Current Allergy and Asthma Reports最新文献

Updates in Metal Allergy: A Review of New Pathways of Sensitization, Exposure, and Treatment. 金属过敏的最新进展：致敏、暴露和治疗的新途径综述。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-06-19 DOI: 10.1007/s11882-025-01209-6

Joshua Bernstein, Levi Keller, Karin Pacheco

{"title":"Updates in Metal Allergy: A Review of New Pathways of Sensitization, Exposure, and Treatment.","authors":"Joshua Bernstein, Levi Keller, Karin Pacheco","doi":"10.1007/s11882-025-01209-6","DOIUrl":"https://doi.org/10.1007/s11882-025-01209-6","url":null,"abstract":"Purpose of review: Metal exposures are widespread, and ensuing allergic sensitization leads to secondary disease processes, especially contact dermatitis, with chronic implications. This review covers recently described mechanisms of sensitization, sources of exposure, and treatment options.Recent findings: Sensitization to metals is similar to other allergic processes: it is triggered by innate responses, which then facilitate allergic priming. Early oral exposures may lead to tolerance, whereas initial cutaneous exposures by piercings start the pathway toward sensitization. Nickel 'allergy' may be ubiquitous because of multiple pathways of immune response. Although the most frequent reaction to metals is a type IV immune response, some metals, including platinum and sometimes nickel, can also trigger a type I IgE mediated response. Current treatment involves avoidance of exposure and suppression of the response, although inducing tolerance by early oral exposure may be the best method to avoid disease. Better understanding of the factors and contacts that drive metal sensitization will enable better management of the types and timing of exposure, which then may instead induce tolerance and prevent disease.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"28"},"PeriodicalIF":5.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI-Driven Biomarker Discovery and Personalized Allergy Treatment: Utilizing Machine Learning and NGS. 人工智能驱动的生物标志物发现和个性化过敏治疗：利用机器学习和NGS。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-06-03 DOI: 10.1007/s11882-025-01207-8

Mahbod Fazlali, Maedeh Nasira, Ali Moravej

{"title":"AI-Driven Biomarker Discovery and Personalized Allergy Treatment: Utilizing Machine Learning and NGS.","authors":"Mahbod Fazlali, Maedeh Nasira, Ali Moravej","doi":"10.1007/s11882-025-01207-8","DOIUrl":"https://doi.org/10.1007/s11882-025-01207-8","url":null,"abstract":"PURPOSE OF REVIEW: This review explores the transformative potential of artificial intelligence (AI) and next-generation sequencing (NGS) in allergy diagnostics and treatment. It focuses on leveraging these technologies to enhance precision in biomarker discovery, patient stratification, and personalized management strategies for allergic diseases. RECENT FINDINGS: AI-driven algorithms, particularly machine learning and deep learning, have enabled the identification of complex molecular patterns and predictive markers in allergies, such as IgE levels and cytokine profiles. Integration with NGS techniques, including single-cell RNA sequencing, has uncovered unique immune response signatures, providing insights into molecular mechanisms driving allergic reactions. These innovations have advanced diagnostic accuracy, treatment personalization, and real-time monitoring capabilities, especially in allergen immunotherapy. Combining AI and NGS technologies represents a paradigm shift in allergy research and clinical practice. These advancements facilitate precision diagnostics and personalized treatments, ensuring safer and more effective interventions tailored to individual patient profiles. Despite data integration and clinical implementation challenges, these technologies promise improved outcomes and quality of life for allergy sufferers.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"27"},"PeriodicalIF":5.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypereosinophilia in Children. 儿童嗜酸性粒细胞增多症。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-05-23 DOI: 10.1007/s11882-025-01205-w

Tyesha Coleman, Richard Bickel, John Noel, Kathleen R May

{"title":"Hypereosinophilia in Children.","authors":"Tyesha Coleman, Richard Bickel, John Noel, Kathleen R May","doi":"10.1007/s11882-025-01205-w","DOIUrl":"https://doi.org/10.1007/s11882-025-01205-w","url":null,"abstract":"Purpose of review: Hypereosinophilia is defined as an absolute eosinophil count greater than 1500 cells/mm3. This is a condition often observed in the pediatric population, with benign/self-resolving to life-threatening etiologies. Identifying the cause of hypereosinophilia can be challenging, given its broad associated differential diagnosis and diversity of presentations. This review provides an overview of eosinophil biology and explores causes of hypereosinophilia in children, emphasizing diagnostic and therapeutic challenges, while underscoring the importance of recognizing rare causes including primary hypereosinophilic syndrome (HES).Recent findings: Classification of hypereosinophilic subtypes has evolved, as has understanding of etiologies with advances in modern diagnostic tools. Newer therapeutic options with low side-effect profiles have expanded treatment options in patients with HES. Despite recent improvements in medical management, HES remains a serious medical condition with considerable morbidity and potential mortality. Early identification and appropriate treatment can improve prognosis and reduce the burden of disease in children.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"26"},"PeriodicalIF":5.4,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory Health Impacts from Natural Disasters and Other Extreme Weather Events: The Role of Environmental Stressors on Asthma and Allergies. 自然灾害和其他极端天气事件对呼吸系统健康的影响：环境应激源在哮喘和过敏中的作用。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-05-21 DOI: 10.1007/s11882-025-01206-9

Chloe K Chou, Raquel Winker, Meghan E Rebuli, Timothy Moran, Julia E Rager

{"title":"Respiratory Health Impacts from Natural Disasters and Other Extreme Weather Events: The Role of Environmental Stressors on Asthma and Allergies.","authors":"Chloe K Chou, Raquel Winker, Meghan E Rebuli, Timothy Moran, Julia E Rager","doi":"10.1007/s11882-025-01206-9","DOIUrl":"10.1007/s11882-025-01206-9","url":null,"abstract":"Purpose of review: The frequency of natural disasters, other extreme weather events, and downstream emissions of emerging contaminants is increasing. One category of health outcome that is now experiencing increased prevalence due to these environmental threats is respiratory disease, specifically asthma and allergies; though a review summarizing current knowledge and research gaps has not been synthesized on this topic in recent years despite growing evidence.Recent findings: We identified recent literature that connects allergy/asthma with environmental events that are increasing in prevalence alongside natural disasters and other extreme weather events, including algal blooms, floods, heat stress, wildfires, and thunderstorms. Coinciding emissions of per-and polyfluoroalkyl substances (PFAS) and microplastics (MPs) are also discussed as downstream outcomes of these environmental events. Available evidence ranged according to environmental event/stressor type, with over 50 papers identified as relevant to this research scope in the last five years. Narrative synthesis of these papers highlighted exposure-disease linkages for stressors related to natural disasters, other extreme weather events, and downstream emissions of emerging contaminants with pulmonary asthma and allergy outcomes. Underlying biological mechanisms are beginning to be elucidated and include widespread inflammation in the lungs and changes in immune cell signaling and function across the pulmonary system. Take home points in this review pave the way for future investigations to better understand the impacts of these environmental events amongst the complex milieu of threats becoming increasingly prevalent worldwide.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"25"},"PeriodicalIF":5.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomics in Childhood Asthma - a Promising Tool to Meet Various Clinical Needs. 代谢组学在儿童哮喘-一个有前途的工具，以满足各种临床需要。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-05-09 DOI: 10.1007/s11882-025-01198-6

Natalia Rzetecka, Jan Matysiak, Joanna Matysiak, Paulina Sobkowiak, Irena Wojsyk-Banaszak, Anna Bręborowicz, Kacper Packi, Agnieszka Klupczyńska-Gabryszak

{"title":"Metabolomics in Childhood Asthma - a Promising Tool to Meet Various Clinical Needs.","authors":"Natalia Rzetecka, Jan Matysiak, Joanna Matysiak, Paulina Sobkowiak, Irena Wojsyk-Banaszak, Anna Bręborowicz, Kacper Packi, Agnieszka Klupczyńska-Gabryszak","doi":"10.1007/s11882-025-01198-6","DOIUrl":"https://doi.org/10.1007/s11882-025-01198-6","url":null,"abstract":"Purpose of review: The aim of our review is to summarize the available literature where metabolomics was used in studies on childhood asthma, and to find metabolites that are diagnostic biomarker candidates in childhood asthma. Moreover, the review also describes studies related to metabo-endotypes and heterogeneity of childhood asthma, severity of the disease, and response to drug treatment.Recent findings: Metabolomics has opened up new perspectives in childhood asthma investigation. Based on the available literature, we found nine metabolites that demonstrated the highest diagnostic potential for differentiation between children with asthma and healthy controls: adenine, adenosine, benzoic acid, hypoxanthine, p-cresol, taurocholate, threonine, tyrosine, and 1-methyl nicotinamide. Many of the identified metabolites are closely associated with inflammatory processes responsible for asthma. Metabolomic analysis also contributed to characterizing new asthma endotypes highlighting the heterogeneity of pediatric asthma. Metabolomics can bring about valuable insights, which, when integrated with other omic disciplines, can facilitate the diagnosis and management of childhood asthma and the search for new biomarkers of the disease. Improvements in the detection of asthma in preschool children, including asthma endotypes, will ease application of proper treatment and enable elimination of unnecessary test treatment of corticosteroids in young patients.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"24"},"PeriodicalIF":5.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Systemic Autoinflammatory Disorders: An Overview. 儿童全身性自身炎症性疾病：综述。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-04-29 DOI: 10.1007/s11882-025-01203-y

Julisa M Patel

{"title":"Pediatric Systemic Autoinflammatory Disorders: An Overview.","authors":"Julisa M Patel","doi":"10.1007/s11882-025-01203-y","DOIUrl":"https://doi.org/10.1007/s11882-025-01203-y","url":null,"abstract":"Purpose of review: Systemic autoinflammatory disorders (SAIDs) are a group of diseases that are characterized by recurrent or persistent unprovoked attacks of inflammation resulting from innate immunity dysregulation and leading to significant sequelae in many cases. The concept of autoinflammatory disorders has been widely studied in the last 28 years since the genetic mutation responsible for familial Mediterranean fever (FMF) was discovered. These disorders are mainly hereditary autoinflammatory diseases with key immunological pathways affected and particularly involving inflammasomes, nuclear factor-κB dysregulation and interferon upregulation. This article serves as an overview of pediatric systemic autoinflammatory disorders, their presentation, workup, complications, and therapeutic management.Recent findings: Advances in genetic analysis have allowed for the rapid identification of mutations responsible for many autoinflammatory disorders. Advances in biomolecular techniques, which have allowed for identifying key players such as inflammasomes, have led to treatment options that have significantly improved morbidity and mortality in affected patients. This review provides an overview of the proposed pathogenesis, presenting features, potential complications and suggested therapies of systemic autoinflammatory disorders. Providers should have a high clinical suspicion for autoinflammatory disorders in children who present with fever, a heightened inflammatory response and negative evaluation for an infectious, malignant, and autoimmune etiology. Understanding and identifying these disorders in a timely manner and implementing prompt treatment allow for the best possible outcome for these patients.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"23"},"PeriodicalIF":5.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational Respiratory Allergy to Flour in the Modern Era. 现代对面粉的职业性呼吸道过敏。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-04-28 DOI: 10.1007/s11882-025-01204-x

Olivier Vandenplas, Virginie Doyen, Monika Raulf

{"title":"Occupational Respiratory Allergy to Flour in the Modern Era.","authors":"Olivier Vandenplas, Virginie Doyen, Monika Raulf","doi":"10.1007/s11882-025-01204-x","DOIUrl":"https://doi.org/10.1007/s11882-025-01204-x","url":null,"abstract":"Purpose of the review: A comprehensive literature review was conducted in order to identify and summarize recent research on IgE-mediated occupational respiratory allergy to flour, focusing on the impact of modern developments in the baking industry characterized by industrialization of production processes and a growing use of baking \"improvers\".Recent findings: Although respiratory allergy to flour is a potentially preventable condition through effective workplace control measures, available data indicate that exposure to flour dust has not decreased in the last decade and flour remains the most prevalent cause of occupational respiratory allergy. The development of the baking industry has led to the introduction of new allergen sources, although their contribution to the development of clinical respiratory allergy remains largely uncertain. In recent years, the diagnostic performance of serum-specific IgE antibody determination against wheat/rye flour and α-amylase compared with specific inhalation challenge with flour as the reference standard has been clarified, making these tests a first-line component of diagnostic algorithms. Available information on the prevalence and incidence of respiratory allergy to flour in recent decades indicates that this condition still imposes a substantial health and socioeconomic burden worldwide. Available data highlight the need to reinforce workplace health-related policies and regulations.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"22"},"PeriodicalIF":5.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Chronic Urticaria in Children: An Update. 儿童慢性荨麻疹的管理：最新进展。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-04-07 DOI: 10.1007/s11882-025-01202-z

Luis Felipe Ensina, Larissa Brandão, Elena Netchiporouk, Moshe Bem-Shoshan

{"title":"Managing Chronic Urticaria in Children: An Update.","authors":"Luis Felipe Ensina, Larissa Brandão, Elena Netchiporouk, Moshe Bem-Shoshan","doi":"10.1007/s11882-025-01202-z","DOIUrl":"10.1007/s11882-025-01202-z","url":null,"abstract":"Purpose of review: To provide an update and new insights into the management of pediatric patients with chronic urticaria.Recent findings: Chronic urticaria in children may be more prevalent than previously thought, with a high resolution rate within two years. Patient-reported outcome measures (PROMs) are effective tools for assessing disease severity and control in pediatric populations. Children with chronic urticaria generally respond better to H1-antihistamines compared to adults. For patients refractory to antihistamines, omalizumab has shown excellent efficacy. Additionally, dupilumab has emerged as a potential treatment option, as it has been approved for chronic spontaneous urticaria in some countries. Managing chronic urticaria in children remains a diagnostic and therapeutic challenge. However, advancements in understanding disease mechanisms, the validation of tools to assess disease activity and control, the development of reliable biomarkers, and the availability of novel therapies offer significant promise. These developments will enable more effective treatment and improved outcomes for pediatric patients.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"21"},"PeriodicalIF":5.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climate Change and the Future of Allergies and Asthma. 气候变化和过敏和哮喘的未来。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-03-27 DOI: 10.1007/s11882-025-01201-0

Allison J Burbank

引用次数: 0

Basophil Activation Test for the Improved Diagnosis of Peanut and Tree Nut Allergy. 嗜碱性粒细胞激活试验对花生和树坚果过敏诊断的改进。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2025-03-20 DOI: 10.1007/s11882-025-01200-1

Orlee Marini-Rapoport, Moumita Bhowmik, Sarita U Patil

引用次数: 0