Acta Paediatrica最新文献_第8页

Multifactorial Nature of Childhood Stroke Presents a Major Challenge for Diagnosis and Management: A Population-Based Study From Southern Finland. 儿童中风的多因素性质对诊断和管理提出了重大挑战：一项来自芬兰南部的基于人群的研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-07-01 DOI: 10.1111/apa.70667

Jussi V Leinonen, Samu Kurki, Siina Pamilo, Juho Immonen, Juha Knuuttila, Matti Hero, Mia Westerholm-Ormio, Pirjo Isohanni, Miika Koskinen

{"title":"Multifactorial Nature of Childhood Stroke Presents a Major Challenge for Diagnosis and Management: A Population-Based Study From Southern Finland.","authors":"Jussi V Leinonen, Samu Kurki, Siina Pamilo, Juho Immonen, Juha Knuuttila, Matti Hero, Mia Westerholm-Ormio, Pirjo Isohanni, Miika Koskinen","doi":"10.1111/apa.70667","DOIUrl":"10.1111/apa.70667","url":null,"abstract":"Aim: Childhood ischemic stroke is rare but causes substantial long-term morbidity, and its heterogeneous aetiology complicates timely diagnosis and management.Methods: We conducted a retrospective population-based observational study using hospital data and chart review to describe diagnostics, treatment and outcomes of ischemic stroke in patients aged 1 month to 18 years treated at HUS Helsinki University Hospital between 2010 and 2023. Hemorrhagic strokes were excluded.Results: Among 137 patients, the median annual incidence was 2.5 per 100 000 children. The five largest aetiological subgroups were idiopathic (18%), arteriopathy (16%), major surgery (13%), cardiac embolism (13%) and infection (12%). More than half of patients with available data were diagnosed more than 24 h after symptom onset. Hemiplegia was the most frequent symptom (44%), followed by seizures (25%), which were particularly common in infants. At follow-up, about half of the patients had motor and/or neuropsychological deficits. Epilepsy developed in 20 (15%) patients and recurrent stroke occurred in 8 (6%).Conclusion: Childhood ischemic strokes in our population had heterogeneous causes and substantial long-term morbidity. Diagnostic delays were frequent, underscoring the need to improve recognition of paediatric stroke. The low recurrence rate highlights the importance of population-specific factors when interpreting risk and outcomes.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2332-2340"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reader's Forum: Gestational Age Remains the Dominant Predictor of Severe Retinopathy of Prematurity. 读者论坛：胎龄仍然是严重早产儿视网膜病变的主要预测因子。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-18 DOI: 10.1111/apa.70658

Kelechi Udochu, Aneesha Sidhumanjith Singh, Prakash Kannan Loganathan, Vrinda Nair

引用次数: 0

Medical Skills Curriculum for Interdisciplinary Neonatal Transport Teams: A European Delphi Consensus Study. 跨学科新生儿运输团队的医疗技能课程：欧洲德尔菲共识研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-02 DOI: 10.1111/apa.70635

Emma Therese Bay, Niklas Breindahl, Christian Heiring, Mathilde Maagaard Nielsen, Ulrich Terheggen, Martin Groennebaek Tolsgaard, Lise Aunsholt

{"title":"Medical Skills Curriculum for Interdisciplinary Neonatal Transport Teams: A European Delphi Consensus Study.","authors":"Emma Therese Bay, Niklas Breindahl, Christian Heiring, Mathilde Maagaard Nielsen, Ulrich Terheggen, Martin Groennebaek Tolsgaard, Lise Aunsholt","doi":"10.1111/apa.70635","DOIUrl":"10.1111/apa.70635","url":null,"abstract":"Aim: This study aimed to identify and prioritise medical skills for inclusion in a simulation-based training curriculum for interdisciplinary neonatal interhospital transport teams.Methods: A modified three-round Delphi process was conducted. We included 144 healthcare professionals (101 physicians and 43 non-physician healthcare professionals including nurses, nurse practitioners, paramedics and respiratory therapists) with neonatal transport experience from 14 European countries. In Round 1, participants suggested medical skills. In Round 2, skills were prioritised using a modified Copenhagen Academy for Medical Education and Simulation Needs Assessment Formula. In Round 3, skills were re-prioritised and eliminated based on consensus (> 75% agreement).Results: Consensus was reached on 21 medical skills for physicians and 34 for non-physician healthcare professionals. The highest-ranked skills for physicians included manual non-invasive ventilation, set-up of mechanical ventilation, chest compressions, endotracheal intubation and umbilical venous catheterisation. For non-physician healthcare professionals, the highest-ranked skills included set-up of the transport incubator, monitoring, administration of intravenous infusions and set-up of infusion drivers.Conclusion: This study identified and prioritised medical skills for physicians and non-physician healthcare professionals on neonatal transport teams, which supports the development of simulation-based training aligned with the clinical complexity and interdisciplinary nature of neonatal transport.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2218-2227"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148145170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Point-of-Care Ultrasound in Paediatric Functional Constipation: Expanding Follow-Up Beyond Symptom Resolution. 儿科功能性便秘的点超声：扩大症状解决后的随访。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-25 DOI: 10.1111/apa.70660

Thirunavukkarasu Arun Babu

引用次数: 0

Corrigendum to 'Negligible Allergen Presence in Hospital Dogs After Washing'. “医院里洗过的狗狗中存在可忽略的过敏原”的勘误表。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-07-08 DOI: 10.1111/apa.70673

引用次数: 0

A Swedish Population-Based Study Found That Muscle Hypertonia in Children With Cerebral Palsy Varied by Age, Subtype, Functional Level, and Muscle Group. 瑞典一项基于人群的研究发现，脑瘫儿童的肌肉强直因年龄、亚型、功能水平和肌肉群而异。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-13 DOI: 10.1111/apa.70649

Gunnar Hägglund, Ann I Alriksson-Schmidt

{"title":"A Swedish Population-Based Study Found That Muscle Hypertonia in Children With Cerebral Palsy Varied by Age, Subtype, Functional Level, and Muscle Group.","authors":"Gunnar Hägglund, Ann I Alriksson-Schmidt","doi":"10.1111/apa.70649","DOIUrl":"10.1111/apa.70649","url":null,"abstract":"Aim: We examined how lower limb muscle tone was related to age, sex, Gross Motor Function Classification System (GMFCS) level, and the cerebral palsy (CP) subtype in Swedish children with CP.Methods: This registry-based cohort study from 2023 to 2024 used data on all 3 216 children aged 1-15 from the Swedish follow-up program and national CP Registry. Muscle tone was assessed with the Ashworth Scale in the gastrocsoleus, hamstring, and adductor muscles. Associations between muscle tone and age, GMFCS level, sex, and CP subtype were analysed using descriptive statistics and logistic regression.Results: Hypertonia, defined as Ashworth grade ≥ 1, was present in the gastrocsoleus in 84% of the children, in the hamstrings in 52%, and in the adductors in 34%. Prevalence increased with higher GMFCS levels and varied across age and muscle groups. Gastrocsoleus hypertonia peaked at 7-9 years and then declined. Hamstring hypertonia increased steadily up to 13-15 years. Adductor hypertonia showed a U-shaped pattern across age groups. Children with bilateral spastic or dyskinetic CP had the highest hypertonia levels in all muscle groups.Conclusion: Muscle hypertonia in children with CP varied by age, GMFCS level, CP subtype, and muscle group. This should be considered when planning treatment strategies.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2261-2268"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal Outcomes Following Antenatal Identification of Twin-To-Twin Transfusion Syndrome. 产前鉴定双胎输血综合征后的新生儿结局。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-22 DOI: 10.1111/apa.70659

M Yeoh, A McCreery, N Ranson, P G Davis, S Malone, S Cole, K A Hodgson

引用次数: 0

RETRACTION: Treatment Trajectories among Children and Adolescents Referred to the Norwegian National Center for Gender Incongruence. 撤回：儿童和青少年的治疗轨迹参考挪威国家性别不一致中心。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-07-30 DOI: 10.1111/apa.70717

{"title":"RETRACTION: Treatment Trajectories among Children and Adolescents Referred to the Norwegian National Center for Gender Incongruence.","authors":"","doi":"10.1111/apa.70717","DOIUrl":"10.1111/apa.70717","url":null,"abstract":"Retraction: C. B. Nyquist, L. Torgersen, L. W. David, T. H. Diseth, K. Gulbrandsen, and A. Waehre, \"Treatment Trajectories among Children and Adolescents Referred to the Norwegian National Center for Gender Incongruence,\" Acta Paediatrica 114, no. 5 (2024): 1006-1014. https://doi.org/10.1111/apa.17530. The above article, published online on 08 December 2024 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Hugo Lagercrantz; Foundation Acta Paediatrica; and John Wiley & Sons Ltd. The Commission on Research Integrity at Oslo University Hospital, Akershus University Hospital and Department of Clinical Medicine at the Medical Faculty University of Oslo determined through an official investigation that the research reported in this article did not receive appropriate approvals from a Regional Committee for Medical and Health Research Ethics (REK) and that proper informed consent procedures were not followed. The Commission on Research Integrity therefore recommended that this article should be retracted. Based on this determination, all parties agree that the article should be retracted. All authors were notified about the retraction.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2356"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148622719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accidental Skin Contact With Food Allergens Does Not Trigger Anaphylaxis in Children: A Prospective Multicentre Study. 意外皮肤接触食物过敏原不会引发儿童过敏反应：一项前瞻性多中心研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-06-18 DOI: 10.1111/apa.70655

Idit Lachover-Roth, Sharon Polakow-Farkash, Ido Lusky, Avraham Biegelman

{"title":"Accidental Skin Contact With Food Allergens Does Not Trigger Anaphylaxis in Children: A Prospective Multicentre Study.","authors":"Idit Lachover-Roth, Sharon Polakow-Farkash, Ido Lusky, Avraham Biegelman","doi":"10.1111/apa.70655","DOIUrl":"10.1111/apa.70655","url":null,"abstract":"Aim: Children with food allergies (FA) and their parents frequently fear that accidental skin contact with allergenic foods may cause severe systemic reactions. This study aimed to evaluate the risk of systemic allergic reactions following controlled skin exposure to common food allergens in children with confirmed FA.Methods: In this multicentre study, children aged 1-18 years with FA underwent patch testing with allergenic food applied to the forearm for 15 min. Two age- and sex-matched control groups were included (with atopic comorbidities without FA and healthy controls). Clinical reactions were monitored.Results: 293 children enrolled, including 192 (65.5%) with FA. Among 263 patch tests in the FA group, 220 (83.7%) were negative, 40 (15.2%) resulted in mild local skin reactions, and 3 (1.1%) induced more extensive skin reactions limited to the tested arm. No systemic reactions or anaphylaxis occurred. Cow's milk was associated with a higher rate of skin reactions: 16/68 (23.5%) mild local and 2/68 (2.9%) more extensive reactions. Younger age was the main predictor of skin reactivity.Conclusions: In this cohort, skin contact with allergenic foods in children with FA did not induce anaphylaxis and rarely results in mild local symptoms. These findings support that incidental skin exposure poses minimal risk and may help reduce unnecessary environmental restrictions and their associated psychosocial burden.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2286-2298"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critically Ill Children Show Disrupted Sleep Patterns and Atypical Electroencephalograms: An Observational Cohort Study. 危重儿童表现出睡眠模式紊乱和非典型脑电图：一项观察性队列研究。

IF 1.8 4区医学

Acta Paediatrica Pub Date : 2026-10-01 Epub Date: 2026-07-01 DOI: 10.1111/apa.70666

Eris van Twist, Arnout B G Cramer, Sascha C A T Verbruggen, Maartje Louter, Karlien Veldscholte, Koen F M Joosten, Matthijs de Hoog, Karla Biesheuvel, Dirk C G Straver, Rogier C J de Jonge

{"title":"Critically Ill Children Show Disrupted Sleep Patterns and Atypical Electroencephalograms: An Observational Cohort Study.","authors":"Eris van Twist, Arnout B G Cramer, Sascha C A T Verbruggen, Maartje Louter, Karlien Veldscholte, Koen F M Joosten, Matthijs de Hoog, Karla Biesheuvel, Dirk C G Straver, Rogier C J de Jonge","doi":"10.1111/apa.70666","DOIUrl":"10.1111/apa.70666","url":null,"abstract":"Aim: Sleep disruptions are common in hospitalised children. This study described sleep in critically ill and non-critically ill hospitalised children, including young infants and patients with central nervous system injuries.Methods: This observational cohort study included two groups: critically ill children admitted to a paediatric intensive care unit with expected stay of ≥ 48 h, and non-critically ill children with suspected sleep disordered breathing. Critically ill children were recruited within two clinical studies conducted between 2020 and 2022. Non-critically ill children were recruited from a retrospective database spanning between 2017 and 2021. Sleep was measured using polysomnography and compared with age-specific reference ranges.Results: We included 25 critically ill and 120 non-critically ill children. Median ages were 3.6 (1.0-20.4) and 36.7 (6.1-107.7) months, respectively. In critically ill children, nighttime total sleep time accounted for only 50.9% (49.5-55.5) of 24 h sleep. Rapid eye movement (REM) and deep sleep were reduced in 96.0% and 66.7%, respectively. Electroencephalographic (EEG) abnormalities were common (76.0%). Non-critically ill children had reduced REM sleep in early infancy and shorter, fragmented sleep in older children.Conclusion: Critically ill children had disrupted sleep and atypical EEG, while non-critically ill children mainly had reduced fragmented sleep.","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":"2323-2331"},"PeriodicalIF":1.8,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13552596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0