不同化学型白皮精油的生物技术潜力N.E.Br。前布里顿和p威尔逊

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2022-01-01 DOI:10.37360/blacpma.22.21.6.44

S. D. de Morais, Antonio Carlos Nogueira Sobrinho, Hortensia Ribeiro Liberato, R. Pereira, C. Pessoa, D. R. Alves, Raquel Oliveira dos Santos Fontanelle

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引用次数: 1

摘要

本文报道了在巴西不同地区采集的7种Lippia albasiens的生物技术重要性，并对其杀灭伊蚊的活性进行了评价。抗皮肤真菌;对SNB-19(星形细胞瘤)、HCT-116(人结肠癌)和PC-3(人前列腺)癌细胞系的细胞毒性，以及对乙酰胆碱酯酶(AChE)的抑制作用。精油的提取率约为1.24 w/w±0.9%，其化学成分存在差异，可视为化学型。以植物和香椿为主要成分的精油对HCT-116细胞株的IC50值为9.22 μg/mL，对虫媒病毒的LC50值为1.59 μg/mL，对乙酰胆碱酯酶(AChE)的抑制作用为1 cm。单萜类精油的MIC值为0.15 ~ 1.25 mg/mL，抑菌效果较好。这种化学和生物学特性可能对生物技术应用有用。

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Biotechnological potential of essential oils from different chemotypes of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson

This study reports the biotechnological importance of seven Lippia albaspecimens collected in different places in Brazil, and evaluation of some activities as larvicidal against Aedesspp., antifungal against dermatophytes; cytotoxicity against SNB-19 (astrocytoma), HCT-116 (human colon) and PC-3 (human prostate) cancer cell lines, and inhibition of the enzyme acetylcholinesterase (AChE).The essential oils, whose extraction yield was about 1.24 w/w ± 0.9%, showed differences in their chemical composition and considered as chemotypes. The essential oils containing neral and geranial as main constituents showed better action against HCT-116 cell lines (IC50 value was 9.22 μg/mL), larvicidal activity against arbovirus vectors (LC50 value against A. aegyptiwas 1.59 μg/mL) and inhibition of AChE (halo inhibition zone was 1 cm). The essential oils containing mainly monoterpenoids showed better antifungal action with MIC values range from 0.15 to 1.25 mg/mL. This chemical and biological characterization may be useful for biotechnological applications.

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.