Acta Paediatrica最新文献_第5页

Further Exploration of the Influence of Immune Proteins in Sudden Infant Death Syndrome (SIDS). 免疫蛋白对婴儿猝死综合征（SIDS）影响的进一步探讨。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-23 DOI: 10.1111/apa.70197

Linda Ferrante, Siri H Opdal, Roger W Byard

{"title":"Further Exploration of the Influence of Immune Proteins in Sudden Infant Death Syndrome (SIDS).","authors":"Linda Ferrante, Siri H Opdal, Roger W Byard","doi":"10.1111/apa.70197","DOIUrl":"https://doi.org/10.1111/apa.70197","url":null,"abstract":"Aim: This study aimed to further explore immune protein patterns in cases of sudden infant death syndrome (SIDS) by describing additional findings from an initial proteomic study to investigate whether an unbalanced immune response may contribute to the occurrence of SIDS in certain cases.Method: The subjects included 46 SIDS cases and 39 controls autopsied at the Department of Forensic Sciences, Oslo, Norway. The causes of death in the controls were accidents/trauma. The normalised protein expression of 92 proteins were analysed in samples of cerebrospinal fluid (CSF) by Proximity Extension Assay (PEA).Results: For the purpose of this report, 17 of the immune system-related proteins in the assay were chosen for a more in-depth analysis. The major finding was a downregulation in the proteins Retinoic Acid-Inducible Gene I (DDX58/RIG-I), Phosphoinositide-3-Kinase Adaptor Protein 1(PIK3AP1), Interferon Regulatory Factor 9 (IRF9), Tripartite Motif Containing 5 (TRIM5), TRAF Family Member-Associated Nuclear factor kappa B (NF-Κb) Activator (TANK) and TNF Receptor Associated Factor 2 (TRAF2), and upregulation of CXADR Ig-like cell adhesion molecule (CXADR).Conclusions: The results are in keeping with the findings of earlier studies, supporting the role of immune system dysregulation as a potential predisposing factor for SIDS.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Younger Age and Viral Triggers Were Associated With Post-Infectious Bronchiolitis Obliterans in French Children. 法国儿童感染后闭塞性细支气管炎的年龄和病毒诱因相关

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-23 DOI: 10.1111/apa.70188

Julie Mazenq, Marine Crebassa, Alice Hadchouel, Souad Ghattas, Philippe Reix, Laurianne Coutier, Christophe Marguet, Nadia Nathan, Lisa Giovannini-Chami, Caroline Thumerelle, François Galode, Marie-Catherine Renoux, Léa Roditis, Eglantine Hullo, Pierrick Cros, Laurence Weiss, Sébastien Kiefer, Marie Tochon, Brahim Allali, Katia Bessaci Kabouya, Céline Delestrain, Louisa Goumidi, Hortense Petat, Véronique Houdouin, Jean-Christophe Dubus

{"title":"Younger Age and Viral Triggers Were Associated With Post-Infectious Bronchiolitis Obliterans in French Children.","authors":"Julie Mazenq, Marine Crebassa, Alice Hadchouel, Souad Ghattas, Philippe Reix, Laurianne Coutier, Christophe Marguet, Nadia Nathan, Lisa Giovannini-Chami, Caroline Thumerelle, François Galode, Marie-Catherine Renoux, Léa Roditis, Eglantine Hullo, Pierrick Cros, Laurence Weiss, Sébastien Kiefer, Marie Tochon, Brahim Allali, Katia Bessaci Kabouya, Céline Delestrain, Louisa Goumidi, Hortense Petat, Véronique Houdouin, Jean-Christophe Dubus","doi":"10.1111/apa.70188","DOIUrl":"10.1111/apa.70188","url":null,"abstract":"Aim: Post-infectious bronchiolitis obliterans (PIBO) is a rare but severe chronic paediatric obstructive lung disease, characterised by the obliteration of small airways following severe lower respiratory tract infections. Epidemiological data in Europe remain limited.Methods: This multicentre retrospective study examined the characteristics of paediatric patients diagnosed with PIBO from 2017 to 2023. Carried out by the French Reference Centre of Rare Lung Diseases network, it was based on clinical and radiological criteria and included age at diagnosis, medical history, symptoms, initial triggers, treatment, and outcomes.Results: The study comprised 147 patients (58.5% male) diagnosed by 18 tertiary centres at a median age of 22 months. Most (83.7%) were hospitalised for the suspected initial infection: 36.7% in intensive care units and 47.0% in acute care wards. A younger age at diagnosis was associated with higher hospitalisation rates (p = 0.01). Microbiological triggers were identified in 66.0%, mostly adenoviruses (28.5%) and the respiratory syncytial virus (26.4%), often as co-infections. Lung function tests were performed on 23.1% of patients and bronchoscopies on 66.9%. Treatment included inhaled corticosteroids (90.5%), azithromycin (59.2%) and intravenous corticosteroid pulses (40.8%).Conclusion: Age and causative agents were key factors in the initial severity of the infection that led to paediatric PIBO in our study.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Viral Acquired Idiopathic Purpura Fulminans Caused by Anti-Protein S Antibodies. 抗蛋白S抗体引起的病毒后获得性特发性紫癜。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-23 DOI: 10.1111/apa.70193

Alexandre Theron, Christine Biron-Andreani, Eric Jeziorski

引用次数: 0

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations. 儿科卡介苗世纪：从历史成功到未来创新。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-23 DOI: 10.1111/apa.70182

Stefan H E Kaufmann

{"title":"The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations.","authors":"Stefan H E Kaufmann","doi":"10.1111/apa.70182","DOIUrl":"https://doi.org/10.1111/apa.70182","url":null,"abstract":"Aim: The tuberculosis (TB) vaccine, Bacille-Calmette-Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults.Methods: A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health Organization.Results: Protection against TB includes innate and acquired cellular immunity and infants are more susceptible due to immature immunity. Immunopathology of infant TB is characterised by formation of small granulomas in the lung often followed by dissemination to other organs. Infection in adults is frequently contained until immunity is weakened and TB disease develops. Novel vaccines are being developed mostly for adolescents and adults, but two live attenuated vaccines are currently assessed in infants in Phase III clinical trials. Globally, TB remains a major health threat and countries of the global south bear the major TB burden. Today, Sweden, similar to other high-income countries, has a low incidence. General vaccination has therefore been terminated and targeted BCG vaccination is offered to infants at higher risk.Conclusion: Together with short-treatment and rapid diagnosis, novel vaccines profoundly contribute to the fight against TB in all age groups.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal Outcomes Among Infants of Mothers With Advanced Maternal Age: A National Cohort Study. 高龄产妇的新生儿结局：一项国家队列研究。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-22 DOI: 10.1111/apa.70185

S Voss, A Josefsson, C Ekéus

{"title":"Neonatal Outcomes Among Infants of Mothers With Advanced Maternal Age: A National Cohort Study.","authors":"S Voss, A Josefsson, C Ekéus","doi":"10.1111/apa.70185","DOIUrl":"https://doi.org/10.1111/apa.70185","url":null,"abstract":"Aim: Maternal age has increased steadily worldwide over the last few decades. This study aimed to investigate how different degrees of advanced maternal were associated with adverse neonatal outcomes.Methods: A nationwide register-based study was conducted using the Swedish Medical Birth Register. This comprised all singleton births to women aged 35 years plus from 2010 to 2022. The women were divided into three groups based on maternal age: 35-39 was the reference group, and 40-44 and 45 years plus were the advanced and very advanced maternal age groups, respectively.Results: We studied 312 221 singleton pregnancies. There were increased odds risks (95% confidence intervals) for infants born to women aged 40-44 (17.8%) and 45 years plus (1.1%), compared to those aged 35-39. These included stillbirths at 1.27 (1.12-1.45) and 1.80 (1.24-2.61) and infants being small for gestational age at 1.26 (1.19-1.33) and 1.46 (1.22-1.75). Risks for preterm birth, Apgar scores below seven at 5 min, and hypoglycaemia also increased.Conclusion: Severe adverse neonatal outcomes were uncommon in Sweden but were higher in the advanced and very advanced maternal age groups than the younger reference group. Healthcare providers make women more aware of the risks of postponed childbearing.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144369577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey Shows Limited Adoption of the Avoidance of Mechanical Ventilation in Japan: A Cross-Sectional Study. 一项横断面研究显示，日本对机械通气的回避采用有限。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-21 DOI: 10.1111/apa.70198

Takashi Shima, Takeshi Kusuda, Nobuhiko Kan, Tadamune Kinjo, Mallinath Chakraborty, Ian Paul Morris

{"title":"Survey Shows Limited Adoption of the Avoidance of Mechanical Ventilation in Japan: A Cross-Sectional Study.","authors":"Takashi Shima, Takeshi Kusuda, Nobuhiko Kan, Tadamune Kinjo, Mallinath Chakraborty, Ian Paul Morris","doi":"10.1111/apa.70198","DOIUrl":"10.1111/apa.70198","url":null,"abstract":"Aim: To investigate Japanese perspectives on the avoidance of mechanical ventilation strategy for extremely preterm infants.Methods: A web-based questionnaire was sent to the perinatal centres enrolled in the Japanese Neonatologist Association and the Japanese Society of Perinatal and Neonatal Circulatory Management. The enrollment window was between the 21st of July and the 31st of December 2021.Results: This survey covered 59% of the general perinatal centres in Japan. The study revealed that 64% of respondents would not attempt early continuous positive airway pressure strategy for extremely preterm infants. Intubation-surfactant-extubation and less-invasive surfactant administration were used in 58% and 11% of the institutes, respectively. Technical unfamiliarity, insufficient evidence, lack of videolaryngoscopy and concerns about potential complications hindered the implementation of less-invasive surfactant administration.Conclusions: Early continuous positive airway pressure strategy was uncommon for extremely preterm infants. Intubation-surfactant-extubation was five times more popular than less-invasive surfactant administration. Lack of training, evidence, videolaryngoscopy and assurance were the key limiting factors for the uptake of less-invasive surfactant administration across Japan.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Intervention Improves Nerve Conduction in Malnourished Children Under 5 Years of Age. 营养干预改善5岁以下营养不良儿童的神经传导。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-18 DOI: 10.1111/apa.70179

Nurun Nahar Naila, Md Shabab Hossain, Aklima Alam, Subhasish Das, Gobinda Karmakar, Mustafa Mahfuz, Tahmeed Ahmed, Badrul Islam

{"title":"Nutritional Intervention Improves Nerve Conduction in Malnourished Children Under 5 Years of Age.","authors":"Nurun Nahar Naila, Md Shabab Hossain, Aklima Alam, Subhasish Das, Gobinda Karmakar, Mustafa Mahfuz, Tahmeed Ahmed, Badrul Islam","doi":"10.1111/apa.70179","DOIUrl":"https://doi.org/10.1111/apa.70179","url":null,"abstract":"Aim: Adequate early nutrition supports neurological development, but data linking malnutrition to nerve conduction are limited. Our study aimed to assess how different forms of malnutrition affect nerve electrophysiology in children under 5 years of age and whether nutritional intervention can improve neurophysiological outcomes.Method: A community-based study was conducted from 2021 to 2022 in Dhaka, Bangladesh. Children with severe acute malnutrition (SAM) stunting, and wasting were recruited from the Mirpur slum area, Dhaka, and Dhaka Hospital, Bangladesh, respectively. Sensory and motor nerve conduction studies (NCSs) were performed before and after a 60-day nutritional intervention. A standard nerve electrophysiology tool was used for assessment and analysis.Results: A total of 83 malnourished children (30 stunted, 22 with SAM, and 31 wasted) and 45 healthy children were enrolled. The median age was 2.1 years (range: 6 months-5 years), and 56% were male. Malnourished children had significantly slower nerve conduction velocities compared to healthy controls (p < 0.01). Following intervention, children with SAM showed significant improvements in motor (median, peroneal, tibial; p < 0.05) and sensory (sural, peroneal; p < 0.05) nerve conduction.Conclusion: Nutritional rehabilitation improved nerve conduction in undernourished children, particularly those with SAM, underscoring the need for early intervention.Trial registration: NCT05891457.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Therapeutic Hypothermia for Neonatal HIE: Neurodevelopmental Outcomes and Predictors. 现实世界治疗性低温治疗新生儿HIE：神经发育结果和预测因素。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-18 DOI: 10.1111/apa.70186

Luca Bedetti, Licia Lugli, Isotta Guidotti, Maria Federica Roversi, Elisa Della Casa Muttini, Marisa Pugliese, Natascia Bertoncelli, Eugenio Spaggiari, Alessandra Todeschini, Gina Ancora, Sara Grandi, Giancarlo Gargano, Claudio Gallo, Mario Motta, Piero Catenazzi, Luigi Tommaso Corvaglia, Vittoria Paoletti, Agostina Solinas, Elisa Ballardini, Serafina Perrone, Sabrina Moretti, Marcello Stella, Alberto Berardi, Fabrizio Ferrari

{"title":"Real-World Therapeutic Hypothermia for Neonatal HIE: Neurodevelopmental Outcomes and Predictors.","authors":"Luca Bedetti, Licia Lugli, Isotta Guidotti, Maria Federica Roversi, Elisa Della Casa Muttini, Marisa Pugliese, Natascia Bertoncelli, Eugenio Spaggiari, Alessandra Todeschini, Gina Ancora, Sara Grandi, Giancarlo Gargano, Claudio Gallo, Mario Motta, Piero Catenazzi, Luigi Tommaso Corvaglia, Vittoria Paoletti, Agostina Solinas, Elisa Ballardini, Serafina Perrone, Sabrina Moretti, Marcello Stella, Alberto Berardi, Fabrizio Ferrari","doi":"10.1111/apa.70186","DOIUrl":"https://doi.org/10.1111/apa.70186","url":null,"abstract":"Aim: This study assessed neurodevelopmental outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH) outside randomised controlled trials (RCTs). It also aimed to identify predictors of outcomes and evaluate TH practices across centres.Methods: A prospective, area-based observational study was conducted in eight Italian NICUs (2016-2021), including neonates treated with TH for any grade of HIE. A 2-year neurodevelopmental follow-up was performed. Severe functional disability (SFD) was defined as cerebral palsy (Gross Motor Function Classification Level > 2), cognitive score < 2 SD, bilateral blindness/deafness, or epilepsy. Demographic, clinical and MRI data were analysed.Results: Among 283 cooled infants, 11 (3.8%) died and 272 (96.2%) survived. HIE severity was mild (14.0%), moderate (76.1%) and severe (9.9%). Follow-up data were available for 232 (85.3%) survivors, with SFD diagnosed in 27 (11.6%). No infants with mild HIE developed SFD. Severe MRI anomalies were found in 51.9% of SFD cases, while 90.7% of non-SFD children had normal findings. cEEG/aEEG-confirmed seizures (OR = 12.9, CI 3.5-65.0) and severe MRI anomalies (OR = 0.24, CI 0.13-0.44) were strong SFD predictors (AUC = 0.95).Conclusion: Mortality and SFD rates were lower than in RCTs. Seizures and severe MRI anomalies predicted poor outcomes. Further RCTs are needed to refine treatment criteria.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Adolescent Involvement in Type 1 Diabetes Treatment: A Scoping Review of Person-Reported Outcome Instruments. 评估青少年参与1型糖尿病治疗：对个人报告结果工具的范围审查。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-17 DOI: 10.1111/apa.70181

Rikke Bjerre Rokkjær, Caroline Bruun Abild, Kurt Kristensen, Lene Juel Solskov, Annesofie Lunde Jensen

{"title":"Assessing Adolescent Involvement in Type 1 Diabetes Treatment: A Scoping Review of Person-Reported Outcome Instruments.","authors":"Rikke Bjerre Rokkjær, Caroline Bruun Abild, Kurt Kristensen, Lene Juel Solskov, Annesofie Lunde Jensen","doi":"10.1111/apa.70181","DOIUrl":"https://doi.org/10.1111/apa.70181","url":null,"abstract":"Aim: The aim of this study was to identify and map the content, structure, and application of person-reported outcome instruments used to assess the experience of treatment involvement among adolescents with type 1 diabetes.Methods: Studies were identified in PubMed, Embase, CINAHL, PsycINFO, JSTOR, and MedNar. We included studies that used instruments that assess treatment involvement among adolescents (aged 11-18 years) with type 1 diabetes. All review steps involved two reviewers. Data extraction, charting, and analysis were guided by a template focusing on the content, structure, and application of instruments.Results: This scoping review identified 23 instruments used in 52 studies, measuring different kinds of treatment involvement among adolescents with type 1 diabetes, e.g., communication with clinicians, clinicians' commitment, and shared decision-making. Both instrument length and response formats varied across instruments. Some instruments were applicable in adolescents, whereas others were suitable for use in adults.Conclusion: This review details the use of several instruments assessing treatment involvement experiences among adolescents with type 1 diabetes. The findings of this review can guide clinicians and researchers on optimal instrument content, structure, and application to implement a person-centred care practice in paediatric diabetes care.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Body Fat in Normal Weight Girls Was Related to Inflammatory Markers and Cardiometabolic Risk. 正常体重女孩的高体脂与炎症标志物和心脏代谢风险有关。

IF 2.4 4区医学

Acta Paediatrica Pub Date : 2025-06-13 DOI: 10.1111/apa.70144

Ariane Ribeiro de Freitas Rocha, Nubia de Souza de Morais, Francilene Maria Azevedo, Dayane de Castro Morais, Patrícia Feliciano Pereira, Maria do Carmo Gouveia Peluzio, Sylvia do Carmo Castro Franceschini, Silvia Eloiza Priore

{"title":"High Body Fat in Normal Weight Girls Was Related to Inflammatory Markers and Cardiometabolic Risk.","authors":"Ariane Ribeiro de Freitas Rocha, Nubia de Souza de Morais, Francilene Maria Azevedo, Dayane de Castro Morais, Patrícia Feliciano Pereira, Maria do Carmo Gouveia Peluzio, Sylvia do Carmo Castro Franceschini, Silvia Eloiza Priore","doi":"10.1111/apa.70144","DOIUrl":"https://doi.org/10.1111/apa.70144","url":null,"abstract":"Aim: The aim was to evaluate the relationship between body fat (BF) in girls and inflammatory markers and cardiometabolic risk factors.Methods: This was a cross-sectional study of 555 girls aged 10-19 years. They were divided into three body mass index (BMI) and BF groups: normal BMI/BF, normal BMI/high BF, and overweight or obesity, using the WHO definition. BF was assessed using dual-energy X-ray absorptiometry, considering 25% as a cut-off for high BF. We also evaluated systolic and diastolic blood pressures, lipid profile, fasting glucose, insulin, uric acid levels and inflammatory markers.Results: Excess BF was positively correlated with higher levels of blood pressure (r = 0.323), triglycerides (r = 0.146), uric acid (r = 0.358), leptin (r = 0.712), high-sensitivity C-reactive protein (r = 0.336), insulin (r = 0.258) and markers of insulin resistance (r = 0.265, r = 0.159). It was negatively correlated with high-density lipoprotein cholesterol (r = -0.222). In girls with a normal body mass index, excess BF was correlated with an unfavourable lipid profile and the presence of subclinical inflammation; these were similar to those observed in the girls with obesity.Conclusion: High BF in normal weight girls was related to inflammatory markers and cardiometabolic risk. These assessments are important because inflammation and cardiometabolic risk parameters persist or worsen from adolescence to adulthood.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0