Mortality and Neurodevelopmental Outcome in an Italian Cohort of Very Low Birth Weight Infants.

IF 2.1 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2025-08-27 DOI:10.1111/apa.70292

Lugli Licia, Bedetti Luca, Pugliese Marisa, Guidotti Isotta, Ancora Gina, Gargano Giancarlo, Perrone Serafina, Solinas Agostina, Motta Mario, Corvaglia Luigi Tommaso, Sansavini Alessandra, Stella Marcello, Cuoghi Costantini Riccardo, DiCaprio Antonella, Della Casa Muttini Elisa, Roversi Maria Federica, Bertoncelli Natascia, Catenazzi Piero, Ballardini Elisa, Grandi Sara, Moretti Sabrina, Turoli Daniela, Aceti Arianna, Braibanti Silvia, Insalaco Anna, Camilla Migliozzi, Fumagalli Monica, Ferrari Fabrizio, Berardi Alberto

{"title":"Mortality and Neurodevelopmental Outcome in an Italian Cohort of Very Low Birth Weight Infants.","authors":"Lugli Licia, Bedetti Luca, Pugliese Marisa, Guidotti Isotta, Ancora Gina, Gargano Giancarlo, Perrone Serafina, Solinas Agostina, Motta Mario, Corvaglia Luigi Tommaso, Sansavini Alessandra, Stella Marcello, Cuoghi Costantini Riccardo, DiCaprio Antonella, Della Casa Muttini Elisa, Roversi Maria Federica, Bertoncelli Natascia, Catenazzi Piero, Ballardini Elisa, Grandi Sara, Moretti Sabrina, Turoli Daniela, Aceti Arianna, Braibanti Silvia, Insalaco Anna, Camilla Migliozzi, Fumagalli Monica, Ferrari Fabrizio, Berardi Alberto","doi":"10.1111/apa.70292","DOIUrl":null,"url":null,"abstract":"Aim: Preterm infants face high risks of mortality and neurodevelopmental impairment. We aimed to evaluate the outcomes in an Italian cohort of very low birth weight infants.Methods: This multicenter prospective study included very low birth weight infants born in Italy between 2016 and 2020. Severe functional disability was defined as cognitive impairment, cerebral palsy, blindness or deafness.Results: A total of 1381 patients were enrolled (median gestational age: 29.1 weeks; males: 678) and 136 (9.8%) died. Multivariate analysis identified gestational age (OR 0.65), prenatal steroids (OR 0.36), magnesium sulphate (OR 0.48), advanced resuscitation (OR 4.04) and admission body temperature (OR 0.84) as predictors of mortality. A total of 802 (65.5%) completed the 24-month neurodevelopmental follow-up. Severe functional disability was observed in 71/802 (8.9%) infants, including neuropsychological impairment (59.1%), cerebral palsy (4.2%), deafness (1%) and blindness (0.2%). Multivariate analysis identified male gender (OR 1.84), advanced resuscitation (OR 1.92), periventricular leukomalacia (OR 9.94) and periventricular-intraventricular haemorrhage (OR 1.74) as predictors of severe functional disability.Conclusion: Mortality and neurodevelopmental impairments in very low birth weight infants were associated with gestational age and neonatal complications. Early interventions, including prenatal steroids, magnesium sulphate and improved neonatal care, may enhance survival and outcomes.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Paediatrica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/apa.70292","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: Preterm infants face high risks of mortality and neurodevelopmental impairment. We aimed to evaluate the outcomes in an Italian cohort of very low birth weight infants.

Methods: This multicenter prospective study included very low birth weight infants born in Italy between 2016 and 2020. Severe functional disability was defined as cognitive impairment, cerebral palsy, blindness or deafness.

Results: A total of 1381 patients were enrolled (median gestational age: 29.1 weeks; males: 678) and 136 (9.8%) died. Multivariate analysis identified gestational age (OR 0.65), prenatal steroids (OR 0.36), magnesium sulphate (OR 0.48), advanced resuscitation (OR 4.04) and admission body temperature (OR 0.84) as predictors of mortality. A total of 802 (65.5%) completed the 24-month neurodevelopmental follow-up. Severe functional disability was observed in 71/802 (8.9%) infants, including neuropsychological impairment (59.1%), cerebral palsy (4.2%), deafness (1%) and blindness (0.2%). Multivariate analysis identified male gender (OR 1.84), advanced resuscitation (OR 1.92), periventricular leukomalacia (OR 9.94) and periventricular-intraventricular haemorrhage (OR 1.74) as predictors of severe functional disability.

Conclusion: Mortality and neurodevelopmental impairments in very low birth weight infants were associated with gestational age and neonatal complications. Early interventions, including prenatal steroids, magnesium sulphate and improved neonatal care, may enhance survival and outcomes.

查看原文本刊更多论文

意大利极低出生体重儿队列的死亡率和神经发育结局。

目的：早产儿面临高死亡率和神经发育障碍的风险。我们的目的是评估意大利极低出生体重婴儿队列的结果。方法：这项多中心前瞻性研究纳入了2016年至2020年在意大利出生的极低出生体重婴儿。重度功能障碍被定义为认知障碍、脑瘫、失明或耳聋。结果：共纳入1381例患者（中位胎龄：29.1周；男性：678），136例（9.8%）死亡。多因素分析发现，胎龄（OR 0.65）、产前类固醇（OR 0.36）、硫酸镁（OR 0.48）、晚期复苏（OR 4.04）和入院体温（OR 0.84）是死亡率的预测因素。共有802例（65.5%）完成了24个月的神经发育随访。71/802例（8.9%）婴儿出现严重功能障碍，包括神经心理障碍（59.1%）、脑瘫（4.2%）、耳聋（1%）和失明（0.2%）。多因素分析发现，男性（OR 1.84）、晚期复苏（OR 1.92）、脑室周围白质软化（OR 9.94）和脑室周围-脑室内出血（OR 1.74）是严重功能障碍的预测因素。结论：极低出生体重儿的死亡率和神经发育障碍与胎龄和新生儿并发症有关。早期干预，包括产前类固醇、硫酸镁和改善新生儿护理，可能提高生存率和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries