1990年至2021年全球、地区和国家老年人（≥60岁）自身免疫性疾病负担：来自2021年全球疾病负担研究的结果

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-09-10 DOI:10.1016/j.jnha.2025.100681

Su-Qi Zeng , Jun-Hai Zhen , Yu Pu , Chuan Liu , Jia-Ming Hu , Jun-Jie Chen , Xiao-Li Wang , Wei-Guo Dong

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引用次数: 0

摘要

目的分析1990年至2021年全球、地区和国家老年人（≥60岁）自身免疫性疾病（ad）负担并建立模型。方法数据取自204个国家和地区的全球疾病负担（GBD） 2021数据。以95%不确定区间（UIs）计算年龄标准化发病率、患病率、死亡率和残疾调整生命年（DALY）率。使用估计的年百分比变化（EAPC， 95%置信区间[95% CI]）评估时间趋势。使用对数线性年龄-时期-队列模型预测到2035年的未来趋势。结果2021年，美洲和欧洲的老年人ad负担最高。从1990年到2021年，类风湿关节炎（EAPC发病率：0.75,0.70 - 0.79；患病率：0.54,0.50 - 0.58）和1型糖尿病（发病率：0.78,0.70 - 0.86；患病率：0.84,0.81-0.88）的年龄标准化发病率和患病率显著增加。银屑病呈较小但持续的增长，而炎症性肠病仅小幅上升，多发性硬化症保持相对稳定。预测显示，到2035年，大多数ad的年龄标准化发病率和患病率将继续增加。全球老年人的ad负担正在上升，其中美洲和欧洲的比例尤其高。这些发现强调了迫切需要战略性资源分配和有针对性的预防和管理策略来解决老年人群中的ad。

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Global, regional, and national burden of autoimmune disease in older adults (≥60 years) from 1990 to 2021: Results from the Global Burden of Disease Study 2021

Objectives

To analyze and model the global, regional, and national burden of autoimmune diseases (ADs) among older adults (≥60 years) from 1990 to 2021.

Methods

Data were extracted from the Global Burden of Disease (GBD) 2021 data for 204 countries and territories. Age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALY) rates were calculated with 95% uncertainty intervals (UIs). Temporal trends were assessed using estimated annual percentage change (EAPC, with 95% Confidence Intervals [95% CI]). Future trends to 2035 were projected using a log-linear age-period-cohort model.

Results

In 2021, the Americas and Europe had the highest burden of ADs in older adults. From 1990 to 2021, age-standardized incidence and prevalence rates increased notably for rheumatoid arthritis (EAPC for incidence rate: 0.75, 0.70−0.79; for prevalence rate: 0.54, 0.50−0.58) and type 1 diabetes (incidence rate: 0.78, 0.70−0.86; prevalence rate:0.84, 0.81-0.88). Psoriasis showed smaller but consistent increases, while inflammatory bowel disease rose only modestly, and multiple sclerosis remained relatively stable. Projections suggest continued increases in age-standardized incidence and prevalence rates for most ADs through 2035.

Conclusions

The burden of ADs among older adults is rising globally, with particularly high rates in the Americas and Europe. These findings highlight the urgent need for strategic resource allocation and targeted prevention and management strategies to address ADs in aging populations.

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.