Acta Paediatrica最新文献

{"title":"Poor Association Between Clinical Characteristics and Seropositivity in Children With Suspected Long COVID-A Single-Centre Study.","authors":"S Olsson-Åkefeldt, J Luthander, L Anmyr, L Villard, S Arnason, M K Kemani, E Wållgren, S Röstlund, M Tingborn, M Pettersson, E George, M Ryd-Rinder, O Hertting","doi":"10.1111/apa.70034","DOIUrl":"https://doi.org/10.1111/apa.70034","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to compare characteristics and clinical presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody positive or negative children attending a specialist outpatient clinic for suspected paediatric long COVID.</p><p><strong>Methods: </strong>A cross-sectional study was conducted of 113 children and adolescents enrolled between 1 December 2020 to 14 September 2021 in a multidisciplinary programme. Clinical and epidemiological data were collected with standardised interviews and laboratory tests including SARS-CoV-2 spike antibody measurement.</p><p><strong>Results: </strong>A serological link to SARS-CoV-2 infection was found in 52%. Most patients (94.7%) reported several symptoms. Fatigue, post-exertional malaise, dizziness, nausea, headache, and concentration difficulties were the most common. Seronegative children had a higher number of individual symptoms. School absence and drop-out from leisure activities was substantial in both groups with higher numbers for the seronegative group. Self-reported health was low in both groups.</p><p><strong>Conclusion: </strong>Children attending a specialist paediatric long COVID clinic experienced multiple symptoms and poor self-reported health. The symptomatology was similar regardless of serological status, implying multifactorial causes. A multidisciplinary assessment of this cohort was essential considering the broad spectrum of symptoms displayed and their substantial impact on everyday functioning.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paracetamol Overdoses Among Danish Adolescents: A COVID-19 Perspective.","authors":"Oliver Nørholm Kempf, Thora Wesenberg Helt, Jens Jakob Herrche-Petersen, Charlotte Søndergaard, Elke Longin, Annie Ellerman, Marianne Sjølin Frederiksen, Louise Lundby-Christensen, Jesper Andersen, Thomas Houmann Petersen, Rasmus G Nielsen, Bent Windelborg Nielsen, Cæcilie Trier, Louise Jürgensen, Jens Peter Nielsen, Magnus Ove Reynskor, Helene Kvistgaard, Malene Boas, Eva Mosfeldt Jeppesen, Vibeke Brix Christensen","doi":"10.1111/apa.70037","DOIUrl":"https://doi.org/10.1111/apa.70037","url":null,"abstract":"<p><strong>Aim: </strong>This study examines trends in paracetamol overdoses among Danish adolescents during and following the COVID-19 pandemic.</p><p><strong>Methods: </strong>A retrospective observational study was conducted using data from the national databases, covering all paediatric departments in Denmark from January 2016 to December 2023. Patients between 10 and 19 years of age diagnosed with paracetamol overdose were stratified by sex, age and number of hospital admissions. As the dataset covers the entire population, observed values reflect true parameters. A one-sample t-test compared post-COVID-19 values to the pre-COVID-19 mean.</p><p><strong>Results: </strong>A total of 4.448 patients accounted for 5.794 hospital admissions due to paracetamol overdoses, with a majority being girls. During the second year of the pandemic (2021), a rise in overdose cases (26.5%) and hospital admissions (30.3%) was observed, especially among girls. The average number of admissions per patient increased, indicating repeated self-harm attempts. Cases of severe overdoses leading to acute liver failure increased at Rigshospitalet. These trends reversed post-pandemic.</p><p><strong>Conclusion: </strong>The findings suggest an association between pandemic-related isolation and an increase in adolescent paracetamol overdoses. While rates began to normalise after restrictions were lifted, further research is needed to assess the long-term mental health impact of such restrictions.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cause of Pyloric Stenosis of Infancy (PS): The Harald Ernberg Connection.","authors":"Ian Munro Rogers","doi":"10.1111/apa.70033","DOIUrl":"https://doi.org/10.1111/apa.70033","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International Consensus Definition of 'Sport & Exercise' in Toddlers and Young Children, Children, and Adolescents.","authors":"Gavin A Davis, Nicholas Anderson, Franz E Babl, Dustin W Ballard, Karen M Barlow, Michael J Barrett, Miriam H Beauchamp, Meredith L Borland, Silvia Bressan, Louise Crowe, Shu-Ling Chong, Daniel J Corwin, Stuart R Dalziel, Carolyn A Emery, Emmanuelle Fauteux-Lamarre, Gerard A Gioia, Juliet Haarbauer-Krupa, Michael W Kirkwood, Ruth Mari Caroline Löllgen, Christina L Master, Audrey McKinlay, John Olver, Santiago Mintegi, Viviana Pavlicich, Laura Purcell, Radhika Raman, Pedro Rino, Stacy J Suskauer, Itai Shavit, Emma J Tavender, Jacqueline van Ierssel, Keith Owen Yeates, Scott L Zuckerman, Vicki Anderson","doi":"10.1111/apa.70013","DOIUrl":"https://doi.org/10.1111/apa.70013","url":null,"abstract":"<p><strong>Aim: </strong>The study aim was to develop an age-appropriate definition of sport and exercise in children and adolescents for use in concussion research and management.</p><p><strong>Methods: </strong>A modified Delphi methodology, with three rounds and consensus defined a priori as ≥ 80% agreement.</p><p><strong>Results: </strong>Thirty-one participants (13 male, 18 female) from 13 countries, including clinical psychologists, epidemiologists, implementation scientists, neurologists, neuropsychologists, neurosurgeons, paediatric emergency physicians, paediatricians, physiotherapists, rehabilitation physicians, speech-language pathologists, and sports medicine physicians came to a consensus that sport-related paediatric concussion extends beyond the sporting arena, and includes the school yard, playground, park, street, recreational site, and home; excludes non-accidental violence, assault, and passenger vehicle road trauma; may include falls; and age-group terminology includes Toddlers and Young Children (1-4 years), Children (5-12 years), and Adolescents (13 to < 18 years). Sport and exercise categories and individual examples are provided.</p><p><strong>Conclusions: </strong>This consensus definition of sport and exercise in paediatrics for concussion research and management will enable researchers and guideline development groups to expand paediatric concussion research and management guidelines to encompass the broad range of activities commonly associated with sport- and exercise-related concussion in children and adolescents and thus limit exclusion of relevant studies from systematic reviews and guideline development.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Awakening of the Newborn Human Infant and the Emergence of Consciousness.","authors":"Hugo Lagercrantz","doi":"10.1111/apa.70031","DOIUrl":"https://doi.org/10.1111/apa.70031","url":null,"abstract":"<p><p>Consciousness develops gradually in the womb and after birth, rather than being an all or none phenomenon. A newborn infant is aroused and wakes up at birth, due to the enormous sensory stimulation and stress that it undergoes during the transition from an aquatic environment to air. Its first breaths activate the locus coeruleus, as indicated by the large pupils of the newborn. The infant seems to be aware of its body and can recognise its mother's facial expressions, voice and smell. A default mode network matures soon after birth which appears to keep the brain in a conscious state. Thus the newborn infant is probably conscious, albeit at a low level. The foetus also shows some signs of being conscious after about 24 weeks of gestation, although it is mainly asleep in the womb and less aware of its environment. Before that stage, the nerves from the primary somatosensory, visual and auditory areas are not yet connected with the site of consciousness in the cerebral cortex.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Measles Cases in a Province in South-Eastern Turkey Receiving Migration From Syria.","authors":"Özhan Orhan, Murat Solmaz, Mehmet Nur Talay","doi":"10.1111/apa.70008","DOIUrl":"https://doi.org/10.1111/apa.70008","url":null,"abstract":"<p><strong>Aim: </strong>The study aimed to compare the demographic, clinical and vaccination status of measles cases in 2023 in our region receiving migration from Syria and to evaluate the effect of migration on disease dynamics.</p><p><strong>Methods: </strong>This retrospective study analysed the demographic profiles, clinical features and vaccination status of a total of 98 (67 children born and raised in Turkey [group 1] and 31 children of Syrian origin [group 2]) clinically compatible measles patients presenting to all healthcare institutions in Batman, Turkey, in 2023.</p><p><strong>Results: </strong>Significant differences were observed between groups in vaccination coverage (90.3% unvaccinated amongst Group 2 vs. 55.2% amongst Group 1, p < 0.001), IgM positivity (87.1% vs. 26.9%, p < 0.001) and hospitalisation rates (38.7% vs.16.4%, p = 0.015). Group 2 exhibited higher prevalence of fever (93.5% vs. 70.1%, p = 0.010) and cough (58.1% vs. 26.9%, p = 0.003) than Group 1.</p><p><strong>Conclusion: </strong>The study highlights the impact of migration and socio-economic factors on measles dynamics. Lower vaccination rates amongst Syrian migrants contribute to increased measles incidence and severity. Strengthening vaccination programmes and public health initiatives are crucial for controlling measles outbreaks and improving health outcomes, particularly in vulnerable populations.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Screening Guidelines for Hypoglycaemia in Infants Born Small for Gestational Age Showed Numerous Differences and Few Certainties.","authors":"Giulia Remaschi, Carlo Dani","doi":"10.1111/apa.70010","DOIUrl":"https://doi.org/10.1111/apa.70010","url":null,"abstract":"<p><strong>Aim: </strong>Different hypoglycaemia screening guidelines for infants born small for gestational age (SGA) are applied throughout the world. This narrative review analysed the published guidelines and evaluated the characteristic features of hypoglycaemia in SGA infants to assess the relevance of the issue.</p><p><strong>Methods: </strong>PubMed and the Cochrane Database of Systematic Reviews were reviewed for papers regarding hypoglycaemia and hypoglycaemia screening guidelines in term and near-term SGA infants. We also searched government-related websites and national healthcare institution websites for guidelines.</p><p><strong>Results: </strong>Numerous differences among guidelines were found. The American Academy of Pediatrics and the Pediatric Endocrine Society do not specify which SGA infants need screening. Other guidelines suggest screening infants with birth weight < 10th percentile, while still others < 2nd percentile. Depending on the growth curves, the SGA population may change. The hypoglycaemia cut-off value was another relevant variance. The duration of glucose level checks varies from the first 4-24 h of life. The reported incidence of hypoglycaemia was 12%-52%. The timing of hypoglycaemia onset was 2-6 h of life. Specific risk factors for hypoglycaemia in SGA infants were found.</p><p><strong>Conclusion: </strong>Numerous differences were found in the hypoglycaemia guidelines for SGA infants, and further studies are needed to address strong and uniform guidance.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of Seven COL2A1 Variations in Chinese Children With Type II Collagen Disorders.","authors":"Shumin Zhan, Qin He, Jinna Yuan, Xiaoqin Xu, Ke Huang, Guanping Dong, Junfen Fu, Dingwen Wu, Wei Wu","doi":"10.1111/apa.70029","DOIUrl":"https://doi.org/10.1111/apa.70029","url":null,"abstract":"<p><strong>Aim: </strong>Type II collagen, encoded by the collagen type II alpha 1 (COL2A1) gene, is crucial for the structure of cartilage. This study aims to improve our understanding of Spondyloepiphyseal Dysplasia Congenita (SEDC) caused by mutations in COL2A1. We also aim to evaluate the safety and efficacy of growth hormone (GH) therapy in two SEDC patients.</p><p><strong>Methods: </strong>We performed genetic analyses of seven paediatric patients from unrelated Chinese families. Two patients received GH therapy, and their growth trajectories were monitored over 3.5 and 3 years.</p><p><strong>Results: </strong>Genetic screening identified six missense mutations (Gly1110Ser, Gly1107Glu, Gly873Arg, Gly456Ala, Gly1062Ser and Gly1182Arg) and one intron variant in COL2A1. All patients (five girls and two boys, ranging from 2 years and 7 months to 12 years) were diagnosed with SEDC, exhibiting disproportionate short stature and skeletal abnormalities. GH therapy resulted in height increases of 0.76 and 0.27 standard deviation scores over 3.5 and 3 years, respectively, with no significant side effects.</p><p><strong>Conclusion: </strong>This study expands the mutation spectrum of COL2A1 and supports the efficacy and safety of GH therapy in SEDC patients, highlighting the need for multi-center studies to further investigate GH's therapeutic potential.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"During Three Decades Prenatal Diagnoses of Differences in Sex Development Increased and Gonadectomy Rates Declined.","authors":"Amit Eben Chaime, Moshe Phillip, David Ben-Meir, Liat de Vries","doi":"10.1111/apa.70017","DOIUrl":"https://doi.org/10.1111/apa.70017","url":null,"abstract":"<p><strong>Aim: </strong>The therapeutic approach to differences of sex development (DSD) has changed over recent decades. We aimed to describe the evolution of clinical diagnoses of DSD in children attending a tertiary paediatric centre.</p><p><strong>Methods: </strong>This retrospective observational study compared diagnoses and management, before and after the introduction of consensus guidelines for DSD in 2006.</p><p><strong>Results: </strong>The cohort included 87 patients with 46, XY (78.4%), 15 with 46, XX (13.5%) and 9 with sex chromosomal DSD (8.1%). Gonadectomy rates were 27.9%, 6.6% and 66.6% for the respective groups. The mean age at presentation was younger among those with 46, XY than with 46, XX (0.5 ± 2.5 vs. 6.8 ± 8.1 years, p = 0.007) and a higher proportion presented by age one year (93.1% vs. 60.0%, p = 0.001). During 1990-2006, 44 children were diagnosed, and during 2007-2019, 67 children. Prenatal diagnosis increased from 4.5% to 25.4% (p = 0.004). Smaller proportions in the later than earlier period underwent gonadectomy (19.4% vs. 40.9%, p = 0.017) and sex reassignment (1.5% vs. 13.6%, p < 0.02).</p><p><strong>Conclusion: </strong>Over the three-decade period, the rate of prenatal diagnosis increased and the rates of gonadectomy and sex reassignment declined. These findings reflect a shift towards earlier, individualised multidisciplinary care, which was facilitated by advanced diagnostics.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Outdoor Playing During Preschool Was Associated With a Reduced Risk of School-Age Obesity in Japan\".","authors":"","doi":"10.1111/apa.70018","DOIUrl":"https://doi.org/10.1111/apa.70018","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}