Has the Rise of Celiac Disease Incidence in Estonian Children Stopped?

IF 2.4 4区医学 Q1 PEDIATRICS

Acta Paediatrica Pub Date : 2025-04-11 DOI:10.1111/apa.70092

Kärt Simre, Heti Pisarev, Mari-Liis Kumm, Marie Kaivo, Oivi Uibo

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引用次数: 0

Abstract

Aim: The aim of this study was to analyse the incidence and clinical presentation of childhood CD from 2011 to 2020 in Estonia and to compare the incidence with earlier published results of a 35-year period (1976-2010).

Methods: Data was collected retrospectively about children up to 19 years of age who were newly diagnosed with CD from 2011 to 2020 in all of Estonia. CD was diagnosed mostly by biopsy and in only two cases by serology.

Results: From 2011 to 2020, 189 new CD cases were diagnosed (113 girls, 60%, M/F ratio 1:1.49). The median age at diagnosis was 8.6 years. For comparison, from 1976 to 2010, the median age was 2.3 years. There were no differences between boys and girls (p = 0.93). Most frequently, the patients had atypical gastrointestinal symptoms. The incidence rate per 100 000 person-years in 2011-2020 was 6.89 (95% CI: 5.94-7.94). For comparison, in 1976-1980, the incidence rate per 100 000 person-years was 0.1.

Conclusion: The median age at diagnosis increased markedly during the study period. From 1976 onward, there has been almost a 70-fold increase in the incidence rate of CD.

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爱沙尼亚儿童乳糜泻发病率的上升已经停止了吗？

目的：本研究的目的是分析2011年至2020年爱沙尼亚儿童CD的发病率和临床表现，并将发病率与早期发表的35年期间（1976-2010）的结果进行比较。方法：回顾性收集2011年至2020年爱沙尼亚所有新诊断为乳糜泻的19岁以下儿童的数据。乳糜泻主要通过活检诊断，仅有2例通过血清学诊断。结果：2011 - 2020年，我省共确诊新发CD 189例，其中女孩113例，占60%，男/女比1:1.49。诊断时的中位年龄为8.6岁。相比之下，从1976年到2010年，平均年龄为2.3岁。男孩和女孩之间无差异（p = 0.93）。最常见的是患者有不典型的胃肠道症状。2011-2020年每10万人年的发病率为6.89 （95% CI: 5.94-7.94）。相比之下，1976-1980年，每10万人年的发病率为0.1。结论：在研究期间，诊断时的中位年龄明显增加。从1976年开始，乳糜泻的发病率几乎增加了70倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Paediatrica 医学-小儿科

CiteScore

6.50

自引率

5.30%

发文量

384

审稿时长

2-4 weeks

期刊介绍： Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries