Acta Paediatrica最新文献_第3页

Health Economic Evaluation of Varicella Vaccination Within the Swedish National Vaccination Programme for Children. 瑞典国家儿童疫苗接种计划中水痘疫苗接种的健康经济评价。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-03-26 DOI: 10.1111/apa.70506

Frida Kasteng, Gianpaolo Scalia Tomba, Annika Ersson, Ellen Wolff, Sören Andersson, Kari Johansen

{"title":"Health Economic Evaluation of Varicella Vaccination Within the Swedish National Vaccination Programme for Children.","authors":"Frida Kasteng, Gianpaolo Scalia Tomba, Annika Ersson, Ellen Wolff, Sören Andersson, Kari Johansen","doi":"10.1111/apa.70506","DOIUrl":"10.1111/apa.70506","url":null,"abstract":"Aim: To assess the cost-effectiveness of including varicella vaccination in the Swedish national vaccination programme for children together with the added impact of catch-up vaccination of susceptible older children.Methods: An epidemiological transmission model was used to assess the cost-effectiveness of a two-dose national varicella vaccination programme, with and without a catch-up strategy, compared to no varicella vaccination. Parameter estimates were based on scientific publications and data from Swedish national and regional registries.Results: A national varicella vaccination programme would result in health gains and cost-savings from a societal perspective. Cost-savings were primarily due to a reduction in caregiver productivity loss. From a health system perspective, the cost per quality-adjusted life-year gained was estimated at around SEK 200 000 (EUR 18 000), both with and without catch-up vaccination. At a negotiated vaccine price reduction to 30% of the current list price, the cost per quality-adjusted life-year gained would come down to SEK 5 000 (EUR 450).Conclusion: Our analyses suggest that inclusion of varicella vaccination in the national vaccination programme for children would be a cost-saving strategy from a societal perspective, which together with a catch-up vaccination offer for susceptible older children would result in a fast decline of varicella in Sweden.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2533-2544"},"PeriodicalIF":1.8,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Will Extended-Valency Pneumococcal Conjugate Vaccines Offer Enhanced Coverage Against Invasive Pneumococcal Disease for At-Risk Children? 扩展价肺炎球菌结合疫苗是否能提高高危儿童对侵袭性肺炎球菌疾病的覆盖率？

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-03-20 DOI: 10.1111/apa.70503

Robert Cohen, Corinne Levy, Naim Ouldali, Stéphane Béchet, Aude Estivaux, André Birgy, Isabelle Hau, Emmanuelle Varon

引用次数: 0

Past and Present Vaccinations in Sweden. 瑞典过去和现在的疫苗接种。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-09-08 DOI: 10.1111/apa.70698

Sven Arne Silfverdal

引用次数: 0

Recognising and Addressing Vaccine Hesitancy That Is Not Always Directly Voiced by a Child's Parents. 认识并解决并非总是由儿童父母直接表达的疫苗犹豫。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-11-01 Epub Date: 2026-08-31 DOI: 10.1111/apa.70746

Alessandro Diana

引用次数: 0

Changes in Gastrointestinal Symptoms Among Children With Cystic Fibrosis During 12 Months of Elexacaftor/Tezacaftor/Ivacaftor Therapy: A Swedish Multicentre Study. 囊性纤维化儿童在12个月的elexaftor /Tezacaftor/Ivacaftor治疗期间胃肠道症状的变化：一项瑞典多中心研究

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-21 DOI: 10.1111/apa.70807

Marcus Svedberg, Ellen Karlge Nilsson, Per Ekman, Henrik Imberg

{"title":"Changes in Gastrointestinal Symptoms Among Children With Cystic Fibrosis During 12 Months of Elexacaftor/Tezacaftor/Ivacaftor Therapy: A Swedish Multicentre Study.","authors":"Marcus Svedberg, Ellen Karlge Nilsson, Per Ekman, Henrik Imberg","doi":"10.1111/apa.70807","DOIUrl":"https://doi.org/10.1111/apa.70807","url":null,"abstract":"Aim: Elexacaftor/Tezacaftor/Ivacaftor (ETI) has markedly improved clinical outcomes in cystic fibrosis (CF). However, its effects on gastrointestinal (GI) function, nutrition and pancreatic enzyme therapy in children remain insufficiently described. This study aimed to characterise GI-related changes during the first year of ETI treatment in Swedish children with CF.Methods: In this prospective, multicentre study at three paediatric CF centres, children aged 6-17 years who initiated ETI were assessed at baseline, 6 and 12 months. Outcomes included GI symptoms and the use of GI-related medication, health-related quality of life (CFQ-R), nutritional status, PERT use and faecal elastase. Longitudinal changes were analysed using generalised least squares regression.Results: Sixty-two participants (mean age 11.7 years) completed follow-up. The total mean combined number of reported GI symptoms declined from 1.5 to 0.9 (p = 0.005), although no individual symptom changed significantly after 12 months of ETI treatment (p > 0.05). CFQ-R Digestive scores improved by 7.8 points (p = 0.002). PERT dose decreased by 1.3 × 103 units/kg/day (p < 0.001), while BMI z-scores and faecal elastase remained unchanged.Conclusion: ETI therapy reduced gastrointestinal symptoms and improved digestive quality of life in children with CF, accompanied by lower PERT use but unchanged pancreatic function and growth.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Perinatal Stroke Characteristics and Outcome in Southern Finland. 芬兰南部急性围产期卒中的特征和结局。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-21 DOI: 10.1111/apa.70797

Maija Seppä-Moilanen, Siina Pamilo, Jussi Leinonen, Marjo Metsäranta, Samuli Rautava, Pirjo Isohanni, Miika Koskinen

{"title":"Acute Perinatal Stroke Characteristics and Outcome in Southern Finland.","authors":"Maija Seppä-Moilanen, Siina Pamilo, Jussi Leinonen, Marjo Metsäranta, Samuli Rautava, Pirjo Isohanni, Miika Koskinen","doi":"10.1111/apa.70797","DOIUrl":"https://doi.org/10.1111/apa.70797","url":null,"abstract":"Aim: Perinatal stroke can cause lifelong morbidities. Outcome prediction is important for parental guidance and follow-up. We studied characteristics of acute perinatal stroke in a Finnish cohort.Methods: We performed a population-based study, identifying infants with acute neonatal cerebral ischemia or sinovenous thrombosis (CSVT) in Southern Finland from 2010 to 2023. We analysed the incidence of stroke types, seizures, anti-seizure medication use, and outcomes.Results: Altogether 88 infants (1 in 3101 live births) were diagnosed with acute perinatal stroke: 67% with arterial ischemic stroke (AIS), 22% with hemorrhagic stroke (HS) and 11% with CSVT. Seizures and anti-seizure medication use occurred in 78% of infants. Cranial ultrasound infrequently recognized AIS but usually noted haemorrhage. During follow-up, 34% of infants had no adverse outcome diagnosis. The most common outcome was cerebral palsy (CP, 35%). A combination of CP with epilepsy or seizures was more frequent in infants with AIS than in those with other stroke types.Conclusion: The distribution of stroke types, symptoms, and adverse outcomes aligns with the previous literature. Acute seizures were common in AIS and HS patients. No recurrent strokes occurred during follow-up and underlying infant-related etiologies were rarely identified.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Skin-To-Skin Contact and Breastfeeding in Infants Born Before 35 Gestational Weeks: A Register Study. 35孕周前出生婴儿的早期皮肤接触和母乳喂养：一项登记研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-21 DOI: 10.1111/apa.70806

Agnes Härmestad, Agnes Linnér, Caroline-Aleksi Olsson Mägi, Siri Lilliesköld

{"title":"Early Skin-To-Skin Contact and Breastfeeding in Infants Born Before 35 Gestational Weeks: A Register Study.","authors":"Agnes Härmestad, Agnes Linnér, Caroline-Aleksi Olsson Mägi, Siri Lilliesköld","doi":"10.1111/apa.70806","DOIUrl":"https://doi.org/10.1111/apa.70806","url":null,"abstract":"Aim: The aim was to investigate if there was an association between early skin-to-skin contact after preterm birth and breastfeeding status at discharge.Methods: This was a register-based study using data from the Swedish Neonatal Quality register 2020-2024. In total, 9914 infants born before 35 weeks of gestation were included. The outcome was breastfeeding at discharge from the neonatal unit, assessed using two variables: breastfeeding at the breast and receiving breast milk. The exposure was early skin-to-skin contact, defined as within the first 24 h after birth. Odds ratios were estimated for the total population and stratified for gestational age groups.Results: Skin-to-skin contact within the first 24 h was associated with higher odds of partial breastfeeding at the breast at discharge, aOR 1.47 (95% CI 1.32-1.64), and higher odds of partially and exclusively receiving breast milk. Among extremely preterm infants, skin-to-skin contact was associated with higher odds of exclusive breastfeeding at the breast, aOR 2.22 (95% CI 1.35-3.64).Conclusion: Early skin-to-skin contact was associated with higher odds of partial breastfeeding at discharge in the total study population and with exclusive breastfeeding in extremely preterm infants.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149240447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Paracelsus to Precision Medicine: Paediatric Epilepsy as the Paradigm of Individualized Therapy. 从巴拉塞尔苏斯到精准医学：作为个体化治疗范例的儿科癫痫。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-17 DOI: 10.1111/apa.70802

Annamaria Sapuppo, Vincenzo Sortino, Raffaele Falsaperla

引用次数: 0

Decreasing Trends in Birth Prevalence and Severity of Cerebral Palsy in Sweden During 2000-2019: A Population-Based Registry Study. 2000-2019年瑞典脑瘫出生患病率和严重程度的下降趋势：一项基于人群的登记研究

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-16 DOI: 10.1111/apa.70800

Semhal Getachew Teka, Gunnar Hägglund, Ann I Alriksson-Schmidt

{"title":"Decreasing Trends in Birth Prevalence and Severity of Cerebral Palsy in Sweden During 2000-2019: A Population-Based Registry Study.","authors":"Semhal Getachew Teka, Gunnar Hägglund, Ann I Alriksson-Schmidt","doi":"10.1111/apa.70800","DOIUrl":"https://doi.org/10.1111/apa.70800","url":null,"abstract":"Aim: To examine temporal trends in cerebral palsy (CP) birth prevalence and changes in functional severity in Sweden between 2000 and 2019.Methods: This population-based registry study included all children with CP born in Sweden between 2000 and 2019. Annual CP birth prevalence was calculated using Poisson regression. Changes in functional severity were assessed using the Gross Motor Function Classification System (GMFCS) and Manual Ability Classification System (MACS) levels across birth cohorts, with ordinal logistic regression used to examine their association.Results: In total 4281 participants were included. CP birth prevalence decreased over the study period with a rate ratio per year of 0.985 (95% confidence interval 0.980-0.990) corresponding to a 1.5% annual reduction. The proportion of children with milder impairment increased over time. In crude analyses: children born in 2015-2019 had lower odds of higher MACS levels (OR 0.70, 95% CI 0.60-0.83, p ≤ 0.001), and GMFCS level (OR 0.77, 95% CI 0.65-0.92, p = 0.003) than those born in 2000-2004.Conclusion: CP birth prevalence in Sweden decreased significantly between 2000 and 2019. A shift toward milder functional impairment was observed in more recent birth cohorts and occurred alongside changes in CP subtype distribution.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safeguarding in Emergency Care: Clarifying the Targeted 'Child-Check' Protocol. 急救护理中的保障：明确有针对性的“儿童检查”协议。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-16 DOI: 10.1111/apa.70803

Louise Laurell, Andreas Rantala, Pia Lundqvist

引用次数: 0