{"title":"Authors Response: 'Respiratory Function Monitor-Are We Ready for Its Use?'","authors":"Robert Joyce, Eugene Dempsey","doi":"10.1111/apa.70238","DOIUrl":"https://doi.org/10.1111/apa.70238","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dermot Wildes, Atif Awan, Afif El-Khuffash, Michael A Boyle
{"title":"Acute Kidney Injury and the Patent Ductus Arteriosus: A Complex Interplay.","authors":"Dermot Wildes, Atif Awan, Afif El-Khuffash, Michael A Boyle","doi":"10.1111/apa.70246","DOIUrl":"https://doi.org/10.1111/apa.70246","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Hahnefeld, Monika Fink, Elena Hauber, Saskia Le Beherec, Marco Gassner, Matthias Klosinski, Volker Mall
{"title":"Dysregulated Screen Exposure Is Associated With Severity of Language and Communication Impairments in Children With Developmental Disorders.","authors":"Andrea Hahnefeld, Monika Fink, Elena Hauber, Saskia Le Beherec, Marco Gassner, Matthias Klosinski, Volker Mall","doi":"10.1111/apa.70223","DOIUrl":"https://doi.org/10.1111/apa.70223","url":null,"abstract":"<p><strong>Aim: </strong>While rising amounts of screen exposure for young children are reported, speech and language developmental disorders (DD) are also increasing. Vulnerable groups with combined risk factors are more affected, but less represented in the research. Our goal is to assess the amount and context of screen exposure in children referred for treatment and relate this to their language, cognitive and communication impairment.</p><p><strong>Methods: </strong>Retrospective analysis of medical records (parent ratings, child observations, standardised tests) for a random sample of 3-8-year-old children assessed by a multidisciplinary team of child experts at a social paediatric centre. Information about screen exposure in the home environment (screen exposure index, SEI), diagnoses and expert ratings were derived from reports and documentation.</p><p><strong>Results: </strong>Expert ratings yielded dysregulated screen exposure for 53% of the 73 children (mean age 4.7 years, SD 1.3, 82% male). Referred for suspected speech and language DD, 68% of the children were diagnosed with unspecific or mixed DD. Those with higher SEI ratings did not differ in IQ score, but received more unspecific or complex diagnoses and were rated as more severely impaired concerning language and communication.</p><p><strong>Conclusion: </strong>Screen exposure should be considered in diagnostic and therapeutic decisions.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul-Philipp Warth, Christoph Martin Rüegger, Vincent David Gaertner, Wolfgang Braun, Kriszta Molnar, Julian Brozek, Christian Friedrich Poets, Laila Springer
{"title":"Synchronised Non-Invasive Intermittent Positive Pressure Ventilation in Very Preterm Infants After Birth: A Feasibility Study.","authors":"Paul-Philipp Warth, Christoph Martin Rüegger, Vincent David Gaertner, Wolfgang Braun, Kriszta Molnar, Julian Brozek, Christian Friedrich Poets, Laila Springer","doi":"10.1111/apa.70220","DOIUrl":"https://doi.org/10.1111/apa.70220","url":null,"abstract":"<p><strong>Aim: </strong>During perinatal transition, breathing effort in preterm infants is largely inefficient. In the current study, we assessed the feasibility of synchronised non-invasive positive pressure ventilation (S-NIPPV) in very preterm infants as primary respiratory support in the delivery room.</p><p><strong>Methods: </strong>Single-center prospective feasibility study at Tübingen University Hospital. Preterm infants with a gestational age (GA) between 26 and 32 weeks received S-NIPPV during the first 10 min after birth. Synchronisation was achieved using a Graseby capsule; spontaneous breaths were detected by respiratory inductance plethysmography (RIP). Primary outcome was synchronisation rate.</p><p><strong>Results: </strong>Ten preterm infants with a median GA of 28.8 weeks (IQR 27.6-30.4) and a birth weight of 1028 g (819-1213) were included. S-NIPPV was started within 44 (41-73) seconds after arrival on the resuscitaire. Synchrony rate was 68% (56-76) despite infants being handled significantly and 33% (27-40) of the time interventions were performed.</p><p><strong>Conclusion: </strong>S-NIPPV as primary respiratory support after birth is feasible with reasonable synchrony, even though infants are frequently stimulated and handled. Future studies are needed to confirm the results of this small pilot study and to determine the effect of S-NIPPV on physiological and clinical outcomes.</p><p><strong>Trial registration: </strong>Feasibility and Reliability of Synchronized Non-invasive Intermittent Positive Pressure Ventilation in Preterm Infants After Birth (SenSyNoPP); www.</p><p><strong>Clinicaltrials: </strong>gov: NCT05399914.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yazan Al Abed, Araz Rawshani, Aidin Rawshani, Björn Eliasson, Mohammad Al Masri, Gustaf Lernfelt, Daniel Novak, Joanna Pestalozzi, Maria Henningsson
{"title":"The Incidence of Type 1 Diabetes in Sweden During 2008-2021.","authors":"Yazan Al Abed, Araz Rawshani, Aidin Rawshani, Björn Eliasson, Mohammad Al Masri, Gustaf Lernfelt, Daniel Novak, Joanna Pestalozzi, Maria Henningsson","doi":"10.1111/apa.70226","DOIUrl":"https://doi.org/10.1111/apa.70226","url":null,"abstract":"<p><strong>Aims: </strong>We analysed type 1 diabetes incidence in individuals aged 0-24 years from 2008 to 2021, with a focus on age at onset and potential changes during the COVID-19 pandemic.</p><p><strong>Methods: </strong>Type 1 diabetes incidence was assessed using insulin prescriptions from the Prescribed Drug Register. One or more prescriptions defined a case in males; three or more were required in females. Data were stratified into 5-year age groups and analysed over the 2008-2021 period.</p><p><strong>Results: </strong>Type 1 diabetes incidence increased by 12% in individuals aged 0-24 years in 2021 compared to 2008-2019. The highest 2021 incidence was observed in the 0-4, 5-9 and 20-24 age groups. The 10-14 group consistently had the highest rates overall, followed by 5-9, 15-19, 20-24 and 0-4. Incidence was stable prepandemic, and a significant decline in age at onset was observed over time.</p><p><strong>Conclusions: </strong>A shift in the age of onset of type 1 diabetes towards younger ages was observed between 2008 and 2021. The increased incidence in 2021 could be influenced by a possible delayed effect of the widespread SARS-CoV-2 infections during the COVID-19 pandemic.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilari Kuitunen, Panu Kiviranta, Marjut Haapanen, Peter G Davis
{"title":"Development and Content of Core Outcome Sets in Neonatology-A Scoping Review.","authors":"Ilari Kuitunen, Panu Kiviranta, Marjut Haapanen, Peter G Davis","doi":"10.1111/apa.70232","DOIUrl":"https://doi.org/10.1111/apa.70232","url":null,"abstract":"<p><strong>Aim: </strong>To identify subgroups of neonates for whom core outcome sets (COS) have been developed, the outcomes that were included and the methods used in their formulation.</p><p><strong>Methods: </strong>We performed a scoping review and searched databases in April 2025 for published COS. We included COS that reported neonatal outcomes, even when the original interventions targeted pregnant individuals. Methods of COS development and the included outcomes were extracted for descriptive analysis.</p><p><strong>Results: </strong>A total of 363 abstracts were screened and 34 COS studies included for analysis. The most used methods were modified Delphi and Delphi consensus methods, consisting of a median of three rounds and a consensus meeting. Overall, a total of 62 distinct neonatal outcomes were proposed. The five most commonly included outcomes were neonatal mortality, preterm birth, birth weight, need for neonatal intensive care unit admission and neurodevelopment.</p><p><strong>Conclusion: </strong>We found that the neonatal core outcome sets had clear heterogeneity in their selected outcomes. Future primary studies and evidence reviews should aim to focus on including important outcomes, when possible, to improve consistency in reporting.</p><p><strong>Protocol registration: </strong>Protocol was registered to open science framework and is available from https://osf.io/yngbd/.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Risk Factors for Hearing Loss Are Comparable in Preterm Versus Term Children: A Systematic Review.","authors":"Pauline Roehrs, Anna-Katharina Rohlfs, Reinhard Vonthein, Camilla Simon, Juliane Spiegler","doi":"10.1111/apa.70222","DOIUrl":"https://doi.org/10.1111/apa.70222","url":null,"abstract":"<p><strong>Aim: </strong>Hearing loss occurs more frequently in preterm children. However, the influence of prematurity itself is unclear. We examined whether risk factors for hearing loss differ between preterm and term infants.</p><p><strong>Methods: </strong>We conducted a systematic search of three databases in March 2023 for studies comparing risk factors for hearing loss in preterm and term children. Studies on postnatal trauma, chemotherapy or infections after the age of 5 years were excluded. Risk of bias was assessed. Data were extracted and analyzed using logistic regression to yield odds ratios (95% confidence interval).</p><p><strong>Results: </strong>Of 10 300 studies screened, 16 met the inclusion criteria, including 9059 preterm and 10 048 term children. Only one study compared risk factors between preterm and term infants as primary outcomes. It identified an increased risk in the preterm but not term group with mechanical ventilation exceeding 5 days, sepsis, and ototoxic medication. No significant differences were found when both groups shared these risk factors, suggesting that prematurity may not be an independent risk factor. Other studies reported variable results.</p><p><strong>Conclusion: </strong>Evidence of different effect sizes of risk factors in preterm and term children remains inconclusive. Preterm children acquire more risk factors in the neonatal period.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"High Body Fat in Normal Weight Girls Links to Inflammation and Cardiometabolic Risk\".","authors":"Rachana Mehta, Ranjana Sah","doi":"10.1111/apa.70233","DOIUrl":"https://doi.org/10.1111/apa.70233","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patent Ductus Arteriosus in Acute Kidney Injury in Preterm Neonates: One Size Does Not Fit All.","authors":"Sascha Meyer, Martin Poryo","doi":"10.1111/apa.70234","DOIUrl":"https://doi.org/10.1111/apa.70234","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Goldberg, Eva Wiberg-Itzel, Joanna Tingström, Cecilia Ekéus
{"title":"Neonatal Outcomes Among Neonates of Women With and Without Type 1 Diabetes in Sweden From 2010 to 2022.","authors":"Alexandra Goldberg, Eva Wiberg-Itzel, Joanna Tingström, Cecilia Ekéus","doi":"10.1111/apa.70230","DOIUrl":"https://doi.org/10.1111/apa.70230","url":null,"abstract":"<p><strong>Aim: </strong>This register-based study aimed to investigate differences in adverse neonatal outcomes between neonates born to mothers with and without type 1 diabetes in Sweden.</p><p><strong>Methods: </strong>A nationwide cohort study was conducted using the Swedish Medical Birth Register, including all singleton births from 22 gestational weeks between 2010 and 2022. The neonatal outcomes among neonates of women with and without type 1 diabetes were studied with descriptive statistics and logistic regressions. Adjusted odds ratios (aORs) with 95% confidence intervals are presented.</p><p><strong>Results: </strong>The study consisted of 1 402 394 neonates, and 0.5% had a mother with type 1 diabetes. Neonates of mothers with type 1 diabetes had increased odds of stillbirth (aOR 2.54; 95% CI 1.98-3.28), congenital malformations (aOR 1.66; 95% CI 1.50-1.84), preterm birth (aOR 3.80; 95% CI 3.41-4.23), large for gestational age (aOR 22.0; 95% CI 20.9-23.1), hypoglycaemia (aOR 45.85; 95% CI 43.60-48.22), and neonatal death (aOR 4.1; 95% CI 3.00-5.83).</p><p><strong>Conclusion: </strong>Neonates of mothers with type 1 diabetes continue to experience poorer neonatal outcomes, highlighting the need for more research on the causes and how care can be improved for their mothers during pregnancy.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}