Quin E. Denfeld , Shirin O. Hiatt , Susan J. Rosenkranz , Lissi Hansen
{"title":"Obtaining the patient’s perspective on frailty: a mini-review of qualitative studies","authors":"Quin E. Denfeld , Shirin O. Hiatt , Susan J. Rosenkranz , Lissi Hansen","doi":"10.1016/j.jnha.2025.100494","DOIUrl":"10.1016/j.jnha.2025.100494","url":null,"abstract":"<div><div>There is a small, but growing, evidence base on obtaining the patient’s perspective on frailty, which can help guide future research and clinical management strategies. This mini-review provides a brief summary of some qualitative studies on the patient’s perspective on frailty with a focus on the study design and emerging findings to date. We reviewed seven studies in total, examining how they approached the research question and their main findings. We provide a suggestions and considerations for future research on this topic.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100494"},"PeriodicalIF":4.3,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to “Letter to the editor on: Unhealthful plant-based diet associates with frailty risk predominantly in men with low income from the UK Biobank cohort”","authors":"Kerstin Schorr, Marian Beekman","doi":"10.1016/j.jnha.2025.100491","DOIUrl":"10.1016/j.jnha.2025.100491","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100491"},"PeriodicalIF":4.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor on: “Unhealthful plant-based diet associates with frailty risk predominantly in men with low income from the UK Biobank cohort”","authors":"Luying Qiu","doi":"10.1016/j.jnha.2025.100492","DOIUrl":"10.1016/j.jnha.2025.100492","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100492"},"PeriodicalIF":4.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi-Xuan Wang , Wen-Xin Zhao , Zi-Mo Wang , Ning Zhao , Zhao-long Li , Zhi-Yuan Wu , Yong-Peng Diao , Yong-Jun Li
{"title":"Frailty impacts all-cause mortality after endovascular abdominal aortic aneurysm repair: a retrospective cohort study","authors":"Yi-Xuan Wang , Wen-Xin Zhao , Zi-Mo Wang , Ning Zhao , Zhao-long Li , Zhi-Yuan Wu , Yong-Peng Diao , Yong-Jun Li","doi":"10.1016/j.jnha.2025.100489","DOIUrl":"10.1016/j.jnha.2025.100489","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the impact of frailty and inflammation on all-cause mortality in patients with abdominal aortic aneurysm (AAA) who underwent endovascular aneurysm repair (EVAR), and key risk factors were also explored.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 174 patients with AAA who underwent EVAR at Beijing Hospital between 2016 and 2024. Frailty was assessed using the modified five-item Frailty Index (mFI-5). Inflammation was quantified by the red cell distribution width-to-albumin ratio (RAR), a novel inflammatory marker. We examined the associations between frailty, preoperative risk factors, and mortality using Kaplan-Meier survival analysis and Cox proportional hazards models. Mediation analysis was performed to evaluate the role of RAR in the relationship between frailty and mortality.</div></div><div><h3>Results</h3><div>Frailty was found to be an independent risk factor for all-cause mortality following EVAR (HR = 1.95, P = 0.048). Preoperative anemia (HR = 0.98, P = 0.032), elevated creatinine levels (HR = 1.01, P = 0.013), and prolonged operation time (HR = 1.01, P = 0.029) were also independent predictors of mortality. Kaplan-Meier survival analysis revealed significantly lower survival rates for frailty patients (P = 0.004). Additionally, RAR mediated 23.8% of the relationship between frailty and mortality (P = 0.012), underscoring its role as a key indicator of chronic inflammation.</div></div><div><h3>Conclusions</h3><div>Frailty and chronic inflammation, as measured by the innovative RAR marker, are significant contributors to mortality after EVAR. This study highlights the clinical utility of RAR in identifying high-risk AAA patients and its potential for guiding targeted preoperative interventions. Incorporating frailty assessments and inflammation monitoring into routine preoperative evaluations may improve patient outcomes by enabling personalized approaches such as nutritional optimization and inflammation control.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100489"},"PeriodicalIF":4.3,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seo Hee Ko , Jae-Kwang Shim , Eun Hwa Kim , Jong Wook Song , Sarah Soh , Young-Lan Kwak
{"title":"Association between comprehensive geriatric assessment and Days Alive and Out of Hospital at 30 Days After Cardiac Surgery in Older Patients","authors":"Seo Hee Ko , Jae-Kwang Shim , Eun Hwa Kim , Jong Wook Song , Sarah Soh , Young-Lan Kwak","doi":"10.1016/j.jnha.2025.100490","DOIUrl":"10.1016/j.jnha.2025.100490","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the association of comprehensive geriatric assessment (related to diverse aspects of frailty) with postoperative recovery as measured by days alive and out of the hospital at 30 days (DAOH30) in older patients undergoing cardiac surgery.</div></div><div><h3>Design</h3><div>Retrospective observational study using data retrieved from a prospective registry.</div></div><div><h3>Setting</h3><div>Single tertiary hospital in South Korea.</div></div><div><h3>Participants</h3><div>A total of 437 patients aged ≥65 years who underwent cardiac surgery between March 2021 and October 2022 were included.</div></div><div><h3>Measurements</h3><div>Comprehensive geriatric assessment included subjective evaluations of functional frailty (cognitive, emotional, and physical aspects) and objective measurements of malnutrition and anaemia. DAOH30 was analysed using multivariable quantile regression to evaluate its association with these three domains.</div></div><div><h3>Results</h3><div>In the entire cohort (median age 72 years; median DAOH30, 19 days), 85.1% of participants had functional frailty, 9.8% had malnutrition, and 45.8% had anaemia. Older age, cognitive dysfunction, emotional dysregulation, physical decline, malnutrition, and anaemia were associated with shorter DAOH30 (all p < 0.05). In multivariable analysis, malnutrition had the strongest impact, reducing DAOH30 by 6.0 days (95% confidence interval [CI]: −11.103 to −0.263), followed by anaemia (1.2 days, 95% CI: −2.199 to −0.148) and functional frailty (1.0 days, 95% CI: −1.677 to −0.171). Individual components of functional frailty did not retain an independently significant relationship with DAOH30 after adjustment for confounders.</div></div><div><h3>Conclusion</h3><div>Comprehensive geriatric assessment, incorporating functional frailty, malnutrition, and anaemia, demonstrated a significant association with DAOH30 in older patients undergoing cardiac surgery. Among the assessed aspects, malnutrition showed the strongest association, which may underscore the importance of targeted nutritional interventions to improve outcomes in this patient population.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100490"},"PeriodicalIF":4.3,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hélio José Coelho-Júnior , Alejandro Álvarez-Bustos , Anna Picca , Francesco Landi , Emanuele Marzetti
{"title":"Reply to the commentary on “Cross-sectional associations between dietary intake of polyunsaturated fatty acids, physical function, and sarcopenia in community-dwelling older adults”","authors":"Hélio José Coelho-Júnior , Alejandro Álvarez-Bustos , Anna Picca , Francesco Landi , Emanuele Marzetti","doi":"10.1016/j.jnha.2025.100478","DOIUrl":"10.1016/j.jnha.2025.100478","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100478"},"PeriodicalIF":4.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheng-Lun Kao , Jen-Hung Wang , Hsi-Yu Lai , Fei-Yuan Hsiao , Liang-Kung Chen , Ching-Hui Loh
{"title":"Daily Supplementation with Protein-Enriched Lacto-Vegetarian Soups and Muscle Health in Community-Dwelling Older Adults: A Randomized Controlled Trial","authors":"Sheng-Lun Kao , Jen-Hung Wang , Hsi-Yu Lai , Fei-Yuan Hsiao , Liang-Kung Chen , Ching-Hui Loh","doi":"10.1016/j.jnha.2024.100477","DOIUrl":"10.1016/j.jnha.2024.100477","url":null,"abstract":"<div><h3>Background</h3><div>Dietary protein adequacy is crucial for muscle health in aging individuals, posing a particular challenge for vegetarian seniors. This randomized controlled trial (RCT) investigates the impacts of protein-enriched lacto-vegetarian soup supplementation on body composition, physical performance and muscle strength functional assessment as well as cardiometabolic and inflammatory biomarkers in older adults.</div></div><div><h3>Methods</h3><div>We enrolled 100 participants ≥65 years at risk for malnutrition (MNA-SF ≤ 11) and at risk for sarcopenia (SARC-F ≥4 or SARC-CalF ≥11) in this RCT. Participants were randomized assigned to receive a daily protein-enriched lacto-vegetarian soup (24−30 g protein) or usual diet. Primary outcomes of interest including (1) body composition (anthropometric measurements and body composition measured by bioimpedance analysis (BIA)), (2) physical performance (Short Physical Performance Battery, SPPB) and muscle strength (hand grip strength), and (3) functional assessments (including sarcopenia risk scales and nutritional status) as well as secondary outcomes of interests including cardiometabolic and inflammatory biomarkers were assessed at baseline and the 12th week of follow-up.</div></div><div><h3>Results</h3><div>Data of 97 participants (intervention: n = 48, control: n = 49) were analyzed. Despite no significant changes in body composition were observed in the intervention group, compared to the usual diet, those who received protein-enriched lacto-vegetarian soup supplementation had an improved physical performance including an increase in SPPB score (β = 0.83 [95% CI 0.15–1.51], p = 0.02), a decrease in time to complete the 5 times chair rise test (β = −2.25 [−4.04 to −0.44], p = 0.01). Some functional assessments, including improved sarcopenia risk scale (e.g., SARC-F score [β = −0.68, p = 0.04]) and nutritional status (e.g., MNA-SF score [β = 0.44, p = 0.03]) were also observed.</div></div><div><h3>Conclusions</h3><div>Daily supplementation with protein-enriched lacto-vegetarian soups enhanced physical performance and functional assessments (such as sarcopenia risk scale and nutritional status) among older adults at risk of malnutrition and sarcopenia. Further study is needed to explore the long-term benefits of protein-enriched lacto-vegetarian soup supplementation for healthy aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100477"},"PeriodicalIF":4.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary on “Cross-sectional associations between dietary intake of polyunsaturated fatty acids, physical function, and sarcopenia in community-dwelling older adults”","authors":"Funda Yildirim Borazan, Hacer Dogan Varan","doi":"10.1016/j.jnha.2025.100479","DOIUrl":"10.1016/j.jnha.2025.100479","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100479"},"PeriodicalIF":4.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor on: “Adherence to the low-fat diet pattern reduces the risk of lung cancer in American adults aged 55 years and above: a prospective cohort study”","authors":"Lijia Xu , Hao Fang","doi":"10.1016/j.jnha.2025.100485","DOIUrl":"10.1016/j.jnha.2025.100485","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100485"},"PeriodicalIF":4.3,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}