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Comparative study of abdominal pain in the Mayan cultures Tzeltal, Maya Tzotzil and Maya Q ́eqchi ́ and use of Ageratina ligustrinafor the treatment 玛雅文化 "Tzeltal"、"Maya Tzotzil "和 "Maya Q ́eqchi ́"中腹痛与 Ageratina ligustrinafor 治疗方法的比较研究
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-07-30 DOI: 10.37360/blacpma.24.23.4.39
Jorge Mario Vargas, A. Andrade-Cetto
{"title":"Comparative study of abdominal pain in the Mayan cultures Tzeltal, Maya Tzotzil and Maya Q ́eqchi ́ and use of Ageratina ligustrinafor the treatment","authors":"Jorge Mario Vargas, A. Andrade-Cetto","doi":"10.37360/blacpma.24.23.4.39","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.4.39","url":null,"abstract":"The current study is a comparison of the abdominal pain conception produced by gastrointestinal disorders, relieved by Ageratina ligustrina, among inhabitants of the Mayan Tzeltal, Tzotzil, and Q'eqchi' groups ethnomedical, ethnobotanical, and cross-cultural approaches were used to compare previous studies with the present field work. To evaluate the efficacy of A. ligustrinato relieve pain, also through a bibliographic review an inventory of the molecules present in this species was performed, as well as their pharmacological activity. The results showed that the epidemiology of pain produced by GID, its ethnobotany, and the explanatory model of abdominal pain are similar among ethnic groups. Likewise, 27 molecules with anti-inflammatory and anti-nociceptive effects were identified, which could explain why this species is culturally important for the Mayan Tzeltal, Tzotzil, and Q'eqchi' groups for the relief of abdominal pain, while, from a biomedical point of view, it is a species with potential to inhibit visceral pain.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141795745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automatic detection and classification of disease in citrus fruit and leaves using a customized CNN based model 使用基于 CNN 的定制模型自动检测柑橘果实和叶片的病害并进行分类
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-03-30 DOI: 10.37360/blacpma.24.23.2.13
Josephin Shermila P, Akila Victor, S. O. Manoj, E. A. Devi
{"title":"Automatic detection and classification of disease in citrus fruit and leaves using a customized CNN based model","authors":"Josephin Shermila P, Akila Victor, S. O. Manoj, E. A. Devi","doi":"10.37360/blacpma.24.23.2.13","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.2.13","url":null,"abstract":"India's commercial advancement and development depend heavily on agriculture. A common fruit grown in tropical settings is citrus. A professional judgment is required while analyzing an illness because different diseases have slight variations in their symptoms. In order to recognize and classify diseases in citrus fruits and leaves, a customized CNN-based approach that links CNN with LSTM was developed in this research. By using a CNN-based method, it is possible to automatically differentiate from healthier fruits and leaves and those that have diseases such fruit blight, fruit greening, fruit scab, and melanoses. In terms of performance, the proposed approach achieves 96% accuracy, 98% sensitivity, 96% Recall, and an F1-score of 92% for citrus fruit and leave identification and classification and the proposed method was compared with KNN, SVM, and CNN and concluded that the proposed CNN-based model is more accurate and effective at identifying illnesses in citrus fruits and leaves","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140362796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ethnobotanical study of medicinal plants used for cancer treatment at the province of Nador, Morocco 摩洛哥纳祖尔省用于治疗癌症的药用植物的人种植物学研究
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-03-30 DOI: 10.37360/blacpma.24.23.2.22
K. Aberkani, Ahmed Nafis, Zakaria Zgourdeh, Abdelfatah Benchahid, H. Hanine, S. Samri
{"title":"Ethnobotanical study of medicinal plants used for cancer treatment at the province of Nador, Morocco","authors":"K. Aberkani, Ahmed Nafis, Zakaria Zgourdeh, Abdelfatah Benchahid, H. Hanine, S. Samri","doi":"10.37360/blacpma.24.23.2.22","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.2.22","url":null,"abstract":"Morocco has varied wealth of aromatic and medicinal plants (AMPs) which are commonly used for prevention and treatment of various diseases or as complementary therapy such for cancer diseases. An ethnobotanical study was carried out in the province of Nador, located northeast of Morocco. A total of 418 persons were interviewed, information about their profile, type of medicinal plants existing in this area, plant characteristics and uses of those existing plants. Results showed 35 species distributed in 23 families, the most represented were Lamiaceae (7), Apiaceae (5) and Fabaceae (3). This study revealed that the population mainly used seeds (28%), leaves (26%), aerial parts (20%) and fruits (14%). Moreover, it has shown that Nerium oleander were used by the local population for cancer treatments. Biological activity of N. oleandershowed an antimicrobial effect on Escherichia coli, Pseudomonas aeruginosaand Staphylococcus aureus.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140363253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethnobotanical study of the medicinal flora of the province of Trujillo, Peru 秘鲁特鲁希略省药用植物群的人种植物学研究
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-01-30 DOI: 10.37360/blacpma.24.23.1.2
Anthony J. de la Cruz-Castillo, José Mostacero-León, S. López-Medina, A. Gil-Rivero, C. A. Vásquez-Boyer, Juan A Villacorta-Vasquez, Anavely L Alipio-Rodriguez
{"title":"Ethnobotanical study of the medicinal flora of the province of Trujillo, Peru","authors":"Anthony J. de la Cruz-Castillo, José Mostacero-León, S. López-Medina, A. Gil-Rivero, C. A. Vásquez-Boyer, Juan A Villacorta-Vasquez, Anavely L Alipio-Rodriguez","doi":"10.37360/blacpma.24.23.1.2","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.1.2","url":null,"abstract":"Trujillo, one of the main provinces of Peru, is home to a multicultural population, coming from the Coast, Sierra and Selva; of different ideologies, cultures, and ancestral knowledge about the correct use of medicinal flora. In this sense and in an effort to rescue this ancestral knowledge, the ethnobotanical study of the medicinal flora of the province of Trujillo was carried out. For which 96 semi-structured interviews wereapplied, using the \"snowball\" technique; followed by the collection, taxonomic determination and calculation of ethnobotanical indices: Use Value Index (IVU) and Informant Consensus Factor Index (FCI). It is concluded that the inhabitants of Trujillo makeuse of 102 species of medicinal flora, distributed in 95 genera and 46 families for the treatment and/or cure of 62 diseases. Of the total species, 24 turned out to be the most important (according to their IVU) for the cure of diseases of the Trujillo population.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
alidation of an analytical method by HPLC for the quantification of yangambin from the Ocotea duckei species 用高效液相色谱法验证定量分析 Ocotea duckei 物种中洋姜素的分析方法
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-01-30 DOI: 10.37360/blacpma.24.23.1.09
L. Peixoto, J. V. Chaves Junior, F. Andrade, I. Basílio, Fabio Santos de Souza, J. Barbosa Filho
{"title":"alidation of an analytical method by HPLC for the quantification of yangambin from the Ocotea duckei species","authors":"L. Peixoto, J. V. Chaves Junior, F. Andrade, I. Basílio, Fabio Santos de Souza, J. Barbosa Filho","doi":"10.37360/blacpma.24.23.1.09","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.1.09","url":null,"abstract":"Ocotea duckei, known as Louro-de-cheiro, belongs to the Lauraceae family and presents lignoid yangambine (YAN) as the main plant marker. This work aimed to develop and validate an analytical method by high performance liquid chromatography for the quantification of YAN. The sample used was the crude ethanolic extract (CEE) obtained from aerial parts. In the developed method, a C18 column was used. The mobile phase was composed of acetonitrile and water (45:55), whereas the method parameters included mobile phase flow rate at 0.8 mL/min, oven temperature at 40°C, and monitoring at 205 nm. In the validation, the parameters of selectivity, linearity, precision, accuracy, robustness, limits of detection and quantification were evaluated. As a result, the developed method is in accordance with the guidelines for validation of analytical methods and presented satisfactory chromatographic parameters for YAN determination. Thus, the present analytical methodology can be applied in the quality control of O. duckei raw materials.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
cute sarcoidosis Löfgren Syndrome treated by Chinese medicinal formula based on Syndrome Differentiation: A case-based review 基于综合征分型的中药方剂治疗可爱的肉样瘤洛夫格伦综合征：基于病例的综述
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-01-30 DOI: 10.37360/blacpma.24.23.1.1
Xue Li, Jian Liu, M. Liu, Min Liu, Yu-Guang Wang
{"title":"cute sarcoidosis Löfgren Syndrome treated by Chinese medicinal formula based on Syndrome Differentiation: A case-based review","authors":"Xue Li, Jian Liu, M. Liu, Min Liu, Yu-Guang Wang","doi":"10.37360/blacpma.24.23.1.1","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.1.1","url":null,"abstract":"Löfgren syndrome (LS) is a unique acute manifestation of sarcoidosis and characterized by erythema nodosum, bilateral hilar lymphadenectasis, and/or bilateral anklearthritis or periarthritis. A 37-year-old female patient with LS presented with fever accompanied by multiple joint swelling and pain, nodular skin erythema, and bilateral hilar lymphadenectasis. The patient had received treatment involving non-steroidal anti-inflammatory drugs and glucocorticoids in other hospitals, but the effects were poor, and the conditions reemerged. The LS duration has lasted for more than 3 months. Following traditional Chinese medicine (TCM) treatment, syndrome differentiation as well as giving patients oral Chinese medicine decoction, the symptoms of the patient were rapidly relieved within one week and did not recur during a six-month follow-up period. This case is the first clinical report of acute sarcoidosis LS treated using TCM and reflects the significant advantages of this form of therapy in emergency treatment","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The infusion of Baccharis spicata(Lam.) Baill (Asteraceae) has antiviral activity againsthepatitis B virus without cytotoxic effects against several cell lines 百日草（菊科）泡腾片对乙型肝炎病毒具有抗病毒活性，对多种细胞株无细胞毒性作用
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-01-30 DOI: 10.37360/blacpma.24.23.1.11
Joseph T Ortega, Ignacio Agudelo, R. Ricco, L. Cavallaro, Rodolfo Campos
{"title":"The infusion of Baccharis spicata(Lam.) Baill (Asteraceae) has antiviral activity againsthepatitis B virus without cytotoxic effects against several cell lines","authors":"Joseph T Ortega, Ignacio Agudelo, R. Ricco, L. Cavallaro, Rodolfo Campos","doi":"10.37360/blacpma.24.23.1.11","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.1.11","url":null,"abstract":"Medicinal plants are used to cure diseases, and their replacement is frequent and affects public health. The genus Baccharis has representatives within the medicinal flora of Argentina, although the replacement of the species of this genus known under the vulgar name of \"carqueja\" by Baccharis spicata has been detected in herbalists or markets of herbal products. The genotoxic safety of this species has been established in previous work of our group. The aim of this study was to evaluate the antiviral activity of an infusion made from B. spicata leaves against hepatitis B virus with the HepG2.2.15 cellular system and to determine cytotoxicity in HepG2.2,15, A549 and Vero cell lines. Infusion of B. spicata was active to inhibit HBV replication with an EC50of 22.54 μg/mL and a CC50of 190 μg/mL.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ecotoxic and preventive effect of the use of essential oils in bovine mastitis 在牛乳腺炎中使用精油的生态毒性和预防效果
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-01-30 DOI: 10.37360/blacpma.24.23.1.3
Jovanna M Suarez-Barreiro, Martha C. Suarez, Fabian Parada
{"title":"Ecotoxic and preventive effect of the use of essential oils in bovine mastitis","authors":"Jovanna M Suarez-Barreiro, Martha C. Suarez, Fabian Parada","doi":"10.37360/blacpma.24.23.1.3","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.1.3","url":null,"abstract":"The essential oils of Lippia citriodora(Ort.) and Lippia origanoides(Kunth) have shown antimicrobial activity associated with mastitis. The objective of this study was to evaluate its ecotoxic effect withthe Artemia salinabioassay and the prevention of mastitis through an in vivotest in cattle (n=20) with a product based on these oils using a conventional product as a control. Contact hypersensitivity, the effect on somatic cells, and residuality in milk samples were evaluated. The results of the Artemia salinabioassay were 10.05 and 19.36 (μg/mL) respectively. No negative effects or contact hypersensitivity were observed, and no residual metabolites were found in post-test milk. The somatic cell count showed 75% effectiveness in the prevention of mastitis with essential oils compared to 62.5% with the conventional product. The evaluated formulation could be used in the prevention of bovine mastitis safely, further investigation is required.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of cancer inhibitors from Hystrix brachyurabezoar extracts using LC-MS multivariate data analysis and in silico evaluation on Bcl-2, cyclin B/CDK1, VEGF and NM23-H1 利用 LC-MS 多变量数据分析和对 Bcl-2、细胞周期蛋白 B/CDK1、血管内皮生长因子和 NM23-H1 的硅学评估，从 Hystrix brachyurabezoar 提取物中鉴定癌症抑制剂
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-01-30 DOI: 10.37360/blacpma.24.23.1.4
Al'aina Yuhainis Firus Khan, Q. Ahmed, A. Khatib, Z. Ibrahim, Tanzina Sharmin Nipun, H. A. Natto, Mohd Zuwairi Saiman, Z. Zakaria, R. A. Wahab
{"title":"Identification of cancer inhibitors from Hystrix brachyurabezoar extracts using LC-MS multivariate data analysis and in silico evaluation on Bcl-2, cyclin B/CDK1, VEGF and NM23-H1","authors":"Al'aina Yuhainis Firus Khan, Q. Ahmed, A. Khatib, Z. Ibrahim, Tanzina Sharmin Nipun, H. A. Natto, Mohd Zuwairi Saiman, Z. Zakaria, R. A. Wahab","doi":"10.37360/blacpma.24.23.1.4","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.1.4","url":null,"abstract":"Hystrix brachyurabezoar is calcified undigested material found in the gastrointestinal tract known for various medicinal benefits including as an anticancer agent. However, the H. brachyurapopulation has been declining due to its demand and is under Malaysian law protection. Therefore, present study aimed to identify bezoar anticancer active compounds through metabolomics and in-silico approaches. Five replicates of bezoar powder were subjected to extraction using different solvent ratios of methanol-water (100, 75, 50, 25, 0% v/v). Cytotoxicity and metabolite profiling using liquid chromatography-mass spectrometry were conducted. Putative compounds identified were subjected to in-silico analysis with targeted anticancer proteins namely, Bcl-2, Cyclin B/CDK1 complex, VEGF and NM23-H1. The correlation of LC-MS and cytotoxicity profile pinpointed two compounds, mangiferin and propafenone. In-silicostudy showed both compounds exerted good binding scores to all proteins with hydrophobic interaction dominating the ligand-protein complex binding, suggesting the ligands act as hydrophobes in the interactions.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropharmacological and anxiolytic effects of extracts of Passiflora tripartita var. mollissima on mice 西番莲变种 mollissima 提取物对小鼠的神经药理学和抗焦虑作用
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2024-01-30 DOI: 10.37360/blacpma.24.23.1.7
C. Marín-Tello, Jenner Gil-Velasquez, Dennis Diaz-Espinoza, Acxel Gil-Velasquez, J. Vasquez-Kool
{"title":"Neuropharmacological and anxiolytic effects of extracts of Passiflora tripartita var. mollissima on mice","authors":"C. Marín-Tello, Jenner Gil-Velasquez, Dennis Diaz-Espinoza, Acxel Gil-Velasquez, J. Vasquez-Kool","doi":"10.37360/blacpma.24.23.1.7","DOIUrl":"https://doi.org/10.37360/blacpma.24.23.1.7","url":null,"abstract":"Anxiety and depression cause alterations in the physiology of an organism. Extracts from the leaves of several Passiflora species are traditionally used Peru and in many countries as anxiolytic and in treatment for inflammatory problems. This study aimed to determine the neuropharmacological effect of the ethanolic extract of Passiflora tripartita var. mollissima (Kunth) Holm-Niels. & P.Jørg. and its anxiolytic effect on mouse (Mus musculus var. albinus). Anxiety was evaluated with the marble burying test and the depressant effect with the Irwin test (locomotor activity, base of support, wobbly gait, immobility, escape, ease of handling, muscular strength, tight rope, inclined plane, catatonia, nociceptive reflex and death). Doses of 100 mg/Kg/body weight and 200 mg/kg/body weight by intraperitoneal route (i.p.) significantly decreased anxiety levels (p<0.05) in mice, and had a non-significant depressant effect in 11 of the 12 tests, showing a similar direction of correlation between diazepam and Passiflora extract effect. A greater anxiolytic and anti-depressant effects in mice was observed with the extract dose of 200 mg/kg/body weight with neuropharmacological manifestations found where no death was observed at any dose used.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139591368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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