Ariadne Malamitsi-Puchner, Despina D Briana, Josef Neu
{"title":"The Long-Term Effects of Gut Microbiota of Premature Babies and Adult Health.","authors":"Ariadne Malamitsi-Puchner, Despina D Briana, Josef Neu","doi":"10.1111/apa.70286","DOIUrl":"https://doi.org/10.1111/apa.70286","url":null,"abstract":"<p><p>A proposed mechanism of how early life microbiota predisposes to later metabolic syndrome.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ragnhild B Lygre, John Roger Andersen, Rolf Gjestad, Helene Helgeland, Gottfried Greve, Irene Bircow Elgen
{"title":"Paediatric Patients With Multiple Referrals and Complex Health Complaints Experienced Notable Functional Impairment.","authors":"Ragnhild B Lygre, John Roger Andersen, Rolf Gjestad, Helene Helgeland, Gottfried Greve, Irene Bircow Elgen","doi":"10.1111/apa.70278","DOIUrl":"https://doi.org/10.1111/apa.70278","url":null,"abstract":"<p><strong>Aim: </strong>Managing patients with complex health complaints is challenging, because cumulative functional impairment may be overlooked when such complaints are considered individually. This Norwegian study examined functional impairment in paediatric patients with complex somatic and mental health complaints.</p><p><strong>Methods: </strong>Data for this open-label trial were collected from 1 January 2020 to 1 July 2023, before an interdisciplinary intervention for paediatric patients aged 6-16 years with multiple referrals to Haukeland University Hospital. Patients were recruited from the paediatric neurology and gastroenterology departments, and the parents completed the KIDSCREEN-27 tool on health-related quality of life and a questionnaire on school absences.</p><p><strong>Results: </strong>The 71 patients (51% boys) had a mean age of 12 years. Their parents reported that the patients had significantly lower health-related quality of life than norms for the general European population. School absences were high, with 52% of children missing school weekly. Lower health-related quality of life scores were linked to increased school absences, while increased age was associated with reduced school environment scores.</p><p><strong>Conclusion: </strong>Paediatric patients with multiple referrals and complex health complaints experienced notable functional impairment. These patients should be offered holistic assessments of both their complaints and their functional impairment.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges of Cough and Cold Medications or Rituals.","authors":"Sergio Verd, Marianna Mambie","doi":"10.1111/apa.70282","DOIUrl":"https://doi.org/10.1111/apa.70282","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ellinor Nilsson, Jairo H Migueles, Pontus Henriksson, Christine Delisle Nyström, Marie Löf
{"title":"Higher Sedentary Behaviour and Not Following Screen Time Guidelines Were Associated With Unfavourable Cardiometabolic Outcomes in Childhood.","authors":"Ellinor Nilsson, Jairo H Migueles, Pontus Henriksson, Christine Delisle Nyström, Marie Löf","doi":"10.1111/apa.70276","DOIUrl":"https://doi.org/10.1111/apa.70276","url":null,"abstract":"<p><strong>Aim: </strong>Sedentary behaviour may influence children's cardiometabolic health; however, evidence remains limited. This study investigated the associations between sedentary behaviour and cardiometabolic outcomes in nine-year-old children and from 4 to 9 years of age. Associations between adherence to screen time guidelines and cardiometabolic outcomes at 9 years of age were also examined.</p><p><strong>Methods: </strong>Movement behaviours were assessed using accelerometers in 411 children at 4 and 9 years of age. Cardiometabolic outcomes at 9 years of age comprised blood pressure, lipid and glucose biomarkers, and a metabolic syndrome score. Screen time was assessed via questionnaire. Compositional data analysis and analysis of covariance were used.</p><p><strong>Results: </strong>Increasing sedentary behaviour at the expense of physical activity and sleep at 9 years of age was associated with higher systolic (p = 0.021) and diastolic (p = 0.019) blood pressure. Greater sedentary behaviour at 4 years of age was associated with higher diastolic blood pressure (p = 0.050) and lower high-density lipoprotein (p = 0.034) at 9 years of age. Children adhering to screen time guidelines had a lower metabolic syndrome score (p = 0.014), low-density lipoprotein (p = 0.045), and triglycerides (p = 0.022).</p><p><strong>Conclusion: </strong>Higher sedentary behaviour and not adhering to screen time guidelines were associated with unfavourable cardiometabolic outcomes from 4 to 9 years and at 9 years of age.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elin Backman, Richard Lundberg-Ulfsdotter, Sven-Arne Silfverdal, Christina E West, Magnus Domellöf
{"title":"Effects of the COVID-19 Lockdowns on Gross Motor and Fine Motor Neurodevelopment in Toddlers.","authors":"Elin Backman, Richard Lundberg-Ulfsdotter, Sven-Arne Silfverdal, Christina E West, Magnus Domellöf","doi":"10.1111/apa.70266","DOIUrl":"https://doi.org/10.1111/apa.70266","url":null,"abstract":"<p><strong>Aim: </strong>To investigate possible differences in neurodevelopment between lockdown-exposed and non-exposed 18-month-old toddlers in Sweden.</p><p><strong>Methods: </strong>Data were extracted from the prospective NorthPop Birth Cohort Study in Sweden. Neurodevelopment was assessed using the Ages and Stages Questionnaire Third Edition (ASQ-3) and a clinical routine evaluation at the child health care centre for additional validation. Statistical analyses were performed using IBM SPSS Statistics.</p><p><strong>Results: </strong>More lockdown-exposed toddlers fell below the cut-off score on the ASQ-3 \"Gross motor function\" assessment at 18 months, compared to the pre-lockdown category (5.1% vs. 3.6%, adjusted p = 0.002). Conversely, fewer lockdown-exposed toddlers failed the fine motor task \"Can draw scribble\" versus the pre-lockdown category (1.4% vs. 2.4% adjusted p = 0.014).</p><p><strong>Conclusions: </strong>Toddlers who were lockdown-exposed had lower gross motor function but were more successful in the fine motor task at 18 months.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ulrik Lausten-Thomsen, Paula L Hedley, Kristin M Conway, Katrine M Løfberg, Lars S Johansen, Paul A Romitti, Michael Christiansen
{"title":"Nationwide Danish Register Based Study Showed a Stable Prevalence of Congenital Diaphragmatic Hernias From 1994 to 2021 but a Decrease in Syndromic Cases.","authors":"Ulrik Lausten-Thomsen, Paula L Hedley, Kristin M Conway, Katrine M Løfberg, Lars S Johansen, Paul A Romitti, Michael Christiansen","doi":"10.1111/apa.70251","DOIUrl":"https://doi.org/10.1111/apa.70251","url":null,"abstract":"<p><strong>Aim: </strong>Congenital diaphragmatic hernia (CDH) is a severe malformation with high morbidity and mortality. This Danish study evaluated the birth prevalence, co-occurring malformations, and temporal trends of CDH over nearly three decades.</p><p><strong>Methods: </strong>Nationwide data from the Danish Biobank Register were used to identify liveborn infants diagnosed with CDH from 1994 to 2021. They were classified as non-syndromic or syndromic, based on co-occurring structural malformations or genetic or syndromic anomalies. Poisson regression was used to estimate the prevalence, including annual percentage changes.</p><p><strong>Results: </strong>We found that 272 of the 1 696 357 liveborn infants were diagnosed with CDH, with a stable prevalence of 1.60 per 10 000 live births (95% confidence interval 1.42-1.81). The majority (89.3%) had non-syndromic phenotypes: 79.4% of these had isolated CDH and 20.6% had CDH with co-occurring malformations, predominantly cardiac malformations. Syndromic CDH was observed in 29 (10.7%) infants, and its prevalence declined significantly over the study period (p < 0.03).</p><p><strong>Conclusion: </strong>Although the prevalence of liveborn Danish CDH births remained stable, there was a shift towards fewer syndromic cases, possibly due to improved prenatal screening and increased terminations. The high proportion of major, co-occurring malformations emphasises the need for continued monitoring to address the healthcare needs of these patients.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"European Academy of Paediatrics Position Paper: A Response to the 2024 Declaration of Helsinki Update.","authors":"Joe Brierley, Eduard Verhagen","doi":"10.1111/apa.70273","DOIUrl":"https://doi.org/10.1111/apa.70273","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Manuel Rius-Peris, Enrique Palomo-Atance, Eva Muro-Díaz, Cristina Llorente-Ruiz, Laura Murcia-Clemente, Raúl Alcaraz
{"title":"In Response to 'Unequal Access to Respiratory Syncytial Virus Prevention: Is There a Health Equity Issue in Italy?'","authors":"Juan Manuel Rius-Peris, Enrique Palomo-Atance, Eva Muro-Díaz, Cristina Llorente-Ruiz, Laura Murcia-Clemente, Raúl Alcaraz","doi":"10.1111/apa.70271","DOIUrl":"https://doi.org/10.1111/apa.70271","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}