Evidence-based anti-viral and immunomodulatory potential of Black cumin (Nigella sativaL.) in COVID-19

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-03-30 DOI:10.37360/blacpma.22.21.2.11

M. Riaz, Majid Khan, R. Ahmad, L. H. AlLehaibi, N. Rahman, Deqiang Dou

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引用次数: 1

Abstract

Currently, the whole world is facing a life-threatening novel coronavirus 2019 (COVID-19) pandemic. Natural products are well-known for their potential role against viral disease, and some anti-viral agents have been developed to combat these diseases. Herein, the authors investigated the possible effects of this Holy plant Nigella sativaL. (NS), against coronavirus, using evidence-based and mechanistic approaches to conclude the immune-boosting and alleviation of respiratory systemeffects of NS. The pharmacological studies established a prominent role in treating various respiratory, immune systems, cardiovascular, skin, and gastrointestinal disorders. Literature supported the significant anti-viral role and showed an inhibitory role for NS against MHV-A59 CoV (mouse-hepatitis virus–A59) infected Hela, i.e., HeLaCEACAM1a (HeLa-epithelial carcinoembryonic antigen-related cell adhesion molecule 1a) cell. NS is a safe herbal product or dietary supplement and could be an effective and affordable community adjuvant treatment for coronavirus in the current scenario.

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黑孜然(Nigella sativaL.)在COVID-19中的抗病毒和免疫调节潜力

当前，全球正面临一场危及生命的新型冠状病毒2019 (COVID-19)大流行。众所周知，天然产物具有对抗病毒性疾病的潜在作用，一些抗病毒药物已经开发出来对抗这些疾病。本文对这种神圣植物Nigella sativaL的可能作用进行了研究。(NS)抗冠状病毒，采用循证和机制的方法来总结NS的免疫增强和呼吸系统效应的缓解。药理学研究在治疗各种呼吸系统、免疫系统、心血管、皮肤和胃肠道疾病方面发挥了突出作用。文献支持NS具有显著的抗病毒作用，并显示NS对感染Hela的MHV-A59 CoV(小鼠肝炎病毒- a59)即HeLaCEACAM1a (Hela -上皮癌胚抗原相关细胞粘附分子1a)细胞具有抑制作用。NS是一种安全的草药产品或膳食补充剂，在当前情况下可能是一种有效且负担得起的冠状病毒社区辅助治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.