{"title":"Detection of Anaphylaxis Through the Cutaneous Barrier.","authors":"Anjali Sundar, Marc S McMorris, Charles F Schuler","doi":"10.1007/s11882-025-01218-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>The capacity to rapidly and objectively detect impending anaphylaxis is a crucial unmet need in food allergy, as clinical impression remains the only means of anaphylaxis diagnosis. Changes in the cutaneous barrier during an allergic reaction might offer an objective, rapid, and accessible anaphylaxis detection method.</p><p><strong>Recent findings: </strong>Changes in cutaneous temperature and skin permeability might serve as markers of anaphylaxis. Existing methods around facial thermography, cutaneous blood flow measurements, electrical impedance spectroscopy, and transepidermal water loss (TEWL) offer varied data as possible food anaphylaxis biomarkers. Further data is needed to validate these and other methods as a means to non-invasively detect anaphylaxis. This review describes key advances in anaphylaxis detection through the cutaneous barrier, most notably around skin barrier function in the context of atopic dermatitis and food allergy.</p>","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"25 1","pages":"41"},"PeriodicalIF":4.6000,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477081/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Allergy and Asthma Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11882-025-01218-5","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ALLERGY","Score":null,"Total":0}
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Abstract
Purpose of review: The capacity to rapidly and objectively detect impending anaphylaxis is a crucial unmet need in food allergy, as clinical impression remains the only means of anaphylaxis diagnosis. Changes in the cutaneous barrier during an allergic reaction might offer an objective, rapid, and accessible anaphylaxis detection method.
Recent findings: Changes in cutaneous temperature and skin permeability might serve as markers of anaphylaxis. Existing methods around facial thermography, cutaneous blood flow measurements, electrical impedance spectroscopy, and transepidermal water loss (TEWL) offer varied data as possible food anaphylaxis biomarkers. Further data is needed to validate these and other methods as a means to non-invasively detect anaphylaxis. This review describes key advances in anaphylaxis detection through the cutaneous barrier, most notably around skin barrier function in the context of atopic dermatitis and food allergy.
期刊介绍：
The aim of Current Allergy and Asthma Reports is to systematically provide the views of highly selected experts on current advances in the fields of allergy and asthma and highlight the most important papers recently published. All reviews are intended to facilitate the understanding of new advances in science for better diagnosis, treatment, and prevention of allergy and asthma.
We accomplish this aim by appointing international experts in major subject areas across the discipline to review select topics emphasizing recent developments and highlighting important new papers and emerging concepts. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. Over a one- to two-year period, readers are updated on all the major advances in allergy and asthma.
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