草药通过妊娠X受体相互作用

IF 0.7 4区医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI:10.37360/blacpma.23.22.3.24

Yuri Yabu de Barros, A. A. Carneiro, S. B. P. Sinoti, Maria Isadora Gabriel Sampaio, P. O. Magalhães, D. Silveira, L. A. Simeoni, Y. Fonseca-Bazzo

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引用次数: 0

摘要

大头蟹的相互作用电位。, Mikania glomerataSpreng。，大鼠李和钩藤(野生)。Roem交货。采用hPXR的体外模型，在HeLa细胞系中检测经CYP3A4代谢途径代谢的常规药物。中药鹅尾草(1.5 mg/mL干提取物)对受体无明显影响。另一方面，M. glomerata(5.5 mg/mL干提取物)，R. purshiana(1.5 mg/mL干提取物)和U. tomentosa(2.0 mg/mL干提取物)显示为hPXR激动剂，表明与CYP超家族相同亚型代谢的传统药物可能存在相互作用。本研究的结果有助于更安全、更有效地使用这些草药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Herbal-drug interaction through the pregnane X receptor

The interaction potential of Cynara scolymusL.,Mikania glomerataSpreng.,Rhamnus purshianaDC and Uncaria tomentosa(Willd. Ex Roem. & Schult.) with conventional drugs metabolized by the CYP3A4 metabolic route was tested in HeLa cell lines, using the in vitromodel of the hPXR. The herbal medicines C. scolymus(1.5 mg/mL dry extract) did not affect the receptor. On the other hand, M. glomerata(5.5 mg/mL dry extract), R. purshiana(1.5 mg/mL dry extract), and U. tomentosa(2.0 mg/mL dry extract) showed to be hPXR agonist, suggesting a potential interaction with the conventional drugs metabolized by the same isoforms of the CYP superfamily. The results from this study contribute to the use safer and more effective of these herbal medicines.

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来源期刊

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas PHARMACOLOGY & PHARMACY-

CiteScore

1.30

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas (BLACPMA), [Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants]; currently edited by the publishing house MS-Editions, is a bi-monthly international publication that publishes original peerreviewed research in the field of medicinal and aromatic plants, with nearly 20 years of experience. BLACPMA is a scientific journal that publishes two types of articles: Reviews (only in English) and Original Articles (Spanish or English), its main lines of action being agronomy, anthropology and ethnobotany, industrial applications, botany, quality and standardization, ecology and biodiversity, pharmacology, phytochemistry, pharmacognosy, regulatory and legislative aspects. While all areas of medicinal plants are welcome and the experimental approaches used can be broad and interdisciplinary; other areas of research that are not mentioned depend on the Editorial Committee for their acceptance.