Antonaeta Trendafilova, G. Ozek, Suleyman Yurb, F. Goger, T. Ozek, M. Rangelov, M. Todorova, I. Aneva
{"title":"Chemical characterization, antioxidant activity, -amylase and acetylcholinesterase inhibitory potential of Angelica pancicii Vandas ex Velen","authors":"Antonaeta Trendafilova, G. Ozek, Suleyman Yurb, F. Goger, T. Ozek, M. Rangelov, M. Todorova, I. Aneva","doi":"10.37360/blacpma.22.21.4.25","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.4.25","url":null,"abstract":"Comparative study GC-FID/MS of essential oils of fruits, leaves and roots of the endemic plant Angelica panciciiVandas ex Velen. revealed a significant difference in their chemical composition. The enantiomeric purity of the main component in the fruit oil (+)-β-phellandrene was also confirmed. In addition, imperatorin, isoimperatorin, oxypeucedanin, oxypeucedanin hydrate, angeloylpangelin and umbelliprenin were isolated from the fruit hexane extract. The content of these coumarins in the hexane extracts from different plant parts was further determined by HPLC. The essential oils and hexane extracts were assessed for their antioxidant potential and inhibitory effect towards -amylase and acetylcholinesterase enzymes. The fruit and leaf essential oils (> 80%) as well as the fruit hexane extract (> 62%) significantly inhibited acetylcholinesterase enzyme. Distinguish free radical scavenging properties were detected for the leaf (Inh. 95.0 ± 2.2 %) and the root (Inh. 66.0 ± 2.4 %) extracts.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80131486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Riaz, Majid Khan, R. Ahmad, L. H. AlLehaibi, N. Rahman, Deqiang Dou
{"title":"Evidence-based anti-viral and immunomodulatory potential of Black cumin (Nigella sativaL.) in COVID-19","authors":"M. Riaz, Majid Khan, R. Ahmad, L. H. AlLehaibi, N. Rahman, Deqiang Dou","doi":"10.37360/blacpma.22.21.2.11","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.2.11","url":null,"abstract":"Currently, the whole world is facing a life-threatening novel coronavirus 2019 (COVID-19) pandemic. Natural products are well-known for their potential role against viral disease, and some anti-viral agents have been developed to combat these diseases. Herein, the authors investigated the possible effects of this Holy plant Nigella sativaL. (NS), against coronavirus, using evidence-based and mechanistic approaches to conclude the immune-boosting and alleviation of respiratory systemeffects of NS. The pharmacological studies established a prominent role in treating various respiratory, immune systems, cardiovascular, skin, and gastrointestinal disorders. Literature supported the significant anti-viral role and showed an inhibitory role for NS against MHV-A59 CoV (mouse-hepatitis virus–A59) infected Hela, i.e., HeLaCEACAM1a (HeLa-epithelial carcinoembryonic antigen-related cell adhesion molecule 1a) cell. NS is a safe herbal product or dietary supplement and could be an effective and affordable community adjuvant treatment for coronavirus in the current scenario.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76371751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. R. B. Gomes, Silvio Carvalho Marinho, G. O. Everton, Eduardo Fonseca Silva, M. A. Fontenele, W. Lyra, A. C. de Freitas, Virlane Kelly Lima Hunaldo, Romicy Dermondes Souza, H. C. Louzeiro, Maria do Livramento de Paula, Jonas Batista Reis, Andr ea Vasconcelo Melo, V. E. M. Filho
{"title":"Chemical composition and larvicidal activity of the essential oil of Pimenta dioica leaves","authors":"P. R. B. Gomes, Silvio Carvalho Marinho, G. O. Everton, Eduardo Fonseca Silva, M. A. Fontenele, W. Lyra, A. C. de Freitas, Virlane Kelly Lima Hunaldo, Romicy Dermondes Souza, H. C. Louzeiro, Maria do Livramento de Paula, Jonas Batista Reis, Andr ea Vasconcelo Melo, V. E. M. Filho","doi":"10.37360/blacpma.22.21.2.12","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.2.12","url":null,"abstract":"In this study, we investigated the main constituent, the predominant class and biological activity of the essential oil extracted from the leaves of Pimenta dioica and the pattern of the major constituent against larvae in the third stage of Aedes aegypti. For this reason, we extracted the oil by hydrodistillation, identified its components by gas chromatography coupled with mass spectrometry (GC/MS) and calculated the lethal concentration (LC50) of the larvicidal activity using the Reed-Muench method. The results show that the oil consists mainly of eugenol, in which the phenylpropanoid class predominated and the lethal concentration, LC50, was 38.86 μg mL-1at a confidence level of 2.25 μg mL-1, while the eugenol standard presented LC5079.75 μg mL-1at a confidence level of 2.10 μg mL-1. Given the facts, we conclude that the oil is more active than the standard and that it has the potential to replace chemical larvicides.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75364272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anticarcinogenic activity of methanol extract of Melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system","authors":"Zainul Amiruddin Zakaria, Noorsyaza Eddrina Kamsani, Roro Azizah, Lilis Sulistyorini","doi":"10.37360/blacpma.22.21.1.04","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.1.04","url":null,"abstract":"Melastoma malabathricum (M. malabathricum) extracts have been reported to exert various pharmacological activities including antioxidants, anti-inflammatory and antiproliferative activities. The objective of the present study was to determine the anticarcinogenic activity of its methanol extract (MEMM) against the azoxymethane (AOM)-induced early colon carcinogenesis in rats. Rats were randomly assigned to five groups (n=6) namely normal control, negative control, and treatment (50, 250 or 500 mg/kg of MEMM) groups. Colon tissues were harvested for histopathological analysis and endogenous antioxidant system determination. MEMM was also subjected to HPLC analysis. Findings showed that MEMM significantly (p<0.05) reversed the AOM-induced carcinogenicity by: i) reducing the formation of aberrant crypt foci (ACF) in colon tissues, and; ii) enhancing the endogenous antioxidant activity (catalase, superoxide dismutase and glutathione peroxidase). Moreover, various phenolics has been identified in MEMM. In conclusion, MEMM exerts the in vivo anticarcinogenic activity via the activation of endogenous antioxidant system and synergistic action of phenolics.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74135814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Marchi, F. Lívero, Andreia Assuncao Soare, G. Silva, Ana Karina Vargas Soares, Camila Moreno Giarolo, E. Jacomassi, L. M. Souza, W. Bortolucci, Z. C. Gazim, Caio Franco de Araújo Almeida Campos, J. Gonçalves, C. S. A. Araújo, S. Wietzikoski, E. C. W. Lovato
{"title":"Influence of different preparation techniques on the composition and antioxidant action of curcumin and curcuminoids","authors":"J. Marchi, F. Lívero, Andreia Assuncao Soare, G. Silva, Ana Karina Vargas Soares, Camila Moreno Giarolo, E. Jacomassi, L. M. Souza, W. Bortolucci, Z. C. Gazim, Caio Franco de Araújo Almeida Campos, J. Gonçalves, C. S. A. Araújo, S. Wietzikoski, E. C. W. Lovato","doi":"10.37360/blacpma.22.21.1.03","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.1.03","url":null,"abstract":"Epidemiological evidence indicates that plant antioxidants activity can treat or help to prevent the development of various diseases. One species with great potential as an antioxidant is Curcuma longa. However, different extraction techniques can influence isolated chemical compounds. This study investigated chemical composition and antioxidant activity of two rhizome extracts of C. longa: hydroethanolic, obtained by exhaustion (HECLex); and dried by a spray dryer (HECLsd). The phytochemical composition was evaluated by GC/MS. Antioxidant activity was evaluated using DPPH and FRAP assays. Total phenolic compounds and soil analyses were performed. The main components of HECLex were ar-turmerone, γ-curcumene, α-turmerone, and β-sesquiphellandrene. The main components of HECLsd were 9,12,15-octadecatrienoic acid, 2,3-bis([trimethylsilyl]oxy)propyl ester, verrucarol, and 1-monolinoleoylglycerol trimethylsilyl ether. HECLsd had significantly higher levels of phenolic compounds and higher antioxidant capacity compared with HECLex. In conclusion, processes of the preparation of C. longa rhizomes alter the chemical components and consequently their biological activity.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80965567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Castro, Daniel Andrés Villegas Hurtado, A. A. Silva, Danúbia Aparecida Costa Nobre, Geraldo H. Silva, Willian Rodrigues Macedo, Mucuri Valleys
{"title":"Physiological and metabolic alterations in basil (Ocimum basilicum L.) varieties under distinct soil water levels","authors":"L. Castro, Daniel Andrés Villegas Hurtado, A. A. Silva, Danúbia Aparecida Costa Nobre, Geraldo H. Silva, Willian Rodrigues Macedo, Mucuri Valleys","doi":"10.37360/blacpma.22.21.1.06","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.1.06","url":null,"abstract":"Basil (Ocimum basilicum L.) is a medicinal species used in several areas, such as food, medicines and cosmetics, and the understanding of its physiological behavior under environmental conditions is of paramount importance for the improvement of cultivation methods. The objective of this study was to evaluate the influence of different water availability under physiological, biochemical and metabolic characteristics, in three distinct genotypes: 'Alfavaca basilicão', 'Gennaro de menta' and 'Grecco à palla', during two different phenological stages (vegetative and reproductive). It was found that the water deficit promotes physiological changes to tolerate water stress, and the studied genotypes have different routes to achieve this physiological tolerance, which culminates in a distinct accumulation of metabolites in plants, and can be considered interesting if the final product is the production of essential oils.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74951486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. V. Bellaver, Anildo Cunha Junior, Thais Carla Dal Bello, A. Neis, M. Z. Troncarelli, A. Millezi
{"title":"Antibacterial potential of essential oils against planktonic and sessile cells of Escherichia coli isolated from diarrhea cases in swine","authors":"F. V. Bellaver, Anildo Cunha Junior, Thais Carla Dal Bello, A. Neis, M. Z. Troncarelli, A. Millezi","doi":"10.37360/blacpma.22.21.1.05","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.1.05","url":null,"abstract":"Escherichia coli is a pathogen associated with infections in piglets in the post-weaning phase, its pathogenicity is related to the animal's susceptibility to bacterial enterotoxins. The objective of the present study was to determine the EOs activity against E. coli strain, in the form planktonic and sessile. Although the Disc-Diffusion tests to determine the Minimum Inhibitory Concentration, do not fully corroborate with the other analyzes of this study, it was noticed bacteria inhibition. The EOs were prepared at 0.4%, 0.8% and 1.0% for tests. The tested EOs were effective against E. coli planktonic cells (p<0.05). As for the sessile cells, the most significant result was inhibition and 100% sessile cells at the concentration of 1.0% of Cymbopogon citratus EO. Although there was resistance in some treatments, the tested EOs demonstrated inhibition capacity, constituting promising alternatives for the control of E. coli, especially of planktonic cells.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87114267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. D. de Morais, Antonio Carlos Nogueira Sobrinho, Hortensia Ribeiro Liberato, R. Pereira, C. Pessoa, D. R. Alves, Raquel Oliveira dos Santos Fontanelle
{"title":"Biotechnological potential of essential oils from different chemotypes of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson","authors":"S. D. de Morais, Antonio Carlos Nogueira Sobrinho, Hortensia Ribeiro Liberato, R. Pereira, C. Pessoa, D. R. Alves, Raquel Oliveira dos Santos Fontanelle","doi":"10.37360/blacpma.22.21.6.44","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.6.44","url":null,"abstract":"This study reports the biotechnological importance of seven Lippia albaspecimens collected in different places in Brazil, and evaluation of some activities as larvicidal against Aedesspp., antifungal against dermatophytes; cytotoxicity against SNB-19 (astrocytoma), HCT-116 (human colon) and PC-3 (human prostate) cancer cell lines, and inhibition of the enzyme acetylcholinesterase (AChE).The essential oils, whose extraction yield was about 1.24 w/w ± 0.9%, showed differences in their chemical composition and considered as chemotypes. The essential oils containing neral and geranial as main constituents showed better action against HCT-116 cell lines (IC50 value was 9.22 μg/mL), larvicidal activity against arbovirus vectors (LC50 value against A. aegyptiwas 1.59 μg/mL) and inhibition of AChE (halo inhibition zone was 1 cm). The essential oils containing mainly monoterpenoids showed better antifungal action with MIC values range from 0.15 to 1.25 mg/mL. This chemical and biological characterization may be useful for biotechnological applications.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80855635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Mostacero-León, Luis Gilberto Garcìa-Izquierdo, S. López-Medina, Anthony J. de la Cruz-Castillo, A. Gil-Rivero
{"title":"Medicinal use value of the flora used by the Andean Community of Jesús, Cajamarca, Peru","authors":"José Mostacero-León, Luis Gilberto Garcìa-Izquierdo, S. López-Medina, Anthony J. de la Cruz-Castillo, A. Gil-Rivero","doi":"10.37360/blacpma.22.21.5.34","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.5.34","url":null,"abstract":"The medicinal flora plays a valuable role in improvingthe quality of life; ancestral knowledge that constitutes a legacy inherited by the Andean-Amazonian communities. The research was focused on determining the medicinal use value of the flora used by the Andean Community of Jesús. 96 semi-structured interviews were applied, using the \"snowball\" technique. The population of the Andean Community employs 84 species of flora, distributed in 80 genera and 45 families; where the Asteraceae, Lamiaceae, Rutaceae and Fabaceae were the most representative. Likewise, they suffer from 56 diseases, grouped into 11 categories, being the diseases of the Systems: respiratory (FCI=0.68), digestive and gastrointestinal (FCI=0.57), urinary (FCI=0.57), cardiovascular (FCI=0.56), reproductive (FCI=0.54) and Nervous (FCI=0.53), the most treated. Finally, the Andean Community attributes great importance to 54 species of medicinal flora; Therefore, it is urgent to implement projects and research that promote their sustainability.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86413117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ex situ phenological behavior ofLippia integrifolia \"incayuyo\" (Verbenaceae) from a population with a broad genetic base","authors":"Romina Leiva, P. Brunetti","doi":"10.37360/blacpma.22.21.4.31","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.4.31","url":null,"abstract":"Lippia integrifolia\"incayuyo\" is an aromatic, sub-woody shrub used in popular medicine, aperitit drinks and compound herbs. Its choleretic, antispasmodic, biocidal, antibacterial and larvicidal activity has been proven. The objective of the work was to register the phenology of a sample of 70 genotypes from a population with a broad genetic base. The phenophases studied were: vegetative growth, flower bud, flowering and fruiting fortnightly for two years. The initiation, intensity and prolongation of the phenophases were evaluated. The moment of full bloom occurs during the second half of December. Taking this date as a reference, a differentiated beginning of flowering was evidenced. The results of two campaigns were compared, observing that 70% of the specimens had a similar behavor, standing out some genotypes for presenting an early flowering and longer duration. The recorded variability suggests that much of it could be due to intrinsic factors of the plant, and therefore, feasible to be selected.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88539901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}