Anna-Karoliina Ojala, Ulla Koskela, Suvi Mattila, Minna Honkila, Tytti Pokka, Outi Peltoniemi, Juha-Jaakko Sinikumpu, Terhi Ruuska-Loewald
{"title":"Systematic Review and Meta-Analysis Showed That Asymptomatic Viral Respiratory Infections Were Common Among Children Who Underwent Surgery.","authors":"Anna-Karoliina Ojala, Ulla Koskela, Suvi Mattila, Minna Honkila, Tytti Pokka, Outi Peltoniemi, Juha-Jaakko Sinikumpu, Terhi Ruuska-Loewald","doi":"10.1111/apa.70113","DOIUrl":"https://doi.org/10.1111/apa.70113","url":null,"abstract":"<p><strong>Aim: </strong>This study investigated asymptomatic viral respiratory tract infections in children who had undergone surgery and their impact on postoperative outcomes.</p><p><strong>Methods: </strong>A systematic literature search was carried out using the PubMed and Scopus databases, from their inception to 24 May 2024, to identify papers published in English on the subject. A meta-analysis was also carried out.</p><p><strong>Results: </strong>Five studies with 2055 participants from the USA, Brazil, the Netherlands and China met the inclusion criteria. They were published from 2019 to 2023: three were prospective observational studies and two were retrospective cohort studies. Asymptomatic viral respiratory tract infections were detected in 17% of the participants. In one study, asymptomatic viral respiratory tract infections were associated with an increased risk of respiratory complications, and they were associated with an increased risk of mortality in another study. The pooled odds ratios had wide 95% confidence intervals and showed no statistically significant associations with respiratory complications, reintubation or mortality. The meta-analysis was limited by the low number and heterogeneity of the studies.</p><p><strong>Conclusion: </strong>This meta-analysis showed that asymptomatic viral respiratory tract infections were common among surgical paediatric patients. The associations between asymptomatic viral infections and postoperative complications were not conclusive, due to wide confidence intervals.</p><p><strong>Trial registration: </strong>International Prospective Register of Systematic Reviews: CRD42023412102.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Suárez-Bustamante Huélamo, Jose Antonio Alonso-Cadenas, Leticia Pérez Garnica, Cristina Ibarzo Port, Elena Sánchez Arranz, Santiago Mintegi, Roberto Velasco Zúñiga, Borja Gómez
{"title":"Prevalence of Bacterial Meningitis in Febrile Infants Aged 22-90 Days With Abnormal Urine Dipstick Results.","authors":"María Suárez-Bustamante Huélamo, Jose Antonio Alonso-Cadenas, Leticia Pérez Garnica, Cristina Ibarzo Port, Elena Sánchez Arranz, Santiago Mintegi, Roberto Velasco Zúñiga, Borja Gómez","doi":"10.1111/apa.70114","DOIUrl":"https://doi.org/10.1111/apa.70114","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elsa Gustavsson, Martina Kölgran, Maria Jonsson, Kajsa Lamm, Anna Chmielewska
{"title":"Four-Fold Increase of the Number of Children Diagnosed With Paediatric Feeding Disorder in Northern Sweden in 2012-2022.","authors":"Elsa Gustavsson, Martina Kölgran, Maria Jonsson, Kajsa Lamm, Anna Chmielewska","doi":"10.1111/apa.70096","DOIUrl":"https://doi.org/10.1111/apa.70096","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to investigate the annual prevalence and characteristics of Paediatric Feeding Disorder (PFD) in Västerbotten county, Sweden, during the years 2012-2022.</p><p><strong>Methods: </strong>In this retrospective study, medical records of patients attending paediatric clinics with possible feeding problems were identified by applying pre-defined diagnostic and procedure codes. Diagnostic criteria of PFD were verified. Additional data including nutritional status and enteral feeding tube placement were retrieved.</p><p><strong>Results: </strong>Annual prevalence of PFD increased from 1.2 (95% CI, 0.9-1.5) per 1000 children in 2012 to 5.0 (95% CI, 4.4-5.6) per 1000 children in 2022. In 2022, the prevalence in children < 5 years of age was 10.2 (95% CI, 8.7-12.0) per 1000. Of those, 28% had thinness grades 2 or 3 (moderate or severe thinness), and 31% were fed via nasogastric tube or gastrostomy.</p><p><strong>Conclusion: </strong>Prevalence of PFD has increased in the last decade, most notably for children under the age of five. High rates of malnutrition and enteral feeding in our study population indicate that we identified only the most severe cases of PFD. Given the rising prevalence of PFD, further research on the condition is of high priority.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lars Høsøien Skanke, Hilde Lysvand, Sidsel Krokstad, Svein Arne Nordbø, Kari Risnes, Henrik Døllner
{"title":"Clinical Manifestations and Viral Codetections in Infants With Parechovirus A.","authors":"Lars Høsøien Skanke, Hilde Lysvand, Sidsel Krokstad, Svein Arne Nordbø, Kari Risnes, Henrik Døllner","doi":"10.1111/apa.70111","DOIUrl":"https://doi.org/10.1111/apa.70111","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Holger Tingstedt Hövel, Eino Partanen, Ingrid Hansen Pupp, David Ley, Petra S Hüppi, Ingmar Rosén, Johanna Månsson, Minna Huotilainen, Vineta Fellman
{"title":"Very Preterm Infants Auditory Event-Related Potentials at Term Have Low Predictive Value for Cognitive Outcome.","authors":"Holger Tingstedt Hövel, Eino Partanen, Ingrid Hansen Pupp, David Ley, Petra S Hüppi, Ingmar Rosén, Johanna Månsson, Minna Huotilainen, Vineta Fellman","doi":"10.1111/apa.70089","DOIUrl":"https://doi.org/10.1111/apa.70089","url":null,"abstract":"<p><strong>Aim: </strong>To assess the prognostic value of auditory event-related potentials (AERPs) registered at term equivalent age in very preterm infants.</p><p><strong>Methods: </strong>Infants (26.5 ± 2.0 gestational weeks (GWs), n = 41 of 64 recruited) were enrolled prenatally between January 2005 and May 2007 at Skåne University Hospital, Lund, Sweden. AERP and mismatch responses to changes in duration or frequency in pure tones were measured at term-equivalent age using EEG. Neurocognitive outcome was assessed at 2 years of corrected age with Bayley scales of infant development. At 12 years of age, the subgroup of children born before 27 GWs (n = 18) were assessed with Wechsler Intelligence Scale for Children Fifth Edition (WISC-V).</p><p><strong>Results: </strong>Larger negative AERP amplitudes after 250 ms from stimulus onset to the standard and a negative rather than positive mismatch response to the frequency deviant were associated with higher Bayley score in univariable analysis. after adjustment for perinatal factors, only the duration mismatch response was associated with mental developmental index at 2 years of age. AERPs were not predictive of WISC-V test results at 12 years of age.</p><p><strong>Conclusion: </strong>AERPs at term in very preterm infants have a low prognostic value for short-term outcome. However, AERPs do not predict long-term outcome.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J M Wielenga, A Pascual, K Ruhe, C Aarnoudse, A H van Kaam
{"title":"Effect of Shifting From Open Bay to Single-Family Rooms on Closeness in a NICU.","authors":"J M Wielenga, A Pascual, K Ruhe, C Aarnoudse, A H van Kaam","doi":"10.1111/apa.70108","DOIUrl":"https://doi.org/10.1111/apa.70108","url":null,"abstract":"<p><strong>Aim: </strong>To assess the impact of moving from open bay units (OBU) to single-family rooms (SFR) on parental closeness in the Neonatal Intensive Care Unit (NICU).</p><p><strong>Methods: </strong>This observational longitudinal cohort study was conducted between February 2021 and January 2024, during which time the setting changed from OBU to SFR with a mixed phase in between. All parent-infant dyads were eligible for inclusion. The self-reported time present in the unit, lap holding, and skin-to-skin care (SSC) were used to measure parental closeness.</p><p><strong>Results: </strong>833 dyads of parents and infants were included (365 OBU, 140 mixed, 328 SFR phase). Parental presence increased for mothers from 210 min/day in the OBU to 420 min/day (p = 0.000) in the SFR, and for partners from 180 to 360 min/day (p < 0.001). Only for mothers, lap holding time increased from 100 min/day in the OBU to 120 min/day in the SFR phase (p = 0.046). SSC increased from 120 to 160 min/day (p = 0.002) for mothers and from 110 to 130 min/day (p = 0.004) for partners. These findings were independent of gestational age.</p><p><strong>Conclusion: </strong>Moving from an OBU to SFR setting increased parental closeness in the NICU. However, more changes are needed to meet the EFCNI and WHO recommendations.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wen Lun Yuan, Aminata H Cissé, Muriel Tafflet, Elissa El Khoury, Olfa Khalfallah, Laetitia Davidovic, Marie Aline Charles, Barbara Heude
{"title":"The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring's Cardiometabolic Health Profiles.","authors":"Wen Lun Yuan, Aminata H Cissé, Muriel Tafflet, Elissa El Khoury, Olfa Khalfallah, Laetitia Davidovic, Marie Aline Charles, Barbara Heude","doi":"10.1111/apa.70106","DOIUrl":"https://doi.org/10.1111/apa.70106","url":null,"abstract":"<p><strong>Aim: </strong>To describe cardiometabolic health profiles at age 5-6 years, their correlation with age at adiposity rebound (AR) and associations with maternal hyperglycaemia at 24-28 weeks' gestation (gestational diabetes, fasting (FPG), 1-hour postload plasma glucose), in mothers without pre-existing diabetes.</p><p><strong>Methods: </strong>BMI, %fat mass, blood pressure (BP), FPG, HOMA-IR and lipids were assessed in children from the EDEN study, a French bicentric birth cohort. Sex-specific cardiometabolic health profiles were derived using principal component analysis and examined against age at AR with Pearson's correlation. Associations with maternal hyperglycaemia were studied using multiple linear regressions adjusted for parental factors.</p><p><strong>Results: </strong>Among 674 children, four profiles were identified per sex: 'higher adiposity, BP, insulin resistance (IR)'; 'higher BP and lower adiposity'; 'higher IR and lower adiposity'; 'higher triglycerides and LDL-c and lower HDL-c'. The profile of 'higher adiposity, BP, IR' was correlated with earlier age at AR in both sexes. Higher maternal FPG was positively associated with the profile of 'higher adiposity, BP, IR' in boys and 'higher triglycerides and LDL-c and lower HDL-c' in girls.</p><p><strong>Conclusion: </strong>'Higher adiposity, BP, IR' profile at age 5-6 years was associated with earlier age of adiposity rebound. Marginal associations were observed with maternal hyperglycaemia in pregnancy.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marina Pons-Espinal, Noemi López-Perea, Josefa Masa-Calles, Carmen Muñoz-Almagro, David Tarragó, Cristian Launes
{"title":"Trends in Paediatric Viral Meningitis and Encephalitis With Unconfirmed Aetiology: A Spanish Population-Based Study, 2016-2020.","authors":"Marina Pons-Espinal, Noemi López-Perea, Josefa Masa-Calles, Carmen Muñoz-Almagro, David Tarragó, Cristian Launes","doi":"10.1111/apa.70107","DOIUrl":"https://doi.org/10.1111/apa.70107","url":null,"abstract":"<p><strong>Aim: </strong>The prevalence of meningitis and encephalitis of unknown aetiology in Spanish children has not been specifically documented before. The aim of this study is to describe the epidemiology and trends of these clinical conditions between 2016 and 2020.</p><p><strong>Methods: </strong>Retrospective study analysing hospitalised children < 15 years with meningitis and encephalitis/encephalomyelitis of unknown origin (ICD-10 codes) in Spain (2016-2020). Data from National Registry of Hospitalizations and National Institute for Statistics were used to calculate age-stratified hospitalisation rates (HR). Statistical analysis included Poisson regression to calculate hospitalisation rate ratios (HRR) by age groups and years and forecasting methods to predict 2020 HRs.</p><p><strong>Results: </strong>Four thousand six hundred childrens were hospitalised with viral meningitis and encephalitis-encephalomyelitis of unknown origin, resulting in a HR of 7.8/10<sup>5</sup> inhabitants. The highest HR was observed in children under 1 year (49.1/10<sup>5</sup>) and those aged 5-9 (10.4/10<sup>5</sup>). The global HR for viral meningitis (3.64/10<sup>5</sup>) was lower than for encephalitis-encephalomyelitis (4.2/10<sup>5</sup>). Hospitalisations decreased from 1475 (2016) to 452 (2020), attributed to enhanced pathogen detection methods and COVID-19 preventive measures.</p><p><strong>Conclusion: </strong>Undiagnosed central nervous system entities remain a significant cause of paediatric hospitalisations in Spain, despite a declining incidence. Enhanced diagnostic strategies, including expanded microbiological testing and molecular epidemiology surveillance, could prove beneficial.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Negligible Allergen Presence in Hospital Dogs After Washing.","authors":"C Wretman, A Risberg, H Grönlund, A Edner","doi":"10.1111/apa.70112","DOIUrl":"https://doi.org/10.1111/apa.70112","url":null,"abstract":"<p><strong>Aim: </strong>Allergies are a potential risk when introducing dogs in health care. Therefore, I chose to evaluate if allergen levels in Hospital Dogs can be reduced by washing the dogs and thereby develop patient-safe guidelines when implicating Hospital Dogs in Swedish hospitals.</p><p><strong>Methods: </strong>Samples (n = 29) were taken from the dog's fur before and after washing and after the Hospital Dog/child meeting to investigate change in allergens. Further samples were taken when washing with two different shampoos, measuring how long decreased levels of allergens lasted. The dog allergens Can f 1 and Can f 4 were analysed by competitive ELISA.</p><p><strong>Results: </strong>The mean allergen concentration of Can f 1 decreased from 21.8 ± 11.2 ng/mL before wash to 5.8 ± 3.7 ng/mL (p < 0.0001) after wash. Both types of shampoo resulted in a reduction of Can f 1 and Can f 4 and remained low for three days.</p><p><strong>Conclusion: </strong>By washing the Hospital Dogs with shampoo, we have found a significant reduction of the dog allergen Can f 1 and Can f 4 lasting for at least three days. In the work of introducing certified Hospital Dogs into Swedish hospitals, which so far has not been possible in Sweden, this is an important finding.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perfusion Index as a Screening Test for Neonatal Aortic Coarctation: Another Piece of the Jigsaw?","authors":"Andrew K Ewer","doi":"10.1111/apa.70109","DOIUrl":"https://doi.org/10.1111/apa.70109","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}