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Multiplication, morphogenesis and foliar abscision of Schinopsis brasiliensis Engl. in vitro 巴西小檗的增殖、形态发生和叶面脱落。在体外
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.17
F. S. Bacilieri, Ana Valeria Vieira de Souza, J. M. Luz, Roberta Camargos de Oliveira, Herick Fernando de Jesus Silva, R. A. L. S. Rezende, M. Pasqual, J. Dória
{"title":"Multiplication, morphogenesis and foliar abscision of Schinopsis brasiliensis Engl. in vitro","authors":"F. S. Bacilieri, Ana Valeria Vieira de Souza, J. M. Luz, Roberta Camargos de Oliveira, Herick Fernando de Jesus Silva, R. A. L. S. Rezende, M. Pasqual, J. Dória","doi":"10.37360/blacpma.23.22.2.17","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.17","url":null,"abstract":"The objective was to evaluate plant growth regulators and ethylene inhibitors on the development and leaf abscission of Schinopsis brasiliensis Engl. Zeatin (ZEA) was evaluated in concentrations combined with concentrations of indolacetic acid (IAA), naphthalene acetic acid (NAA) and indolbutyric acid (IBA). ZEA and 6-benzylamino purine (BAP) were evaluated in concentrations plus a control. Ethylene inhibitors, silver nitrate and cobalt chloride were evaluated in four concentrations. The addition of 0.2 μL-1 of NAA to 0.4 μL-1 of ZEA promotes a greater number of baraúna sprouts. At concentrations of 5 and 10 μM, cobalt chloride is more efficient than silver nitrate for reducing leaf abscission in baraúna. IAA is the most suitable auxin to be associated with ZEA for higher shoot length and number of buds. Silver nitrate from a concentration of 20 μM completely avoids leaf abscission while cobalt chloride has a maximum reduction in abscission at a concentration of 40 μM.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"34 12 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82782854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Traditional medicinal uses and biological activities of species of the genus Desmodium: a literature review 金缕草属植物的传统药用价值和生物活性:文献综述
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.6.51
Alexander Cueva-Chamba
{"title":"Traditional medicinal uses and biological activities of species of the genus Desmodium: a literature review","authors":"Alexander Cueva-Chamba","doi":"10.37360/blacpma.23.22.6.51","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.6.51","url":null,"abstract":"The genus Desmodium includes about 350 species, distributed in tropical and subtropical regions around the world. The objective of this review was to associate the traditional medicinal uses of the genus Desmodium with its biological activities reported in the scientific literature. Traditional medicinal uses and biological activities were described in 56 species. More than 100 traditional medicinal uses have been reported in 43 countries, highlighting the use in inflammatory, gastrointestinal and infectious processes, muscular pain, rheumatic, renal and hepatic affections. Among the 45 biological activities experimentally evaluated, antioxidant, antimicrobial, anti-inflammatory, hepatoprotective and antinociceptive were the most reported. The species with the highest number of studies were D. gangeticum, D. adscendens and D. styracifolium. In conclusion, several traditional medicinal uses have been experimentally supported, demonstrating the pharmacological potential of this genus.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"42 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82692748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The in vitro cytotoxicity against human melanoma cells, tyrosinase inhibition and antioxidant activity of Grewia tenax leaves extracts 青藤叶提取物对人黑色素瘤细胞的体外细胞毒性、酪氨酸酶抑制及抗氧化活性
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.20
A. Alqathama, A. Yonbawi, Luying Shao, A. Bader, Ashraf N. Abdalla, S. Gibbons, J. Prieto
{"title":"The in vitro cytotoxicity against human melanoma cells, tyrosinase inhibition and antioxidant activity of Grewia tenax leaves extracts","authors":"A. Alqathama, A. Yonbawi, Luying Shao, A. Bader, Ashraf N. Abdalla, S. Gibbons, J. Prieto","doi":"10.37360/blacpma.23.22.2.20","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.20","url":null,"abstract":"Grewia tenax (Forssk.) Fiori (Malvaceae) grows in the Arabian Peninsula and is used for several medicinal purposes. To characterize the dermatological bioactivities of G. tenaxin terms of its antimelanoma, antityrosinase and antioxidant activities. Cytotoxicity was assessed by cell proliferation and mitochondrial viability assays. Ability to inhibit mushroom tyrosinase and scavenge free radicals were evaluated by an enzymatic and DPPH scavenging microtiter assay, respectively. Phytochemical analyses were carried out using TLC, HPLC-UV and NMR. The chloroform extract shown significant cytotoxic activity in terms of mitochondrial viability (43 ± 14 μg/mL). We identified lupeol and b-sitosterol as the main active components for the tyrosinase inhibitory activity of the hexane extract. Scavenging activity of the DPPH· radical was confined to the water extract. Extracts from this plant have the potential to be used as a base in the development of cosmeceutical products intended to whiten skin or to combat radical-induced physiopathological processes.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"25 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90073943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Herbal-drug interaction through the pregnane X receptor 草药通过妊娠X受体相互作用
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.3.24
Yuri Yabu de Barros, A. A. Carneiro, S. B. P. Sinoti, Maria Isadora Gabriel Sampaio, P. O. Magalhães, D. Silveira, L. A. Simeoni, Y. Fonseca-Bazzo
{"title":"Herbal-drug interaction through the pregnane X receptor","authors":"Yuri Yabu de Barros, A. A. Carneiro, S. B. P. Sinoti, Maria Isadora Gabriel Sampaio, P. O. Magalhães, D. Silveira, L. A. Simeoni, Y. Fonseca-Bazzo","doi":"10.37360/blacpma.23.22.3.24","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.3.24","url":null,"abstract":"The interaction potential of Cynara scolymusL.,Mikania glomerataSpreng.,Rhamnus purshianaDC and Uncaria tomentosa(Willd. Ex Roem. & Schult.) with conventional drugs metabolized by the CYP3A4 metabolic route was tested in HeLa cell lines, using the in vitromodel of the hPXR. The herbal medicines C. scolymus(1.5 mg/mL dry extract) did not affect the receptor. On the other hand, M. glomerata(5.5 mg/mL dry extract), R. purshiana(1.5 mg/mL dry extract), and U. tomentosa(2.0 mg/mL dry extract) showed to be hPXR agonist, suggesting a potential interaction with the conventional drugs metabolized by the same isoforms of the CYP superfamily. The results from this study contribute to the use safer and more effective of these herbal medicines.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"16 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84363554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pomoea batatas(L.) Lam. (Convolvulaceae) as a source of polyphenols with antitumor activity and prospects for in vitro production using chemical elicitors -A Review pomoea甘薯(l)林。具有抗肿瘤活性的多酚来源及其化学激发子体外生产的前景综述
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.12
Jose Alberto Salgado Chavez, Luz Stella Ramirez Aristizabal, O. M. Mosquera Martinez
{"title":"pomoea batatas(L.) Lam. (Convolvulaceae) as a source of polyphenols with antitumor activity and prospects for in vitro production using chemical elicitors -A Review","authors":"Jose Alberto Salgado Chavez, Luz Stella Ramirez Aristizabal, O. M. Mosquera Martinez","doi":"10.37360/blacpma.23.22.2.12","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.12","url":null,"abstract":"Ipomoea batatas has an enormous projection as functional food and it is an excellent source of anticancerous or chemopreventive substances. Plant tissue culture offers the possibility of inducing secondary metabolites production under controlled conditions and their projection for industrial purposes. To establish the state of knowledge regarding advances in polyphenols chemical elicitation from I. batatas and the possibility of producing potential anticancerous compounds in vitro culture systems, a bibliometric review and an analysis of information available until 2020 were made. Results showed that research field on which review was carried out is current and has a growing trend; however, sweet potato cell suspensions evaluation is scarce. Elicitation using compounds with hormonal effects represents a good alternative to increase phenolic acids production in this species. Advances in phenols elicitation from sweet potato cell suspensions will require search superior genotypes, and associating this knowledge with in vivo and in silico studies.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"10 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80222532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of ultrasound-assisted extraction of phenolic compounds and flavonoids from Hortia oreadicaleaf 超声辅助提取根叶中酚类化合物和黄酮类化合物的工艺优化
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.6.60
R. Portela, T. Fiuza, D. G. Bezerra, E. F. C. Bailão, J. A. D. de Paula, J. D. de Paula, L. Borges
{"title":"Optimization of ultrasound-assisted extraction of phenolic compounds and flavonoids from Hortia oreadicaleaf","authors":"R. Portela, T. Fiuza, D. G. Bezerra, E. F. C. Bailão, J. A. D. de Paula, J. D. de Paula, L. Borges","doi":"10.37360/blacpma.23.22.6.60","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.6.60","url":null,"abstract":"Hortia oreadica is indiscriminated used by people from Cerrado. However, vegetable raw material quality is decisive in obtaining intermediate and final products. So, this study aimed to establish quality parameters of H. oreadica. For this, we performed the phytochemical screening of H. oreadicaleaf and identified the best extractive conditions for phenolic compounds and flavonoids using factorial experimental design, varying the alcoholic strength, extraction temperature, and solid/liquid ratio in the ultrasound-assisted extraction method. The optimum extraction condition for phenolic compounds and flavonoids was 60% alcoholic strength,40°C temperature, and a solid/liquid ratio of 8 mg/mL. Under this setting, the phenolic and flavonoid contents were 0.171 ± 0.002 mg/mL(predicted value = 0.165) and 0.087 ± 0.002 mg/mL(predicted value = 0.084), respectively. The optimized extraction parameters could be upscaled to develop pharmaceutical drugs or nutraceutical products from this non-traditional plant species using an eco-friendly approach.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"44 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86553159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuro-protective effect of Linalool against spinal cord injury in rats and the mechanism involved 芳樟醇对大鼠脊髓损伤的神经保护作用及其机制
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.16
Lei Zhang, Wendong Sun, Lianjin Li, Xiangqian Zhang, J. Tong
{"title":"Neuro-protective effect of Linalool against spinal cord injury in rats and the mechanism involved","authors":"Lei Zhang, Wendong Sun, Lianjin Li, Xiangqian Zhang, J. Tong","doi":"10.37360/blacpma.23.22.2.16","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.16","url":null,"abstract":"The current study was conducted to determine the neuroprotective role and mechanism of action of Linalool (LIN) in SCI. The SCI in Sprague-Dawley (SD) rats was induced by weight-drop contusion model. Results of the suggested that LIN showed improvement in the locomotor function of SCI rats in a BBB scoring analysis. It was found in agreement with histopathological analysis of spinal cord tissue where LIN improves the neuronal architecture of spinal cord tissues, and protect neurons from degeneration. It also reduces oxidative stress via modulating endogenous antioxidants (MDA, SOD, and GSH) and inhibits the generation of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6). In western blot analysis, LIN showed dose-dependent reduction of expression of toll-like receptor (TLR-4) and nuclear factor-kappa B (NF-ĸB). Our study demonstrated that administration of Linalool alleviated spinal cord injury via anti-inflammatory and antioxidant activities in spinal cord tissues possibly due to inhibition of TLR4/NF-κB activation.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85701087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial activity of medicinal plants against Leptospira spp.: a literature review 药用植物对钩端螺旋体的抑菌活性:文献综述
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.11
A. Melo
{"title":"Antibacterial activity of medicinal plants against Leptospira spp.: a literature review","authors":"A. Melo","doi":"10.37360/blacpma.23.22.2.11","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.11","url":null,"abstract":"Leptospirosis is a zoonosis caused by bacteria of the genus Leptospira that affects animals and humans. This disease is usually treated empirically due to its prevalence in precarious areas without basic sanitation. The use of medicinal plants in less industrialized societies has been one of the main therapeutic resources available. Considering the need touse these natural resources to combat leptospirosis in areas of socioeconomic vulnerability, this study aimed to review the literature on the useof plants with medicinal potential in thetreatment of leptospirosis. The results showed that even though leptospirosis is a common disease in communities lacking basic sanitation and economic development, the number of studies on the use of plants with medicinal potential is scarce. Most of these studies comefrom India, and all plants investigated between 2012 and 2020 had antileptospiral action.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"2006 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90504308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
auhiniaLinnaeus: an overview of the chemistry and bioactivity of essential oils 精油的化学和生物活性综述
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.6.54
E. P. Jung, Raphael Cruz Alves, L. O. Ribeiro, R. Moreira
{"title":"auhiniaLinnaeus: an overview of the chemistry and bioactivity of essential oils","authors":"E. P. Jung, Raphael Cruz Alves, L. O. Ribeiro, R. Moreira","doi":"10.37360/blacpma.23.22.6.54","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.6.54","url":null,"abstract":"Bauhiniagenus comprises 300 diferent species distributed in tropical and subtropical forests. Infusions of some species have been frequently used in folk medicine to treat several ailments, especially diabetes. Studies are focused on the extracts and little is reported about their essential oils. This review aims to compile data about the chemical composition and biological activities of essential oils from diferent species of the genus Bauhinia, in order to show the potential of these oils, since they have a rich composition in terpenoids, with emphasis on sesquiterpenes and diterpenes, which have a broad spectrum of biological actions and can be explored in various application areas.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"98 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90519660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer activity of Inula graveolensby induction of ROS-independent apoptosis and suppression of IL6-IL8 in cervical cancer cells 菊叶通过诱导ros非依赖性凋亡和抑制il - 6- il - 8的抗癌活性
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.3.23
O. Yumrutas, I. Bozgeyik
{"title":"Anticancer activity of Inula graveolensby induction of ROS-independent apoptosis and suppression of IL6-IL8 in cervical cancer cells","authors":"O. Yumrutas, I. Bozgeyik","doi":"10.37360/blacpma.23.22.3.23","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.3.23","url":null,"abstract":"Cancer is an important disease that causing to deaths in the world. Cervical cancer is one of the most common among women and must be treated quickly to prevent cell proliferation. Natural products have been used for cancer treatment due to their antiproliferative and apoptosis induction properties. In the present study, we aimed to determine the antiproliferative and apoptosis induction activities of methanol extract of Inula graveolens(IGME) in the human cerival cancer cell line (HeLa). Antiproliferative activity of IGME was evaluated by using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) method. Apoptosis induction activity was determined by AnnexinV/propodium iodide staining withFACS. ROS induction was determined by DCFH-DA (2′,7′-Dichlorofluorescin diacetate) staining. Interleukin 6 and 8 levels (IL-6 and IL-8) were determined by the Elisa method. IGME exhibited antiproliferative effect and induced apoptosis in the HeLa cells. IL-6, IL-8 and intracellular ROS levels were decreased after treatment of IGME. Consequently, IGME was found to have antiproliferative and apoptosis induction activities as an indicator of the anticancer activity.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"139 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87543745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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