Acta Paediatrica最新文献_第10页

EBNEO Commentary: Review of the 'Norepinephrine Versus Dopamine for Septic Shock in Neonates: A Randomised Controlled Trial'. EBNEO评论：“去甲肾上腺素与多巴胺治疗新生儿感染性休克：一项随机对照试验”综述。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-23 DOI: 10.1111/apa.70241

Gabriel Altit

引用次数: 0

Infant Acid-Suppressant Medication, C. difficile Colonisation, and Childhood Body Mass Index in a Canadian Cohort. 加拿大队列中婴儿抑酸药物、艰难梭菌定植和儿童体重指数。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-22 DOI: 10.1111/apa.70243

Sarah L Bridgman, Kelsea M Drall, Amanda A Lau, Hein M Tun, Nadia P Morales-Lizcano, Hien Q Huynh, Piushkumar J Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, James A Scott, Anita L Kozyrskyj

{"title":"Infant Acid-Suppressant Medication, C. difficile Colonisation, and Childhood Body Mass Index in a Canadian Cohort.","authors":"Sarah L Bridgman, Kelsea M Drall, Amanda A Lau, Hein M Tun, Nadia P Morales-Lizcano, Hien Q Huynh, Piushkumar J Mandhane, Theo J Moraes, Elinor Simons, Stuart E Turvey, Padmaja Subbarao, James A Scott, Anita L Kozyrskyj","doi":"10.1111/apa.70243","DOIUrl":"https://doi.org/10.1111/apa.70243","url":null,"abstract":"Aim: To determine relationships between paediatric use of acid-suppressive medications (ASMs) (proton pump inhibitors (PPI) and histamine-2 receptor antagonists (H2RA)) and preschool body mass index (BMI) and mediation by C. difficile colonisation.Methods: ASMs were parent-reported at age 3, 6 and 12 months in 1025 infants from the CHILD Cohort Study. Targeted qPCR for C. difficile was conducted in stool collected at 3 months, and age/sex adjusted BMI-z scores were calculated at age 5 years. ASM use and BMI-z score associations were assessed by regression, and mediation analyses were conducted.Results: Approximately 4% of infants received H2RAs, most before age 3 months. C. difficile colonisation was twice as likely in 3-month-old infants receiving H2RAs (OR: 2.27, 95% CI: 1.13-4.51) and was associated with higher BMI-z scores at age 5 years (β: 0.31, 95% CI: 0.16, 0.46). Mediation models showed an indirect positive effect of H2RA use on 5-year BMI-z scores, mediated through C. difficile colonisation (β: 0.065, 95% CI: 0.01, 0.13).Conclusions: We found evidence of increased preschool BMI following H2RA use in infants that was mediated through C. difficile colonisation. Further study on ASM use in infancy, the gut microbiome, and pathways to body weight health outcomes is warranted.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Limiting Sternal Tumour of Childhood: Recognition Prevents Unnecessary Diagnostics and Treatment. 儿童自限性胸骨肿瘤：识别防止不必要的诊断和治疗。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-21 DOI: 10.1111/apa.70231

Thomas Mol, Astrid Leus, Nathan Demeyere, Jaques van Heerden, Machiel van den Akker

{"title":"Self-Limiting Sternal Tumour of Childhood: Recognition Prevents Unnecessary Diagnostics and Treatment.","authors":"Thomas Mol, Astrid Leus, Nathan Demeyere, Jaques van Heerden, Machiel van den Akker","doi":"10.1111/apa.70231","DOIUrl":"https://doi.org/10.1111/apa.70231","url":null,"abstract":"Aim: Self-limiting sternal tumour of childhood (SELSTOC) is a rare, benign tumour, characterised by a rapidly growing pre- or parasternal mass in children up to 2 years of age. This review aimed to improve awareness among physicians and summarise the clinical features and outcomes of SELSTOC.Methods: We conducted PubMed and Google Scholar searches to collect data on children diagnosed with SELSTOC from the earliest records until July 2024. Three new cases from two Belgian paediatric hospitals (ZAS Queen Paola Children's Hospital and University Hospital Brussels) were included. Data on demographics, clinical presentation, diagnostics, treatment and outcomes were analysed.Results: Forty-one children were included (3 new cases) with a mean age of 14.0 ± 8.3 months and with a male predominance (25 males, 16 females). Fever occurred in 33% (13/39), pain or tenderness in 55% (21/38), discolouration in 33% (11/33) and warmth in 4% (1/23). Ultrasound was used in 90% (37/41), typically showing a hypoechoic, heterogeneous, avascular mass with pre-, para- and retrosternal components ('dumbbell' shape). All lesions resolved spontaneously within weeks to months.Conclusion: Greater clinical awareness of SELSTOC is essential to prevent unnecessary investigations and treatments, given its benign, self-limiting course.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBNEO Commentary: Reevaluating Dopamine for Hypotension in Extremely Preterm Infants: Insights From the HIP Trial Follow-Up. EBNEO评论：重新评估多巴胺对极早产儿低血压的作用：来自HIP试验随访的见解。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-21 DOI: 10.1111/apa.70236

N Rao, H Gowda

引用次数: 0

Trends in Birth Prevalence of Congenital Heart Defects in Norway-A Population Study 1994-2014. 挪威先天性心脏缺陷出生流行趋势——1994-2014年人口研究

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-21 DOI: 10.1111/apa.70235

Elisabeth Leirgul, Tatiana Fomina, Gottfried Greve, Grethe S Tell, Marit Sandberg, Nina Øyen

{"title":"Trends in Birth Prevalence of Congenital Heart Defects in Norway-A Population Study 1994-2014.","authors":"Elisabeth Leirgul, Tatiana Fomina, Gottfried Greve, Grethe S Tell, Marit Sandberg, Nina Øyen","doi":"10.1111/apa.70235","DOIUrl":"https://doi.org/10.1111/apa.70235","url":null,"abstract":"Aim: The prevalence of severe congenital heart defects (CHDs) has been declining in Europe, possibly because pregnancies with foetal anomalies are often terminated. We present trends in the prevalence of CHD among live births, stillbirths and terminated pregnancies over a 21-year period in Norway.Method: All births and terminated pregnancies registered in Norway's Medical Birth Registry from 1994-2014 were linked to information on CHDs and extracardiac birth defects or chromosomal aberrations found in national administrative and clinical registries.Results: We identified 18 838 individuals with CHD among the 1 261 952 live births, stillbirths and terminated pregnancies, which was 149.3 per 10 000. In live births, the CHD prevalence was 144.6 per 10 000. The prevalence of severe CHD increased from 27.1 in 1994 to 36.1 in 2004, then declined to 27.8 in 2014, with an overall prevalence of 32.1 per 10 000. In live births, the prevalence was 29.0 per 10 000. The prevalence of severe CHD in nonsyndromic births was 20.4 per 10 000, with no time trend. Septal defects increased continuously after 1994.Conclusion: From 2004-2014, the prevalence of severe CHD declined, primarily due to a decrease in syndromic CHD. This could likely be explained by pregnancy terminations. Septal defects increased over the entire study period.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmittance Mode of Time-Resolved Near-Infrared Spectroscopy for Monitoring Deeper Cerebral Tissues in Extremely Low-Birth-Weight Infants. 时间分辨近红外光谱透射模式监测极低出生体重儿深部脑组织。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-21 DOI: 10.1111/apa.70245

Toshiyuki Imanishi, Wakako Sumiya, Chika Kanno, Masayuki Kanno, Ken Kawabata, Masaki Shimizu

{"title":"Transmittance Mode of Time-Resolved Near-Infrared Spectroscopy for Monitoring Deeper Cerebral Tissues in Extremely Low-Birth-Weight Infants.","authors":"Toshiyuki Imanishi, Wakako Sumiya, Chika Kanno, Masayuki Kanno, Ken Kawabata, Masaki Shimizu","doi":"10.1111/apa.70245","DOIUrl":"https://doi.org/10.1111/apa.70245","url":null,"abstract":"Aim: To investigate the potential of the transmittance mode of time-resolved near-infrared spectroscopy, in which the source and detector probes are placed on the bilateral temporal region of the head, compared with the conventional reflectance mode in extremely low-birth-weight (ELBW) infants.Methods: Differences in cerebral tissue oxygen saturation (StO2) and cerebral blood volume (CBV) between the two modes were evaluated. Linear regression was performed to investigate contributing factors to StO2 and CBV.Results: Forty-nine ELBW infants (median gestational age, 24.9 weeks; mean birthweight, 672 g), including nine intraventricular haemorrhage (IVH) cases, were evaluated at a median of 14.0 days of age. StO2 and CBV values were significantly lower in the transmittance mode than in the reflectance mode. IVH was a significant contributor to StO2 and CBV. Two out of four cases with IVH grade 3 had larger ventricular dilations and showed outliers towards low StO2.Conclusion: The transmittance mode detected lower StO2 in ELBW infants as compared to the reflectance mode, especially in IVH cases. This was either due to the optical effects of the IVH itself and/or large dilated ventricles.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Authors Response: ‘Respiratory Function Monitor—Are We Ready for Its Use?’ 作者回应：“呼吸功能监测仪——我们准备好使用它了吗？”

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2025-07-19 DOI: 10.1111/apa.70238

Robert Joyce, Eugene Dempsey

引用次数: 0

Acute Kidney Injury and the Patent Ductus Arteriosus: A Complex Interplay 急性肾损伤与动脉导管未闭：复杂的相互作用。

IF 2.1 4区医学

Acta Paediatrica Pub Date : 2025-07-19 DOI: 10.1111/apa.70246

Dermot Wildes, Atif Awan, Afif El-Khuffash, Michael A. Boyle

引用次数: 0

Dysregulated Screen Exposure Is Associated With Severity of Language and Communication Impairments in Children With Developmental Disorders. 失调的屏幕暴露与发育障碍儿童语言和沟通障碍的严重程度有关。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-18 DOI: 10.1111/apa.70223

Andrea Hahnefeld, Monika Fink, Elena Hauber, Saskia Le Beherec, Marco Gassner, Matthias Klosinski, Volker Mall

{"title":"Dysregulated Screen Exposure Is Associated With Severity of Language and Communication Impairments in Children With Developmental Disorders.","authors":"Andrea Hahnefeld, Monika Fink, Elena Hauber, Saskia Le Beherec, Marco Gassner, Matthias Klosinski, Volker Mall","doi":"10.1111/apa.70223","DOIUrl":"https://doi.org/10.1111/apa.70223","url":null,"abstract":"Aim: While rising amounts of screen exposure for young children are reported, speech and language developmental disorders (DD) are also increasing. Vulnerable groups with combined risk factors are more affected, but less represented in the research. Our goal is to assess the amount and context of screen exposure in children referred for treatment and relate this to their language, cognitive and communication impairment.Methods: Retrospective analysis of medical records (parent ratings, child observations, standardised tests) for a random sample of 3-8-year-old children assessed by a multidisciplinary team of child experts at a social paediatric centre. Information about screen exposure in the home environment (screen exposure index, SEI), diagnoses and expert ratings were derived from reports and documentation.Results: Expert ratings yielded dysregulated screen exposure for 53% of the 73 children (mean age 4.7 years, SD 1.3, 82% male). Referred for suspected speech and language DD, 68% of the children were diagnosed with unspecific or mixed DD. Those with higher SEI ratings did not differ in IQ score, but received more unspecific or complex diagnoses and were rated as more severely impaired concerning language and communication.Conclusion: Screen exposure should be considered in diagnostic and therapeutic decisions.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synchronised Non-Invasive Intermittent Positive Pressure Ventilation in Very Preterm Infants After Birth: A Feasibility Study. 早产儿出生后同步无创间歇正压通气的可行性研究。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-07-16 DOI: 10.1111/apa.70220

Paul-Philipp Warth, Christoph Martin Rüegger, Vincent David Gaertner, Wolfgang Braun, Kriszta Molnar, Julian Brozek, Christian Friedrich Poets, Laila Springer

{"title":"Synchronised Non-Invasive Intermittent Positive Pressure Ventilation in Very Preterm Infants After Birth: A Feasibility Study.","authors":"Paul-Philipp Warth, Christoph Martin Rüegger, Vincent David Gaertner, Wolfgang Braun, Kriszta Molnar, Julian Brozek, Christian Friedrich Poets, Laila Springer","doi":"10.1111/apa.70220","DOIUrl":"https://doi.org/10.1111/apa.70220","url":null,"abstract":"Aim: During perinatal transition, breathing effort in preterm infants is largely inefficient. In the current study, we assessed the feasibility of synchronised non-invasive positive pressure ventilation (S-NIPPV) in very preterm infants as primary respiratory support in the delivery room.Methods: Single-center prospective feasibility study at Tübingen University Hospital. Preterm infants with a gestational age (GA) between 26 and 32 weeks received S-NIPPV during the first 10 min after birth. Synchronisation was achieved using a Graseby capsule; spontaneous breaths were detected by respiratory inductance plethysmography (RIP). Primary outcome was synchronisation rate.Results: Ten preterm infants with a median GA of 28.8 weeks (IQR 27.6-30.4) and a birth weight of 1028 g (819-1213) were included. S-NIPPV was started within 44 (41-73) seconds after arrival on the resuscitaire. Synchrony rate was 68% (56-76) despite infants being handled significantly and 33% (27-40) of the time interventions were performed.Conclusion: S-NIPPV as primary respiratory support after birth is feasible with reasonable synchrony, even though infants are frequently stimulated and handled. Future studies are needed to confirm the results of this small pilot study and to determine the effect of S-NIPPV on physiological and clinical outcomes.Trial registration: Feasibility and Reliability of Synchronized Non-invasive Intermittent Positive Pressure Ventilation in Preterm Infants After Birth (SenSyNoPP); www.Clinicaltrials: gov: NCT05399914.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0