Acta Paediatrica最新文献_第10页

How Hot Is Too Hot? Fever Thresholds for Initiating Antibiotics in Children With Haematological Malignancies. 多热才算太热？血液恶性肿瘤儿童启动抗生素的发热阈值。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-25 DOI: 10.1111/apa.70771

C S V Henriksen, U Nygaard, G Petersen, J Brok, L L Hjalgrim, N V Vissing, M B Mønster

引用次数: 0

Postnatally Acquired Cytomegalovirus Infection in Extremely Premature Infants: A Prospective Observational Cohort Study. 极早产儿出生后获得性巨细胞病毒感染：一项前瞻性观察队列研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-25 DOI: 10.1111/apa.70779

Sara Krøis Holm, Lise Aunsholt, Porntiva Poorisirak, Alex Christian Yde Nielsen, Rune Micha Pedersen, Bo Mølholm Hansen, Anne Mette Plomgaard, Karina Kwi Im Jordan, Hristo Stanchev, Maren Rytter, Tatjana Zaharov, Sven Bonato, Kia Schultz Dungu, Anja Poulsen, Susanne Søndergaard Kappel, Ulrikka Nygaard, Stine Lund

{"title":"Postnatally Acquired Cytomegalovirus Infection in Extremely Premature Infants: A Prospective Observational Cohort Study.","authors":"Sara Krøis Holm, Lise Aunsholt, Porntiva Poorisirak, Alex Christian Yde Nielsen, Rune Micha Pedersen, Bo Mølholm Hansen, Anne Mette Plomgaard, Karina Kwi Im Jordan, Hristo Stanchev, Maren Rytter, Tatjana Zaharov, Sven Bonato, Kia Schultz Dungu, Anja Poulsen, Susanne Søndergaard Kappel, Ulrikka Nygaard, Stine Lund","doi":"10.1111/apa.70779","DOIUrl":"https://doi.org/10.1111/apa.70779","url":null,"abstract":"Aim: Postnatally acquired cytomegalovirus (pCMV) infection may cause severe disease in extremely preterm infants, but its clinical significance remains uncertain. We investigated the incidence, timing, disease burden, and diagnostic performance of saliva screening.Method: In this prospective cohort study, infants born at < 28 weeks of gestation or with a birth weight < 1200 g to CMV-seropositive mothers and fed untreated mothers' own milk underwent weekly saliva and urine CMV polymerase chain reaction testing. Outcomes before discharge and at 2 years corrected age were compared between CMV-positive and CMV-negative infants.Results: Forty-five infants were included, of whom 20 (44%) acquired pCMV. CMV was detected at a median age of 44 days in saliva, 50 days in urine, and 55 days in blood. Two (10%) infected infants developed severe disease requiring antiviral treatment. No significant differences were observed in neonatal morbidity, hospitalisation duration, mortality, or neurodevelopmental outcomes. Saliva PCR demonstrated a sensitivity of 86% and a specificity of 93%.Conclusion: pCMV transmission was common in extremely preterm infants receiving mothers' own milk, but clinically significant disease occurred in only a minority of infected infants. Saliva-based screening demonstrated acceptable diagnostic performance and may facilitate early recognition and targeted management of clinically significant pCMV infection.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Blood Volume Collected and Contamination Rates of Blood Cultures in Paediatric Emergencies: A Study Protocol. 儿科急诊血容量与血培养污染率的关系：一项研究方案。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-24 DOI: 10.1111/apa.70776

Sonia Lorente, Sandra Garzón, Ana Romero, Laura Maestro, Vanessa Bonil, Abel Martínez-Mejías

{"title":"Relationship Between Blood Volume Collected and Contamination Rates of Blood Cultures in Paediatric Emergencies: A Study Protocol.","authors":"Sonia Lorente, Sandra Garzón, Ana Romero, Laura Maestro, Vanessa Bonil, Abel Martínez-Mejías","doi":"10.1111/apa.70776","DOIUrl":"https://doi.org/10.1111/apa.70776","url":null,"abstract":"Aim: Blood culture is the gold standard for diagnosing bloodstream infections and guiding antimicrobial therapy. However, the optimal blood volume for paediatric blood cultures remains uncertain. This study evaluated the effectiveness of a standardized paediatric blood culture collection protocol using age- and weight-adjusted blood volumes to reduce contamination rates while maintaining diagnostic performance.Methods: A cross-sectional study will be conducted in the paediatric emergency department of a tertiary hospital. All patients under 18 years of age undergoing blood culture collection were included. Data on blood collection practices, inoculated blood volume, contamination rates and culture positivity will be collected and analysed using STATA version 18.Results: Implementation of the protocol was expected to reduce blood culture contamination rates without compromising diagnostic yield. The study will assess the feasibility and effectiveness of using lower age- and weight-adjusted blood volumes in routine paediatric emergency care.Conclusions: If effective, this protocol may support the adoption of less invasive blood culture collection strategies, improving sample quality, reducing contamination and enhancing the safety and quality of care for paediatric patients.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response Letter to Dr. Lilitwat. 给Lilitwat博士的回复信。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-23 DOI: 10.1111/apa.70774

Helle Mølsted Alvesson, Ingela Zenk, Reza Rasti, Tobias Alfvén

引用次数: 0

Automated Insulin Delivery Reduces Overnight Diabetes Management by Caregivers While Improving Nocturnal Glycemic Control in Young Children With Type 1 Diabetes. 自动胰岛素输送减少护理人员夜间糖尿病管理，同时改善1型糖尿病幼儿夜间血糖控制

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-22 DOI: 10.1111/apa.70772

A-K Tuomaala, H Falk, P Oksanen, M-A Pulkkinen, T Varimo

引用次数: 0

Clinical Conditions Associated With Elevated Lactate Levels in Hospitalized Children. 住院儿童乳酸水平升高的临床状况

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-22 DOI: 10.1111/apa.70780

Eveliina Kuitunen, Ilari Kuitunen, Miika Arvonen, Marjo Renko

{"title":"Clinical Conditions Associated With Elevated Lactate Levels in Hospitalized Children.","authors":"Eveliina Kuitunen, Ilari Kuitunen, Miika Arvonen, Marjo Renko","doi":"10.1111/apa.70780","DOIUrl":"https://doi.org/10.1111/apa.70780","url":null,"abstract":"Aim: Lactate is included in adult septic shock criteria, but its role in paediatric sepsis is unclear. Recent guidelines propose lactate thresholds, though supporting evidence is limited. We aimed to identify conditions associated with elevated lactate in children and determine where levels are highest.Methods: We conducted a 10-year retrospective cohort study of patients < 17 years admitted to ICU or acute paediatric wards (2013-2023). Patients with elevated lactate were included. Diagnoses were grouped into 11 categories and underlying conditions into five groups. Maximum lactate levels were compared across diagnostic categories.Results: Among 3039 patients (4577 hospitalisations), 175 had lactate ≥ 5 mmol/L. Respiratory infections were most common (45.1%), while sepsis/meningitis accounted for 4%. Median lactate was highest in sepsis/meningitis, exceeding six other categories. Only five patients had lactate ≥ 11 mmol/L, mostly with sepsis/meningitis.Conclusions: Elevated lactate is common in hospitalised children and occurs across diverse conditions. Although highest in sepsis, most cases are non-septic. Lactate should be interpreted in a clinical context.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic Review and Meta-Analysis Suggested That Neutrophils Predominated the Airways of Children With the Respiratory Syncytial Virus. 系统评价和荟萃分析表明，中性粒细胞在呼吸道合胞病毒患儿气道中占主导地位。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-22 DOI: 10.1111/apa.70757

Muhammad Pradhika Mapindra, Naz Chughtai, Muhammad Pradhiki Mahindra, Paul McNamara, Cissy Kartasasmita, Malcolm Gracie Semple, Mahendra Tri Arif Sampurna, Howard Clark, Jens Madsen

{"title":"Systematic Review and Meta-Analysis Suggested That Neutrophils Predominated the Airways of Children With the Respiratory Syncytial Virus.","authors":"Muhammad Pradhika Mapindra, Naz Chughtai, Muhammad Pradhiki Mahindra, Paul McNamara, Cissy Kartasasmita, Malcolm Gracie Semple, Mahendra Tri Arif Sampurna, Howard Clark, Jens Madsen","doi":"10.1111/apa.70757","DOIUrl":"https://doi.org/10.1111/apa.70757","url":null,"abstract":"Aim: The respiratory syncytial virus (RSV) is a predominant aetiology of early-life respiratory infections. This systematic review and meta-analysis compared the cell types involved in airways inflammation in children with and without RSV, noting that immune responses can influence long-term complications and may involve different inflammatory cells.Method: We searched for relevant studies published in English on PubMed, Embase, Google Scholar and Web of Science until 31 August 2025. Bias assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklist. Heatmaps were generated and forest plots were created, with I2 values over 40% indicating heterogeneity.Results: The search identified 126 studies and a quantitative meta-analysis was conducted on six studies that comprised 202 with RSV and 97 unaffected controls. Compared to the controls, children with RSV showed increased percentages of neutrophils and decreased macrophages in their bronchoalveolar lavage fluid. Forest plots revealed that the pooled standard mean differences and 95% confidence intervals for neutrophil and macrophage percentages were 2.12 (1.74 to 2.50) and -3.14 (-4.16 to -2.12), respectively.Conclusion: Overall, this systematic review and meta-analysis suggested that neutrophils predominated in the airways of children with RSV. This highlights the value of investigating these in future studies.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is Screening of Adult Emergency Patients for Child Maltreatment Acceptable? 对儿童虐待的成人急诊病人进行筛查是否可以接受？

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-21 DOI: 10.1111/apa.70773

Staffan Janson, Ingemar Engström

引用次数: 0

Incidence and Risk Factors of Late-Onset Hypoglycemia in Extremely Low Gestational Age or Extremely Low Birth Weight Infants. 极低胎龄或极低出生体重儿迟发性低血糖的发生率及危险因素

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-09-19 DOI: 10.1111/apa.70759

Lara Canova, Roland P Neumann, Sven M Schulzke

引用次数: 0

Point-of-Care Testing Needs a Communication and Safety-Netting Pathway. 护理点测试需要一个沟通和安全网络途径。