{"title":"EBNEO commentary: Dextrose gel prophylaxis for neonatal hypoglycemia and neurocognitive function at an early school age: A randomised dosage trial.","authors":"Ashlee Smith-Patel, Daniela Dinu, Elena Itriago","doi":"10.1111/apa.17528","DOIUrl":"https://doi.org/10.1111/apa.17528","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142793079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Growth hormone treatment in children in Israel: A large-scale retrospective database study.","authors":"Yael Reichenberg, Rachel Bello, Bernice Oberman, Moryia Cohen, Avner Herman Cohen, Vered Shkalim Zemer","doi":"10.1111/apa.17535","DOIUrl":"https://doi.org/10.1111/apa.17535","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the indications, population characteristics and latency between short stature diagnosis to treatment with recombinant growth hormone (GH) therapy in a large cohort of children in Israel.</p><p><strong>Methods: </strong>We performed a retrospective medical chart review of all children treated with GH for conditions associated with short stature in three central districts in Israel from 1 January 2010 to 31 December 2021. Data extracted from the medical files included demographics, time to diagnosis, treatment indications and GH therapy duration.</p><p><strong>Results: </strong>The study group comprised 5148 children aged 1 day to 17 years. A total of 64.1% were diagnosed with idiopathic short stature (ISS), 31.1% with GH deficiency (GHD) and 2.5% with small-for-gestational age (SGA). Males were treated more than females (58.9% vs. 41.1%). The mean age at first documentation of short stature was 6.9 ± 3.5 years. GH therapy was initiated at a mean age of 9.8 ± 3.3 years. A total of 51.2% were of high socio-economic status (SES); 78.2% were non-ultraorthodox Jews, 13%, ultraorthodox Jews, and 8.8% were Arabs.</p><p><strong>Conclusion: </strong>Meticulous growth follow-up from early childhood for all children, specifically females, those of low SES, and minorities is important to provide appropriate referral, treatment and final adult height outcomes.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lina Broström, Lexuri Fernández de Gamarra-Oca, Hedvig Kvanta, Maria Örtqvist, Nelly Padilla, Ulrika Ådén
{"title":"Being born extremely preterm with low-grade intraventricular haemorrhage had no impact on brain volumes or neurodevelopment in later childhood.","authors":"Lina Broström, Lexuri Fernández de Gamarra-Oca, Hedvig Kvanta, Maria Örtqvist, Nelly Padilla, Ulrika Ådén","doi":"10.1111/apa.17517","DOIUrl":"https://doi.org/10.1111/apa.17517","url":null,"abstract":"<p><strong>Aim: </strong>Our aim was to investigate the impact that low-grade intraventricular haemorrhage (IVH) had on neonatal morbidities, brain volumes and neurodevelopmental outcomes in children born extremely preterm (EPT) and compare them with children born EPT without low-grade IVH.</p><p><strong>Methods: </strong>This prospective cohort study was carried out in Stockholm, Sweden. It focused on 103 children born EPT from 2004 to 2007, at less than 27 weeks of gestation, without major brain injuries. The group with low-grade IVH, defined as grades I-II, were compared with children born EPT without IVH. Around half (45%) underwent MRI scans at 10 years of age and 55% had neurodevelopmental assessments at 12 years.</p><p><strong>Results: </strong>The low-grade IVH group was sicker during the neonatal period than the children born EPT without IVH. They had lower gestational ages at birth, more days on mechanical ventilation, a higher incidence of necrotising enterocolitis and were more likely to need surgical ligation of patent ductus arteriosus. However, they did not have significantly smaller brain volumes at 10 years of age or worse neurodevelopmental outcomes at 12 years of age.</p><p><strong>Conclusion: </strong>Brain volumes or neurodevelopment were not affected in children born EPT with low-grade IVH, compared to children born EPT without IVH.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Turkka Kirjavainen, Pia Vuola, Janne Suominen, Anne Saarikko
{"title":"Micrognathia and cleft palate as a cause of obstructive sleep apnoea in infants.","authors":"Turkka Kirjavainen, Pia Vuola, Janne Suominen, Anne Saarikko","doi":"10.1111/apa.17540","DOIUrl":"https://doi.org/10.1111/apa.17540","url":null,"abstract":"<p><strong>Aim: </strong>Obstructive sleep apnoea (OSA) is common in Robin sequence (RS). We investigated the significance of micrognathia, cleft palate and sleep positioning on OSA in infants.</p><p><strong>Methods: </strong>We analysed our 13-year national reference centre polysomnography (PSG) dataset. PSG was performed as daytime recordings (97%) in the supine-, side- and prone sleeping position at the median age of 5 weeks (interquartile range 3-8 weeks).</p><p><strong>Results: </strong>Our study included 113 infants with RS and cleft palate, 10 infants with RS but intact palate and 32 infants with cleft palate without micrognathia. The degree of OSA in infants with cleft palate without micrognathia was less severe than in infants with RS in terms of obstructive events (median OAHI 4 vs. 32 h<sup>-1</sup>, respectively), SpO<sub>2</sub> desaturations (ODI<sub>≥3</sub>OAH 0.4 vs. 3 h<sup>-1</sup>), transcutaneous pCO<sub>2</sub> levels (TcCO<sub>2</sub>P<sub>95</sub>, 41 vs. 46 mmHg) (p < 0.0001) and work of breathing (p = 0.01). In the RS group, OSA was sleep-position dependent, with fewer obstructive events apparent in the side (18 vs. 24 h<sup>-1</sup>, p = 0.005) and prone (39 vs. 27 h<sup>-1</sup>, p = 0.003) sleeping positions than when supine.</p><p><strong>Conclusions: </strong>The degree of OSA in RS infants is more dependent on micrognathia than on cleft palate.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Understanding the context of injury data is crucial to improving safety and avoiding accidents.","authors":"Isain Zapata","doi":"10.1111/apa.17541","DOIUrl":"https://doi.org/10.1111/apa.17541","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Letter to the Editor: 'New French height velocity growth charts: An innovative big-data approach based on routine measurements'.","authors":"Pauline Scherdel, Martin Chalumeau, Barbara Heude","doi":"10.1111/apa.17516","DOIUrl":"https://doi.org/10.1111/apa.17516","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stable prevalence of overweight but increasing levels of obesity in adolescents in surveys of 42982 children in China 2010 to 2020.","authors":"Chengyue Li, Zhidong Zhou, Haiwen Cui","doi":"10.1111/apa.17522","DOIUrl":"https://doi.org/10.1111/apa.17522","url":null,"abstract":"<p><strong>Aim: </strong>Excessive weight gain in childhood has been associated with poor health outcomes throughout life span and has a strong tracking effect in adulthood. This study aimed to investigate trends in the prevalence of overweight, obesity and severe obesity among Chinese children from 2010 to 2020.</p><p><strong>Methods: </strong>A total of 42 982 Chinese children aged 2-18 years were included in the Chinese Family Panel Studies carried out every 2 years from 2010 to 2020. Height and mass were reported by them or by their guardians and body mass index was calculated. The prevalence was estimated according to the International Obesity Task Force cut-offs.</p><p><strong>Results: </strong>There was no significant trend in the prevalence of overweight. The prevalence of obesity and severe obesity for the total population decreased from 8.3% and 3.7% in 2010 to 7.1% and 2.6% in 2020, respectively (p < 0.001). However, these decreases were attributed mostly to children aged 2-6 years and the prevalence increased among children aged 13-18 years. Male, rural residential area and younger age were risk factors for overweight and obesity.</p><p><strong>Conclusion: </strong>A decrease in the prevalence of excessive weight was a positive finding, but strategies that promote the health and well-being of priority populations were needed.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of COVID-19 on paediatric care in Japan: Analysis of national health insurance claims data.","authors":"Takuma Ohnishi, Mari Kinoshita, Satoshi Narumi","doi":"10.1111/apa.17533","DOIUrl":"https://doi.org/10.1111/apa.17533","url":null,"abstract":"<p><strong>Aim: </strong>To quantify the impact of the COVID-19 pandemic on paediatric care use compared to adult care and identify affected subdomains.</p><p><strong>Methods: </strong>Data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) for six fiscal years (FY2016-2021) were analysed. Pre-pandemic (FY2016-FY2019) and pandemic years (FY2020, FY2021) were compared to delineate changes in medical services for paediatric and adult patients. Virtually all individuals who received medical care in Japan during this period were included.</p><p><strong>Results: </strong>In FY2019, healthcare utilisation by the paediatric population (under 15 years) accounted for 24% of 245 million first outpatient visits, 7% of 1.2 billion follow-up visits, and 2.6% of 297 million patient-days hospitalisations. In FY2020, outpatient visits of those aged 0-4 years decreased by 44% (first visit) and 24% (follow-up visit) compared to FY2019, and hospitalisations decreased by 47%, with the largest declines observed in community medical institutions across all age groups.</p><p><strong>Conclusion: </strong>The COVID-19 pandemic led to a substantial reduction in paediatric healthcare utilisation in Japan, varying by age and type of care. These findings may inform the rational allocation of healthcare resources during public health emergencies.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sari Ahlqvist-Björkroth, Nancy Feeley, Jeffrey Alberts, Rosario Montirosso, Liisa Lehtonen
{"title":"Parenting interventions in neonatal intensive care units take different approaches.","authors":"Sari Ahlqvist-Björkroth, Nancy Feeley, Jeffrey Alberts, Rosario Montirosso, Liisa Lehtonen","doi":"10.1111/apa.17526","DOIUrl":"https://doi.org/10.1111/apa.17526","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}