Current Allergy and Asthma Reports最新文献

Metabolomics in Childhood Asthma - a Promising Tool to Meet Various Clinical Needs. 代谢组学在儿童哮喘-一个有前途的工具，以满足各种临床需要。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-05-09 DOI: 10.1007/s11882-025-01198-6

Natalia Rzetecka, Jan Matysiak, Joanna Matysiak, Paulina Sobkowiak, Irena Wojsyk-Banaszak, Anna Bręborowicz, Kacper Packi, Agnieszka Klupczyńska-Gabryszak

{"title":"Metabolomics in Childhood Asthma - a Promising Tool to Meet Various Clinical Needs.","authors":"Natalia Rzetecka, Jan Matysiak, Joanna Matysiak, Paulina Sobkowiak, Irena Wojsyk-Banaszak, Anna Bręborowicz, Kacper Packi, Agnieszka Klupczyńska-Gabryszak","doi":"10.1007/s11882-025-01198-6","DOIUrl":"https://doi.org/10.1007/s11882-025-01198-6","url":null,"abstract":"Purpose of review: The aim of our review is to summarize the available literature where metabolomics was used in studies on childhood asthma, and to find metabolites that are diagnostic biomarker candidates in childhood asthma. Moreover, the review also describes studies related to metabo-endotypes and heterogeneity of childhood asthma, severity of the disease, and response to drug treatment.Recent findings: Metabolomics has opened up new perspectives in childhood asthma investigation. Based on the available literature, we found nine metabolites that demonstrated the highest diagnostic potential for differentiation between children with asthma and healthy controls: adenine, adenosine, benzoic acid, hypoxanthine, p-cresol, taurocholate, threonine, tyrosine, and 1-methyl nicotinamide. Many of the identified metabolites are closely associated with inflammatory processes responsible for asthma. Metabolomic analysis also contributed to characterizing new asthma endotypes highlighting the heterogeneity of pediatric asthma. Metabolomics can bring about valuable insights, which, when integrated with other omic disciplines, can facilitate the diagnosis and management of childhood asthma and the search for new biomarkers of the disease. Improvements in the detection of asthma in preschool children, including asthma endotypes, will ease application of proper treatment and enable elimination of unnecessary test treatment of corticosteroids in young patients.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"24"},"PeriodicalIF":5.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Systemic Autoinflammatory Disorders: An Overview. 儿童全身性自身炎症性疾病：综述。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-04-29 DOI: 10.1007/s11882-025-01203-y

Julisa M Patel

{"title":"Pediatric Systemic Autoinflammatory Disorders: An Overview.","authors":"Julisa M Patel","doi":"10.1007/s11882-025-01203-y","DOIUrl":"https://doi.org/10.1007/s11882-025-01203-y","url":null,"abstract":"Purpose of review: Systemic autoinflammatory disorders (SAIDs) are a group of diseases that are characterized by recurrent or persistent unprovoked attacks of inflammation resulting from innate immunity dysregulation and leading to significant sequelae in many cases. The concept of autoinflammatory disorders has been widely studied in the last 28 years since the genetic mutation responsible for familial Mediterranean fever (FMF) was discovered. These disorders are mainly hereditary autoinflammatory diseases with key immunological pathways affected and particularly involving inflammasomes, nuclear factor-κB dysregulation and interferon upregulation. This article serves as an overview of pediatric systemic autoinflammatory disorders, their presentation, workup, complications, and therapeutic management.Recent findings: Advances in genetic analysis have allowed for the rapid identification of mutations responsible for many autoinflammatory disorders. Advances in biomolecular techniques, which have allowed for identifying key players such as inflammasomes, have led to treatment options that have significantly improved morbidity and mortality in affected patients. This review provides an overview of the proposed pathogenesis, presenting features, potential complications and suggested therapies of systemic autoinflammatory disorders. Providers should have a high clinical suspicion for autoinflammatory disorders in children who present with fever, a heightened inflammatory response and negative evaluation for an infectious, malignant, and autoimmune etiology. Understanding and identifying these disorders in a timely manner and implementing prompt treatment allow for the best possible outcome for these patients.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"23"},"PeriodicalIF":5.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational Respiratory Allergy to Flour in the Modern Era. 现代对面粉的职业性呼吸道过敏。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-04-28 DOI: 10.1007/s11882-025-01204-x

Olivier Vandenplas, Virginie Doyen, Monika Raulf

{"title":"Occupational Respiratory Allergy to Flour in the Modern Era.","authors":"Olivier Vandenplas, Virginie Doyen, Monika Raulf","doi":"10.1007/s11882-025-01204-x","DOIUrl":"https://doi.org/10.1007/s11882-025-01204-x","url":null,"abstract":"Purpose of the review: A comprehensive literature review was conducted in order to identify and summarize recent research on IgE-mediated occupational respiratory allergy to flour, focusing on the impact of modern developments in the baking industry characterized by industrialization of production processes and a growing use of baking \"improvers\".Recent findings: Although respiratory allergy to flour is a potentially preventable condition through effective workplace control measures, available data indicate that exposure to flour dust has not decreased in the last decade and flour remains the most prevalent cause of occupational respiratory allergy. The development of the baking industry has led to the introduction of new allergen sources, although their contribution to the development of clinical respiratory allergy remains largely uncertain. In recent years, the diagnostic performance of serum-specific IgE antibody determination against wheat/rye flour and α-amylase compared with specific inhalation challenge with flour as the reference standard has been clarified, making these tests a first-line component of diagnostic algorithms. Available information on the prevalence and incidence of respiratory allergy to flour in recent decades indicates that this condition still imposes a substantial health and socioeconomic burden worldwide. Available data highlight the need to reinforce workplace health-related policies and regulations.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"22"},"PeriodicalIF":5.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Chronic Urticaria in Children: An Update. 儿童慢性荨麻疹的管理：最新进展。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-04-07 DOI: 10.1007/s11882-025-01202-z

Luis Felipe Ensina, Larissa Brandão, Elena Netchiporouk, Moshe Bem-Shoshan

{"title":"Managing Chronic Urticaria in Children: An Update.","authors":"Luis Felipe Ensina, Larissa Brandão, Elena Netchiporouk, Moshe Bem-Shoshan","doi":"10.1007/s11882-025-01202-z","DOIUrl":"10.1007/s11882-025-01202-z","url":null,"abstract":"Purpose of review: To provide an update and new insights into the management of pediatric patients with chronic urticaria.Recent findings: Chronic urticaria in children may be more prevalent than previously thought, with a high resolution rate within two years. Patient-reported outcome measures (PROMs) are effective tools for assessing disease severity and control in pediatric populations. Children with chronic urticaria generally respond better to H1-antihistamines compared to adults. For patients refractory to antihistamines, omalizumab has shown excellent efficacy. Additionally, dupilumab has emerged as a potential treatment option, as it has been approved for chronic spontaneous urticaria in some countries. Managing chronic urticaria in children remains a diagnostic and therapeutic challenge. However, advancements in understanding disease mechanisms, the validation of tools to assess disease activity and control, the development of reliable biomarkers, and the availability of novel therapies offer significant promise. These developments will enable more effective treatment and improved outcomes for pediatric patients.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"21"},"PeriodicalIF":5.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate Change and the Future of Allergies and Asthma. 气候变化和过敏和哮喘的未来。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-03-27 DOI: 10.1007/s11882-025-01201-0

Allison J Burbank

引用次数: 0

Basophil Activation Test for the Improved Diagnosis of Peanut and Tree Nut Allergy. 嗜碱性粒细胞激活试验对花生和树坚果过敏诊断的改进。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-03-20 DOI: 10.1007/s11882-025-01200-1

Orlee Marini-Rapoport, Moumita Bhowmik, Sarita U Patil

引用次数: 0

T Cell Exhaustion in Allergic Diseases and Allergen Immunotherapy: A Novel Biomarker? 过敏性疾病中的T细胞耗竭和过敏原免疫治疗：一种新的生物标志物？

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-03-17 DOI: 10.1007/s11882-025-01199-5

Qingxiu Xu, Le Li, Rongfei Zhu

{"title":"T Cell Exhaustion in Allergic Diseases and Allergen Immunotherapy: A Novel Biomarker?","authors":"Qingxiu Xu, Le Li, Rongfei Zhu","doi":"10.1007/s11882-025-01199-5","DOIUrl":"10.1007/s11882-025-01199-5","url":null,"abstract":"Purpose of review: This review explores the emerging role of T cell exhaustion in allergic diseases and allergen immunotherapy (AIT). It aims to synthesize current knowledge on the mechanisms of T cell exhaustion, evaluate its potential involvement in allergic inflammation, and assess its implications as a novel biomarker for predicting and monitoring AIT efficacy.Recent findings: Recent studies highlight that T cell exhaustion, characterized by co-expression of inhibitory receptors (e.g., PD-1, CTLA-4, TIM-3), diminished cytokine production, and altered transcriptional profiles, may suppress type 2 inflammation in allergic diseases. In allergic asthma, exhausted CD4 + T cells exhibit upregulated inhibitory receptors, correlating with reduced IgE levels and airway hyperreactivity. During AIT, prolonged high-dose allergen exposure drives allergen-specific Th2 and T follicular helper (Tfh) cell exhaustion, potentially contributing to immune tolerance. Notably, clinical improvements in AIT correlate with depletion of allergen-specific Th2 cells and persistent expression of exhaustion markers (e.g., PD-1, CTLA-4) during maintenance phases. Blockade of inhibitory receptors (e.g., PD-1) enhances T cell activation, underscoring their dual regulatory role in allergy. T cell exhaustion represents a double-edged sword in allergy: it may dampen pathological inflammation in allergic diseases while serving as a mechanism for AIT-induced tolerance. The co-expression of inhibitory receptors on allergen-specific T cells emerges as a promising biomarker for AIT efficacy. Future research should clarify the transcriptional and metabolic drivers of exhaustion in allergy, validate its role across diverse allergic conditions, and optimize strategies to harness T cell exhaustion for durable immune tolerance. These insights could revolutionize therapeutic approaches and biomarker development in allergy management.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"18"},"PeriodicalIF":5.4,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases. 高IgE综合征：弥合免疫缺陷，特应性和过敏性疾病之间的差距。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-03-14 DOI: 10.1007/s11882-025-01196-8

Henry Sutanto, Galih Januar Adytia, Deasy Fetarayani

{"title":"Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases.","authors":"Henry Sutanto, Galih Januar Adytia, Deasy Fetarayani","doi":"10.1007/s11882-025-01196-8","DOIUrl":"10.1007/s11882-025-01196-8","url":null,"abstract":"Purpose of review: It seeks to answer key questions about the molecular and cellular mechanisms underlying Hyper IgE Syndrome (HIES), the genetic mutations responsible, and their contributions to both immunodeficiency and allergic manifestations. Additionally, it aims to explore diagnostic strategies and therapeutic approaches that address these overlapping domains, thereby improving disease management.Recent findings: Recent research has identified several pivotal genetic mutations, including those in STAT3, DOCK8, and PGM3, which play critical roles in disrupting immune pathways such as Th17 differentiation and IgE regulation. These molecular defects have been linked to the hallmark features of HIES, including recurrent infections and elevated serum IgE levels, as well as its overlap with atopic conditions like eczema, asthma, and food allergies. Advances in diagnostic tools, such as biomarker identification and genetic testing, have improved the differentiation of HIES from more common atopic disorders. Therapeutic advancements, including the use of targeted biologics and interventions addressing both immunodeficiency and allergic symptoms, have shown promise in enhancing patient outcomes. This review highlights the role of specific genetic mutations in shaping the clinical and immunological phenotype of HIES. Key takeaways include the necessity of integrating molecular insights with clinical observations for accurate diagnosis and the potential of emerging targeted therapies to address both immunological and allergic aspects of the syndrome.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"17"},"PeriodicalIF":5.4,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbal Medicine in Acute and Chronic Sinusitis; Still a Cinderella? 急慢性鼻窦炎的中药治疗还是灰姑娘？

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-03-11 DOI: 10.1007/s11882-025-01195-9

Alexios Vardouniotis, Maria Doulaptsi, Georgia Liva, Ioannis Vlastos, Alexander Karatzanis, Emmanuel Prokopakis

{"title":"Herbal Medicine in Acute and Chronic Sinusitis; Still a Cinderella?","authors":"Alexios Vardouniotis, Maria Doulaptsi, Georgia Liva, Ioannis Vlastos, Alexander Karatzanis, Emmanuel Prokopakis","doi":"10.1007/s11882-025-01195-9","DOIUrl":"10.1007/s11882-025-01195-9","url":null,"abstract":"Purpose of review: To set the context of current knowledge regarding the role of herbal medicine in acute and chronic rhinosinusitis treatment.Recent findings: It is estimated that adults experience 1-3 episodes of viral rhinosinusitis per year and this number increases up to 8-10 episodes in preschool children. The symptoms of acute rhinosinusitis tend to significantly overlap with symptoms of other upper respiratory infections, making the diagnosis quite difficult. The division of rhinosinusitis into bacterial or non-bacterial is clinically important in order to determine appropriate treatment and the administration of antibiotic treatment. Treatment of acute rhinosinusitis is symptomatic and includes nasal rinsing, decongestants, corticosteroids, and combinations of the above. Herbal medicine has been traditionally underestimated in Western world. Nowadays, however, treatment of diseases with the use of medicinal plant treatments is gaining more and more followers. In this context, certain herbal extracts have been tested for viral, post- viral and chronic rhinosinusitis. Phytoneering is an innovative pharmaceutical technique in research and production of herbal medicines. Herbal extracts produced with phytoneering vary in quality and active substances. In terms of quality, safety and efficacy, herbal medicines are at least on par with synthetically produced medicines, having significantly less unwanted side effects. Certain herbal extracts have been tested, and in cases of acute rhinosinusitis are effective. In chronic sinusitis those extracts show promising results and might prove a good alternative without side effects.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"15"},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the Environment and Occupational Exposures in Chronic Rhinosinusitis. 环境和职业暴露在慢性鼻窦炎中的作用。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-03-11 DOI: 10.1007/s11882-025-01197-7

W Jared Martin, Yasine Mirmozaffari, Lauren M Cook, Ezer H Benaim, Aurelia S Monk, Michael Armstrong, Jackson Vuncannon, Cristine Klatt-Cromwell, Charles S Ebert, Brian D Thorp, Brent A Senior, Tom Raz Yarkoni, Adam J Kimple

{"title":"The Role of the Environment and Occupational Exposures in Chronic Rhinosinusitis.","authors":"W Jared Martin, Yasine Mirmozaffari, Lauren M Cook, Ezer H Benaim, Aurelia S Monk, Michael Armstrong, Jackson Vuncannon, Cristine Klatt-Cromwell, Charles S Ebert, Brian D Thorp, Brent A Senior, Tom Raz Yarkoni, Adam J Kimple","doi":"10.1007/s11882-025-01197-7","DOIUrl":"10.1007/s11882-025-01197-7","url":null,"abstract":"Purpose of review: The purpose of the review is to summarize the current literature and evaluate how different environmental exposures may contribute to the development and course of chronic rhinosinusitis (CRS). The review aims to explore the relationship between host factors and environmental exposures in the pathogenesis of CRS.Recent findings: Recent studies have helped establish the role of air pollutants, tobacco smoke, occupational exposures, and microplastics in the pathogenesis of CRS. These exposures have been shown to cause epithelial dysfunction and promote inflammation through different mechanisms and to different degrees. The pathogenesis of CRS is complex and multifactorial, with environmental exposures playing a key role in its onset and exacerbation. Research indicates that pollutants can damage the sinonasal epithelial barrier and disrupt the microbiome, leading to increased inflammation. A deeper understanding of the mechanisms behind this inflammatory process and its link to environmental exposures could enhance strategies for preventing and treating CRS.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"16"},"PeriodicalIF":5.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0