immune and serology testing within this window were categorised as the per-protocol-group (PPG), while others were categorised as the protocol-deviated-group (PDG).Results: Among 19 PPG patients, 57.9% required major and 36.8% minor modifications to recommended revaccination guidelines, with major modifications more common among hematologic malignancies than solid tumours (83.3% vs. 46.2%, p < 0.0001). In the intention-to-treat (ITT) cohort (n = 52), 40.4% required major and 57.7% minor modifications; hematologic survivors again had higher rates of major modifications (52.9% vs. 34.3%, p = 0.008).Conclusions: Immune recovery following paediatric cancer therapy is highly variable, particularly among hematologic malignancies. Personalised revaccination strategies incorporating comprehensive immunological workups may optimise protection against vaccine-preventable diseases.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2603-2615"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Exposure Hepatitis B-Treatment in Newborns: A Qualitative Study on Interprofessional Practices in Norway. 新生儿暴露后乙肝治疗：挪威跨专业实践的定性研究

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-01-21 DOI: 10.1111/apa.70455

Brita Askeland Winje, Kristine Follstad, Ida Ueland, Signe Zenia Hulgaard-Bruvold, Margrethe Greve-Isdahl

{"title":"Post-Exposure Hepatitis B-Treatment in Newborns: A Qualitative Study on Interprofessional Practices in Norway.","authors":"Brita Askeland Winje, Kristine Follstad, Ida Ueland, Signe Zenia Hulgaard-Bruvold, Margrethe Greve-Isdahl","doi":"10.1111/apa.70455","DOIUrl":"10.1111/apa.70455","url":null,"abstract":"Aim: Children born to mothers with chronic Hepatitis B virus (HBV) infection are at substantial risk of developing chronic HBV-infection without appropriate perinatal post-exposure treatment. This study aimed to explore midwives' and public health nurses' (PHNs) experiences with HBV-post-exposure treatment for infants and identify factors influencing the timeliness of follow-up care.Methods: Data were collected through individual and focus group interviews with midwives and PHNs in hospitals and catchment-area municipalities and analysed with thematic analysis.Results: The study revealed significant vulnerabilities in the care pathway, primarily due to fragmented information sharing and a lack of seamless interprofessional collaboration between hospital and municipal healthcare services. Unclear roles, poor communication, and inconsistent documentation impede timely intervention. High workload and reliance on temporary staff further compromised continuity of care. Contrary, the within-hospital joint mother-child medical record and co-location of PHNs, general practitioners, and municipal antenatal care midwives enhanced implementation.Conclusions: Despite individual awareness of responsibilities, significant system-level challenges persist in ensuring effective interprofessional collaboration and holistic mother-infant pathways after perinatal HBV-exposure in Norway. System-based improvements, such as electronic pregnancy records and automated reporting to the National Immunisation Registry could improve documentation, easing communication and ensuring appropriate and timely follow-up for all high-risk infants.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2595-2602"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Inequality in the Uptake of Varicella Vaccination: A Danish Nationwide Observational Study. 水痘疫苗接种的社会不平等：丹麦全国观察性研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-05-16 DOI: 10.1111/apa.70593

Anne Cathrine Falch-Jørgensen, Rikke Færgemann Hansen, Natalie Clausen, Mette Boie, Thomas Le Fevre, Lasse Boding

{"title":"Social Inequality in the Uptake of Varicella Vaccination: A Danish Nationwide Observational Study.","authors":"Anne Cathrine Falch-Jørgensen, Rikke Færgemann Hansen, Natalie Clausen, Mette Boie, Thomas Le Fevre, Lasse Boding","doi":"10.1111/apa.70593","DOIUrl":"10.1111/apa.70593","url":null,"abstract":"Aim: Varicella is a highly contagious disease affecting approximately 90% of children before the age of 10, constituting a substantial health and societal burden. This study investigates the association between socio-demographic and socio-economic factors and uptake of varicella vaccination in Denmark, 2019-2024.Methods: This Danish cohort study included 1 356 841 individuals aged 1-18 years. Socio-demographic and socio-economic factors for children and their parents were obtained from Statistics Denmark's registers and linked to varicella vaccination status in the Danish Vaccination Register. We estimated yearly vaccination initiation and cumulative vaccine coverage. Associations were assessed using crude and adjusted multivariable logistic regression models.Results: As of 2024, 16 903 1-18 year olds had received at least one dose of the varicella vaccine, of whom 84% completed the series. Coverage increased markedly from 2019 to 2024 and was highest in the Capital Region and metropolitan municipalities. Vaccination was more likely among children of parents with higher education (aOR: 4.98, 95% CI: 4.05-6.12), higher income (aOR: 3.08, 95% CI: 2.85-3.33) and a background in medicine or nursing (aOR: 1.79, 95% CI: 1.72-1.88).Conclusion: Varicella vaccination uptake is higher among children from families with high socio-economic status, and this pattern persists over a 6-year period.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2545-2554"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paracetamol versus Ibuprofen Before and After Paediatric Vaccination: A Clinical Evidence Review. 对乙酰氨基酚与布洛芬在儿科疫苗接种前后：临床证据回顾。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-05-04 DOI: 10.1111/apa.70571

Gianvincenzo Zuccotti, Virginia Rossi, Valeria Calcaterra

{"title":"Paracetamol versus Ibuprofen Before and After Paediatric Vaccination: A Clinical Evidence Review.","authors":"Gianvincenzo Zuccotti, Virginia Rossi, Valeria Calcaterra","doi":"10.1111/apa.70571","DOIUrl":"10.1111/apa.70571","url":null,"abstract":"Aim: Post-vaccination fever is a common adaptive immune response. Antipyretics are frequently used in paediatric practice to manage symptoms; however, concerns have emerged regarding potential interference with vaccine-induced immunogenicity, particularly when administered prophylactically.Methods: A narrative review of paediatric studies assessing prophylactic and therapeutic use of paracetamol and ibuprofen after routine vaccinations was conducted. Evidence was derived from randomized trials, systematic reviews, and real-world health-economic analyses, focusing on fever, reactogenicity, antibody titers, and clinical safety.Results: Prophylactic paracetamol consistently reduced fever but was associated with attenuated antibody titers during the primary vaccine series, notably with pneumococcal conjugate vaccines. Ibuprofen showed no measurable immunogenic suppression but is not recommended as a routine preventive strategy. Therapeutic antipyretic use, administered only after symptom onset, demonstrated no negative effect on immune responses. Ibuprofen was more effective than paracetamol for fever reduction in symptomatic children but is unsuitable in infants < 6 months. Prophylactic paracetamol is selectively justified only in high-reactogenicity contexts (e.g., 4CMenB) or in children at risk of febrile seizures.Conclusions: Routine pre-dosing of antipyretics should be avoided. A symptom-based approach optimizes immune priming, ensures clinical safety, and supports adherence to vaccination schedules.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2491-2497"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0