Journal of Nutrition Health & Aging最新文献

{"title":"A cluster randomized controlled trial of a train-the-trainer behavioral intervention delivered via respite care centers to improve nutritional outcomes and quality of life persons with dementia and their caregivers.","authors":"Suparna Qanungo, Mohan Madisetti, Martina Mueller, Teresa J Kelechi","doi":"10.1016/j.jnha.2025.100710","DOIUrl":"https://doi.org/10.1016/j.jnha.2025.100710","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate a behavioral intervention, Partners at Meals (PAM), designed to empower caregivers (CGs) to improve caloric intake, weight, and quality of life (QOL) of persons with dementia (PWD), and to address dysfunctional behaviors during mealtime. The study also aimed to assess differences in caregiver psychosocial outcomes, including depression, burden, and QOL.</p><p><strong>Design: </strong>A cluster randomized controlled experimental design was used, in which participating Respite Care Centers (RCCs) were randomized to either the PAM intervention group (n = 3) or the control enhanced usual care (EUC) group (n = 3). Enrolled PWD/CG dyads were assigned to PAM or EUC based on the RCCs they attended.</p><p><strong>Setting and participants: </strong>This longitudinal 6-month clinical trial was conducted across six RCCs in the Southeast coastal region of the United States. A total of 53 PWD/CG dyads provided post-enrollment data: PAM (n = 27) and EUC (n = 26).</p><p><strong>Methods: </strong>The PAM intervention was delivered using a train-the-trainer approach, based on the C3P (Change the Person, Change the People, Change the Place) model, and was implemented through RCC volunteers who provided adaptive mealtime strategies via telehealth to CGs in the home. Primary outcome measures for PWD were changes in body weight and feeding/dysfunctional behaviors from baseline to 6-month follow-up or end of study. Secondary outcomes included mid-upper arm circumference (MUAC), caloric intake, and QOL. Caregiver outcomes included changes in burden, depression, and QOL. Between- and within-group comparisons were performed using pooled and paired t-tests or chi-square tests as appropriate. Generalized linear mixed models (GLMM) were used to assess outcomes over time.</p><p><strong>Results: </strong>At enrollment, PWD participants had a diagnosis of mild to moderate Alzheimer's disease or related dementia, with a mean age of 77.6 ± 9.8 years. The mean age of caregivers was 66.3 ± 11.8 years. The PWDs in the PAM group started with greater weight loss prior to study enrollment but showed a slightly lower > 5% weight loss from baseline to end of study (20.8%), compared to the EUC group (22.7%), although not statistically significant (p = 0.275). While the EUC group experienced a slight decrease in MUAC from baseline to follow-up of 0.2 ± 7 cm, those in the PAM group showed an increase of 1.0 ± 2.0 cm, suggesting better maintenance of nutritional status. The estimated mean daily caloric intake between the PWD groups upon enrollment (368 ± 131, p = 0.006) showed the EUC group consumed more calories than the PAM group throughout the study. Although no significant differences were found in the unadjusted changes in mealtime scores for feeding difficulty (-0.8 ± 3.1, p = 0.411), dysfunctional behavior (-1.4, 6.0, p = 0.605) or QOL (0.3 ± 6.6, p = 0.482), the PAM group exhibited a decrease in dysfunctional mealtime behaviors over the stud","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"100710"},"PeriodicalIF":4.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiovascular health assessed by Life’s Essential 8 and diabetic retinopathy: The mediating role of phenotypic age and biological age","authors":"Jia Wang ,&nbsp;Mingrui Jin ,&nbsp;Zhenkang Qiu ,&nbsp;Mao Li ,&nbsp;Jing Ma","doi":"10.1016/j.jnha.2025.100711","DOIUrl":"10.1016/j.jnha.2025.100711","url":null,"abstract":"<div><h3>Background</h3><div>The American Heart Association (AHA) recently updated the Life's Essential 8 (LE8) metrics to measure ideal cardiovascular health (CVH). Diabetic retinopathy (DR) is the leading cause of vision impairment, exhibiting a rising prevalence globally. However, the association between LE8 and DR, as well as the mediating role of phenotypic age (PA) and biological age (BA), is still unclear.</div></div><div><h3>Methods</h3><div>LE8 scores were categorized into three groups: low (0–49), moderate (50–74), and high (75–100). PA and BA were computed using validated algorithms incorporating clinical biomarkers. Weighted logistic regression and linear analysis were employed to assess the relationship between LE8 and DR. The mediation analysis was conducted to explore the mediating role of PA and BA.</div></div><div><h3>Results</h3><div>Our study included 1129 participants with non-DR and 329 participants with DR from the National Health and Nutrition Examination Survey (NHANES). Higher LE8 scores were inversely associated with DR prevalence after adjusting for all covariates (OR = 0.24; 95% CI: 0.11–0.50; <em>P</em> for trend &lt; 0.001). Each 10-point LE8 increase was related to a 23% decrease of DR (OR = 0.77, 95% CI: 0.69–0.84). Mediation analysis indicated that PA and BA partially mediated 35.61% and 46.38% of the association between LE8 and DR, respectively.</div></div><div><h3>Conclusions</h3><div>The LE8 scores were negatively associated with the incidence of DR, while PA and BA partially mediated the association between LE8 scores and DR.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"100711"},"PeriodicalIF":4.0,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific associations of serum 25-hydroxyvitamin D concentrations with incident sarcopenia in older adults: A 2-year follow-up study","authors":"Sihan Song ,&nbsp;Joong-Yeon Lim ,&nbsp;Miji Kim ,&nbsp;Chang Won Won ,&nbsp;Hyun-Young Park","doi":"10.1016/j.jnha.2025.100713","DOIUrl":"10.1016/j.jnha.2025.100713","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to explore the association of circulating vitamin D levels with incidence of sarcopenia and its diagnostic components in older men and women.</div></div><div><h3>Design</h3><div>Two-year longitudinal study.</div></div><div><h3>Setting</h3><div>Nationwide Korean Frailty and Aging Cohort Study.</div></div><div><h3>Participants</h3><div>A total of 1,292 adults (53% women) aged 70–84 years without sarcopenia at baseline and who completed the 2-year follow-up sarcopenia assessment were included.</div></div><div><h3>Measurements</h3><div>Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured using a chemiluminescent immunoassay and categorized into sex- and blood collection period-specific quartiles. The appendicular skeletal muscle mass was assessed using dual-energy X-ray absorptiometry. Muscle strength was evaluated using handgrip strength, and physical performance was assessed using the five-times-sit-to-stand test, usual gait speed, and Short Physical Performance Battery. Sarcopenia was defined in accordance with the 2019 consensus of the Asian Working Group for Sarcopenia. Logistic regression and generalized linear models were used to assess the association of serum 25(OH)D concentrations with sarcopenia and its components.</div></div><div><h3>Results</h3><div>Over the 2-year follow-up, incident sarcopenia occurred in 15.7% of men and 12.1% of women. Serum 25(OH)D concentrations were inversely associated with incident sarcopenia in men (odds ratio [OR] for the highest vs. lowest quartile, 0.47; 95% confidence interval [CI], 0.23–0.94; P for trend = 0.03), whereas no significant association was observed in women. When examining the association between serum 25(OH)D concentrations and components of sarcopenia, the third quartile was associated with lower odds of low muscle mass in men (OR, 0.39; 95% CI, 0.20–0.77) and low physical performance in women (OR, 0.32; 95% CI, 0.15–0.68), compared to the first quartile. Additionally, higher serum 25(OH)D concentrations were associated with more favorable annual changes in usual gait speed in men but not in women.</div></div><div><h3>Conclusion</h3><div>Low serum 25(OH)D concentrations are associated with a higher likelihood of incident sarcopenia and its components, particularly among men. Adequate 25(OH)D concentrations may help slow age-related decline in muscle mass and function, with potential sex differences.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100713"},"PeriodicalIF":4.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cMIND diet adherence and frailty among Chinese older adults: A 10-year longitudinal study","authors":"Lin Yang ,&nbsp;Mengying Li ,&nbsp;Jing Shu ,&nbsp;Lizheng Cao","doi":"10.1016/j.jnha.2025.100709","DOIUrl":"10.1016/j.jnha.2025.100709","url":null,"abstract":"<div><h3>Background</h3><div>Both cognitive impairment and diet are significant factors associated with frailty, however, the association between the Chinese Mediterranean-DASH Intervention for Neurodegenerative Delay (cMIND) diet and frailty remains unclear.</div></div><div><h3>Methods</h3><div>This longitudinal study analyzed data from 1,943 adults aged ≥65 in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) spanning 2008–2018. Adherence to the cMIND diet was assessed using a food frequency questionnaire, whereas frailty status was determined using the frailty index. The cMIND dietary scores were categorized into three groups based on tertiles: (T1:0−4; T2:4.5–5.5; T3:6–12). The association between cMIND adherence and frailty incidence was assessed using Cox proportional hazards models, while the dose-response relationship was examined with restricted cubic splines (with knots at the 5th, 35th, 65th, and 95th percentiles).</div></div><div><h3>Results</h3><div>The mean age was 74.9 ± 7.3 years; 50.5% were female. The restricted cubic spline model revealed a significant nonlinear association between baseline cMIND dietary scores and frailty risk (nonlinear <em>p</em> &lt; 0.05). Subsequently, the Cox proportional hazards model showed that, after adjusting for covariates, participants in the highest tertile of cMIND scores exhibited a 16% reduction in frailty risk compared to those in the lowest tertile (HR = 0.84, 95% CI: 0.72−0.97, <em>p</em> = 0.022). However, subgroup analyses revealed that the association varied according to baseline cognitive function. A significant inverse association was present in those with normal cognition (HR = 0.91, 95% CI: 0.86−0.96) but absent in those with cognitive impairment (HR = 1.01, 95% CI: 0.93–1.09; interaction <em>p</em> = 0.037).</div></div><div><h3>Conclusion</h3><div>Higher adherence to the cMIND diet is associated with a lower risk of frailty among older adults in China, specifically in those with normal cognitive function at baseline.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100709"},"PeriodicalIF":4.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145318867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building a roadmap to nutrition for Healthy Ageing: a brief report on the ILSI Europe Healthy Ageing Task Force","authors":"Leonie Lang ,&nbsp;Thomas Hunt ,&nbsp;David Vauzour ,&nbsp;Philipe de Souto Barreto ,&nbsp;Miguel Gueimonde ,&nbsp;Renger Witkamp ,&nbsp;Isabelle Guelinckx ,&nbsp;Bruno Pot ,&nbsp;Simon McArthur ,&nbsp;Louise Dye ,&nbsp;Lesley Hoyles ,&nbsp;Nils Billecke ,&nbsp;Andrea Bertocco ,&nbsp;Maria Camprubi Robles ,&nbsp;Caroline Perreau ,&nbsp;Gabriele Civiletto ,&nbsp;Maria Tonti","doi":"10.1016/j.jnha.2025.100683","DOIUrl":"10.1016/j.jnha.2025.100683","url":null,"abstract":"<div><div>At the end of October 2024, ILSI Europe brought together industry and academic experts from different fields to identify research gaps and challenges in nutritional interventions supporting healthy ageing. The objectives of the Healthy Ageing Working Group workshop were to address the urgent need to define ageing outcomes and associated biomarkers, determine the trajectory of functional ageing across the lifespan, and leverage technology to tailor nutritional and lifestyle interventions for healthy ageing. This brief report presents the key points highlighted during this workshop.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100683"},"PeriodicalIF":4.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why frailty must be central in anti-amyloid therapies for Alzheimer’s disease","authors":"Jorge G. Ruiz","doi":"10.1016/j.jnha.2025.100708","DOIUrl":"10.1016/j.jnha.2025.100708","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100708"},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lemon myrtle extract enhances muscle hypertrophy induced by low-load bodyweight resistance training in older adults: Findings from two independent randomized controlled trials","authors":"Shuji Sawada ,&nbsp;Azusa Nishino ,&nbsp;Shinichi Honda ,&nbsp;Yuji Tominaga ,&nbsp;Shiori Makio ,&nbsp;Hayao Ozaki ,&nbsp;Shuichi Machida","doi":"10.1016/j.jnha.2025.100706","DOIUrl":"10.1016/j.jnha.2025.100706","url":null,"abstract":"<div><h3>Objectives</h3><div>Previous literature has shown that combining lemon myrtle (LM) leaf extract with low-load resistance training may promote muscle hypertrophy. The current our studies aimed to verify the effects of LM intake combined with different training volumes on anterior thigh (AT) muscle thickness in older adults.</div></div><div><h3>Design</h3><div>Two independent randomized, double-blind, placebo-controlled trials.</div></div><div><h3>Setting</h3><div>Community-based training intervention program.</div></div><div><h3>Participants</h3><div>A total of 125 Japanese adults aged ≥65 years, with self-reported declines in muscle strength or walking ability. Study 1 (n = 47; LM group: n = 25, placebo group: n = 22) and Study 2 (n = 41; LM group: n = 22, placebo group: n = 19) were conducted independently, each with separate randomization into LM and placebo groups.</div></div><div><h3>Intervention</h3><div>Both studies involved low-load bodyweight resistance training twice weekly for 12 weeks. Study 1 compared LM + three sets of training with placebo + three sets; whereas Study 2 compared LM + one set with placebo + one set.</div></div><div><h3>Measurements</h3><div>AT muscle thickness (primary outcome) was assessed using B-mode ultrasound at baseline, 6, and 12 weeks. Secondary outcomes were normal walking speed (10-m walk test, m/s), maximum walking speed (10-m walk test, m/s), and 30-second chair stand (CS-30, repetitions).</div></div><div><h3>Results</h3><div>In Study 1, the LM + exercise group showed a greater increase in AT muscle thickness than the placebo + exercise group (12-week difference: 1.29 mm; 95% CI: −0.17 to 2.75 mm), although the difference was not statistically significant. In Study 2, the LM + exercise group showed a significant increase in AT muscle thickness compared with the placebo + exercise group (1.59 mm; 95% CI: 0.19–2.98 mm). No significant group-by-time interaction was found for secondary outcomes in either study.</div></div><div><h3>Conclusions</h3><div>LM intake may enhance muscle hypertrophy when combined with low-load resistance training in older adults with self-reported declines in muscle strength decline, particularly under low-volume training conditions. Further studies are needed to establish its clinical relevance.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100706"},"PeriodicalIF":4.0,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor regarding “Effects of nutritional education intervention on frailty status in lung cancer patients”","authors":"Parth Aphale ,&nbsp;Shashank Dokania ,&nbsp;Himanshu Shekhar","doi":"10.1016/j.jnha.2025.100707","DOIUrl":"10.1016/j.jnha.2025.100707","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100707"},"PeriodicalIF":4.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between serum leptin and accelerated biological aging in US adults: Findings from NHANES III","authors":"Kai Wei","doi":"10.1016/j.jnha.2025.100695","DOIUrl":"10.1016/j.jnha.2025.100695","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100695"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain trajectories in relation to incident functional limitation among older adults: A prospective cohort study","authors":"Qiao Xiang ,&nbsp;Yuxiao Li ,&nbsp;Ziyi Zhong ,&nbsp;Wei Huang ,&nbsp;Jielei Chu ,&nbsp;Taiping Lin ,&nbsp;Birong Dong ,&nbsp;Jirong Yue ,&nbsp;Masoud Isanejad","doi":"10.1016/j.jnha.2025.100704","DOIUrl":"10.1016/j.jnha.2025.100704","url":null,"abstract":"<div><h3>Objectives</h3><div>We aimed to identify pain trajectories and examine their associations with incident functional limitation in older adults, including activities of daily living (ADL) and instrumental ADL (IADL).</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting</h3><div>Community-based setting in western China.</div></div><div><h3>Participants</h3><div>We included participants with pain score information during 2018–2022, no prevalent functional limitation by 2022, and sufficient follow-up data for functional limitation assessment during 2023–2024.</div></div><div><h3>Measurements</h3><div>Group-based trajectory modeling was applied to identify pain trajectories based on the Numeric Rating Scale pain scores. Multivariate logistic regression models were used to assess the association between pain trajectories and incident ADL and IADL limitation. Sensitivity analyses were conducted using generalized estimating equations. Subgroup analyses were performed to assess potential interaction effects.</div></div><div><h3>Results</h3><div>A total of 887 older adults (all aged ≥60 years) were finally included in the analytic sample, of whom 139 (15.7%) and 198 (22.3%) individuals developed incident ADL and IADL limitation during the two-year follow-up, respectively. Four pain trajectories were identified: ‘<em>Persistently Pain-Free</em>’ (43.0%), ‘<em>Pain Remission</em>’ (16.7%), ‘<em>Developing Mild Pain</em>’ (21.9%), and ‘<em>Persistent Mild-to-Moderate Pain</em>’ (18.5%). Compared to the ‘<em>Persistently Pain-Free</em>’ group, only participants in the ‘<em>Persistent Mild-to-Moderate Pain</em>’ group had a significantly higher risk of developing ADL limitation (adjusted odds ratio = 2.19, 95% CI 1.32–3.63). No significant associations were found between any pain trajectory and the risk of incident IADL limitation. No significant interactions were observed in the subgroup analyses for either ADL or IADL (P for interaction &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Persistent pain, even at mild-to-moderate levels, independently predicts incident limitation in ADL rather than IADL in older adults, while achieving pain remission may help prevent functional decline in ADL. These findings underscore the importance of early identification and management of persistent pain to help maintain functional independence.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100704"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}