Acta Paediatrica最新文献_第2页

Fever duration enhanced biomarker sensitivity in diagnosing radiographically confirmed community-acquired pneumonia in children.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-16 DOI: 10.1111/apa.17531

Ori Goldberg, Einat Shmueli, Yoel Levinsky, Yoav Vardi, Noga Yaniv, Ophir Bar-On, Hagit Levine, Ron Berant, Meir Mei Zahav, Dario Prais, Patrick Stafler

{"title":"Fever duration enhanced biomarker sensitivity in diagnosing radiographically confirmed community-acquired pneumonia in children.","authors":"Ori Goldberg, Einat Shmueli, Yoel Levinsky, Yoav Vardi, Noga Yaniv, Ophir Bar-On, Hagit Levine, Ron Berant, Meir Mei Zahav, Dario Prais, Patrick Stafler","doi":"10.1111/apa.17531","DOIUrl":"https://doi.org/10.1111/apa.17531","url":null,"abstract":"Aim: Our aim was to examine how fever duration affected the ability of biomarkers to diagnose community-acquired pneumonia (CAP).Methods: This was a retrospective cohort study of children aged 2-18 years who attended the emergency department at Schneider Children's Medical Centre of Israel with CAP from June 2015 to May 2020. The children underwent biomarker measurements and chest radiographs and optimal biomarker thresholds were identified. Biomarker predictions of x-ray positive CAP were analysed, using receiver operating characteristic curves and area under the curve calculations.Results: We screened 3346 children, 509 met the inclusion criteria and 363 of those had x-ray positive CAP. White blood counts of >15 000/mm3 and absolute neutrophil counts of >11 200/mm3 showed significant discriminatory power on day 2 of a fever. A neutrophil to lymphocyte ratio (NLR) of >4.5 displayed significant discriminatory power from days 2-5 and peaked on day 4. C-reactive protein of 6.23 mg/dL was discriminatory on day 4.Conclusion: Fever duration affected how effectively biomarkers diagnosed x-ray positive CAP and all were unreliable on day 1. The NLR showed the most consistent reliability and may be suitable for clinical decision-making. Fever duration should be considered to optimise diagnostic accuracy.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closed-loop automated oxygen control in late preterm and term, ventilated infants: A randomised controlled trial. 晚期早产儿和足月通气婴儿的闭环自动氧气控制：随机对照试验。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-14 DOI: 10.1111/apa.17549

Ourania Kaltsogianni, Allan Jenkinson, Christopher Harris, Eleanor Jeffreys, Oishi Sikdar, Anne Greenough, Theodore Dassios

{"title":"Closed-loop automated oxygen control in late preterm and term, ventilated infants: A randomised controlled trial.","authors":"Ourania Kaltsogianni, Allan Jenkinson, Christopher Harris, Eleanor Jeffreys, Oishi Sikdar, Anne Greenough, Theodore Dassios","doi":"10.1111/apa.17549","DOIUrl":"https://doi.org/10.1111/apa.17549","url":null,"abstract":"Aim: To compare the time spent above the target oxygen saturation range (SpO2 > 96%) and the duration of supplemental oxygen between ventilated infants receiving closed-loop automated oxygen control (CLAC) or manual oxygen control in late preterm and term ventilated infants.Methods: Infants were randomised to receive CLAC or manual oxygen control from recruitment and within 24 h of mechanical ventilation until successful extubation.Results: Forty infants with a median (IQR) gestational age of 37.4 (35.9-38.5) weeks were studied at a corrected postmenstrual age of 37.6 (36.0-38.7) weeks. In infants randomised to CLAC (n = 18) the time spent above the target oxygen saturation range was reduced by 20% (p < 0.001), and the time spent in the target range (92%-96%) was increased by 32% (p < 0.001) and the time spent in hyperoxia was reduced (p = 0.003). CLAC reduced the time spent in hypoxemia (SpO2 < 85%) (p = 0.017) and there were fewer manual adjustments to the inspired oxygen concentration (FiO2) (p < 0.001). There was no significant difference in the duration of supplemental oxygen (p = 0.271).Conclusion: CLAC in ventilated infants born at or near term was associated with reduced time spent in hyperoxemia, more time spent in the target oxygen range, and fewer manual adjustments to the FiO2.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary concerning 'The prevalence of overweight among 4-year-old during and after the COVID-19 pandemic was associated with socioeconomic burden'.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-13 DOI: 10.1111/apa.17538

Benjamin Tangkamolsuk, Quang La, David F Lo

引用次数: 0

Paediatric acute peripheral facial palsy: To LP or not to LP? An emerging dilemma in Central and Northern Europe.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-12 DOI: 10.1111/apa.17547

Ioannis Orfanos

引用次数: 0

Reducing severe intraventricular haemorrhage rates in <26-week preterm infants with bedside assessment and care bundle implementation.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-12 DOI: 10.1111/apa.17542

Ian Tang, Simone Huntingford, Lindsay Zhou, Catherine Fox, Taryn Miller, Mohan B Krishnamurthy, Flora Y Wong

{"title":"Reducing severe intraventricular haemorrhage rates in <26-week preterm infants with bedside assessment and care bundle implementation.","authors":"Ian Tang, Simone Huntingford, Lindsay Zhou, Catherine Fox, Taryn Miller, Mohan B Krishnamurthy, Flora Y Wong","doi":"10.1111/apa.17542","DOIUrl":"https://doi.org/10.1111/apa.17542","url":null,"abstract":"Aim: To assess staff adherence to a 'Preterm Brain Injury Prevention Bundle', and its effectiveness in reducing severe intraventricular haemorrhage (IVH) rates and risk factors in extremely preterm infants born at <26 weeks' gestation.Methods: Adherence to the bundle was assessed using a novel bedside assessment tool, with immediate feedback to bedside staff post-assessment. Data on IVH rates and associated risk factors were stratified by IVH severity, and compared between pre- and post-bundle implementation.Results: Of 203 bedside assessments, good adherence was observed in 12/28 items (43%), while the remaining items required improvement. Rates of grade 3/4 IVH reduced (39.2% pre-bundle vs. 19.0% post-bundle, p = 0.13). Thermoregulation and base excess improved (p = 0.02 and p = 0.04 respectively) after bundle implementation.Conclusion: Reduced severe IVH rates post-bundle implementation may be attributed to staff education and improved clinical parameters. Adherence to the bundle interventions varied which highlighted target areas for future education.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonattendance in preventive child health examinations associated with increased risk of school-aged obesity in Denmark.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-12 DOI: 10.1111/apa.17545

Signe Heuckendorff, René Børge Korsgaard Brund, Charlotte Nørkjær Eggertsen, Janus Laust Thomsen, Kirsten Fonager

{"title":"Nonattendance in preventive child health examinations associated with increased risk of school-aged obesity in Denmark.","authors":"Signe Heuckendorff, René Børge Korsgaard Brund, Charlotte Nørkjær Eggertsen, Janus Laust Thomsen, Kirsten Fonager","doi":"10.1111/apa.17545","DOIUrl":"https://doi.org/10.1111/apa.17545","url":null,"abstract":"Aim: The aim of this study is to investigate associations between attending routine preventive child health examinations in general practice and the risk of obesity and overweight at age six, focusing on psychosocial risk factors.Methods: Data from nationwide Danish registers on 725 926 children born between 2000 and 2012 were analysed. Information on examination attendance and BMI was obtained. Regression analyses assessed the association between examination attendance and obesity or overweight risk.Results: Non-attendance in preventive child health examinations was associated with a risk of obesity of 18%-31% at age six. The highest risk was observed in children of parents with low educational attainment who missed all examinations, a four- to five-fold increase compared to children of parents with high educational attainment who attended all or missed only one exam. A smaller association of one to 2% was found between missing examinations and risk of overweight in the general population. However, children of parents with low educational attainment who did not attend were 8%-9% more likely to have overweight.Conclusion: Associations were found between obesity and overweight and not attending preventive child health examinations in general practice. Further research is needed to understand the mechanisms and develop targeted interventions to address health disparities in childhood obesity.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal changes in smoking prevalence among adolescents across 23 countries.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-11 DOI: 10.1111/apa.17543

Seohyun Hong, Yejun Son, Myeongcheol Lee, Jaeyu Park, Hayeon Lee, Hyeri Lee, Hojae Lee, Hyejun Kim, Elena Dragioti, Guillaume Fond, Laurent Boyer, Guillermo F López Sánchez, Mark A Tully, Masoud Rahmati, Selin Woo, Dong Keon Yon, Lee Smith

{"title":"Temporal changes in smoking prevalence among adolescents across 23 countries.","authors":"Seohyun Hong, Yejun Son, Myeongcheol Lee, Jaeyu Park, Hayeon Lee, Hyeri Lee, Hojae Lee, Hyejun Kim, Elena Dragioti, Guillaume Fond, Laurent Boyer, Guillermo F López Sánchez, Mark A Tully, Masoud Rahmati, Selin Woo, Dong Keon Yon, Lee Smith","doi":"10.1111/apa.17543","DOIUrl":"https://doi.org/10.1111/apa.17543","url":null,"abstract":"Aim: This study aimed to investigate temporal changes in smoking prevalence among adolescents aged 13-15 across 23 countries and to assess individual and country-level factors influencing smoking behaviour.Methods: This study used data from 168 286 young adolescents aged 13-15 years obtained from the Global School-based Student Health, 2003-2021. Linear regression models and meta-analyses were conducted to analyse the changes in current smoking prevalence among young adolescents.Results: Among the 23 countries, smoking prevalence decreased in six countries, including Argentina, Fiji, Jamaica, Samoa, Tonga and Uruguay, while it increased in four countries, namely Guyana, Morocco, Thailand and Vanuatu. The prevalence of smoking was higher among male adolescents at 15.5% (95% CI 13.8%-17.2%) compared to females at 8.0% (95% CI 6.7%-9.3%). Adolescents exposed to secondhand smoke had a prevalence of 16.3% (95% CI 14.5%-18.2%), significantly higher than 4.2% (95% CI 3.7-4.6) in those not exposed. Smoking prevalence was 16.5% (95% CI 14.8%-18.2%) among those with smoking parents or guardians, compared to 8.1% (95% CI 7.1%-9.1%) among those without.Conclusion: The findings highlight the need for tailored tobacco control measures to reduce adolescent smoking globally. Strengthening policy enforcement and addressing social determinants of smoking are critical to achieving further reductions.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amplitude-integrated electroencephalography showed alterations in cerebral activity in monochorionic twins with twin-to-twin transfusion syndrome.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-09 DOI: 10.1111/apa.17532

Christina Schreiner, Anna Staudt, Vera Neubauer, Ursula Kiechl-Kohlendorfer, Elke Griesmaier

{"title":"Amplitude-integrated electroencephalography showed alterations in cerebral activity in monochorionic twins with twin-to-twin transfusion syndrome.","authors":"Christina Schreiner, Anna Staudt, Vera Neubauer, Ursula Kiechl-Kohlendorfer, Elke Griesmaier","doi":"10.1111/apa.17532","DOIUrl":"https://doi.org/10.1111/apa.17532","url":null,"abstract":"Aim: Monochorionic twins are at higher risk of perinatal mortality and morbidity, primarily due to pregnancy-related complications, such as twin-to-twin transfusion syndrome (TTTS). We aimed to investigate whether amplitude-integrated electroencephalography (aEEG) signals are different between monochorionic twins with and without TTTS.Methods: This was a retrospective single-centre study conducted at Innsbruck Medical University Hospital, Austria. Preterm infants born before 32 weeks of gestation between 6 November 2010 and 6 December 2022 were eligible. The aEEG was analysed for the total maturation score, its component scores and the number of sleep-wake cycles per hour.Results: We enrolled 79 monochorionic twin infants (48% male) and 157 dichorionic (62% male) twin infants. We found no differences between these two groups of preterm infants regarding the total maturation and component scores, or the number of sleep wake cycles. Monochorionic twins with TTTS showed significantly lower total maturation scores and individual component scores compared to monochorionic twins without TTTS.Conclusion: Preterm infants with TTTS showed differences in neonatal aEEG signals. Whether these differences are caused by prematurity-related or TTTS-related factors, such as hemodynamic and metabolic changes due to placental anastomoses, should be investigated in future prospective studies, to gain more insight into this important topic.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between growth and childhood body composition in very preterm, late preterm and term children.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-09 DOI: 10.1111/apa.17534

David A Nyakotey, Greg D Gamble, Christopher J D McKinlay, Frank H Bloomfield, Jane E Harding

{"title":"Associations between growth and childhood body composition in very preterm, late preterm and term children.","authors":"David A Nyakotey, Greg D Gamble, Christopher J D McKinlay, Frank H Bloomfield, Jane E Harding","doi":"10.1111/apa.17534","DOIUrl":"https://doi.org/10.1111/apa.17534","url":null,"abstract":"Aim: To determine how gestational age at birth and postnatal growth relate to body composition in childhood.Methods: We calculated conditional growth (birth-2 years, 2 years-6 years) and measured body composition at 2 and 6 years using bioelectrical impedance in cohorts of New Zealand children born very preterm (VPT; 23-31 weeks), late preterm (LPT; 35- <37 weeks) and term (≥37 weeks). We explored the relationships between growth and fat mass (FM) index and fat-free mass (FFM) index at 6 years using multivariable linear regression.Results: Of 1125 children (51% male), 202 were VPT, 114 LPT and 809 Term. Compared to Term, VPT but not LPT were lighter and shorter at 2 and 6 years and had lower FM index and FFM index. The association between weight growth from 2 to 6 years and both FM index and FFM index at 6 years was stronger than for weight growth from birth to 2 years or height growth at any period in all gestational age groups.Conclusions: Size and body composition at 2 and 6 years are different between infants born VPT, but not LPT, and at term. Later weight growth is more strongly associated with childhood body composition than earlier growth.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep profiles and their associations with adiposity and cardiorespiratory fitness among adolescents.

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2024-12-09 DOI: 10.1111/apa.17537

Peter Bakalár, David Janda, Michaela Kostičová, Jaroslava Kopčáková, Peter Kolarčik, Petr Badura, Aleš Gába

{"title":"Sleep profiles and their associations with adiposity and cardiorespiratory fitness among adolescents.","authors":"Peter Bakalár, David Janda, Michaela Kostičová, Jaroslava Kopčáková, Peter Kolarčik, Petr Badura, Aleš Gába","doi":"10.1111/apa.17537","DOIUrl":"https://doi.org/10.1111/apa.17537","url":null,"abstract":"Aim: This study aimed to identify sleep profiles in a representative sample of Slovak adolescents and investigate their associations with adiposity indicators and cardiorespiratory fitness.Methods: Data from the 2022 Health Behaviour in School-aged Children (HBSC) study conducted in Slovakia were analysed. Survey questions on sleep duration and problems from the entire HBSC sample (n = 8906) were used to identify sleep profiles. Associations with adiposity indicators and cardiorespiratory fitness were investigated in a subsample of 924 adolescents (average age 13.3 ± 1.48; 56.2% boys) who completed the HBSC survey, bioimpedance analysis, and 20-metre shuttle run test.Results: Three sleep profiles were identified-optimal sleepers, optimal sleepers with sporadic sleep problems and poor sleepers. Crude models showed that poor sleepers had significantly higher body fat percentage and fat mass index, along with lower cardiorespiratory fitness, compared to optimal sleepers. After adjustment, only the association between sleep profiles and cardiorespiratory fitness remained significant.Conclusion: The observed associations between sleep profiles and cardiorespiratory fitness may help better target future intervention resources towards adolescents with low cardiorespiratory fitness levels.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0