Journal of Nutrition Health & Aging最新文献

{"title":"Linking social support network deficits to late-life malnutrition: The hidden psychological pathway","authors":"Miao Miao,&nbsp;Yu Zhou,&nbsp;Chen Qiu,&nbsp;Doris Sau Fung Yu","doi":"10.1016/j.jnha.2025.100686","DOIUrl":"10.1016/j.jnha.2025.100686","url":null,"abstract":"<div><h3>Objectives</h3><div>Social and mental health significantly influence the nutritional status of older adults. While a relationship exists between social support network deficits and malnutrition, the underlying mechanisms remain unclear. This study aims to explore the associations and potential psychological pathways among social support network deficits, depressive symptoms, and malnutrition in older adults.</div></div><div><h3>Methods</h3><div>A secondary analysis was conducted using data from the Jockey Club Pathway to Healthy Aging project, collected between May 2022 and June 2024. Structural equation modeling was employed to examine the relationships among social support network deficits, depressive symptoms, and malnutrition, as well as the mediating role of depressive symptoms in the overall participants and across body mass index subgroups.</div></div><div><h3>Results</h3><div>The study included 5,286 older adults, with an undernourishment prevalence of 14.8%. Social support network deficits (β = −0.044, <em>p</em> = 0.004) and depressive symptoms (β = −0.150, <em>p</em> &lt; 0.001) were significantly negatively associated with malnutrition scores, with depressive symptoms mediating 55.1% of the total effect (β = −0.098, <em>p</em> &lt; 0.001). Depressive symptoms acted as a complete mediator in the normal weight group, while it served as a partial mediator in the overweight and obese groups.</div></div><div><h3>Conclusions</h3><div>The risk of malnutrition in older adults is associated with social support network deficits and depressive symptoms. Preventive strategies should differ based on body mass index, focusing on social factors for overweight and obese individuals while addressing negative emotions in those with normal weight to encourage healthy dietary habits and lifestyles.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100686"},"PeriodicalIF":4.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between omega-3 fatty acid intake and risk of diabetic retinopathy: A systematic review and meta-analysis","authors":"Kai-Yang Chen ,&nbsp;Hoi-Chun Chan ,&nbsp;Chi-Ming Chan","doi":"10.1016/j.jnha.2025.100632","DOIUrl":"10.1016/j.jnha.2025.100632","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic Retinopathy is a significant microvascular complication of diabetes mellitus characterized by progressive damage to the retinal vasculature. Current management strategies focus on modifying risk factors and treating established disease. Omega-3 polyunsaturated fatty acids (PUFAs) demonstrate anti-inflammatory, antioxidative, and vasculoprotective properties.</div></div><div><h3>Objectives</h3><div>To evaluate the protective effects of omega-3 fatty acids on DR incidence, progression, and microvascular health across diverse diabetic populations.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted via PubMed, EBSCO Open Research, ScienceDirect, Wiley Online Library, and Google Scholar. A reviewer screened the potential articles against prespecified eligibility criteria. The risk of bias in the eligible studies was then evaluated using the Newcastle Ottawa Scale (NOS), a Risk of Bias visualization tool developed by the Cochrane Collaboration (ROB 2.0). Data were then systematically extracted and analyzed.</div></div><div><h3>Results</h3><div>Fourteen studies involving 139,879 participants were analyzed. Omega-3 fatty acid intake of ≥500 mg/day significantly reduced the risk of sight-threatening diabetic retinopathy (DR) by 48% (HR = 0.52; 95% CI: 0.31–0.88; p = 0.001). Subgroup meta-analysis showed a stronger associated protective effect in type 2 diabetes (T2D) compared to type 1 (T1D), with a pooled hazard ratio of 0.71 (log HR = −0.339; SE = 0.0667; p &lt; 0.000001). The antioxidant benefits were linked by a pooled mean difference of −1.399 in oxidative stress markers (MDA/TBARS) (95% CI: −1.432 to −1.366; Z = 83.29; p &lt; 0.00001), with no significant heterogeneity (I² = 0%). Further stratification showed robust effects in both RCTs (HR = 0.743; p = 0.002) and non-RCTs (HR = 0.514; p = 0.005). These findings support omega-3s—especially in T2D—as a non-pharmacologic intervention for DR prevention, likely through anti-inflammatory and vasoprotective mechanisms.</div></div><div><h3>Conclusion</h3><div>Omega-3 fatty acid intake is associated with dose-dependent protection against diabetic retinopathy, with the greatest benefits from whole food sources, optimal omega-6/omega-3 ratios, and in well-controlled T2D patients.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100632"},"PeriodicalIF":4.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition disorders and related conditions—Prevalence, overlap and relation to one year survival in geriatric patients","authors":"Frida Ostonen Peelen ,&nbsp;Maria Enge ,&nbsp;Rikke Lundsgaard Nielsen ,&nbsp;Anne Marie Beck ,&nbsp;Ann Ödlund Olin ,&nbsp;Tommy Cederholm ,&nbsp;Anne-Marie Boström ,&nbsp;Ingvild Paur","doi":"10.1016/j.jnha.2025.100682","DOIUrl":"10.1016/j.jnha.2025.100682","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the overlap between the nutrition disorders (malnutrition, low-intake dehydration, obesity) and nutrition related conditions (frailty, sarcopenia, sarcopenic obesity), and the significance of each of these and their combinations for survival among older patients admitted to geriatric care.</div></div><div><h3>Methods</h3><div>This exploratory study was based on a cross-sectional study with 100 patients (≥65 years) admitted to two geriatric departments. Data was retrieved from the Electronic Patient Record. Malnutrition was defined according to the Global Leadership Initiative on Malnutrition (GLIM) criteria with no prior screening. A low-intake dehydration equation, using proxy urea, was applied. Obesity was diagnosed at BMI &gt; 29.9 kg/m². Frailty was assessed by Clinical Frailty Scale, whereas sarcopenia was diagnosed according to the European Working Group of Sarcopenia in Older People (EWGSOP2). Sarcopenic obesity was defined as the combination of sarcopenia and obesity. Mortality was recorded up to one year after discharge.</div></div><div><h3>Main findings</h3><div>The nutrition disorders and nutrition related conditions displayed considerable overlaps, and the prevalences were; frailty 67%, low-intake dehydration 62%, malnutrition 58%, sarcopenia 30%, obesity 13%, and sarcopenic obesity 0%. Higher numbers of nutrition disorders and nutrition related conditions combined, and malnutrition (according to GLIM) alone, were related to decreased one-year survival as show in Kaplan Meier plots.</div></div><div><h3>Conclusion</h3><div>The prevalence and overlap of the nutrition disorders; malnutrition, and low-intake dehydration and the nutrition related conditions; frailty and sarcopenia were high in patients acutely admitted to geriatric departments. Increasing number of nutrition disorders and nutrition related conditions combined, and malnutrition alone were associated with decreased survival.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100682"},"PeriodicalIF":4.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Frequent Ramen consumption and increased mortality risk in specific subgroups: A Yamagata cohort study” [J Nutr Health Aging, 29 (2025) 100643]","authors":"Miho Suzuki ,&nbsp;Natsuko Suzuki ,&nbsp;Ri Sho ,&nbsp;Masayoshi Souri ,&nbsp;Tsuneo Konta","doi":"10.1016/j.jnha.2025.100684","DOIUrl":"10.1016/j.jnha.2025.100684","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100684"},"PeriodicalIF":4.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145094982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applicability and predictive validity of the global leadership initiative on malnutrition criteria for older patients with sepsis according to different muscle mass assessment methods","authors":"Na Shang ,&nbsp;Qiujing Li ,&nbsp;Haijing Zhou ,&nbsp;Xiangqun Zhang ,&nbsp;Shubin Guo ,&nbsp;Xue Mei","doi":"10.1016/j.jnha.2025.100685","DOIUrl":"10.1016/j.jnha.2025.100685","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the applicability of the Global Leadership Initiative on Malnutrition (GLIM) criteria in older patients with sepsis and to compare the predictive validity for 28-day mortality of different muscle mass assessment methods in the emergency department.</div></div><div><h3>Design</h3><div>Prospective cohort study.</div></div><div><h3>Setting</h3><div>Emergency department.</div></div><div><h3>Patients</h3><div>Older patients (≥65 years) with sepsis.</div></div><div><h3>Measurements</h3><div>Muscle mass was assessed using three methods: (1) the skeletal muscle index at the third lumbar vertebra (L3) on computed tomography (CT) scans; (2) calf circumference (CC), and (3) mid-upper-arm circumference (MAC). Cox regression analysis was performed to assess the association between the GLIM criteria and 28-day all-cause mortality. Additionally, the C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to evaluate the predictive validity of the three instruments. Survival curves were assessed using the Kaplan–Meier method and compared using the log-rank test.</div></div><div><h3>Results</h3><div>A total of 598 patients with sepsis were included. The prevalence of malnutrition according to GLIM-CT, GLIM-CC, and GLIM-MAC was 53.3%, 63.0%, and 40.8%, respectively. Cox regression analysis revealed that the GLIM criteria were independent risk factors for all-cause 28-day mortality. Incorporation of GLIM-CT, GLIM-CC, or GLIM-MAC into a base model significantly improved the C-statistic. The model including GLIM-CT had the highest C-statistic, improving the C-statistic of the base model from 0.780 (95% confidence interval [CI]: 0.741−0.819) to 0.823 (95% CI: 0.789−0.857). This improvement in risk prediction was also confirmed via category-free NRI and IDI, suggesting that GLIM-CT had the best performance. Kaplan–Meier survival analysis showed that patients with malnutrition defined according to the GLIM criteria had a greater probability of 28-day mortality (log-rank, <em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Malnutrition, defined via any of the three methods, was predictive of 28-day mortality among older patients with sepsis in the emergency department. GLIM-CT had the best predictive validity.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100685"},"PeriodicalIF":4.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping multimorbidity cluster-specific intrinsic capacity impairment patterns and mortality risks in a community-dwelling aging population cohort","authors":"Fei Song ,&nbsp;Jagadish K. Chhetri ,&nbsp;Mengjin Hu ,&nbsp;Boyu Li ,&nbsp;Jinggang Xia ,&nbsp;Chunlin Yin","doi":"10.1016/j.jnha.2025.100687","DOIUrl":"10.1016/j.jnha.2025.100687","url":null,"abstract":"<div><h3>Background</h3><div>Growing evidence indicate that chronic diseases have distinct clusters, each potentially influencing intrinsic capacity (IC) through unique pathological pathways. This raises two critical questions: (1) How do different multimorbidity clusters preferentially impact specific IC domains? (2) Which multimorbidity cluster would have the highest risk of mortality in individuals with IC impairment?</div></div><div><h3>Methods</h3><div>We used data from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative cohort study in China. Multimorbidity was defined as the presence of two or more chronic conditions. IC impairment was assessed across six domains: cognition, locomotion, vitality, psychology, hearing and vision. We identified multimorbidity clusters using latent class analysis (LCA). Logistic regression was used to evaluate the association between identified multimorbidity clusters and domain specific IC decline, while Kaplan-Meier analysis and cox regression analysis were used to assess the mortality risk.</div></div><div><h3>Results</h3><div>Among the 4333 participants with multimorbidity, 48.6% were male, with mean age of 59.5 years. LCA method identified four distinct multimorbidity clusters: arthritis-metabolic (24.8%), stomach-arthritis (29.4%), respiratory (16.5%), metabolic-vascular (29.4%) clusters. Multimorbidity cluster-specific patterns of IC impairment revealed markedly elevated risks of decline in the cognitive, psychological, hearing, and vitality domains within the respiratory cluster. Similarly, the stomach-arthritis cluster was associated with significantly higher risks of impairment in the psychological, visual, hearing, and vitality domains. In contrast, the arthritis-metabolic cluster demonstrated significantly increased risks specifically in the cognitive and psychological domains. Survival analysis revealed significant mortality differences across multimorbidity clusters (<em>p</em> &lt; 0.001). After multivariate adjustment, intrinsic capacity impairment remained significantly associated with increased mortality in the respiratory cluster (HR = 1.74, 95%CI:1.06−2.87, <em>p</em> = 0.029), demonstrating pattern-dependent prognostic value of IC.</div></div><div><h3>Conclusions</h3><div>Our findings revealed a significant heterogeneity in IC impairment patterns across different multimorbidity clusters, showing cluster-specific IC impairment and cluster-dependent risk of mortality according to IC impairment.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100687"},"PeriodicalIF":4.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of autoimmune disease in older adults (≥60 years) from 1990 to 2021: Results from the Global Burden of Disease Study 2021","authors":"Su-Qi Zeng ,&nbsp;Jun-Hai Zhen ,&nbsp;Yu Pu ,&nbsp;Chuan Liu ,&nbsp;Jia-Ming Hu ,&nbsp;Jun-Jie Chen ,&nbsp;Xiao-Li Wang ,&nbsp;Wei-Guo Dong","doi":"10.1016/j.jnha.2025.100681","DOIUrl":"10.1016/j.jnha.2025.100681","url":null,"abstract":"<div><h3>Objectives</h3><div>To analyze and model the global, regional, and national burden of autoimmune diseases (ADs) among older adults (≥60 years) from 1990 to 2021.</div></div><div><h3>Methods</h3><div>Data were extracted from the Global Burden of Disease (GBD) 2021 data for 204 countries and territories. Age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALY) rates were calculated with 95% uncertainty intervals (UIs). Temporal trends were assessed using estimated annual percentage change (EAPC, with 95% Confidence Intervals [95% CI]). Future trends to 2035 were projected using a log-linear age-period-cohort model.</div></div><div><h3>Results</h3><div>In 2021, the Americas and Europe had the highest burden of ADs in older adults. From 1990 to 2021, age-standardized incidence and prevalence rates increased notably for rheumatoid arthritis (EAPC for incidence rate: 0.75, 0.70−0.79; for prevalence rate: 0.54, 0.50−0.58) and type 1 diabetes (incidence rate: 0.78, 0.70−0.86; prevalence rate:0.84, 0.81-0.88). Psoriasis showed smaller but consistent increases, while inflammatory bowel disease rose only modestly, and multiple sclerosis remained relatively stable. Projections suggest continued increases in age-standardized incidence and prevalence rates for most ADs through 2035.</div></div><div><h3>Conclusions</h3><div>The burden of ADs among older adults is rising globally, with particularly high rates in the Americas and Europe. These findings highlight the urgent need for strategic resource allocation and targeted prevention and management strategies to address ADs in aging populations.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100681"},"PeriodicalIF":4.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between long-term burden of sarcopenia and cardiorespiratory multimorbidity","authors":"Zuolin Lu ,&nbsp;Yunyuan Kong ,&nbsp;Weihao Shao ,&nbsp;Jiawen Ke ,&nbsp;Yachen Wang ,&nbsp;Xiaoxia Wei ,&nbsp;Yabing Hou ,&nbsp;Ruitai Shao","doi":"10.1016/j.jnha.2025.100670","DOIUrl":"10.1016/j.jnha.2025.100670","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia, the progressive loss of muscle mass and function, is a common condition in older adults and has been linked to both cardiovascular disease (CVD) and chronic respiratory diseases (CRD). However, the association between long-term changes of sarcopenia and cardiorespiratory multimorbidity remains underexplored. This study aims to investigate how changes in sarcopenia burden over time relate to cardiorespiratory multimorbidity in Chinese adults.</div></div><div><h3>Methods</h3><div>Data from the China Health and Retirement Longitudinal Study (CHARLS) were used, including 5186 participants aged 45 and older. Sarcopenia was assessed using criteria for muscle mass, strength, and physical performance. Sarcopenia trajectories were identified using group-based trajectory modeling, and associations with cardiorespiratory multimorbidity (CVD and CRD) were assessed using multivariable-adjusted logistic regression models.</div></div><div><h3>Results</h3><div>The study included 5186 participants with mean age of 58.2 ± 8.4 years. A total of 301 (5.8%) participants experienced cardiorespiratory multimorbidity. Four distinct sarcopenia trajectory groups were identified: persistently low, moderate-to-low, low-to-high, and persistently high burden. Compared to the reference (persistently low group), the low-to-high trajectory of sarcopenia burden had the strongest association with cardiorespiratory multimorbidity (OR: 2.64, 95% CI: 1.73–4.04), followed by the persistently high group (OR: 2.05, 95% CI: 1.46–2.89) and moderate-to-low group (OR: 1.90; 95% CI: 1.38–2.60).</div></div><div><h3>Conclusions</h3><div>Changes in sarcopenia burden are significantly associated with cardiorespiratory multimorbidity, with a rapid increase in sarcopenia burden (low-to-high trajectory) being particularly detrimental. Monitoring sarcopenia progression and early intervention may be crucial in preventing cardiorespiratory multimorbidity. Further research is needed to explore underlying mechanisms and evaluate interventions.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100670"},"PeriodicalIF":4.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and the short-term prognosis of patients with intracranial hemorrhage: A meta-analysis","authors":"Caiyun Li,&nbsp;Fei Xia,&nbsp;Yang Ni,&nbsp;Yiwen Liu","doi":"10.1016/j.jnha.2025.100655","DOIUrl":"10.1016/j.jnha.2025.100655","url":null,"abstract":"<div><h3>Background</h3><div>Frailty is increasingly recognized as a predictor of poor outcomes in acute neurological conditions. However, its impact on the short-term prognosis of patients with intracranial hemorrhage (ICrH) remains unclear. This meta-analysis aimed to evaluate the association between frailty and short-term mortality and functional outcomes in patients with ICrH.</div></div><div><h3>Methods</h3><div>A systematic literature search was conducted in PubMed, Embase, and Web of Science from inception to February 10, 2025. Cohort studies evaluating the association between frailty and prognosis in ICrH patients were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model by incorporating the influence of heterogeneity.</div></div><div><h3>Results</h3><div>Twelve cohort studies involving 70,664 patients with ICrH were included. Frailty was significantly associated with increased short-term mortality (OR: 1.79, 95% CI: 1.36–2.35, <em>p</em> &lt; 0.001; I² = 72%) and poor functional outcome (OR: 1.75, 95% CI: 1.33–2.30, <em>p</em> &lt; 0.001; I² = 67%). Subgroup analyses were performed for mortality outcomes and confirmed consistent associations across different patient demographics, frailty assessment tools, and follow-up durations (<em>p</em> for subgroup difference all &gt;0.05). Sensitivity analyses by excluding one study at a time showed similar results (<em>p</em> all &lt; 0.05), which demonstrated robustness.</div></div><div><h3>Conclusion</h3><div>Our study suggests that frailty may be associated with an increased risk of short-term mortality and poor functional outcomes in patients with ICrH. These findings highlight the importance of frailty assessment in risk stratification and clinical decision-making for ICrH patients.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100655"},"PeriodicalIF":4.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the MIND-NL diet, Dutch dietary guidelines, and global cognitive function in an older population at risk for cognitive decline","authors":"Sonja Beers ,&nbsp;Marian A.E. de van der Schueren ,&nbsp;Pol Grootswagers ,&nbsp;Ondine van de Rest ,&nbsp;Lisa Waterink ,&nbsp;Sietske A.M. Sikkes ,&nbsp;Kay Deckers ,&nbsp;Lion M. Soons ,&nbsp;Jurgen A.H.R. Claassen ,&nbsp;Nynke Smidt ,&nbsp;Wiesje M. van der Flier ,&nbsp;Sebastian Köhler ,&nbsp;Esther Aarts ,&nbsp;Yannick Vermeiren ,&nbsp;Lisette CPGM de Groot ,&nbsp;on behalf of MOCIA consortium FINGER-NL consortium","doi":"10.1016/j.jnha.2025.100680","DOIUrl":"10.1016/j.jnha.2025.100680","url":null,"abstract":"<div><h3>Objectives</h3><div>This study examined the association between adherence to the Dutch MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay, MIND-NL) and the Dutch dietary guidelines (DHD2015-index) with global cognitive function in older adults at risk of cognitive decline.</div></div><div><h3>Design and setting</h3><div>A cross-sectional study was conducted using baseline data of the FINGER-NL trial.</div></div><div><h3>Participants</h3><div>A total of 1,135 older adults, aged 60–80 years, at risk for cognitive decline with complete dietary data and complete neuropsychological tests were included in the analyses.</div></div><div><h3>Measurements</h3><div>A validated 72-item Food Frequency Questionnaire (FFQ) was used to assess adherence to the dietary patterns. Global cognitive function was assessed by calculating a composite score based on four subtests of a neuropsychological test battery. Multiple linear regression analyses, adjusted for age, sex, education level, socioeconomic status (SES), body mass index (BMI), physical activity level, smoking status, and cardiovascular risk factors, were applied to examine potential associations between MIND-NL diet score and global cognitive function, and between DHD2015-index and global cognitive function. Interaction and subsequent subgroup analyses were conducted based on age, sex, education, SES, and physical activity. Explorative network analyses were applied to identify links between individual dietary intake components and global cognitive function.</div></div><div><h3>Results</h3><div>The median [IQR] age of the participants was 67 [64−71] years. Overall, neither the MIND-NL diet nor the DHD2015-index was associated with the global cognition composite score (β = 0.014, 95%CI: -0.016, 0.045, p = 0.35 and β = 0.003, 95%CI: -0.000, 0.006, p = 0.07, respectively). The association between MIND-NL diet score and global cognition was moderated by age (p_interaction = 0.06), with adults under 70 years of age showing a positive trend. Although no significant interaction was noted (p_interaction = 0.28), an association was found between DHD2015-index and global cognition in participants aged under 70 years (β = 0.004, 95%CI: 0.000, 0.008, p = 0.048). Dietary intake of fruiting vegetables and vitamin E were positively correlated with global cognitive function.</div></div><div><h3>Conclusion</h3><div>In this study, adherence to the Dutch dietary guidelines was associated with better global cognitive function among older adults under the age of 70 years at risk of cognitive decline. Future research aims at investigating longitudinal associations and confirming the moderating effect of age.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100680"},"PeriodicalIF":4.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}