Acta Paediatrica最新文献_第7页

Serum Growth Differentiation Factor 15 Levels in School-Aged Children Born Preterm. 学龄期早产儿血清生长分化因子15水平的研究

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-06 DOI: 10.1111/apa.70795

Miwa Goto, Anna Kobayashi, Hiroaki Kanai, Nobuyuki Katsumata, Atsushi Naito, Emi Sawanobori

引用次数: 0

Children Captured in the Swedish National Airway Register Have Increased Familial Atopy, More Severe Disease and Higher Socioeconomic Status. 在瑞典国家气道登记的儿童有增加的家族性特应性，更严重的疾病和更高的社会经济地位。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-06 DOI: 10.1111/apa.70785

Hanna Karim, Cecilia Lundholm, Bronwyn Brew, Emma Caffrey Osvald, Caroline Stridsman, Resthie R Putri, Jon Roald Konradsen, Catarina Almqvist

{"title":"Children Captured in the Swedish National Airway Register Have Increased Familial Atopy, More Severe Disease and Higher Socioeconomic Status.","authors":"Hanna Karim, Cecilia Lundholm, Bronwyn Brew, Emma Caffrey Osvald, Caroline Stridsman, Resthie R Putri, Jon Roald Konradsen, Catarina Almqvist","doi":"10.1111/apa.70785","DOIUrl":"https://doi.org/10.1111/apa.70785","url":null,"abstract":"Aim: We estimated the coverage of children recorded in the Swedish National Airway Register (SNAR) and identified predictors of registration among those with asthma and moderate to severe asthma.Methods: This study comprised 85 656 children aged 5-17 years with asthma, born 2000-2019 and living in Stockholm. The children were identified through diagnoses and dispensed medication in national and regional health registers. Registration in the SNAR was assessed. Logistic regression compared characteristics of registered and unregistered children, with associations presented as odds ratios (OR) and 95% confidence intervals (CI).Results: Overall, 33 815 (39.5%) of children with asthma were registered in the SNAR. Registration was more common among children with allergic rhinitis (OR 1.83, 95% CI 1.77-1.88), parental asthma and allergic rhinitis (maternal OR 1.47, 95% CI 1.43-1.51), higher parental income and education (OR 1.09, 95% CI 1.05-1.12), and moderate to severe asthma (OR 1.37, 95% CI 1.32-1.42). Findings were similar in the moderate to severe asthma sub-cohort.Conclusion: Nearly 40% of children with asthma in Stockholm were registered in the SNAR, and they were more likely to have familial atopy, higher socioeconomic status, and more severe disease. The SNAR is being developed to increase coverage, support standardized registration, and improve care.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver Transplantation in Inborn Errors of Metabolism: A Retrospective Study of a National Experience. 肝移植治疗先天性代谢缺陷：一个国家经验的回顾性研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-06 DOI: 10.1111/apa.70792

Adi Efron-Srour, Eyal Reller, Michal Gafner, Danit Javasky, Chen Barazani Chayat, Galit Tal, Orna Staretz-Chacham, Ronen Spiegel, Yael Mozer-Glassberg, Michal Rozenfeld Bar-Lev, Michael Gurevich, Orith Waisbourd-Zinman, Yuval E Landau

{"title":"Liver Transplantation in Inborn Errors of Metabolism: A Retrospective Study of a National Experience.","authors":"Adi Efron-Srour, Eyal Reller, Michal Gafner, Danit Javasky, Chen Barazani Chayat, Galit Tal, Orna Staretz-Chacham, Ronen Spiegel, Yael Mozer-Glassberg, Michal Rozenfeld Bar-Lev, Michael Gurevich, Orith Waisbourd-Zinman, Yuval E Landau","doi":"10.1111/apa.70792","DOIUrl":"https://doi.org/10.1111/apa.70792","url":null,"abstract":"Aim: Over the past four decades, liver transplantation has been performed worldwide for metabolic diseases, mainly to ameliorate the metabolic defect. However, little has been described regarding the indications and outcomes of the procedure.Methods: Data were collected retrospectively from medical records of 28 paediatric patients with metabolic diseases who underwent liver transplantation in Israel since 2008, considering both metabolic and liver transplant outcomes.Results: The underlying diagnoses for liver transplantation included urea cycle defects, organic acidemias, aminoacidopathies, glycogen storage disease, congenital disorder of glycosylation and a mitochondrial disorder. The mean age at transplantation was 49.5 ± 49.8 months. The mean follow-up time was 53.1 ± 46.8 months. Metabolic crises per year decreased, from a mean 3.8 ± 3.9 pre-transplant to none post-transplant (p < 0.001), and hospitalization frequency decreased from 7.1 ± 5.4 to 1.6 ± 1.7 (p < 0.001). Both surgical and late-term complications were mostly similar to those of nonmetabolic paediatric liver transplantations. Only three patients exhibited new neurological issues after transplant, two of which were likely attributed to the neurotoxic effects of immunosuppression.Conclusions: Liver transplantation is a promising alternative for the treatment of certain metabolic diseases, offering potential benefits in metabolic crises and hospitalization frequency, dietary restrictions, medication regimens and neurodevelopmental status.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Words Matter: A Neonatologist's Perspective on Language and Dignity in the Neonatal Intensive Care Unit. 词语很重要：新生儿专科医生对新生儿重症监护病房的语言和尊严的看法。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-06 DOI: 10.1111/apa.70787

Sowjanya Sivakoti

引用次数: 0

Incidence of Culture-Proven Neonatal Sepsis and Its Correlation With Nurse Staffing in a Level IV Neonatal Intensive Care Unit: A Six-Year Cohort Study. 培养证实的新生儿脓毒症发生率及其与四级新生儿重症监护病房护士配置的相关性：一项为期六年的队列研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-03 DOI: 10.1111/apa.70783

A Gudiksen, M Breindahl, F B Hertz, J D Knudsen, S A Beck, S G Herrmann, L Aunsholt, E M Carlsen

{"title":"Incidence of Culture-Proven Neonatal Sepsis and Its Correlation With Nurse Staffing in a Level IV Neonatal Intensive Care Unit: A Six-Year Cohort Study.","authors":"A Gudiksen, M Breindahl, F B Hertz, J D Knudsen, S A Beck, S G Herrmann, L Aunsholt, E M Carlsen","doi":"10.1111/apa.70783","DOIUrl":"https://doi.org/10.1111/apa.70783","url":null,"abstract":"Aim: To assess the incidence of culture-proven sepsis and examine the correlation between positive blood cultures and nurse staffing in a Level IV neonatal intensive care unit (NICU).Methods: This retrospective cohort study included neonates with ≥ 1 positive blood culture and signs of infection between 2018 and 2023. Infection episodes were defined as culture-proven sepsis treated with antibiotics for ≥ 3 days and divided into early-onset sepsis (EOS), ≤ 72 h after birth or late-onset sepsis (LOS), > 72 h after birth. Nurse staffing was prospectively recorded and expressed as the ratio of actual to recommended attendance according to British Association of Perinatal Medicine standards.Results: Among 6 856 admissions, 514 episodes of positive blood cultures were identified in 310 neonates; 421 (82%) were classified as infections. Coagulase-negative staphylococci were the predominant pathogen. The incidence of positive blood cultures increased from 5.4% in 2018-2020 to 6.9% in 2021-2023. EOS increased (from 0.6% to 1.1%, p = 0.02). There was an inverse correlation between nurse staffing levels and number of LOS episodes (p < 0.01).Conclusion: Culture-proven sepsis increased over time in this NICU, primarily driven by EOS. Higher numbers of LOS episodes correlated with lower nurse staffing levels, suggesting a potential role of adequate staffing in infection prevention.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disclosing AI. 披露AI。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-03 DOI: 10.1111/apa.70786

Danilo Buonsenso, Francesco Mariani

引用次数: 0

Early Catch-Down Growth in the Offspring of Mothers With Gestational Diabetes. 妊娠期糖尿病母亲的后代早期发育

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-03 DOI: 10.1111/apa.70790

Leena Hintikka, Tuomas Selander, Henrikki Nordman, Raimo Voutilainen, Hanna Huopio, Jarmo Jääskeläinen

引用次数: 0

Low Serum Alkaline Phosphatase Levels in Paediatric sepsis Correlate With Acute Kidney Injury: A Multicenter Retrospective Study. 儿童脓毒症低血清碱性磷酸酶水平与急性肾损伤相关：一项多中心回顾性研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-28 DOI: 10.1111/apa.70665

Evgenia Gurevich, Ido Levi, Yehonatan Marziano, Michael Kalinin, Natalya Bilenko, Daniel Landau

{"title":"Low Serum Alkaline Phosphatase Levels in Paediatric sepsis Correlate With Acute Kidney Injury: A Multicenter Retrospective Study.","authors":"Evgenia Gurevich, Ido Levi, Yehonatan Marziano, Michael Kalinin, Natalya Bilenko, Daniel Landau","doi":"10.1111/apa.70665","DOIUrl":"10.1111/apa.70665","url":null,"abstract":"Aims: To investigate the association between serum ALP levels and the development of AKI in paediatric patients with sepsis.Methods: Retrospective screening of a computerized database of 4 Israeli regional hospitals for children (0-18 years) hospitalized between 1.01.2000-1.06.2024 with ICD-9 sepsis-related diagnoses (study group) and age- and sex-matched non-septic febrile patients (controls). Serum ALP levels were sex- and age-adjusted and described as standard deviation scores (SDS).Results: Of 809 952 screened hospitalizations, 701 records comprised the study group. Their median (IQR) age was 17 (10-38) months, 53% were males. Nadir ALP-SDS was lower in the sepsis group compared to controls (-1.65 ± 1.11 vs. -0.97 ± 1.36, p < 0.001) and further lower in those with AKI, which occurred in 23% of the sepsis cohort (-1.95 ± 1.16 vs. -1.56 ± 1.09, p < 0.001). Hospital stay was longer in the AKI compared to non-AKI group [median (IQR): 7 (4, 12) vs. 4 (3, 5) days, p < 0.001]. Lower ALP-SDS was independently associated with AKI [OR (95% CI): 0.7 (0.6-0.8), p < 0.001], after controlling for CRP and leucocyte count.Conclusions: ALP was lower in sepsis patients compared to controls, and significantly lower in AKI vs. non-AKI group, suggesting it as an additional marker of infection severity.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2315-2322"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBNEO Commentary: Impact of Attending Neonatologist Presence on Neonatal Intubation Success and Adverse Events: A Cohort Study. EBNEO评论：参加新生儿医生在场对新生儿插管成功和不良事件的影响：一项队列研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-04-28 DOI: 10.1111/apa.70566

Christopher Angus, Prakash Kannan Loganathan

引用次数: 0

Sepsis and Antibiotics in Extremely Preterm Infants: Early Empirical Treatment Was Common, While Late-Onset Sepsis Accounted for Most Cases and Antibiotic Use. 极早产儿的脓毒症和抗生素：早期经验治疗是常见的，而迟发性脓毒症占大多数病例和抗生素的使用。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-09 DOI: 10.1111/apa.70637

Anna Bjerager Arnesen, Nini Møller, Louise Dyrberg Vibede, Kristian Vestergaard, Sara Krøis Holm, Cæcilie Trier, Hristo Stanchev, Gholamreza Dayani, Ulrikka Nygaard, Bo Mølholm Hansen, Emma Malchau Carlsen

{"title":"Sepsis and Antibiotics in Extremely Preterm Infants: Early Empirical Treatment Was Common, While Late-Onset Sepsis Accounted for Most Cases and Antibiotic Use.","authors":"Anna Bjerager Arnesen, Nini Møller, Louise Dyrberg Vibede, Kristian Vestergaard, Sara Krøis Holm, Cæcilie Trier, Hristo Stanchev, Gholamreza Dayani, Ulrikka Nygaard, Bo Mølholm Hansen, Emma Malchau Carlsen","doi":"10.1111/apa.70637","DOIUrl":"10.1111/apa.70637","url":null,"abstract":"Aim: The aim was to investigate the incidence of sepsis and use of antibiotics among extremely preterm infants, given the limited number of population-based studies examining this.Methods: This retrospective study in Eastern Denmark included all liveborn infants from 23 + 0 weeks/days to 27 + 6 weeks/days of gestation from 2019 to 21. Data on dispensed intravenous antibiotics were obtained from the regional joint electronic health platform. Early-onset sepsis was defined as occurring within the first 72 h of life and late-onset sepsis from 3 to 90 days. Positive blood culture episodes were classified as proven sepsis.Results: Within the first six months of life, 187 of the 232 (81%) infants received intravenous antibiotics. Empirical treatment was initiated for early-onset sepsis in 164 of the 232 infants (71%) and late-onset sepsis in 118 (51%). Late-onset sepsis accounted for 90% of proven sepsis, predominantly caused by Staphylococcus aureus and Coagulase-negative Staphylococcus. Antibiotic use for late-onset sepsis was three-fold higher than for early-onset sepsis (9902 versus 3413 days per 1000 live births). Sepsis caused two deaths (9 per 1000 live births infants).Conclusion: Suspected early-onset sepsis was the most common indication for antibiotic initiation, but late-onset accounted for most proven sepsis episodes and antibiotic exposure in extremely preterm infants.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2228-2236"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148206961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0