Journal of Nutrition Health & Aging最新文献

{"title":"Muscle power predicts frailty and other adverse events across different settings","authors":"Alejandro Álvarez-Bustos ,&nbsp;Helio J. Coelho-Junior ,&nbsp;Jose A. Carnicero ,&nbsp;Irene Molina-Hermosilla ,&nbsp;Blanca Alfonso-López ,&nbsp;Ignacio Peinado ,&nbsp;Marta Checa-López ,&nbsp;Leocadio Rodríguez-Mañas","doi":"10.1016/j.jnha.2025.100555","DOIUrl":"10.1016/j.jnha.2025.100555","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the association between lower-limb muscle power (MP) and frailty, measured using eight different scales, in older adults from four clinical settings. Additionally, to examine the predictive capacity of MP for adverse health events.</div></div><div><h3>Design</h3><div>A cross-sectional and longitudinal analysis using data from the Spanish cohort of the Frailtools project.</div></div><div><h3>Setting</h3><div>Nursing homes, primary care clinics, geriatric inpatient wards, and outpatient clinics.</div></div><div><h3>Participants</h3><div>245 older adults (mean age 82 ± 4.6 years, 64% women).</div></div><div><h3>Measurements</h3><div>MP measures were estimated using the five-time sit-to-stand (5STS) test and validated equations to obtain absolute (AMP), relative to body weight (RMP), and allometric (ALMP) values. Frailty was evaluated using eight scales, including the Frailty Phenotype and the Frailty Trait Scale. The incidence of adverse events (e.g., frailty, hospitalization, falls, and disability) was recorded over 12 months.</div></div><div><h3>Results</h3><div>Frailty prevalence varied significantly across scales and settings, with the lowest rates observed in primary care and the highest in nursing homes. Cross-sectional analysis revealed significant associations between all MP measures and frailty for most scales. RMP demonstrated the strongest associations, particularly with the Frailty Trait Scale-5 and FRAIL scale, across primary care, nursing homes, and outpatient clinics. Longitudinally, RMP was significantly associated with incident frailty and several adverse events, including hospitalizations (AUC: 0.71) and disability in activities of daily living (AUC: 0.71). Sex-specific MP cut-off points were identified for predicting health events. No significant differences were observed among MP measurements.</div></div><div><h3>Conclusion</h3><div>Lower-limb MP is a valid clinical biomarker associated with frailty and negative health events in older adults. The degree of associations varied according to frailty scale and clinical context, but no significant differences were observed when we compared their predictive ability. The proposed MP cut-off points may enhance frailty assessment and screening, particularly in primary care, nursing homes, and outpatient clinics. These findings highlight the clinical potential of incorporating MP measures into frailty tools and stress the need for further research to refine age-specific cut-off points and explore the influence of body composition.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100555"},"PeriodicalIF":4.3,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is poor chewing ability a risk factor for malnutrition? A six-year longitudinal study of older adults in Sweden","authors":"Duangjai Lexomboon ,&nbsp;Abhishek Kumar ,&nbsp;Sara Freyland ,&nbsp;Weili Xu ,&nbsp;Gunilla Sandborgh-Englund","doi":"10.1016/j.jnha.2025.100554","DOIUrl":"10.1016/j.jnha.2025.100554","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate if poor chewing ability increases the risk of malnutrition and to compare its impact with other contributing factors.</div></div><div><h3>Design</h3><div>Longitudinal observational study.</div></div><div><h3>Setting</h3><div>Population-based survey.</div></div><div><h3>Participants</h3><div>1,596 community dwelling individuals aged 60 years or older who participated in the Swedish National Study on Aging and Care at Kungsholmen in 2001–2004 (baseline) and in 2007–2011 (follow-up) and were not at risk for malnutrition nor malnourished at baseline.</div></div><div><h3>Measurements</h3><div>The exposures were baseline chewing ability and change in chewing ability at follow-up. The primary outcome was malnutrition risk or being malnourished, as assessed by the Mini Nutritional Assessment Short-Form. The secondary outcome was weight loss over 10% at follow-up. Logistic regressions assessed the associations between the exposures and the outcomes. The average marginal effects (percentage points) compared the effect of the exposure versus covariates on outcome probability.</div></div><div><h3>Results</h3><div>150 (9.4%) reported having difficulty chewing hard food, while 191 (12.0%) had persistent difficulties chewing hard food or lost the ability during the follow-up. At the time of follow-up, 212 (13.3%) were at risk or malnourished, while 179 (11.2%) had weight loss of more than 10%. Self-reported difficulty chewing hard food increased the odds of being at risk or malnourished at follow-up (OR = 1.64, 95% CI = 1.06, 2.53) and having weight loss of more than 10% (OR = 1.72, 95% CI = 1.10, 2.68). Individuals who had persistent difficulty chewing hard food or lost the ability to chew hard food during the follow-up period were more likely to be at risk or malnourished (OR = 1.87, 95% CI = 1.26, 2.79) or had a weight loss of more than 10% (OR = 1.73, 95% CI = 1.12, 2.65). Having difficulty chewing hard food at baseline increased the probability of the two outcomes by approximately 6 percentage points, whereas the covariates increased or decreased the probabilities by 4–16 percentage points.</div></div><div><h3>Conclusion</h3><div>Poor chewing ability may be a low-risk factor for malnutrition in older individuals. Self-reported difficulty chewing hard food during dental visits should be addressed.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100554"},"PeriodicalIF":4.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143746483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of 12-weeks Nutritional supplementation on Nutritional Intake and Status among Indonesian Older Outpatients with Malnutrition Risk, the Prolansia study: a randomized controlled trial","authors":"Esthika Dewiasty ,&nbsp;Sjors Verlaan ,&nbsp;Rahmi Istanti ,&nbsp;Fariza Rahmah ,&nbsp;Eugene Satryo ,&nbsp;Lisette CPGM de Groot ,&nbsp;Siti Setiati","doi":"10.1016/j.jnha.2025.100548","DOIUrl":"10.1016/j.jnha.2025.100548","url":null,"abstract":"<div><h3>Background</h3><div>Standard care for older outpatients who are at risk of malnutrition in Indonesia is still based on the 2017’s recommendations of the Indonesian Geriatrics Society. and does not provide nutritional supplementation as recommended by ESPEN guidelines 2019/2022.</div></div><div><h3>Objective</h3><div>We compared the effects of supplementation of at least 400 kcal/day including 30 g or more of protein/day as nutritional intervention as recommended by the ESPEN Guideline with standard care recommended by The Indonesian Geriatrics Society, in Indonesian older adults who are at risk of malnutrition.</div></div><div><h3>Methods</h3><div>Older outpatients (60 years or older) at a geriatric clinic of the national referral hospital with or at risk of malnutrition were recruited. They were randomly allocated to 12 weeks of supplementation with a nutrient dense drink twice a day on top of standard care compared to standard care only. We assessed energy and nutrient intake at baseline, after 6 and 12 weeks and nutritional status, physical performance, and vitamin D level at baseline and after 12 weeks. Data analyses were blinded.</div></div><div><h3>Results</h3><div>As many as 105 older outpatients (65 % women, mean age 72.5 years, SD = 6.3) were randomly assigned to the intervention (n = 54) and the control group (n = 51). One hundred and one participants completed the intervention, with an average compliance of 90% to the nutritional intervention. Nutritional supplementation significantly increased daily intake of energy, protein, total fat, vitamin D, vitamin B12, calcium (all p values &lt;0.001) and carbohydrate (p = 0.002) in both men and women after 12 weeks. The intervention group showed an increase in vitamin D levels (p = 0.008). Furthermore, the intervention group gained more body weight than the control group did (p = 0.021)), especially in women (p = 0.017). Women in the intervention group also showed more increase in skeletal muscle mass (p = 0.023). Improvements in muscle strength and physical performance were not statistically different between the groups. No significant adverse effects were noted.</div></div><div><h3>Conclusion</h3><div>Nutritional supplementation is effective in improving nutritional intake and status among Indonesian outpatients with malnutrition risk, which has the potential to support and enhance the standard of care.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100548"},"PeriodicalIF":4.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A vegan dietary pattern is associated with high prevalence of inadequate protein intake in older adults; a simulation study","authors":"Jos W. Borkent ,&nbsp;Pol Grootswagers ,&nbsp;Joost Linschooten ,&nbsp;Annet J.C. Roodenburg ,&nbsp;Marga Ocké ,&nbsp;Marian A.E. de van der Schueren","doi":"10.1016/j.jnha.2025.100536","DOIUrl":"10.1016/j.jnha.2025.100536","url":null,"abstract":"<div><h3>Background</h3><div>A more sustainable diet with fewer animal-based products has a lower ecological impact but might lead to a lower protein quantity and quality. The extent to which shifting to more plant-based diets impacts the adequacy of protein intake in older adults needs to be studied.</div></div><div><h3>Objectives</h3><div>We simulated how a transition towards a more plant-based diet (flexitarian, pescetarian, vegetarian, or vegan) affects protein availability in the diets of older adults.</div></div><div><h3>Setting</h3><div>Community.</div></div><div><h3>Participants</h3><div>Data from the Dutch National Food Consumption Survey 2019–2021 of community-dwelling older adults (n = 607) was used.</div></div><div><h3>Measurements</h3><div>Food consumption data was collected via two 24-h dietary recalls per participant. Protein availability was expressed as total protein, digestible protein, and utilizable protein (based on digestibility corrected amino acid score) intake. The percentage below estimated average requirements (EAR) for utilizable protein was assessed using an adjusted EAR.</div></div><div><h3>Results</h3><div>Compared to the original diet (∼62% animal-based), utilizable protein intake decreased by about 5% in the flexitarian, pescetarian and vegetarian scenarios. In the vegan scenario, both total protein intake and utilizable protein were lower, leading to nearly 35% less utilizable protein compared to the original diet. In the original diet, the protein intake of 7.5% of men and 11.1% of women did not meet the EAR. This slightly increased in the flexitarian, pescetarian, and vegetarian scenarios. In the vegan scenario, approximately 60% had a protein intake below EAR.</div></div><div><h3>Conclusions</h3><div>Replacing animal-based protein sources with plant-based food products in older adults reduces both protein quantity and quality, albeit minimally in non-vegan plant-rich diets. In a vegan scenario, the risk of an inadequate protein intake is imminent.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100536"},"PeriodicalIF":4.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordance between physical and cognitive health problems over one year after critical care: Insights from severe COVID-19 patients","authors":"Leandro U. Taniguchi ,&nbsp;Natalia G. Gonçalves ,&nbsp;Naomi V. Ferreira ,&nbsp;Laiss Bertola ,&nbsp;Thiago J. Avelino-Silva ,&nbsp;Murilo B. Dias ,&nbsp;Ludhmila A. Hajjar ,&nbsp;Wilson Jacob-Filho ,&nbsp;Claudia K. Suemoto ,&nbsp;Márlon J.R. Aliberti ,&nbsp;on behalf of the CO-FRAIL Study Group EPICCoV Study Group and COVID HCFMUSP Study Group","doi":"10.1016/j.jnha.2025.100547","DOIUrl":"10.1016/j.jnha.2025.100547","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the longitudinal evolution of physical and cognitive problems after hospital discharge in survivors of severe COVID-19; to describe the co-occurrence of these health problems domains in the following year after discharge; and evaluate if results are different taking into account the use of invasive mechanical ventilation.</div></div><div><h3>Design</h3><div>Prospective cohort study.</div></div><div><h3>Setting</h3><div>A large academic medical center in Brazil.</div></div><div><h3>Participants</h3><div>Patients aged ≥50 years who survived hospitalization for COVID-19 requiring critical care.</div></div><div><h3>Measurements</h3><div>We evaluated participants’ status before hospital admission and one, three, six, nine, and twelve months after hospital discharge using validated questionnaires to measure frailty, persistent physical symptoms, and cognitive function. Clusters of physical and cognitive problems were defined using sequential analysis. Concordance was studied between different problems and trajectories, and after stratifying for use of invasive mechanical ventilation during ICU stay.</div></div><div><h3>Results</h3><div>We included 428 participants (median age was 63 years, 57% were male, 14% were frail before COVID-19, and 61% required mechanical ventilation). Physical and/or cognitive problems were experienced in 83% of responders at least once during follow-up, and half reported any problem even after one year. Most participants experienced health problems in a single health domain, with co-occurrence less than 9% in every assessment (Cramer’s V bias-corrected less than 0.1 in any assessment). Sequential analysis identified three clusters each of cognitive and physical trajectories, with different evolution and no concordance. Stratifying the sample based on the use of mechanical ventilation did not change the results.</div></div><div><h3>Conclusions</h3><div>Severe COVID-19 survivors frequently experience physical and/or cognitive problems, yet these conditions and their trajectories are discordant. Multidimensional evaluations post-ICU discharge can aid in delivering tailored rehabilitation programs.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100547"},"PeriodicalIF":4.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CUN-BAE adiposity index prediction of incident type 2 diabetes: the Seguimiento Universidad de Navarra prospective cohort","authors":"Ligia J. Dominguez ,&nbsp;Carmen Sayón-Orea ,&nbsp;Alfredo Gea ,&nbsp;Estefania Toledo-Atucha ,&nbsp;Maira Bes-Rastrollo ,&nbsp;Mario Barbagallo ,&nbsp;Miguel A. Martínez-González","doi":"10.1016/j.jnha.2025.100545","DOIUrl":"10.1016/j.jnha.2025.100545","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is currently a pandemic and a cardinal risk factor for incident diabetes, a parallel growing pandemic. Measures commonly used to define obesity, i.e., BMI and waist circumference, do not accurately reflect body fatness.</div></div><div><h3>Methods</h3><div>We examined the prognostic value of body fatness assessed with the ‘Clínica Universidad de Navarra-Body Adiposity Estimator’ (CUN-BAE, range: 18.4–65.0 %) in 18,594 participants of the \"Seguimiento Universidad de Navarra\" prospective longitudinal cohort (60.5% women) without diabetes at baseline. Participants were followed-up with biennial questionnaires and multivariable-adjusted Cox models were used to estimate incident diabetes.</div></div><div><h3>Results</h3><div>During 13.7 years of median follow-up, 209 participants developed diabetes. Progressively ascending quartiles of CUN-BAE were significantly associated with incident diabetes in multivariable-adjusted models, even after adjusting for BMI &gt; 30 kg/m². For each 2-unit increment in the CUN-BAE index, diabetes risk relatively increased by 46% in men and women (95% CI: 33%–62%). When comparing ROC AUC for CUN-BAE and BMI the association was stronger for CUN-BAE (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>CUN-BAE index, an easy equation that can be used in any clinical setting, predicted better the risk of incident diabetes compared to BMI. Our results emphasize the importance of reducing and maintaining a low adiposity in order to prevent diabetes.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100545"},"PeriodicalIF":4.3,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of iodized salt intake with the risk of physical frailty in patients with type 2 diabetes","authors":"Jiang Li ,&nbsp;Jie Li ,&nbsp;Ying Sun ,&nbsp;Yanqi Fu ,&nbsp;Wenqi Shen ,&nbsp;Lingli Cai ,&nbsp;Fei Xu ,&nbsp;Ling Gao ,&nbsp;Ningjian Wang ,&nbsp;Bin Wang ,&nbsp;Yingli Lu","doi":"10.1016/j.jnha.2025.100543","DOIUrl":"10.1016/j.jnha.2025.100543","url":null,"abstract":"<div><h3>Objectives</h3><div>We aimed to investigate the association of the status of iodized salt in terms of consumption of salt type and urinary iodine concentration (UIC) in diabetes, with frailty and examine whether this association could be modified by thyroid function.</div></div><div><h3>Design</h3><div>A population-based cohort study.</div></div><div><h3>Setting and participants</h3><div>We included 850 patients with type 2 diabetes from 11 communities in Shanghai, who completed five-year follow-up.</div></div><div><h3>Measurements</h3><div>The type of salt consumed was collected through a standardized questionnaire and UIC was measured by an inductively coupled plasma-mass spectrometer. Frailty was assessed by frailty phenotype. Serum thyroid-stimulating hormone (TSH) and free thyroxine (FT4) were measured by electrochemiluminescence. Modified Poisson regression model with robust variance was used to estimate the relative risks (RRs) with 95% confidence intervals (CIs) for frailty in relation to iodized salt consumption and UIC.</div></div><div><h3>Results</h3><div>In this five-year follow-up study in patients with diabetes, 111 (12.9%) patients progressed to frailty. Patients who consumed non-iodized salt (RR: 1.09, 95% CI: 1.01–1.18) had an increased risk of frailty, compared to patients who consumed iodized salt. Lower UIC was associated with a higher risk of frailty (1.10, 1.01–1.19). In patients with high TSH and low FT4, the RRs of frailty were 1.20 (1.08–1.34) and 1.15 (1.02–1.29) for non-iodized salt, and 1.14 (1.02–1.28) and 1.12 (0.99–1.27) for low UIC.</div></div><div><h3>Conclusions</h3><div>Non-iodized salt consumed and low UIC were associated with an increased risk of frailty in diabetes, particularly in those with high TSH and low FT4. Maintaining adequate iodine intake is critically important for preventing frailty in diabetes, especially for individuals with potential thyroid dysfunction.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100543"},"PeriodicalIF":4.3,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota-derived resveratrol metabolites: New biomarkers of red wine consumption are inversely associated with inflammation in a longitudinal study of a Mediterranean population","authors":"Francesc M. Campins-Machado ,&nbsp;Rosa Casas ,&nbsp;Rosa M. Lamuela-Raventós ,&nbsp;Polina Galkina ,&nbsp;Miguel Ángel Martínez-González ,&nbsp;Montserrat Fitó ,&nbsp;Emilio Ros ,&nbsp;Ramon Estruch ,&nbsp;Inés Domínguez-López ,&nbsp;Maria Pérez","doi":"10.1016/j.jnha.2025.100542","DOIUrl":"10.1016/j.jnha.2025.100542","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the association between urinary microbiota-derived resveratrol metabolites, which may serve as specific biomarkers of red wine consumption, and plasma circulating proinflammatory markers.</div></div><div><h3>Design, settings, and participants</h3><div>One-year longitudinal study included 179 participants at high cardiovascular risk (mean age 69 years, 49% women) enrolled in the PREDIMED trial.</div></div><div><h3>Measurements</h3><div>Plasma inflammatory biomarkers and urinary microbiota-derived resveratrol metabolites were analyzed using xMAP technology and high-performance liquid chromatography coupled to mass spectrometry, respectively. Receiver operating characteristic (ROC) analyses were performed to evaluate the reliability of urine resveratrol metabolites as biomarkers of red wine consumption, as reported in the food frequency questionnaires (FFQs) of the participants. The relationship between baseline values and 1-year changes in urinary microbiota-derived resveratrol metabolites and plasma levels of circulating inflammatory molecules were assessed.</div></div><div><h3>Results</h3><div>ROC curves confirmed that urinary dihydroresveratrol glucuronide (DHRg) [AUC = 0.835] and sulfate (DHRs) [AUC = 0.803] metabolites are reliable and specific biomarkers of red wine consumption. Baseline urinary concentrations of DHRs were negatively associated with plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) (−0.40 ng/mL per 1-SD increase, <em>p</em> = 0.012). After one year of follow-up, changes in urinary concentrations of DHRg also showed a negative association with plasma circulating sVCAM-1 levels (−0.39 ng/mL per 1-SD increase, p-value = 0.028). No significant associations were detected at baseline and after one year of follow-up when FFQ information of red wine consumption was used to perform the regression analysis with circulating inflammatory molecules.</div></div><div><h3>Conclusions</h3><div>Light to moderate red wine consumption (10 to 20 grams of alcohol per day), which can be monitored by microbiota-derived resveratrol metabolites excreted in urine, is associated with lower plasma concentrations of sVCAM-1, an inflammatory biomarker related to atherosclerosis. Biomarkers of consumption offer advantages compared to FFQ data, since they provide objective and more accurate information about nutrient intake and metabolism. Without specific biomarkers of red wine consumption, no significant associations would have been found in the present study.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100542"},"PeriodicalIF":4.3,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of wine consumption and lipid profile: A systematic review and meta-analysis of clinical trials","authors":"Maribel Lucerón-Lucas-Torres ,&nbsp;Marta C. Ruiz-Grao ,&nbsp;Iván Cavero-Redondo ,&nbsp;Chiara di Lorenzo ,&nbsp;Carlos Pascual-Morena ,&nbsp;Susana Priego-Jiménez ,&nbsp;Dolores Gómez-Guijarro ,&nbsp;Celia Álvarez-Bueno","doi":"10.1016/j.jnha.2025.100539","DOIUrl":"10.1016/j.jnha.2025.100539","url":null,"abstract":"<div><h3>Background and objective</h3><div>The aim of this study was to analyze the effects of wine consumption on the lipid profile, distinguishing between triglycerides, total cholesterol, LDL, HDL and fibrinogen.</div></div><div><h3>Methods</h3><div>We examined the MEDLINE (via PubMed), Scopus, Cochrane, and Web of Science databases to conduct this systematic review and meta-analysis. PROSPERO has already recorded this study under registration number CRD42023396666.</div></div><div><h3>Results</h3><div>Thirty-three studies were included in this systematic review, and 29 were included in the meta-analysis. The pooled ES for the effect of red wine consumption on the different lipid profile parameters was significant only for the effect of red wine on the LDL parameter in the prepost studies (−0.29 (95% CI −0.54, −0.05)). The pooled ES for the effect of white wine in prepost studies and clinical trials for the effect of wine consumption on the different parameters did not show any significant results.</div></div><div><h3>Conclusion</h3><div>This systematic review and meta-analysis revealed that wine consumption has an effect on reducing LDL and has no effect on total cholesterol, HDL, triglycerides, or fibrinogen. This research revealed that the duration of the intervention affects triglyceride and total cholesterol levels, indicating that longer interventions are more effective for these two parameters.</div></div><div><h3>Registration ID</h3><div>CRD42023396666 (PROSPERO).</div></div><div><h3>URL registration</h3><div><span><span>https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=396666</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100539"},"PeriodicalIF":4.3,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifestyle interventions in older adults with type 2 diabetes mellitus: The key for healthy ageing","authors":"Juan Luis Sánchez-Sánchez ,&nbsp;Pedro L. Valenzuela","doi":"10.1016/j.jnha.2025.100546","DOIUrl":"10.1016/j.jnha.2025.100546","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100546"},"PeriodicalIF":4.3,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}