Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas最新文献

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Valorization of Campomanesia xanthocarpaleaves: Chemical composition and antioxidant activity of crude extract and fractions 黄杉的增值作用:粗提取物和馏分的化学成分和抗氧化活性
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.3.22
Rosângela Rumi Sugauara, W. Bortolucci, C. M. Fernandez, M. Cabral, R. A. C. Gonçalves, M. Sarragiotto, J. Gonçalves, N. Colauto, G. Linde, M. Nunes, S. P. Ruiz, Z. C. Gazim
{"title":"Valorization of Campomanesia xanthocarpaleaves: Chemical composition and antioxidant activity of crude extract and fractions","authors":"Rosângela Rumi Sugauara, W. Bortolucci, C. M. Fernandez, M. Cabral, R. A. C. Gonçalves, M. Sarragiotto, J. Gonçalves, N. Colauto, G. Linde, M. Nunes, S. P. Ruiz, Z. C. Gazim","doi":"10.37360/blacpma.23.22.3.22","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.3.22","url":null,"abstract":"Campomanesia xanthocarpaleaves are a byproduct of fruit production without studies on antioxidant activity. Thus, this study aimed to identify the antioxidant compounds of C. xanthocarpaleaves by ultra-high performance liquid chromatography coupled with electrospray ionization-quadrupole-time of flight-mass spectrometry (UHPLC-ESI/qTOF) and by different in vitroantioxidant methods. The crude extract of C. xanthocarpaleaves had a yield of 15.2% and only five out of 37 fractions of the crude extract had antioxidant activity. The crude extract presented greater antioxidant activity than the isolated fractions. The identified antioxidant compounds were phenolic acids (gallic acid and chlorogenic acid), flavonoids (quercetin and naringenin 7,4’-dimethoxy) and an organic acid (quinic acid). Leaves of C. xanthocarpahave high concentration of antioxidant compounds and it is a promising plant for the development of applications in the food, cosmetic, and pharmaceutical fields. The extraction of antioxidant compounds can add value to the productive chain of this plant.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"43 5-6 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85975062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review 秘鲁亚马逊地区药用植物抗糖尿病潜力综述
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.3.21
Gabriel Vargas-Arana, Elsa Rengifo-Salgado, M. Simirgiotis
{"title":"Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review","authors":"Gabriel Vargas-Arana, Elsa Rengifo-Salgado, M. Simirgiotis","doi":"10.37360/blacpma.23.22.3.21","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.3.21","url":null,"abstract":"Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyper-glycemia that is accompanied, to a greater or lesser extent, by alterations in the metabolism of carbohydrates, proteins and lipids. It is the leading cause of death in developed countries. Current antidiabetic drug treatments present several adverse effects for which it has started searching for new oral hypoglycemic agents from vegetal species. This review presents the medicinal plants from the Peruvian Amazon used in the treatment of diabetes and a systematic review of their hypoglycemic properties reported in the literature in the last twenty years used in different bibliographic databases. Seventy seven medicinal plants are reported as being used for the treatment of diabetes by Amazonian indigenous people, which 46.75% of species report hypoglycemic activity, evidencing that traditional knowledge is a great source for to searching antidiabetic drugs and also an alternative for future research.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"124 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82549427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological potential of parasitic Angiosperms against microorganisms 寄生被子植物抗微生物的药理潜力
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.13
Vanessa Suaza-Gaviria, A. M. Mesa Vanegas, Zulma Monsalve Fonegra
{"title":"Pharmacological potential of parasitic Angiosperms against microorganisms","authors":"Vanessa Suaza-Gaviria, A. M. Mesa Vanegas, Zulma Monsalve Fonegra","doi":"10.37360/blacpma.23.22.2.13","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.13","url":null,"abstract":"Parasitic habit plants arouse great interest for their extraordinary growth adaptations and produce different secondary metabolites that allow them to survive the extreme conditions in which they develop. This can provide a range of compounds with multiple uses. However, those plants have been poorly explored and there is very little information about their natural compounds, some healing properties attributed to several communities have been scientifically supported. Articles were consulted in databases (Google Scholar, PubMed, Scielo, Science Direct, Scopus) considering the biological activity reported until June 2021. Parasitic plants present mainly antibacterial activity, some species antifungal moderate activity, and to a lesser extent were found reports of antiprotozoal activity. The composition of parasitic plants should continue to be investigated, which could be an alternative to combat various microorganisms that cause diseases, even resistant to traditional medicines.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"31 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91231556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Field establishment of vitroplants of “Peperina de las Lomas” (Hedeoma multiflora Benth.) as a contribution to its ex situ conservation “红椒”(Hedeoma multiflora Benth.)试管植物的野外建立对其迁地保护的贡献
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.3.25
P. A. Peralta, Julián Guariniello, Herfnan Geronimo Bach
{"title":"Field establishment of vitroplants of “Peperina de las Lomas” (Hedeoma multiflora Benth.) as a contribution to its ex situ conservation","authors":"P. A. Peralta, Julián Guariniello, Herfnan Geronimo Bach","doi":"10.37360/blacpma.23.22.3.25","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.3.25","url":null,"abstract":"Hedeoma multifloraBenth. (Lamiaceae) is an aromatic-medicinal species native to Argentina, Uruguay and southern Brazil that is in a state of vulnerability due to overexploitation. It is used in the preparation of flavored yerba mate and in popular medicine, mainly in abdominal conditions. The objective of this work was to adjust the micropropagation technique, study the field behavior of vitroplants, compare the seeds generated and close their cultivation cycle. Different concentrations of growth regulators were evaluated on Murashige-Skoog medium. The implantation was successful. There are no differences between the evaluated plants. It was possible to efficiently close the complete cycle in vitro, with 100% survival, flowering and production of viable seeds. This methodology will serve for its introduction to the field, subsequent domestication, reintroduction into its natural environment and mitigate the process of degradation of the populations.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"39 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85615134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ethnobotanical and ethnopharmacological survey of medicinal species utilized in the Coqueiros Community, Brazil 巴西Coqueiros社区药用物种的民族植物学和民族药理学调查
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-11-30 DOI: 10.37360/blacpma.22.21.6.42
Núbia Alves Mariano Teixeira Pires Gomides, G. G. Neto, M. P. Martins, L. Kato, V. G. Severino
{"title":"Ethnobotanical and ethnopharmacological survey of medicinal species utilized in the Coqueiros Community, Brazil","authors":"Núbia Alves Mariano Teixeira Pires Gomides, G. G. Neto, M. P. Martins, L. Kato, V. G. Severino","doi":"10.37360/blacpma.22.21.6.42","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.6.42","url":null,"abstract":"This paper explores the medicinal plants used by Coqueiros Community, Brazil, for the treatment of various ailments. We apply the structured interview and the participant observation, and the local knowledge was analyzed using quantitative measures applied to the general sampling to contribute to selection of promising species for biotechnological development. This community cited 105 species from 53 plant families. The most representative families were Fabaceae, Asteraceae, Anacardiaceae, Myrtaceae, Annonaceae, Apocynaceae, Lamiaceae and Rutaceae. Among the species mentioned in this survey, 66,7% of them occur in the Cerrado as native vegetation. The species considered the most important by interviewees are those with action forthe largest number of health problems. Thus, the statistical indexes used here, such as Relative Impotance (RI), Informant Consensus Factor (ICF) and Relative Frequency of Citation (RFC), contributed to identify these species. To conclude, from this research we have known the potential of the Brazilian vegetation for the development of biotechnology.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"116 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79631707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1 枸杞HBK叶和茎乙醇提取物对肺癌细胞株SK-LU-1的细胞毒活性
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-09-30 DOI: 10.37360/blacpma.22.21.5.40
M. E. Frias-Zepeda, Jorge Ibarra-Berumen, C. Ordaz-Pichardo, M. Rosales-Castro
{"title":"Cytotoxic activity of ethanolic extracts of Lippia graveolens HBK leaves and stem against lung cancer cell line SK-LU-1","authors":"M. E. Frias-Zepeda, Jorge Ibarra-Berumen, C. Ordaz-Pichardo, M. Rosales-Castro","doi":"10.37360/blacpma.22.21.5.40","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.5.40","url":null,"abstract":"Lippia graveolens HBK (Verbenaceae) is an aromatic herb of economic importance in Mexico, known as oregano. The leaves are usedas condiments, and people use this species for respiratory and digestive disorders. The aim of this work was to evaluate the cytotoxic effect of ethanolic extracts obtained from free-oil leaves (L9) and stem (S15), against lung cancer cell line SK-LU-1, through tetrazolium salt (MTT) assay. Extracts concentrations of 0.3 to 300 μg/mL were used and HFF-1 as normal control cells. Both L9 and S15 extracts, showed cytotoxic effect, although stem was stronger than leaves and without damage to normal cell control. The phenolic compounds caffeic acid and acacetin werein higher concentration in L9, whereas naringenin, taxifolin, eriodictyol, luteolin, and apigenin had higher concentrations in S15. The ethanolic extracts of L. graveolens have excellent cytotoxic activity, and have a wide possibility of use in lung cancer treatment.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"15 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82324061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical characterization, antioxidant activity, -amylase and acetylcholinesterase inhibitory potential of Angelica pancicii Vandas ex Velen 白芷化学性质、抗氧化活性、-淀粉酶和乙酰胆碱酯酶抑制潜力
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-07-30 DOI: 10.37360/blacpma.22.21.4.25
Antonaeta Trendafilova, G. Ozek, Suleyman Yurb, F. Goger, T. Ozek, M. Rangelov, M. Todorova, I. Aneva
{"title":"Chemical characterization, antioxidant activity, -amylase and acetylcholinesterase inhibitory potential of Angelica pancicii Vandas ex Velen","authors":"Antonaeta Trendafilova, G. Ozek, Suleyman Yurb, F. Goger, T. Ozek, M. Rangelov, M. Todorova, I. Aneva","doi":"10.37360/blacpma.22.21.4.25","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.4.25","url":null,"abstract":"Comparative study GC-FID/MS of essential oils of fruits, leaves and roots of the endemic plant Angelica panciciiVandas ex Velen. revealed a significant difference in their chemical composition. The enantiomeric purity of the main component in the fruit oil (+)-β-phellandrene was also confirmed. In addition, imperatorin, isoimperatorin, oxypeucedanin, oxypeucedanin hydrate, angeloylpangelin and umbelliprenin were isolated from the fruit hexane extract. The content of these coumarins in the hexane extracts from different plant parts was further determined by HPLC. The essential oils and hexane extracts were assessed for their antioxidant potential and inhibitory effect towards -amylase and acetylcholinesterase enzymes. The fruit and leaf essential oils (> 80%) as well as the fruit hexane extract (> 62%) significantly inhibited acetylcholinesterase enzyme. Distinguish free radical scavenging properties were detected for the leaf (Inh. 95.0 ± 2.2 %) and the root (Inh. 66.0 ± 2.4 %) extracts.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"66 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80131486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence-based anti-viral and immunomodulatory potential of Black cumin (Nigella sativaL.) in COVID-19 黑孜然(Nigella sativaL.)在COVID-19中的抗病毒和免疫调节潜力
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-03-30 DOI: 10.37360/blacpma.22.21.2.11
M. Riaz, Majid Khan, R. Ahmad, L. H. AlLehaibi, N. Rahman, Deqiang Dou
{"title":"Evidence-based anti-viral and immunomodulatory potential of Black cumin (Nigella sativaL.) in COVID-19","authors":"M. Riaz, Majid Khan, R. Ahmad, L. H. AlLehaibi, N. Rahman, Deqiang Dou","doi":"10.37360/blacpma.22.21.2.11","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.2.11","url":null,"abstract":"Currently, the whole world is facing a life-threatening novel coronavirus 2019 (COVID-19) pandemic. Natural products are well-known for their potential role against viral disease, and some anti-viral agents have been developed to combat these diseases. Herein, the authors investigated the possible effects of this Holy plant Nigella sativaL. (NS), against coronavirus, using evidence-based and mechanistic approaches to conclude the immune-boosting and alleviation of respiratory systemeffects of NS. The pharmacological studies established a prominent role in treating various respiratory, immune systems, cardiovascular, skin, and gastrointestinal disorders. Literature supported the significant anti-viral role and showed an inhibitory role for NS against MHV-A59 CoV (mouse-hepatitis virus–A59) infected Hela, i.e., HeLaCEACAM1a (HeLa-epithelial carcinoembryonic antigen-related cell adhesion molecule 1a) cell. NS is a safe herbal product or dietary supplement and could be an effective and affordable community adjuvant treatment for coronavirus in the current scenario.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"4 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76371751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chemical composition and larvicidal activity of the essential oil of Pimenta dioica leaves 洋红叶精油的化学成分及杀虫活性研究
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-03-30 DOI: 10.37360/blacpma.22.21.2.12
P. R. B. Gomes, Silvio Carvalho Marinho, G. O. Everton, Eduardo Fonseca Silva, M. A. Fontenele, W. Lyra, A. C. de Freitas, Virlane Kelly Lima Hunaldo, Romicy Dermondes Souza, H. C. Louzeiro, Maria do Livramento de Paula, Jonas Batista Reis, Andr ea Vasconcelo Melo, V. E. M. Filho
{"title":"Chemical composition and larvicidal activity of the essential oil of Pimenta dioica leaves","authors":"P. R. B. Gomes, Silvio Carvalho Marinho, G. O. Everton, Eduardo Fonseca Silva, M. A. Fontenele, W. Lyra, A. C. de Freitas, Virlane Kelly Lima Hunaldo, Romicy Dermondes Souza, H. C. Louzeiro, Maria do Livramento de Paula, Jonas Batista Reis, Andr ea Vasconcelo Melo, V. E. M. Filho","doi":"10.37360/blacpma.22.21.2.12","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.2.12","url":null,"abstract":"In this study, we investigated the main constituent, the predominant class and biological activity of the essential oil extracted from the leaves of Pimenta dioica and the pattern of the major constituent against larvae in the third stage of Aedes aegypti. For this reason, we extracted the oil by hydrodistillation, identified its components by gas chromatography coupled with mass spectrometry (GC/MS) and calculated the lethal concentration (LC50) of the larvicidal activity using the Reed-Muench method. The results show that the oil consists mainly of eugenol, in which the phenylpropanoid class predominated and the lethal concentration, LC50, was 38.86 μg mL-1at a confidence level of 2.25 μg mL-1, while the eugenol standard presented LC5079.75 μg mL-1at a confidence level of 2.10 μg mL-1. Given the facts, we conclude that the oil is more active than the standard and that it has the potential to replace chemical larvicides.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75364272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anticarcinogenic activity of methanol extract of Melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system 黑草叶甲醇提取物的抗癌活性与酚类化合物的存在和内源性抗氧化系统的激活有关
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-01-30 DOI: 10.37360/blacpma.22.21.1.04
Zainul Amiruddin Zakaria, Noorsyaza Eddrina Kamsani, Roro Azizah, Lilis Sulistyorini
{"title":"Anticarcinogenic activity of methanol extract of Melastoma malabathricum leaves is attributed to the presence of phenolics compounds and the activation of endogenous antioxidant system","authors":"Zainul Amiruddin Zakaria, Noorsyaza Eddrina Kamsani, Roro Azizah, Lilis Sulistyorini","doi":"10.37360/blacpma.22.21.1.04","DOIUrl":"https://doi.org/10.37360/blacpma.22.21.1.04","url":null,"abstract":"Melastoma malabathricum (M. malabathricum) extracts have been reported to exert various pharmacological activities including antioxidants, anti-inflammatory and antiproliferative activities. The objective of the present study was to determine the anticarcinogenic activity of its methanol extract (MEMM) against the azoxymethane (AOM)-induced early colon carcinogenesis in rats. Rats were randomly assigned to five groups (n=6) namely normal control, negative control, and treatment (50, 250 or 500 mg/kg of MEMM) groups. Colon tissues were harvested for histopathological analysis and endogenous antioxidant system determination. MEMM was also subjected to HPLC analysis. Findings showed that MEMM significantly (p<0.05) reversed the AOM-induced carcinogenicity by: i) reducing the formation of aberrant crypt foci (ACF) in colon tissues, and; ii) enhancing the endogenous antioxidant activity (catalase, superoxide dismutase and glutathione peroxidase). Moreover, various phenolics has been identified in MEMM. In conclusion, MEMM exerts the in vivo anticarcinogenic activity via the activation of endogenous antioxidant system and synergistic action of phenolics.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"95 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74135814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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