Francisco Javier Gómez-Manzano, Esperanza Barroso-Corroto, José Alberto Laredo-Aguilera, Rosa María Molina-Madueño, Sergio Rodríguez-Cañamero, Juan Manuel Carmona-Torres
{"title":"Urination Stimulation Techniques for Collecting Clean Urine Samples in Infants Under One Year: Systematic Review and Meta-Analysis.","authors":"Francisco Javier Gómez-Manzano, Esperanza Barroso-Corroto, José Alberto Laredo-Aguilera, Rosa María Molina-Madueño, Sergio Rodríguez-Cañamero, Juan Manuel Carmona-Torres","doi":"10.1111/apa.70091","DOIUrl":"https://doi.org/10.1111/apa.70091","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the efficacy of spontaneous urination stimulation techniques in infants under 1 year to obtain a clean and valid urine sample for analysis.</p><p><strong>Methods: </strong>Systematic review of randomised clinical trials. The databases consulted were PUBMED, SCOPUS, WEB OF SCIENCE, CINALH and the Virtual Health Library. The risk of bias was assessed via the RoB2 scale. A meta-analysis was performed to analyse the success rate of urine collection for both techniques and the contamination rate of the urine samples.</p><p><strong>Results: </strong>Seven studies were included in this review. The participants included 1122 infants, of whom a stimulation technique was performed in 667 (the technique of Herreros et al. was performed in 419 infants, and the \"Quick-Wee\" technique was performed in 248 infants). Success was measured by obtaining a midstream urine sample in less than 5 min. Urination stimulation is effective in obtaining a urine sample, especially at < 6 months of age.</p><p><strong>Conclusion: </strong>Stimulation of urination in infants is a noninvasive, fast, safe, economic and effective procedure that allows the capture of a valid urine sample in the middle of the stream for analysis.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Line Norman Kvenshagen, Anne Lee Solevåg, Siren Rettedal, Amalie Kibsgaard, Joar Eilevstjønn, Kari Holte, Ketil Størdal
{"title":"Preterm Infants Who Did Not Need Positive Pressure Ventilation Had a Lower Heart Rate Immediately After Birth Than Healthy Term Infants.","authors":"Line Norman Kvenshagen, Anne Lee Solevåg, Siren Rettedal, Amalie Kibsgaard, Joar Eilevstjønn, Kari Holte, Ketil Størdal","doi":"10.1111/apa.70079","DOIUrl":"https://doi.org/10.1111/apa.70079","url":null,"abstract":"<p><strong>Aim: </strong>Our aim was to use electrocardiograms immediately after birth to determine the heart rates of healthy newborn infants by gestational age and mode of delivery.</p><p><strong>Methods: </strong>This prospective observational study was performed in two Norwegian hospitals from March 2019 to June 2021. We included infants with gestational ages of ≥ 28 weeks and no need for positive pressure ventilation. Continuous heart rate data were collected using dry electrode technology and were used to create percentile charts and compare heart rates by groups.</p><p><strong>Results: </strong>We enrolled 214 preterm and 2191 term newborn infants. The median (quartiles) heart rate at 60 s of age was 166 (150-181) beats per minute for preterm infants and 174 (158-187) for term infants (p < 0.05). Term infants born using vacuum extraction, forceps or emergency Caesarean sections had significantly higher heart rates than term infants born by unassisted vaginal deliveries or planned Caesarean sections. The median heart rates of the groups were all within the normal range.</p><p><strong>Conclusion: </strong>This study provided normative heart rate data for healthy newborn infants, by gestational age and delivery mode. Although the differences between the groups were statistically significant, they were of limited clinical significance and would not support changes in neonatal resuscitation measures.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Has the Misuse of Antibiotics Compromised a Vital 20th-Century Medical Advancement.","authors":"Ian K Hewitt","doi":"10.1111/apa.70061","DOIUrl":"https://doi.org/10.1111/apa.70061","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A New Way of Knowing When a Newborn's Jaundice Is Dangerous: Are We Ready for 'R'?","authors":"David K Stevenson, Ronald J Wong","doi":"10.1111/apa.70088","DOIUrl":"https://doi.org/10.1111/apa.70088","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brain Activity Study Showed the Benefits of Parents Reading Printed Books to Their Children Rather Than Using Tablets.","authors":"Mikael Heimann","doi":"10.1111/apa.70083","DOIUrl":"https://doi.org/10.1111/apa.70083","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tim Malmström, Zivile Bekassy, Martin Salö, Anna Röckert Tjernberg, Pernilla Stenström
{"title":"Clinical Outcomes and Follow-Up in Children With Prenatally Detected Unilateral Ureteropelvic Junction Obstruction.","authors":"Tim Malmström, Zivile Bekassy, Martin Salö, Anna Röckert Tjernberg, Pernilla Stenström","doi":"10.1111/apa.70086","DOIUrl":"https://doi.org/10.1111/apa.70086","url":null,"abstract":"<p><strong>Aim: </strong>To explore the possibility of reducing the diagnostic burden in children with prenatally detected unilateral ureteropelvic junction obstruction.</p><p><strong>Methods: </strong>Children with unilateral ureteropelvic junction obstruction (2012-2020) were identified from a prenatal hydronephrosis registry. The frequency of adverse events, predictors for event-free follow-up beyond 1 year of age, and examination burden in children with conservatively managed unilateral ureteropelvic junction obstruction were assessed. Adverse events included febrile urinary tract infections, > 10% decline in differential renal function, or both, leading to surgery. Follow-up ended at clinical conclusion or surgical decision.</p><p><strong>Results: </strong>Forty-seven children were included, with a follow-up of median 22.5 (2-115, min-max) months. Overall, 43% (20/47) had no adverse events. Adverse events occurred within 2 years in 85% (23/27). Predictors of event-free follow-up beyond 1 year were a postnatal anteroposterior diameter < 15 mm at 12 months (p < 0.001) or a stable anteroposterior diameter during the first year (p = 0.04). Patients without adverse events underwent a median of eight (3-26, min-max) diagnostic imaging examinations.</p><p><strong>Conclusions: </strong>In children with antenatally detected ureteropelvic junction obstruction, 43% had no adverse events, but a substantial examination burden. Predictors of a non-eventful trace, useful in guidelines, were a postnatal anteroposterior diameter < 15 mm or stable at 12 months.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joakim Bloch, Lisbeth Schmidt, Nadja Vissing, Jonathan Peter Glenthøj, Birgitte Smith, Alfred Peter Born, Anja Poulsen, Anne-Mette Lebech, Ulrikka Nygaard
{"title":"Oral Doxycycline Was a Safe and Feasible Treatment in Young Children With Neuroborreliosis.","authors":"Joakim Bloch, Lisbeth Schmidt, Nadja Vissing, Jonathan Peter Glenthøj, Birgitte Smith, Alfred Peter Born, Anja Poulsen, Anne-Mette Lebech, Ulrikka Nygaard","doi":"10.1111/apa.70085","DOIUrl":"https://doi.org/10.1111/apa.70085","url":null,"abstract":"<p><strong>Aim: </strong>There is limited evidence on the use of oral doxycycline in young children. We evaluated the feasibility and effectiveness of doxycycline in children under 9 years with neuroborreliosis.</p><p><strong>Methods: </strong>This retrospective study included all children under 9 years of age treated for neuroborreliosis in the Capital Region of Denmark from 2019 to 2023. Patients were identified through Borrelia burgdorferi antibody tests and International Classification of Disease, 10th revision codes. Outcomes were change of treatment route, intolerable adverse effects of oral doxycycline, progression of symptoms after treatment cessation, continuous symptoms of neuroborreliosis exceeding 6 months, and relapse of neuroborreliosis.</p><p><strong>Results: </strong>Of 116 children, 63 (54%) received doxycycline initially, 4 (6%) of whom switched to intravenous treatment due to adverse effects or symptom worsening during treatment. Of 46 (40%) receiving intravenous antibiotics followed by doxycycline, 45 (98%) completed the remaining treatment on doxycycline. Seven (6%) patients received intravenous antibiotics only. Of 109 patients receiving doxycycline, two (2%) experienced photosensitivity rash. Symptoms lasting over 6 months were observed in two patients. No patients had symptom progression or relapse during the follow-up period (median 41 months, range 12-66).</p><p><strong>Conclusion: </strong>Oral doxycycline was effective and feasible in children under 9 years with neuroborreliosis.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical Partnership Between Two Children's Hospitals in Ukraine and Sweden.","authors":"Zhovnir Volodymyr, Svante Norgren","doi":"10.1111/apa.70087","DOIUrl":"https://doi.org/10.1111/apa.70087","url":null,"abstract":"","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Swedish Boys Were Almost Twice as Likely to be Referred for Suspected Language Difficulties Than Girls and at an Earlier Age.","authors":"Anton Dahlberg, AnnaKarin Larsson, Anna Fäldt","doi":"10.1111/apa.70080","DOIUrl":"https://doi.org/10.1111/apa.70080","url":null,"abstract":"<p><strong>Aim: </strong>This study investigated gender differences in referrals to speech and language therapy (SLT) services in children 1.5-6.0 years of age and the distribution of children identified through universal language screening at 2.5-3.0 years within Swedish child health services.</p><p><strong>Methods: </strong>We conducted a population-based, cross-sectional study using register data from 53 595 children. Data were collected from eight Swedish regions between 1 May 2015 and 1 June 2023, including gender, referral details and screening outcomes.</p><p><strong>Results: </strong>Of all children, 9.60% (n = 5144) were referred. Boys were referred significantly more often than girls (12.26% vs. 6.79%), χ<sup>2</sup>(df = 1, N = 53 595) = 701.38, p < 0.001. The odds of referral were 1.94 times higher for boys (OR = 1.94, 95% CI 1.85 to 2.04). Boys were also referred at a younger median age (3.08 vs. 3.58 years). Among children who failed screening, boys were more likely to be referred within 3 months (17.2% vs. 13.5%), OR = 1.63, 95% CI 1.45 to 1.84.</p><p><strong>Conclusion: </strong>Significant gender disparities exist in both screening and referral practices, with boys referred more frequently and at younger ages. Refining screening protocols is essential to ensure early and equitable intervention access for all children.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}