Achim Fieß, Alica Hartmann, Alexander K Schuster, Mareike Ernst, Eva Mildenberger, Dirk Wackernagel, Stephanie D Grabitz, Michael S Urschitz, Norbert Pfeiffer, Manfred E Beutel, Sandra Gißler, Jonas Tesarz
{"title":"Timing of First Cuddling After Preterm Birth Improved Over Five Decades, While Delays Were Linked to Negative Maternal Experiences.","authors":"Achim Fieß, Alica Hartmann, Alexander K Schuster, Mareike Ernst, Eva Mildenberger, Dirk Wackernagel, Stephanie D Grabitz, Michael S Urschitz, Norbert Pfeiffer, Manfred E Beutel, Sandra Gißler, Jonas Tesarz","doi":"10.1111/apa.70304","DOIUrl":"https://doi.org/10.1111/apa.70304","url":null,"abstract":"<p><strong>Aim: </strong>Early physical contact after birth is critical for families of preterm infants, who face higher risks of psychological stress. This study examined changes in first cuddling over five decades and its relation to parental birth experiences and perceptions of early parenthood.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at the University Medical Center Mainz, Germany. Parents completed questionnaires and structured interviews about birth experiences, timing of first cuddling and perceptions of parenthood. Multivariable logistic regression was used to analyse associations of gestational age and cuddling delay with parental outcomes.</p><p><strong>Results: </strong>Data were obtained from 940 mothers and 614 fathers of 1559 children (median age 15 years, range 4-52, 824 female). Time to first cuddling in extremely preterm infants decreased from several weeks in the 1970s to about 1 week in the 2010s. Mothers of preterm or delayed-cuddling infants more often perceived birth as an emergency, felt less prepared for discharge and reported negative feelings towards motherhood. Fathers showed similar but weaker associations.</p><p><strong>Conclusion: </strong>The time until first cuddling decreased markedly over five decades, reflecting greater clinical awareness. However, delayed cuddling remained strongly linked to negative maternal perceptions, underlining the importance of prioritising early physical contact in neonatal care.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ariadne Malamitsi-Puchner, Despina D Briana, Gian Carlo Di Renzo
{"title":"Vaccinations During Pregnancy Protect the Mother-Infant Dyad and Are Generally Safe.","authors":"Ariadne Malamitsi-Puchner, Despina D Briana, Gian Carlo Di Renzo","doi":"10.1111/apa.70301","DOIUrl":"https://doi.org/10.1111/apa.70301","url":null,"abstract":"<p><strong>Aim: </strong>Vaccination in pregnancy has a critical impact on mothers, foetuses and infants. The aim of this paper was to summarise key points presented by experts attending the 12th Maria Delivoria-Papadopoulos Perinatal Symposium in March 2025 and further expand and update them.</p><p><strong>Methods: </strong>We discuss the benefits and potential side effects of vaccines for tetanus-diphtheria-acellular pertussis, influenza, COVID-19, respiratory syncytial virus and monkeypox. The future use of cytomegalovirus and group B streptococcus vaccines is also covered. Vaccine hesitancy, mainly due to fears of harming the foetus, including preterm delivery, is addressed. The use of evidence-based information to allay fears is explored. Ethical issues about the potential side effects of vaccinating mothers, primarily for the good of the infant, are discussed.</p><p><strong>Results: </strong>The vaccines we looked at were generally effective and safe, with no considerable adverse effects for the mother-infant dyad. Vaccination hesitancy was predominately based on fears about the adverse effects on the foetus. These can mainly be combated by health professionals providing clear information on the impact on both the mother and her offspring.</p><p><strong>Conclusion: </strong>The vaccines discussed in the paper were generally effective and safe for the mother, foetus and infant.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Authors' Response to Reader's Form.","authors":"Gavin A Davis, Franz E Babl, Vicki Anderson","doi":"10.1111/apa.70313","DOIUrl":"https://doi.org/10.1111/apa.70313","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145179480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justyna Wyszyńska, Anna Turska-Kmieć, Daniel Neunhaeuserer, Giovani di Salvo, Stefano Del Torso, Berthold Koletzko, Süleyman Yildiz, Zacchi Grossman, Adamos Hadjipanayis, Teresa Jackowska, Ann De Guchtenaere, Dieter Haffner, Justine Bacchetta, Marija Jelusic, Antonio Ruggiero, Rafaella Nenna, Maria Roberta Cilio, Dana Craiu, Ana Margarida Neves, Luigi Titomanlio, Artur Mazur
{"title":"Sport Activities for Children and Adolescents: Part 2. Joint Position Statement of Paediatric Societies on Physical Activity and Sport Recommendations for Children With Specific Chronic Disease Conditions.","authors":"Justyna Wyszyńska, Anna Turska-Kmieć, Daniel Neunhaeuserer, Giovani di Salvo, Stefano Del Torso, Berthold Koletzko, Süleyman Yildiz, Zacchi Grossman, Adamos Hadjipanayis, Teresa Jackowska, Ann De Guchtenaere, Dieter Haffner, Justine Bacchetta, Marija Jelusic, Antonio Ruggiero, Rafaella Nenna, Maria Roberta Cilio, Dana Craiu, Ana Margarida Neves, Luigi Titomanlio, Artur Mazur","doi":"10.1111/apa.70311","DOIUrl":"https://doi.org/10.1111/apa.70311","url":null,"abstract":"<p><strong>Aim: </strong>To provide consensus-based recommendations on safe and effective physical activity and sports participation for children and adolescents with chronic health conditions.</p><p><strong>Methods: </strong>The Task Force of the European Academy of Pediatrics (EAP) reviewed English-language meta-analyses, systematic reviews, randomised clinical trials and observational studies published between 2000 and 2024 in major databases (Scopus, PubMed/MEDLINE, Cochrane Library, Science Direct, MEDLINE and EBSCO). Evidence from scientific organisations, including the WHO, was also considered. Recommendations were developed through expert consensus.</p><p><strong>Results: </strong>The position statement provides tailored guidelines for children with juvenile idiopathic arthritis, congenital osteoarticular and musculoskeletal defects, haemophilia, asthma, cystic fibrosis, diabetes, sickle cell trait, hypertension, nephrotic syndrome, inflammatory bowel disease, epilepsy, a history of severe allergic reactions and reduced nephron number. Practical recommendations are summarised for each condition.</p><p><strong>Conclusion: </strong>This consensus statement offers a structured, evidence-based framework for healthcare professionals, parents and caregivers to promote safe physical activity and sport participation in pediatric populations with chronic diseases, thereby supporting quality of life and long-term health outcomes.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina Gande, Michael Bloching, Christoph Hochmayr, Anna Staudt, Ulrike Pupp Peglow, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
{"title":"Developmental Trajectories of Very Preterm Infants and Implications for Routine Neurodevelopmental Follow-Up.","authors":"Nina Gande, Michael Bloching, Christoph Hochmayr, Anna Staudt, Ulrike Pupp Peglow, Ursula Kiechl-Kohlendorfer, Elke Griesmaier","doi":"10.1111/apa.70306","DOIUrl":"https://doi.org/10.1111/apa.70306","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to assess a longitudinal trajectory of very preterm infants from corrected 1-5 years and examined how well performances on the Bayley Scales of Infant and (Toddler) Development (BSI(T)D) at 1 and 2 years predict cognitive outcome at preschool age.</p><p><strong>Methods: </strong>From 2011 to 2018, 499 very preterm infants admitted to the Medical University of Innsbruck were assessed. Cognitive outcomes at 1 and 2 years were measured with BSID-II/BSITD-III, and at 5 years, full scale intelligence quotient (IQ) was evaluated.</p><p><strong>Results: </strong>Of the 499 infants, 345 (69.1%) completed assessments at all three time points. Most had normal cognitive outcomes: 92.2% at 1 year, 80.3% at 2 years and 80.9% at 5 years. The 2-year assessment demonstrated a stronger predictive value than the 1-year assessment, both for identifying cognitive delay at 5 years (< 85 points; AUC 0.88 vs. 0.77) and for predicting full-scale IQ scores in linear regression models (R<sup>2</sup> = 46% vs. 36%).</p><p><strong>Conclusion: </strong>The 1-year assessment had limited predictive value, whereas the 2-year assessment more effectively predicted preschool cognitive outcomes. A combination of BSITD at 1 and 2 years gave the best prediction at preschool age.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mathilde Grapin, Lucas Rabaux, Mathilde Glenisson, Eva Mille, Nathalie Biebuyck, Evgenia Preka, Olivia Boyer, Kiarash Taghavi, Guillaume Dorval, Thomas Blanc
{"title":"Pelvi-Ureteric Junction Obstruction in a Solitary Functioning Kidney in Children: An Unfavourable Combination.","authors":"Mathilde Grapin, Lucas Rabaux, Mathilde Glenisson, Eva Mille, Nathalie Biebuyck, Evgenia Preka, Olivia Boyer, Kiarash Taghavi, Guillaume Dorval, Thomas Blanc","doi":"10.1111/apa.70303","DOIUrl":"https://doi.org/10.1111/apa.70303","url":null,"abstract":"<p><strong>Aim: </strong>Solitary functioning kidney (SFK) is linked to chronic kidney disease (CKD) in children, particularly when associated with congenital anomalies of the kidney and urinary tract (CAKUT). Pelvi-ureteric junction obstruction (PUJO) is the most frequent obstructive uropathy in SFK. This study aimed to evaluate long-term kidney function in children operated on for PUJO in an SFK.</p><p><strong>Methods: </strong>Among a retrospective cohort study of children with an SFK, a subgroup analysis was performed: primary SFK with operated PUJO (n = 35); primary SFK without CAKUT (n = 108); primary SFK with CAKUT other than PUJO (n = 24). Markers of CKD and measured glomerular filtration rate were assessed during follow-up.</p><p><strong>Results: </strong>Surgery was indicated because of neonatal acute kidney injury (AKI) (n = 21), worsening renal pelvis dilation (n = 10). The median age at surgery was 15 months (1.2-30 months). At a median age of 13 years at last follow-up, the proportion of CKD was higher in primary SFK with PUJO compared to primary SFK without CAKUT (43% vs. 12%, p = 0.0008). In SFK/PUJO, neonatal AKI was predictive of subsequent CKD (OR 4.8, p = 0.04).</p><p><strong>Conclusion: </strong>PUJO in an SFK is associated with a high rate of CKD during childhood, particularly when neonatal AKI is present.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding the High Incidence of Pertussis in Norway: The Role of Test Activity.","authors":"Margrethe Greve-Isdahl, Elina Seppälä","doi":"10.1111/apa.70308","DOIUrl":"https://doi.org/10.1111/apa.70308","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Permanent or Transient Congenital Hypothyroidism: A Diagnostic Dilemma.","authors":"Dermitzaki Niki, Serbis Anastasios, Baltogianni Maria, Balomenou Foteini, Giapros Vasileios","doi":"10.1111/apa.70312","DOIUrl":"https://doi.org/10.1111/apa.70312","url":null,"abstract":"<p><strong>Aim: </strong>Distinguishing between transient congenital hypothyroidism (TCH) and permanent congenital hypothyroidism (PCH) remains clinically challenging and is typically deferred until the age of 2-3 years, to minimise the potential risk of adverse neurodevelopmental effects due to treatment cessation. However, evidence suggests that earlier discrimination may be feasible, thus avoiding unnecessary, potentially harmful, prolonged levothyroxine (LT4) treatment. This narrative review aims to provide an overview of the current literature regarding potential predictive markers for distinguishing PCH from TCH.</p><p><strong>Methods: </strong>A comprehensive search of the PubMed and Google Scholar databases was independently performed by two authors to identify studies that evaluated the utility of several predictive factors.</p><p><strong>Results: </strong>A total of 27 studies were included. The most commonly proposed predictors were thyroid imaging findings, thyroid-stimulating hormone (TSH) levels at diagnosis, LT4 doses at various time points during the treatment period, absolute daily LT4 dose, and episodes of TSH elevation above the reference interval during treatment.</p><p><strong>Conclusions: </strong>Despite these advances, no single marker or combination of markers has yet proven definitive in reliably differentiating PCH from TCH. Further research is needed to establish predictive models that could facilitate the early identification of TCH and the timely and safe treatment withdrawal.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inbal Kestenbom, Shaked Bar-Moshe, Gidon Test, Or Kaplan, Tal Grupel, Michael Shilo, Natalya Bilenko, Michael Friger, Michal S Maimon, Dennis Scolnik
{"title":"Risk-Stratified Observation After Asymptomatic Paediatric Scorpion Envenomation May Safely Reduce Emergency Department Stay.","authors":"Inbal Kestenbom, Shaked Bar-Moshe, Gidon Test, Or Kaplan, Tal Grupel, Michael Shilo, Natalya Bilenko, Michael Friger, Michal S Maimon, Dennis Scolnik","doi":"10.1111/apa.70310","DOIUrl":"https://doi.org/10.1111/apa.70310","url":null,"abstract":"<p><strong>Aim: </strong>Current emergency department (ED) protocols in prone regions recommend monitoring for at least 4-6 h after paediatric scorpion envenomation. Since only limited evidence supports these guidelines, particularly for asymptomatic children, we evaluated routine ED observation in these patients.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of southern Israeli children presenting with scorpion envenomation over a 15-month period using a validated envenomation severity score. The primary outcome was the development of delayed systemic symptoms requiring intervention. Children with Grade 1 scores (mild) were compared to those with Grade ≥ 2 scores (more severe).</p><p><strong>Results: </strong>Of 287 patients, 238 (83%) presented with mild, and 49 (17%) with more severe envenomation. Less than 1% of mild patients developed delayed symptoms, all of which resolved with conservative management, and 99% were discharged. More severe patients were younger (median age 3.1 vs. 5.8 years), had a higher prevalence of allergy (31% vs. 13%), and 94% developed immediate symptoms requiring hospitalisation.</p><p><strong>Conclusion: </strong>A risk-stratified approach taking into consideration age, time since envenomation, history of allergies, and symptom severity could safely reduce ED observation time since children with mild scorpion envenomation symptoms had a low risk of developing significant delayed complications.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}