Seohyun Hong, Yejun Son, Myeongcheol Lee, Jaeyu Park, Hayeon Lee, Hyeri Lee, Hojae Lee, Hyejun Kim, Elena Dragioti, Guillaume Fond, Laurent Boyer, Guillermo F López Sánchez, Mark A Tully, Masoud Rahmati, Selin Woo, Dong Keon Yon, Lee Smith
{"title":"Temporal changes in smoking prevalence among adolescents across 23 countries.","authors":"Seohyun Hong, Yejun Son, Myeongcheol Lee, Jaeyu Park, Hayeon Lee, Hyeri Lee, Hojae Lee, Hyejun Kim, Elena Dragioti, Guillaume Fond, Laurent Boyer, Guillermo F López Sánchez, Mark A Tully, Masoud Rahmati, Selin Woo, Dong Keon Yon, Lee Smith","doi":"10.1111/apa.17543","DOIUrl":"https://doi.org/10.1111/apa.17543","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to investigate temporal changes in smoking prevalence among adolescents aged 13-15 across 23 countries and to assess individual and country-level factors influencing smoking behaviour.</p><p><strong>Methods: </strong>This study used data from 168 286 young adolescents aged 13-15 years obtained from the Global School-based Student Health, 2003-2021. Linear regression models and meta-analyses were conducted to analyse the changes in current smoking prevalence among young adolescents.</p><p><strong>Results: </strong>Among the 23 countries, smoking prevalence decreased in six countries, including Argentina, Fiji, Jamaica, Samoa, Tonga and Uruguay, while it increased in four countries, namely Guyana, Morocco, Thailand and Vanuatu. The prevalence of smoking was higher among male adolescents at 15.5% (95% CI 13.8%-17.2%) compared to females at 8.0% (95% CI 6.7%-9.3%). Adolescents exposed to secondhand smoke had a prevalence of 16.3% (95% CI 14.5%-18.2%), significantly higher than 4.2% (95% CI 3.7-4.6) in those not exposed. Smoking prevalence was 16.5% (95% CI 14.8%-18.2%) among those with smoking parents or guardians, compared to 8.1% (95% CI 7.1%-9.1%) among those without.</p><p><strong>Conclusion: </strong>The findings highlight the need for tailored tobacco control measures to reduce adolescent smoking globally. Strengthening policy enforcement and addressing social determinants of smoking are critical to achieving further reductions.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Schreiner, Anna Staudt, Vera Neubauer, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
{"title":"Amplitude-integrated electroencephalography showed alterations in cerebral activity in monochorionic twins with twin-to-twin transfusion syndrome.","authors":"Christina Schreiner, Anna Staudt, Vera Neubauer, Ursula Kiechl-Kohlendorfer, Elke Griesmaier","doi":"10.1111/apa.17532","DOIUrl":"https://doi.org/10.1111/apa.17532","url":null,"abstract":"<p><strong>Aim: </strong>Monochorionic twins are at higher risk of perinatal mortality and morbidity, primarily due to pregnancy-related complications, such as twin-to-twin transfusion syndrome (TTTS). We aimed to investigate whether amplitude-integrated electroencephalography (aEEG) signals are different between monochorionic twins with and without TTTS.</p><p><strong>Methods: </strong>This was a retrospective single-centre study conducted at Innsbruck Medical University Hospital, Austria. Preterm infants born before 32 weeks of gestation between 6 November 2010 and 6 December 2022 were eligible. The aEEG was analysed for the total maturation score, its component scores and the number of sleep-wake cycles per hour.</p><p><strong>Results: </strong>We enrolled 79 monochorionic twin infants (48% male) and 157 dichorionic (62% male) twin infants. We found no differences between these two groups of preterm infants regarding the total maturation and component scores, or the number of sleep wake cycles. Monochorionic twins with TTTS showed significantly lower total maturation scores and individual component scores compared to monochorionic twins without TTTS.</p><p><strong>Conclusion: </strong>Preterm infants with TTTS showed differences in neonatal aEEG signals. Whether these differences are caused by prematurity-related or TTTS-related factors, such as hemodynamic and metabolic changes due to placental anastomoses, should be investigated in future prospective studies, to gain more insight into this important topic.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David A Nyakotey, Greg D Gamble, Christopher J D McKinlay, Frank H Bloomfield, Jane E Harding
{"title":"Associations between growth and childhood body composition in very preterm, late preterm and term children.","authors":"David A Nyakotey, Greg D Gamble, Christopher J D McKinlay, Frank H Bloomfield, Jane E Harding","doi":"10.1111/apa.17534","DOIUrl":"https://doi.org/10.1111/apa.17534","url":null,"abstract":"<p><strong>Aim: </strong>To determine how gestational age at birth and postnatal growth relate to body composition in childhood.</p><p><strong>Methods: </strong>We calculated conditional growth (birth-2 years, 2 years-6 years) and measured body composition at 2 and 6 years using bioelectrical impedance in cohorts of New Zealand children born very preterm (VPT; 23-31 weeks), late preterm (LPT; 35- <37 weeks) and term (≥37 weeks). We explored the relationships between growth and fat mass (FM) index and fat-free mass (FFM) index at 6 years using multivariable linear regression.</p><p><strong>Results: </strong>Of 1125 children (51% male), 202 were VPT, 114 LPT and 809 Term. Compared to Term, VPT but not LPT were lighter and shorter at 2 and 6 years and had lower FM index and FFM index. The association between weight growth from 2 to 6 years and both FM index and FFM index at 6 years was stronger than for weight growth from birth to 2 years or height growth at any period in all gestational age groups.</p><p><strong>Conclusions: </strong>Size and body composition at 2 and 6 years are different between infants born VPT, but not LPT, and at term. Later weight growth is more strongly associated with childhood body composition than earlier growth.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peter Bakalár, David Janda, Michaela Kostičová, Jaroslava Kopčáková, Peter Kolarčik, Petr Badura, Aleš Gába
{"title":"Sleep profiles and their associations with adiposity and cardiorespiratory fitness among adolescents.","authors":"Peter Bakalár, David Janda, Michaela Kostičová, Jaroslava Kopčáková, Peter Kolarčik, Petr Badura, Aleš Gába","doi":"10.1111/apa.17537","DOIUrl":"https://doi.org/10.1111/apa.17537","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to identify sleep profiles in a representative sample of Slovak adolescents and investigate their associations with adiposity indicators and cardiorespiratory fitness.</p><p><strong>Methods: </strong>Data from the 2022 Health Behaviour in School-aged Children (HBSC) study conducted in Slovakia were analysed. Survey questions on sleep duration and problems from the entire HBSC sample (n = 8906) were used to identify sleep profiles. Associations with adiposity indicators and cardiorespiratory fitness were investigated in a subsample of 924 adolescents (average age 13.3 ± 1.48; 56.2% boys) who completed the HBSC survey, bioimpedance analysis, and 20-metre shuttle run test.</p><p><strong>Results: </strong>Three sleep profiles were identified-optimal sleepers, optimal sleepers with sporadic sleep problems and poor sleepers. Crude models showed that poor sleepers had significantly higher body fat percentage and fat mass index, along with lower cardiorespiratory fitness, compared to optimal sleepers. After adjustment, only the association between sleep profiles and cardiorespiratory fitness remained significant.</p><p><strong>Conclusion: </strong>The observed associations between sleep profiles and cardiorespiratory fitness may help better target future intervention resources towards adolescents with low cardiorespiratory fitness levels.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Issue highlights","authors":"Anna Käll, Hugo Lagercrantz","doi":"10.1111/apa.17520","DOIUrl":"https://doi.org/10.1111/apa.17520","url":null,"abstract":"<p>Dahlén and Kimland analysed nearly 4.6 million prescriptions dispensed to more than 2 million children aged 0–17 years in Sweden.<span><sup>1</sup></span> Just under half of the children (47%) received at least one drug in 2019 and 34% received three or more different drugs. The most common drugs were for respiratory tract issues, followed by psychoanaleptics and melatonin for the nervous system and dermatologicals. The average number of prescriptions almost doubled from 2.3 in 2007 to 4.5 in 2019. Garnemark and Kindblom comment on the findings in an editorial.<span><sup>2</sup></span> https://doi.org/10.1111/apa.17425.</p><p>Height velocity is a key tool for monitoring growth and detecting serious health conditions early. Scherdel et al. have produced new annual and biannual height velocity charts for French children up to 15 years of age, using values routinely collected in primary care settings.<span><sup>3</sup></span> The median curves were close to the 1979 French and 2009 World Health Organization values, but there were important differences in the standard deviation curves. An editorial by Van Dommelen states that the same data collection method could be used by other countries to produce velocity charts with minimal extra effort.<span><sup>4</sup></span> https://doi.org/10.1111/apa.17454.</p><p>Cholestasis is highly prevalent in very low birth weight infants. It is predominantly caused by parenteral nutrition, and Oh et al. found that this condition developed at about 1 month of age.<span><sup>5</sup></span> They report that it took approximately 2 months for direct bilirubin to normalise, even when parenteral nutrition ceased and full enteral feeding was established. More time was required to normalise aspartate transferase and alanine aminotransferase levels. An editorial by Teng et al. states that understanding the dynamics of biochemical liver markers in pre-term infants with parenteral nutrition-associated cholestasis may prevent unnecessary invasive examinations.<span><sup>6</sup></span> https://doi.org/10.1111/apa.17427.</p><p>Tracheomalacia causes considerable morbidity in children and the best treatment options are still being debated. Møller et al. present a case series of seven Danish children who underwent surgical interventions, including tracheopexy and aortopexy, to reduce the respiratory symptoms caused by tracheal collapse. They report favourable clinical outcomes, particularly when there was an early intervention, and discuss the indications, timing and potential benefits of this surgery.<span><sup>7</sup></span> https://doi.org/10.1111/apa.17452.</p><p>Neonatal intensive care has improved for infants born extremely preterm, but it has not been matched by similar progress in post-discharge interventions. Baraldi et al. conducted a randomised clinical trial of 130 children born extremely preterm, to evaluate an interaction-based home-visiting programme during the first year after discharge.<span><sup>8</sup></span> Th","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":"114 1","pages":"6-7"},"PeriodicalIF":2.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.17520","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Kajsa G Jessen, Thora W Helt, Lars S Johansen, Rasmus N Gaardskær, Christian Heiring, Helene Kvistgaard, Michael A Madsen, Jane A Simonsen, Søren Møller, Vibeke B Christensen, Lise Borgwardt
{"title":"Thresholds for conjugated hyperbilirubinaemia and hepatobiliary scintigraphy in biliary atresia: A 12-year national follow-up.","authors":"Anna Kajsa G Jessen, Thora W Helt, Lars S Johansen, Rasmus N Gaardskær, Christian Heiring, Helene Kvistgaard, Michael A Madsen, Jane A Simonsen, Søren Møller, Vibeke B Christensen, Lise Borgwardt","doi":"10.1111/apa.17536","DOIUrl":"https://doi.org/10.1111/apa.17536","url":null,"abstract":"<p><strong>Aim: </strong>To investigate liver biochemistry in infants screened for biliary atresia (BA) at the time of hepatobiliary scintigraphy (HS) and to evaluate the effect of change in threshold for HS.</p><p><strong>Methods: </strong>Infants born from 2010 to 2021, who underwent HS <6 months postpartum for BA, were included and data sourced from electronic medical records. The change in threshold in 2018 from ≥20 (and/or if conjugated bilirubin exceeds 20% of total bilirubin) to ≥17 μM (regardless of total bilirubin) was evaluated.</p><p><strong>Results: </strong>In the cohort of 635 infants, 48 had BA, 247 had AATD, and the remaining 343 were categorised as 'other'. After the threshold adjustment, HS timing was unaffected (p = 0.27), but the annual HS rate rose from 39 to 87, yet evaluations following the new guideline only accounted for 12%. All liver parameters were elevated in the BA group compared with the additional groups (p < 0.001). Amongst the 104 patients with non-excretory HS, gamma-glutamyl transferase (p < 0.001) and alanine aminotransferase (p = 0.002) remained elevated for BA. The lowest conjugated bilirubin measured in BA children was 36 μM.</p><p><strong>Conclusion: </strong>After threshold change, HS use increased without earlier BA diagnostics, but most were not due to the new guideline. Alanine aminotransferase and gamma-glutamyl transferase should be considered in BA diagnostics.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cecilie Bjertness Nyquist, Leila Torgersen, Linda W David, Trond Haaken Diseth, Kjersti Gulbrandsen, Anne Waehre
{"title":"Treatment trajectories among children and adolescents referred to the Norwegian National Center for Gender Incongruence.","authors":"Cecilie Bjertness Nyquist, Leila Torgersen, Linda W David, Trond Haaken Diseth, Kjersti Gulbrandsen, Anne Waehre","doi":"10.1111/apa.17530","DOIUrl":"https://doi.org/10.1111/apa.17530","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to describe treatment trajectories, detransition and mortality rate among children and adolescents referred to the Norwegian National Center for Gender Incongruence (NCGI).</p><p><strong>Methods: </strong>The cohort included all 1258 persons under 18 years at referral to the NCGI from 2000 to 2020. Trajectories were registered until end of 2023.</p><p><strong>Results: </strong>In total, 861/1258 (68.4%) were assigned female gender at birth (AFAB). Mean age at referral was 14.4 years. Puberty suppression with gonadotropin-releasing hormone agonists (GnRHa) was initiated among 135/1258 (10.7%), significantly more persons assigned male gender at birth (AMAB) than AFAB (p < 0.001). Gender-affirming hormonal treatment (GAHT) was initiated in 783/1258 (62.2%). The continuation rate from GnRHa to GAHT was 97%. Discharge rate from NCGI without gender-affirming medical treatment among those who attended at least one appointment, was 264/1198 (22.0%). Eighteen AFAB detransitioned after initiated GAHT, eleven due to a cessation of transgender identity. Mortality rate in the cohort until end of 2023 was 11/1258 (0.9%).</p><p><strong>Conclusion: </strong>Different trajectories including medical pathways and assessments without gender-affirming treatment were observed. GAHT was initiated in 783/1258 (62.2%), including eighteen AFAB detransitioning after testosterone treatment. There was a high continuation rate from GnRHa to GAHT. Various trajectories highlights the need for long-term follow-up in care.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manon Midavaine, Nicolas Vinit, Victor Sartorius, Elsa Kermorvant-Duchemin, Alexandre Lapillonne
{"title":"Complex trajectories are associated with neurological impairment in infants with congenital gastrointestinal malformations aged two.","authors":"Manon Midavaine, Nicolas Vinit, Victor Sartorius, Elsa Kermorvant-Duchemin, Alexandre Lapillonne","doi":"10.1111/apa.17523","DOIUrl":"https://doi.org/10.1111/apa.17523","url":null,"abstract":"<p><strong>Aim: </strong>Our aims were to describe the neurodevelopment of infants with congenital gastrointestinal malformations at 2 years of age and to investigate the association between developmental delay and complex trajectories.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study. Infants operated on for oesophageal atresia, abdominal wall defects, intestinal malformation, congenital diaphragmatic hernia and anorectal malformation were analysed. Neurodevelopment was assessed using the Ages and Stages Questionnaire at 24 months. The primary outcome was the presence of developmental delay, defined as ASQ-24 months of total score ≤ 185.</p><p><strong>Results: </strong>Of 118 patients, 11 (9%) had an ASQ-24 months ≤185. Factors associated with an ASQ-24 months ≤185 were earlier gestational age (p = 0.045), longer invasive ventilation (p = 0.046), longer parenteral nutrition (p = 0.043) and ≥2 hospitalisations in the first 2 years (p = 0.022). They had a significantly longer stay in the neonatal intensive care unit and subsequent hospitalisations (p = 0.007). After adjustment for prematurity and breastfeeding, this association remained statistically significant.</p><p><strong>Conclusion: </strong>Nine per cent of children with a gastrointestinal malformation show a developmental delay at the age of two. A prolonged stay in the neonatal intensive care unit and subsequent hospitalisations are associated with an increased risk of neurodevelopmental disorders, while breastfeeding may have a protective effect.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"EBNEO commentary: Dextrose gel prophylaxis for neonatal hypoglycemia and neurocognitive function at an early school age: A randomised dosage trial.","authors":"Ashlee Smith-Patel, Daniela Dinu, Elena Itriago","doi":"10.1111/apa.17528","DOIUrl":"https://doi.org/10.1111/apa.17528","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Growth hormone treatment in children in Israel: A large-scale retrospective database study.","authors":"Yael Reichenberg, Rachel Bello, Bernice Oberman, Moryia Cohen, Avner Herman Cohen, Vered Shkalim Zemer","doi":"10.1111/apa.17535","DOIUrl":"https://doi.org/10.1111/apa.17535","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the indications, population characteristics and latency between short stature diagnosis to treatment with recombinant growth hormone (GH) therapy in a large cohort of children in Israel.</p><p><strong>Methods: </strong>We performed a retrospective medical chart review of all children treated with GH for conditions associated with short stature in three central districts in Israel from 1 January 2010 to 31 December 2021. Data extracted from the medical files included demographics, time to diagnosis, treatment indications and GH therapy duration.</p><p><strong>Results: </strong>The study group comprised 5148 children aged 1 day to 17 years. A total of 64.1% were diagnosed with idiopathic short stature (ISS), 31.1% with GH deficiency (GHD) and 2.5% with small-for-gestational age (SGA). Males were treated more than females (58.9% vs. 41.1%). The mean age at first documentation of short stature was 6.9 ± 3.5 years. GH therapy was initiated at a mean age of 9.8 ± 3.3 years. A total of 51.2% were of high socio-economic status (SES); 78.2% were non-ultraorthodox Jews, 13%, ultraorthodox Jews, and 8.8% were Arabs.</p><p><strong>Conclusion: </strong>Meticulous growth follow-up from early childhood for all children, specifically females, those of low SES, and minorities is important to provide appropriate referral, treatment and final adult height outcomes.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}