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Diuretic activity of Sambucus nigraL. ssp. palmensis(Link) R. Bolli, an endemic Canary Islands species 黑参的利尿作用。ssp。棕榈属(Link) R. Bolli，加那利群岛特有种
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-07-30 DOI: 10.37360/blacpma.23.22.4.37
Sandra Devora Gutierrez, F. Hernández-Luis, D. Martin-Herrera, Chaxiraxi C. Morales-Marrero, S. Abdala
{"title":"Diuretic activity of Sambucus nigraL. ssp. palmensis(Link) R. Bolli, an endemic Canary Islands species","authors":"Sandra Devora Gutierrez, F. Hernández-Luis, D. Martin-Herrera, Chaxiraxi C. Morales-Marrero, S. Abdala","doi":"10.37360/blacpma.23.22.4.37","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.4.37","url":null,"abstract":"o determine the diuretic activity of Sambucus nigraL. ssp. palmensis(Link) R. Bolli (SP). SP was evaluated in adult female Swiss mice. Urinary excretion volume was measured and the concentration of sodium, potassium, chloride, pH and specific conductance of 3 doses of aqueous extract (35.0, 52.2 and 70.0 mg kg-1) were determined. SP (70.0 mg kg-1) produced ahigher urinary excretion (6.41 mL) and diuretic index (15%) than hydrochlorothiazide (HCTZ) (6.27 mLand 12%, respectively). The saluretic index indicates a lower sodium excretion than HCTZ (13%) and inversely proportional to the dose (8% -5%). The same is observed for potassium excretion (0.0172-0.0162 mEq.K+/100 g/6 h), which achieves a lower value than the control group (0.0166 mEq.K+/100 g/6 h), suggesting potassium retention. These results support the use of this plant species as a diuretic in Canarian folk medicine.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"38 3 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91176706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Madia sativa (Asteraceae), an Araucanian plant
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-07-30 DOI: 10.37360/blacpma.23.22.4.33
E. Téllez, R. Ramírez-Tagle, C. León
{"title":"Madia sativa (Asteraceae), an Araucanian plant","authors":"E. Téllez, R. Ramírez-Tagle, C. León","doi":"10.37360/blacpma.23.22.4.33","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.4.33","url":null,"abstract":"Madia sativaremains important to the traditional culture of many first peoples of Chile and is being studied for its biological abilities by medical researchers. The used of this specie in Chile isresearched through a series of retrospective analysis. This research indicated the use this plant populations mapuche a long time ago.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"13 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81345878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vicenin-2 and vitexin participate in the in vitromodulation of the anti-inflammatory and antioxidant activities exerted by two Urtica circularis extracts 维青素-2和牡荆素参与了两种荨麻提取物抗炎和抗氧化活性的体外调节
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-30 DOI: 10.37360/blacpma.23.22.1.4
Carla Marrassini, Elina Malen Saint Martin, M. R. Alonso, Claudia Anesini
{"title":"Vicenin-2 and vitexin participate in the in vitromodulation of the anti-inflammatory and antioxidant activities exerted by two Urtica circularis extracts","authors":"Carla Marrassini, Elina Malen Saint Martin, M. R. Alonso, Claudia Anesini","doi":"10.37360/blacpma.23.22.1.4","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.1.4","url":null,"abstract":"Urtica circularisis an Argentinean species traditionally used to treat inflammation symptoms and oxidative stress-related diseases. Considering the uses in folk medicine, the purpose of this work was to evaluate and compare the anti-inflammatory and antioxidant activities of two different U. circularisextracts. The contribution of vicenin-2 and vitexin, two compounds identified in the phytochemical analysis, in the biological activity of the extracts was evaluated. The anti-inflammatory activity of the extracts and the isolated compounds was tested on lipopolysaccharide (LPS)-stimulated macrophages, while the antioxidant activity was evaluated through the 2,2 ́ diphenyl-1-picrylhydrazyl (DPPH) radical and 2,2 ́-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) diammonium salt (ABTS) scavenging activities. The popular uses of both extracts were validated, i.e., the use of U. circularisethanol extract for the treatment of inflammation, and the use of the aqueous extract to treat oxidative stress related-diseases. The differences in the biological activities observed between the extracts are probably due to qualitative and/or quantitative differences in the chemical composition and/or the occurrence of synergism between compounds.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"55 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85889503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitroantiparasitic and antibacterial evaluation of organic extracts of Salvadoran flora 萨尔瓦多植物有机提取物体外抗寄生虫及抗菌评价
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-30 DOI: 10.37360/blacpma.23.22.1.2
Marvin J. Núñez, Alma D. Paz-González, Lenci K. Vázquez-Jiménez, Ulises G. Castillo, R. Moo-Puc, Jesús M. Chan-Bacab, Guadalupe Aguilera-Arreola, Lucero Catalán-Gonzalez, Alexis Uriel Quintana-Gómez, Jorge Ismael Castañeda-Sánchez, Julieta Luna-Herrera, G. Rivera
{"title":"In vitroantiparasitic and antibacterial evaluation of organic extracts of Salvadoran flora","authors":"Marvin J. Núñez, Alma D. Paz-González, Lenci K. Vázquez-Jiménez, Ulises G. Castillo, R. Moo-Puc, Jesús M. Chan-Bacab, Guadalupe Aguilera-Arreola, Lucero Catalán-Gonzalez, Alexis Uriel Quintana-Gómez, Jorge Ismael Castañeda-Sánchez, Julieta Luna-Herrera, G. Rivera","doi":"10.37360/blacpma.23.22.1.2","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.1.2","url":null,"abstract":"Currently, in developing countries, parasitic and bacterial diseases as amebiasis, giardiasis, trichonomiasis, leishmaniasis, trypanosomiasis, tuberculosis, and nocardiasis are a public health problem. The pharmacological treatment for these diseases is not completely effective and causes several side effects in patients. Therefore, the searchfor new compounds with biological activity is very important to develop new drugs safely and more efficiently. In this study, different organic extracts obtained from thirty-seven species of the Salvadoran flora were evaluated in several in vitromodels to determine their potential activity against five protozoa (Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Leishmania mexicana, and Trypanosoma cruzi) and three bacteria (Acinetobacter baumanni, Mycobacterium tuberculosis, and Nocardia brasiliensis). The results showed the activity of eight extracts with IC50values of less than 100 μg/mL against L. mexicanaand five extracts with MICs values less than <50 μg/mL against M. tuberculosis. Besides, seven plant species showed MICs ≤3.125 μg/mL against N. brasiliensis. Additionally, secondary metabolites (flavonoids and monoterpene oxygenate) previously reported as active were fingerprint by UPLC-MS to establish a potential correlation with the biological activity showed.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"31 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84976288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening for acetylcholinesterase inhibition, lipid peroxidation inhibition and antioxidant activity of medicinal plants from Morocco 摩洛哥药用植物乙酰胆碱酯酶抑制、脂质过氧化抑制及抗氧化活性的筛选
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-30 DOI: 10.37360/blacpma.23.22.1.1
Smail Aazza, Soukaina El-Guendouz, M. Miguel
{"title":"Screening for acetylcholinesterase inhibition, lipid peroxidation inhibition and antioxidant activity of medicinal plants from Morocco","authors":"Smail Aazza, Soukaina El-Guendouz, M. Miguel","doi":"10.37360/blacpma.23.22.1.1","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.1.1","url":null,"abstract":"Acetylcholinesterase (AChE), hydrolyzes acetylcholine to choline and acetate, thereby terminating this neurotransmitter effect at cholinergic synapses. Therefore, AChE inhibition is used for counterbalance the cholinergic deficit in Alzheimer’s disease (AD) patients. In the present work, in order to find new plant acetylcholinesterase inhibitors, the hydroalcoholic extracts from seventeen medicinal plant species were screened for their acetylcholinesterase inhibition activity, as well as total phenolic (TPC) and flavonoids contents (TFC) and antioxidant activity using ORAC (Oxygen Radical Absorbance Capacity) assay, and their ability to inhibit lipid peroxidation. The results revealed that Rumex acetosa, Taraxacum officinaleand Hypericum perforatumextracts possessing the highest TPC and TFC, were the most effective in terms of ORAC antioxidant activity, and acetylcholinesterase inhibition, in addition to their ability to inhibit liposomes peroxidation, suggesting that those plant species may provide a substantial source of secondary metabolites, which act as natural antioxidants and acetylcholinesterase inhibitors, and may be beneficial in the treatment of AD.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"43 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73309133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concomitant use of allopathic medicine and herbal products for weight-loss among people with overweight or obesity from Central Mexico 墨西哥中部超重或肥胖人群同时使用对抗疗法药物和草药产品进行减肥
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.14
Angel Josabad Alonso-CastroAlan, A. J. Ruiz-Padilla, Eleazar Carranza, M. Ramirez-Morales, M. Isiordia-Espinoza, L. Ibarra-Reynoso, Fabiola Dominguez, Yeniley Ruiz-Noa, L. M. Brennan-Bourdon, Christian Blanco-Sandate, Gerardo Morales-Hernandez
{"title":"Concomitant use of allopathic medicine and herbal products for weight-loss among people with overweight or obesity from Central Mexico","authors":"Angel Josabad Alonso-CastroAlan, A. J. Ruiz-Padilla, Eleazar Carranza, M. Ramirez-Morales, M. Isiordia-Espinoza, L. Ibarra-Reynoso, Fabiola Dominguez, Yeniley Ruiz-Noa, L. M. Brennan-Bourdon, Christian Blanco-Sandate, Gerardo Morales-Hernandez","doi":"10.37360/blacpma.23.22.2.14","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.14","url":null,"abstract":"This study evaluated the prevalence of concomitant use of herbal products for weight loss (HPWL) and allopathic medicine. Factors associated with the prevalence, adverse reactions, and the alteration of medication adherence with the concomitant use of HPWL alone and in combination with allopathic medicine, were assessed. The study was descriptive and cross-sectional using a questionnaire conducted among people with overweight or obesity (n=662) from five cities of Central Mexico. Adherence to medications was measured using the Morisky Medication Adherence Scale. The prevalence of adverse reactions induced by the concomitant use of HPWL, and allopathic medicine was 25.3%. The use of HPWL affected medication adherence by 68%. There is a high prevalence (45.2%) of concomitant use of HPWL and allopathic medicine in people with overweight or obesity in Central Mexico. The concomitant use of HPWL and allopathic medicine induces adverse reactions, mainly gastrointestinal, and thus, medication adherence is affected.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"28 9","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72591918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial activity of Tetradenia riparia leaf essential oil 河豚叶精油的抗菌活性研究
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.19
J. Scanavacca, W. Bortolucci, E. Jacomassi, I. P. Baretta, M. G. I. Faria, C. M. Fernandez, V. Tešević, J. Glamočlija, M. Soković, N. Colauto, G. Linde, Z. C. Gazim
{"title":"Antimicrobial activity of Tetradenia riparia leaf essential oil","authors":"J. Scanavacca, W. Bortolucci, E. Jacomassi, I. P. Baretta, M. G. I. Faria, C. M. Fernandez, V. Tešević, J. Glamočlija, M. Soković, N. Colauto, G. Linde, Z. C. Gazim","doi":"10.37360/blacpma.23.22.2.19","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.19","url":null,"abstract":"Food spoilage is a widely neglected problem and the constant use of synthetic fungicides could develop resistant fungi. The objective of this study was to evaluate the chemical composition and antimicrobial activity of Tetradenia riparia leaf essential oil against foodborne disease microorganisms. Leaf essential oil was obtained by hydrodistillation and identified by gas chromatography coupled to mass spectrometry. The antimicrobial activity was studied by broth microdilution. The major compounds identified were oxygenated sesquiterpenes (43.6%): 14-hydroxy-9-epi-(E)-cariophylene (20.8%) and τ-cadinol (18.4%); followed by oxygenated diterpenes (24.6%): 6,7-dehydroroyleanone (12.6%) and 9β, 13β-epoxy-7-abiethene (10.6%); sesquiterpenic hydrocarbons (17.1%) and oxygenated monoterpenes (7.4%): fenchone (5.6%). The essential oil had broad antibacterial and antifungal activity, mainly against A. versicolor and P. ochrochloron with fungistatic and fungicidal activities and B. cereus, L. monocytogenes, and S. aureus with bacteriostatic and bactericidal activities. T. riparia leaf essential oil is a potential alternative to control microorganisms.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"56 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86421173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The effect of altitude and soil properties on the essential oil components of Turkish sage (Salvia fruticosa Mill.) 海拔和土壤性质对土耳其鼠尾草挥发油成分的影响
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.15
Isin Kocabas Oguz, M. Kaplan
{"title":"The effect of altitude and soil properties on the essential oil components of Turkish sage (Salvia fruticosa Mill.)","authors":"Isin Kocabas Oguz, M. Kaplan","doi":"10.37360/blacpma.23.22.2.15","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.15","url":null,"abstract":"In this study, the effects of altitude and soil properties on the essential oil amounts and essential oil components of the Turkish sage (Salvia fruticosa Mill.) plant were investigated. A location in the south of Turkey in the Kaş district of Antalya with altitude ranges of 0-200 m, 300-500 m, and 600-800 m was defined as the study area. During the full flowering period of S. fruticosa, plants and soil samples were collected. The contents of the essential oils of the plants were analyzed using GC-MS. According to theresults obtained, the essential oil content of plants varied between 1.91% and 5.10%. The main component of the essential oils of the plants collected from all study areas was 1,8-cineol, at 44.93%. It was concluded that variations in the proportions of the components limonene and linalool, which are essential oil components of plants, are not only dependent on altitude but also on changes in soil texture and the total CaCO3 content of the soil.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"60 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86966425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethnobotanical survey of wild plants used in Gümüşhane province (Turkey) 土耳其g<s:1>姆<e:1>哈内省野生植物民族植物学调查
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.2.18
S. Akbulut, Z. Zengin
{"title":"Ethnobotanical survey of wild plants used in Gümüşhane province (Turkey)","authors":"S. Akbulut, Z. Zengin","doi":"10.37360/blacpma.23.22.2.18","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.2.18","url":null,"abstract":"This study aimed to document the traditional uses of plants in Gümüşhane province. Ethnobotanical data on 74 taxa from 135 informants were collected between March 2018 and September 2019. Data were analyzed using quantitative indices of use-value (UV), information consent factor (ICF), and fidelity level (FL). The plants were used for different purposes, mainly for medicinal, food, and equipment. Malva neglecta, was the most used taxa for medicinal purposes. Polygonum aviculare was the most used taxon for food. Quercus petraea subsp. iberica and Pinus sylvestris were the most preferred species for equipment. Salvia verticillata, Rhamnus cathartica, Bilacunaria microcarpa, Taraxacum bessarabicum, Silene vulgaris, Carduus nutans, Helichrysum plicatum, Euphorbia esula subsp. tommasiniana, Thymus pubescens, and Phlomis herba-venti subsp. pungensare reported for the first time in the present study for various purposes.","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"74 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75673430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ethyl acetate extract of Clausena execavatapromotes growth inhibition of Burkitt’s lymphoma cell line via apoptotic activities 克氏菌乙酸乙酯提取物对伯基特淋巴瘤细胞株的生长抑制作用是通过细胞凋亡活性来实现的
IF 0.7 4区 医学
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Pub Date : 2023-01-01 DOI: 10.37360/blacpma.23.22.3.26
S. Albaayit
{"title":"Ethyl acetate extract of Clausena execavatapromotes growth inhibition of Burkitt’s lymphoma cell line via apoptotic activities","authors":"S. Albaayit","doi":"10.37360/blacpma.23.22.3.26","DOIUrl":"https://doi.org/10.37360/blacpma.23.22.3.26","url":null,"abstract":"Clausena excavatais a famous folklore medicinal plant in Asian region that is being used for the treatment of different disorders. This study investigated the cytotoxic effects of leaf extracts via MTT assay, as well as the in vitroapoptotic activities of the ethyl acetate C. excavataleaf extract (EACE) on human Burkitt’s lymphoma, Raji, cell line using annexin-V-FITC/propidium iodide flow cytometric assays. Pro-apoptotic (BAX) and anti-apoptotic (BCL-2, c-MYC) gene expressions were determined via real-time quantitative PCR. Phytochemical screening was done by Gas chromatography-mass spectrometry (GC-MS). EACE has the lowest IC50(19.3 ± 0.35 μg/mL) among extracts. EACE-treated Raji cells after 48 h underwent apoptosis as evident by loss of cell viability and increase in the percentage of early and late apoptotic cells. The results also showed EACE mediated decreased in the BCL-2 and c-MYC gene expressions and increased in the BAX gene. C. excavatais a potential treatment for Burkitt lymphomathrough activation of apoptosis","PeriodicalId":55342,"journal":{"name":"Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas","volume":"1 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82829164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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