Current Allergy and Asthma Reports最新文献_第10页

Allergen Stability in Food Allergy: A Clinician's Perspective. 过敏原在食物过敏中的稳定性：临床医生的观点。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-10-01 Epub Date: 2023-09-04 DOI: 10.1007/s11882-023-01107-9

Larissa Koidl, Salvatore Alessio Gentile, Eva Untersmayr

引用次数: 0

Effects of Allergen Exposure and Environmental Risk Factors in Schools on Childhood Asthma. 学校过敏原暴露和环境危险因素对儿童哮喘的影响。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-10-01 Epub Date: 2023-08-31 DOI: 10.1007/s11882-023-01108-8

Eva Yarsky, Tina M Banzon, Wanda Phipatanakul

引用次数: 0

Multiple Sclerosis Pathogenesis and Updates in Targeted Therapeutic Approaches. 多发性硬化的发病机制和靶向治疗方法的最新进展。

IF 5.5 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-09-01 DOI: 10.1007/s11882-023-01102-0

Eleni S Vasileiou, Kathryn C Fitzgerald

{"title":"Multiple Sclerosis Pathogenesis and Updates in Targeted Therapeutic Approaches.","authors":"Eleni S Vasileiou, Kathryn C Fitzgerald","doi":"10.1007/s11882-023-01102-0","DOIUrl":"https://doi.org/10.1007/s11882-023-01102-0","url":null,"abstract":"Purpose of review: In this review, we provide a comprehensive update on current scientific advances and emerging therapeutic approaches in the field of multiple sclerosis.Recent findings: Multiple sclerosis (MS) is a common disorder characterized by inflammation and degeneration within the central nervous system (CNS). MS is the leading cause of non-traumatic disability in the young adult population. Through ongoing research, an improved understanding of the disease underlying mechanisms and contributing factors has been achieved. As a result, therapeutic advancements and interventions have been developed specifically targeting the inflammatory components that influence disease outcome. Recently, a new type of immunomodulatory treatment, known as Bruton tyrosine kinase (BTK) inhibitors, has surfaced as a promising tool to combat disease outcomes. Additionally, there is a renewed interested in Epstein-Barr virus (EBV) as a major potentiator of MS. Current research efforts are focused on addressing the gaps in our understanding of the pathogenesis of MS, particularly with respect to non-inflammatory drivers. Significant and compelling evidence suggests that the pathogenesis of MS is complex and requires a comprehensive, multilevel intervention strategy. This review aims to provide an overview of MS pathophysiology and highlights the most recent advances in disease-modifying therapies and other therapeutic interventions.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"23 9","pages":"481-496"},"PeriodicalIF":5.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10039919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Podcasting in Clinical Allergy and Immunology: Our Experience and a Review of the Current Landscape. 播客在临床过敏和免疫学:我们的经验和当前景观的回顾。

IF 5.5 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-09-01 DOI: 10.1007/s11882-023-01098-7

Payel Gupta, Wajiha Kazmi, Gregory Della Penna, Kortney Kwong Hing

引用次数: 0

Computer-Assisted Clinical Diagnosis and Treatment. 计算机辅助临床诊断与治疗。

IF 5.5 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-09-01 DOI: 10.1007/s11882-023-01097-8

Nadia Hamid, Jay M Portnoy, Aarti Pandya

{"title":"Computer-Assisted Clinical Diagnosis and Treatment.","authors":"Nadia Hamid, Jay M Portnoy, Aarti Pandya","doi":"10.1007/s11882-023-01097-8","DOIUrl":"https://doi.org/10.1007/s11882-023-01097-8","url":null,"abstract":"Purpose of review: Computer-assisted diagnosis and treatment (CAD/CAT) is a rapidly growing field of medicine that uses computer technology and telehealth to aid in the diagnosis and treatment of various diseases. The purpose of this paper is to provide a review on computer-assisted diagnosis and treatment. This technology gives providers access to diagnostic tools and treatment options so that they can make more informed decisions leading to improved patient outcomes.Recent findings: CAD/CAT has expanded in allergy and immunology in the form of digital tools that enable remote patient monitoring such as digital inhalers, pulmonary function tests, and E-diaries. By incorporating this information into electronic medical records (EMRs), providers can use this information to make the best, evidence-based diagnosis and to recommend treatment that is likely to be most effective. A major benefit of CAD/CAT is that by analyzing large amounts of data, tailored recommendations can be made to improve patient outcomes and reduce the risk of adverse events. Machine learning can assist with medical data acquisition, feature extraction, interpretation, and decision support. It is important to note that this technology is not meant to replace human professionals. Instead, it is designed to assist healthcare professionals to better diagnose and treat patients.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"23 9","pages":"509-517"},"PeriodicalIF":5.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10393425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air Pollution and Diet: Potential Interacting Exposures in Asthma. 空气污染和饮食:哮喘的潜在相互作用暴露。

IF 5.5 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-09-01 DOI: 10.1007/s11882-023-01101-1

Emily Brigham, Alisa Hashimoto, Neil E Alexis

{"title":"Air Pollution and Diet: Potential Interacting Exposures in Asthma.","authors":"Emily Brigham, Alisa Hashimoto, Neil E Alexis","doi":"10.1007/s11882-023-01101-1","DOIUrl":"https://doi.org/10.1007/s11882-023-01101-1","url":null,"abstract":"Purpose of review: To provide a review of emerging literature describing the impact of diet on the respiratory response to air pollution in asthma.Recent findings: Asthma phenotyping (observable characteristics) and endotyping (mechanistic pathways) have increased the specificity of diagnostic and treatment pathways and opened the doors to the identification of subphenotypes with enhanced susceptibility to exposures and interventions. Mechanisms underlying the airway immune response to air pollution are still being defined but include oxidative stress, inflammation, and activation of adaptive and innate immune responses, with genetic susceptibility highlighted. Of these, neutrophil recruitment and activation appear prominent; however, understanding neutrophil function in response to pollutant exposures is a research gap. Diet may play a role in asthma pathogenesis and morbidity; therefore, diet modification is a potential target opportunity to protect against pollutant-induced lung injury. In particular, in vivo and in vitro data suggest the potential for diet to modify the inflammatory response in the airways, including impacts on neutrophil recruitment and function. Murine models provide compelling results in regard to the potential for dietary components (including fiber, antioxidants, and omega-3 fatty acids) to buffer against the inflammatory response to air pollution in the lung. Precision lifestyle approaches to asthma management and respiratory protection in the context of air pollution exposures may evolve to include diet, pending the results of further epidemiologic and causal investigation and with neutrophil recruitment and activation as a candidate mechanism.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"23 9","pages":"541-553"},"PeriodicalIF":5.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10094839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of Small Molecule Ligands in IgE-Mediated Allergy. 小分子配体在 IgE 媒介过敏中的作用

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-09-01 Epub Date: 2023-06-23 DOI: 10.1007/s11882-023-01100-2

Kriti Khatri, Andrea O'Malley, Christina Linn, Krzysztof Kowal, Maksymilian Chruszcz

引用次数: 0

Establishing a Virtual Home Assessment Program: from Concept to Implementation as a Result of the COVID-19 Pandemic. 建立虚拟家庭评估计划:基于COVID-19大流行的从概念到实施

IF 5.5 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-09-01 DOI: 10.1007/s11882-023-01099-6

Ryan Allenbrand, Anita DiDonna, Jenny Marshall, Kevin Kennedy

{"title":"Establishing a Virtual Home Assessment Program: from Concept to Implementation as a Result of the COVID-19 Pandemic.","authors":"Ryan Allenbrand, Anita DiDonna, Jenny Marshall, Kevin Kennedy","doi":"10.1007/s11882-023-01099-6","DOIUrl":"https://doi.org/10.1007/s11882-023-01099-6","url":null,"abstract":"Purpose of review: Environmental home assessments have traditionally been performed in-person at the homes of Children's Mercy Kansas City patients. The COVID-19 pandemic brought many challenges to the way patients interact with their healthcare providers, including home visiting programs. Reaching out to patients with high-risk asthma and immunocompromised health was still needed, despite the pandemic. This project's purpose was to develop a virtual (telemedicine) healthy home assessment protocol that would continue to meet patients' needs during the isolation resulting from the pandemic.Recent findings: This is a newly developing approach to performing home environmental assessments with limited published research. Research on the effective use of telemedicine as an alternative to in-person clinic visits has shown that for some health conditions telemedicine represents a useful technique to engage with patients and caregivers. For some conditions, like pediatric asthma, it provides a similar level of efficacy in disease management while providing a more efficient form of interaction. This article describes the development and delivery process, timelines of caregiver interaction, and guidelines for performing virtual home assessments. It summarizes the challenges and benefits of using a virtual process for delivering home assessment services for asthma and allergy patients. Overall, caregivers indicated they found the use of virtual technology had significant benefits for them including their personal comfort and the time efficiency gained by using virtual visits to interact with Healthy Homes Program staff.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"23 9","pages":"531-540"},"PeriodicalIF":5.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10034542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Exposure to Foods as a Risk Factor for Food Allergy. 食物环境暴露是食物过敏的危险因素。

IF 5.5 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-08-01 DOI: 10.1007/s11882-023-01091-0

Andrew V Turner, Johanna M Smeekens

引用次数: 0

Allergies Come Clean: The Role of Detergents in Epithelial Barrier Dysfunction. 变态反应一清二楚：洗涤剂在上皮屏障功能障碍中的作用。

IF 5.4 2区医学

Current Allergy and Asthma Reports Pub Date : 2023-08-01 Epub Date: 2023-05-26 DOI: 10.1007/s11882-023-01094-x

Benjamin L Wright, Mia Y Masuda, Danna R Ortiz, Adelyn Dao, Blake Civello, Grace C Pyon, Aliviya R Schulze, James A Yiannas, Matthew A Rank, Hirohito Kita, Alfred D Doyle

{"title":"Allergies Come Clean: The Role of Detergents in Epithelial Barrier Dysfunction.","authors":"Benjamin L Wright, Mia Y Masuda, Danna R Ortiz, Adelyn Dao, Blake Civello, Grace C Pyon, Aliviya R Schulze, James A Yiannas, Matthew A Rank, Hirohito Kita, Alfred D Doyle","doi":"10.1007/s11882-023-01094-x","DOIUrl":"10.1007/s11882-023-01094-x","url":null,"abstract":"Purpose of review: The prevalence and incidence of allergic disease have been rising in Westernized countries since the twentieth century. Increasingly, evidence suggests that damage to the epithelium initiates and shapes innate and adaptive immune responses to external antigens. The objective of this review is to examine the role of detergents as a potential risk factor for developing allergic disease.Recent findings: Herein, we identify key sources of human detergent exposure. We summarize the evidence suggesting a possible role for detergents and related chemicals in initiating epithelial barrier dysfunction and allergic inflammation. We primarily focus on experimental models of atopic dermatitis, asthma, and eosinophilic esophagitis, which show compelling associations between allergic disease and detergent exposure. Mechanistic studies suggest that detergents disrupt epithelial barrier integrity through their effects on tight junction or adhesion molecules and promote inflammation through epithelial alarmin release. Environmental exposures that disrupt or damage the epithelium may account for the increasing rates of allergic disease in genetically susceptible individuals. Detergents and related chemical compounds represent possible modifiable risk factors for the development or exacerbation of atopy.","PeriodicalId":55198,"journal":{"name":"Current Allergy and Asthma Reports","volume":"23 8","pages":"443-451"},"PeriodicalIF":5.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10065170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0