Gianvincenzo Zuccotti, Virginia Rossi, Valeria Calcaterra
{"title":"Paracetamol versus Ibuprofen Before and After Paediatric Vaccination: A Clinical Evidence Review.","authors":"Gianvincenzo Zuccotti, Virginia Rossi, Valeria Calcaterra","doi":"10.1111/apa.70571","DOIUrl":"https://doi.org/10.1111/apa.70571","url":null,"abstract":"<p><strong>Aim: </strong>Post-vaccination fever is a common adaptive immune response. Antipyretics are frequently used in paediatric practice to manage symptoms; however, concerns have emerged regarding potential interference with vaccine-induced immunogenicity, particularly when administered prophylactically.</p><p><strong>Methods: </strong>A narrative review of paediatric studies assessing prophylactic and therapeutic use of paracetamol and ibuprofen after routine vaccinations was conducted. Evidence was derived from randomized trials, systematic reviews, and real-world health-economic analyses, focusing on fever, reactogenicity, antibody titers, and clinical safety.</p><p><strong>Results: </strong>Prophylactic paracetamol consistently reduced fever but was associated with attenuated antibody titers during the primary vaccine series, notably with pneumococcal conjugate vaccines. Ibuprofen showed no measurable immunogenic suppression but is not recommended as a routine preventive strategy. Therapeutic antipyretic use, administered only after symptom onset, demonstrated no negative effect on immune responses. Ibuprofen was more effective than paracetamol for fever reduction in symptomatic children but is unsuitable in infants < 6 months. Prophylactic paracetamol is selectively justified only in high-reactogenicity contexts (e.g., 4CMenB) or in children at risk of febrile seizures.</p><p><strong>Conclusions: </strong>Routine pre-dosing of antipyretics should be avoided. A symptom-based approach optimizes immune priming, ensures clinical safety, and supports adherence to vaccination schedules.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sami-Matti Ruuska, Katinka Tuisku, Timo Holttinen, Riittakerttu Kaltiala
{"title":"Response to the Critique by Bahry of Ruuska et al.","authors":"Sami-Matti Ruuska, Katinka Tuisku, Timo Holttinen, Riittakerttu Kaltiala","doi":"10.1111/apa.70573","DOIUrl":"https://doi.org/10.1111/apa.70573","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EBNEO Commentary: Expectant Management Versus Medication for Patent Ductus Arteriosus in Preterm Infants-The PDA RCT.","authors":"Tim Hundscheid, Willem P de Boode","doi":"10.1111/apa.70563","DOIUrl":"https://doi.org/10.1111/apa.70563","url":null,"abstract":"<p><p>Critically Appraised Summary Table (CAST) for the \"Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants: The PDA Randomized Clinical Trial.\"</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta PaediatricaPub Date : 2026-05-01Epub Date: 2026-02-28DOI: 10.1111/apa.70495
Lotta Immeli, Pamela Douglas, Kaija-Leena Kolho
{"title":"Response to 'From Medicalisation to Avoidance: How Social Media Distorts Risk in Infant Health Care'.","authors":"Lotta Immeli, Pamela Douglas, Kaija-Leena Kolho","doi":"10.1111/apa.70495","DOIUrl":"10.1111/apa.70495","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"1135-1136"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta PaediatricaPub Date : 2026-05-01Epub Date: 2026-02-10DOI: 10.1111/apa.70473
Noora Carpén, Otto Helve, Sture Andersson, Emmi Helle
{"title":"Response to the Letter: Perioperative Interventions: A Critical Omission in Delivery Mode Research on Neonatal Gene Expression.","authors":"Noora Carpén, Otto Helve, Sture Andersson, Emmi Helle","doi":"10.1111/apa.70473","DOIUrl":"10.1111/apa.70473","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"1137-1138"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta PaediatricaPub Date : 2026-05-01Epub Date: 2026-02-28DOI: 10.1111/apa.70494
Erwin Jiayuan Khoo
{"title":"From Medicalisation to Avoidance: How Social Media Distorts Risk in Infant Health Care.","authors":"Erwin Jiayuan Khoo","doi":"10.1111/apa.70494","DOIUrl":"10.1111/apa.70494","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"1133-1134"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta PaediatricaPub Date : 2026-05-01Epub Date: 2026-01-30DOI: 10.1111/apa.70470
Johanna Baker, Harsha Gowda
{"title":"EBNEO Commentary: Early Full Enteral Feeding Compared With Gradual Feeding Increase in Preterm Infants.","authors":"Johanna Baker, Harsha Gowda","doi":"10.1111/apa.70470","DOIUrl":"10.1111/apa.70470","url":null,"abstract":"<p><p>of Key Findings and Limitations of FEED1 trial.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"1139-1140"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}