Journal of Nutrition Health & Aging最新文献

{"title":"Dietary inflammatory index and the risk of cardiovascular disease and mortality: A prospective cohort study of Chinese community-dwelling older adults","authors":"Shu-Yi Li ,&nbsp;Zhi-Hui Lu ,&nbsp;Jason C.S. Leung ,&nbsp;Yi Su ,&nbsp;Blanche W.M. Yu ,&nbsp;Timothy C.Y. Kwok","doi":"10.1016/j.jnha.2025.100624","DOIUrl":"10.1016/j.jnha.2025.100624","url":null,"abstract":"<div><h3>Objectives</h3><div>Inflammation is a contributory factor for cardiovascular disease (CVD), and diet can modulate inflammation. This study aimed to investigate the association between dietary inflammatory index (DII) and CVD outcomes, and the mediating roles of cardiovascular risk factors.</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting and participants</h3><div>A total of 3,013 Chinese community-dwelling older adults aged ≥65 years without CVD were included between 2001 and 2003 in Hong Kong.</div></div><div><h3>Measurements</h3><div>DII was calculated using a 280-item validated food frequency questionnaire. CVD outcomes included incident CVD, coronary heart disease (CHD), stroke, and CVD mortality, which were obtained from official records. Cox proportional hazards models examined the association between tertiles of DII and CVD outcomes. Mediation analysis explored the mediating roles of cardiovascular risk factors, including inflammatory biomarkers, impaired renal function, abnormal ankle-brachial index (ABI), obesity, central obesity, diabetes mellitus, and hypertension.</div></div><div><h3>Results</h3><div>There were 263 CVD cases, 147 CHD cases, and 130 strokes during a median follow-up of 5.7 years. There were 277 CVD deaths during a median follow-up of 16.8 years. The highest tertile of DII was associated with increased risks of CVD incidence (HR: 1.43, 95% CI: 1.05–1.96) and CVD mortality (HR: 1.45, 95% CI: 1.03–2.03) compared with the lowest tertile. No significant associations were found for CHD and stroke. Impaired renal function, abnormal ABI, and hyperhomocysteinemia mediated the effects of a pro-inflammatory diet on CVD risk, with mediated proportions ranging from 3.68% to 7.78%.</div></div><div><h3>Conclusion</h3><div>A pro-inflammatory diet increased the risks of CVD incidence and mortality, mediated by impaired renal function, abnormal ABI, and hyperhomocysteinemia.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100624"},"PeriodicalIF":4.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of circadian syndrome with functional disability among middle-aged and older adults in China","authors":"Yuhan Huang ,&nbsp;Kaiyuan Wang ,&nbsp;Yue He,&nbsp;Wenjing Wang,&nbsp;Chengxiang Hu,&nbsp;Kexin Jiang,&nbsp;Jiaqi Zhang,&nbsp;Yuchun Tao ,&nbsp;Lina Jin","doi":"10.1016/j.jnha.2025.100621","DOIUrl":"10.1016/j.jnha.2025.100621","url":null,"abstract":"<div><h3>Background</h3><div>Circadian syndrome (CircS) is a complex syndrome involving disorders of biological rhythms and multidimensional health risks. The objective of this research is to explore the association between CircS and functional disability.</div></div><div><h3>Methods</h3><div>This research utilized data from CHARLS, spanning the years 2011–2015. In the cross-sectional study, data from 12,758 Chinese adults aged 45 years and above in 2011 were used, and logistic regression models were employed to explore the association of CircS and its components with functional disability. A total of 8538 eligible subjects participated in the longitudinal study, and Cox regression models were used to analyze the longitudinal association and subgroup analysis.</div></div><div><h3>Results</h3><div>The cross-sectional analysis revealed positive associations of CircS with both ADL disability (OR = 1.68, 95% CI: 1.41, 2.00, <em>p</em> &lt; 0.001) and IADL disability (OR = 1.74, 95% CI: 1.49, 2.04, <em>p</em> &lt; 0.001). Longitudinal analysis also indicated that CircS was significantly associated with an elevated risk of developing both ADL disability (HR = 1.57, 95% CI: 1.33, 1.86, <em>p</em> &lt; 0.001) and IADL disability (HR = 1.22, 95% CI: 1.05, 1.43, <em>p</em> = 0.012). Subgroup analysis found that the association between CircS and ADL disability had significant interactions with gender (<em>p</em> for interaction = 0.046) and smoking status (<em>p</em> for interaction &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Our findings find a positive association between CircS and functional disability, and the importance of gender and smoking status in these associations are emphasized.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100621"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition risk as a predictor of quality of life and skeletal muscle depletion following upper gastrointestinal cancer diagnosis: A longitudinal analysis","authors":"Lauren Hanna ,&nbsp;Kay Nguo ,&nbsp;Judi Porter ,&nbsp;Daniel Croagh ,&nbsp;Catherine E Huggins","doi":"10.1016/j.jnha.2025.100623","DOIUrl":"10.1016/j.jnha.2025.100623","url":null,"abstract":"<div><h3>Objectives</h3><div>Low skeletal muscle index (SMI) and radiodensity (SMD) are established prognostic indicators in cancer. This study investigated risk factors for low and decreasing SMI and low SMD in upper gastrointestinal cancer and examined the influence of malnutrition risk on the association between SMI and health-related quality of life (HRQOL).</div></div><div><h3>Design</h3><div>Longitudinal analysis of randomised controlled trial outcome data.</div></div><div><h3>Setting</h3><div>Three health services in Victoria, Australia.</div></div><div><h3>Participants</h3><div>Adults newly diagnosed with oesophageal, gastric or pancreatic cancer.</div></div><div><h3>Measurements</h3><div>Outcomes assessed at diagnosis, and three- and six-month follow-up. SMI and SMD were assessed via computed tomography imaging analysis, with low values determined using established sex-specific thresholds. Malnutrition risk was assessed using the Patient Generated Subjective Global Assessment (Short Form), and HRQOL with the EORTC QLQ-C30. Multiple logistic regression identified risk factors for low SMI and low SMD at baseline, and SMI decline (≥5%) from baseline to 3 months. Associations between SMI and HRQOL were examined using multiple linear regression, adjusting for malnutrition risk.</div></div><div><h3>Results</h3><div>Among 105 participants (43% oesophageal, 20% gastric, 37% pancreatic cancer), older age predicted low SMI and low SMD. Low SMI risk was higher in females and lower with higher BMI. At three months, 57% (37/65) experienced ≥5% SMI loss, associated with higher malnutrition risk, higher baseline SMI, and post-diagnosis weight loss. Malnutrition risk was a strong independent predictor of poorer HRQOL score at all timepoints. Lower or decreasing SMI (≥5%) was also independently associated with poorer HRQOL on some scales.</div></div><div><h3>Conclusion</h3><div>Malnutrition risk independently predicted lower HRQOL and muscle loss, and may confound the relationship between SMI and HRQOL. As a modifiable factor, addressing malnutrition risk could improve HROQL and preserve muscle in upper gastrointestinal cancer.</div></div><div><h3>Trial registration</h3><div>Australian New Zealand Clinical Trials Registry, 27 January 2017 (12617000152325).</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100623"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum klotho is inversely associated with girth in older women but is not associated with falls or musculoskeletal measures in either sex","authors":"Bess Dawson-Hughes ,&nbsp;Elsa M. Konieczynski ,&nbsp;Lisa Ceglia","doi":"10.1016/j.jnha.2025.100618","DOIUrl":"10.1016/j.jnha.2025.100618","url":null,"abstract":"<div><h3>Objective</h3><div>Serum klotho, a biomarker of aging, has been associated with cardiovascular disease, kidney disease, and osteoarthritis, but information on an association with muscle and bone aging is limited. We assessed serum klotho as a potential biomarker of age-related changes in body composition, odds of falling, muscle strength and bone mineral density (BMD) in older adults.</div></div><div><h3>Design</h3><div>Exploratory analysis within the STOP IT clinical trial.</div></div><div><h3>Setting</h3><div>USDA Human Nutrition Research Center on Aging at Tufts University.</div></div><div><h3>Participants</h3><div>Healthy adults (178 men; 209 women) age ≥65 years treated daily for 3 years with either 700 IU of vitamin D₃ plus 500 mg of calcium or placebo.</div></div><div><h3>Methods</h3><div>We examined associations of serum klotho (at 6 or 12 months) with odds of falling, and with baseline and 3-year changes in body composition, grip strength and spine and hip BMD by dual-energy X-ray absorptiometry (DXA).</div></div><div><h3>Results</h3><div>Serum klotho levels did not differ significantly in the two treatment arms. In the arms combined, klotho was inversely associated with waist circumference (β= -0.007, p = 0.01) in the women but not in the men, after adjustment for age, physical activity, treatment assignment, kidney function, season and time of klotho measurement. Serum klotho was not associated with odds of falling or with proportion of body fat or lean mass, grip strength, or spine or hip BMD or their 3-year changes in men or women.</div></div><div><h3>Conclusion</h3><div>Serum klotho is inversely related to waist circumference in healthy older women but not men. Serum klotho does not appear to be a useful biomarker of musculoskeletal status in older women or men.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100618"},"PeriodicalIF":4.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of n-3 fatty acid intake with muscle mass and strength in older adults: A cross-sectional analysis of the UK biobank data","authors":"Maha Timraz ,&nbsp;Marion Guerrero Wyss ,&nbsp;Terry J. Quinn ,&nbsp;Emilie Combet ,&nbsp;Carlos Celis-Morales ,&nbsp;Stuart R. Gray","doi":"10.1016/j.jnha.2025.100622","DOIUrl":"10.1016/j.jnha.2025.100622","url":null,"abstract":"<div><h3>Objectives</h3><div>The main aim was to investigate the association of n-3 fatty acid intake and the n-6/n-3 fatty acid intake ratio with muscle mass and strength in older adults.</div></div><div><h3>Methods</h3><div>This study included 61,381 individuals (28,187 men and 33,194 women) aged ≥60 years. Grip strength and muscle mass index were assessed and n-3 and n-6 fatty acid intake were determined. Regression models adjusted for age, deprivation index, ethnicity, month of assessment, total energy intake, multimorbidity, lifestyle factors and physical activity. A sensitivity analysis was conducted in participants aged ≥65 years and in people with sarcopenia.</div></div><div><h3>Results</h3><div>Data are presented as trend for quintiles from fully adjusted models. Higher n-3 fatty acid intake was associated with a higher grip strength in both men (0.114 kg; 95% CI: 0.02 to 0.21) and women (0.115 kg; 95% CI: 0.05 to 0.18). Similar results were reported for grip strength index, with no associations observed for muscle mass index. No associations were seen in people ≥65 years. In people with sarcopenia no associations of n-3 fatty acid intake with grip strength or grip strength index were seen, but a positive association with muscle mass index was noted in men (0.197 kg/m²; 95% CI: 0.05 to 0.33). The n-6/n-3 fatty acid intake ratio was associated with grip strength in women (0.081 kg; 95% CI: −0.16 to 0.000) and with muscle mass index in men (−0.016 kg/m²; 95% CI: −0.02 to 0.00), no other associations were observed. No associations were seen in people with sarcopenia or people ≥65 years.</div></div><div><h3>Conclusion</h3><div>Higher n-3 fatty acid intake, with no consistent association with the n-6/n-3 fatty acid intake, was modestly associated with grip strength, with effects varying by sex and age, suggesting limited benefit for sarcopenia prevention at typical intake levels in older adults.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100622"},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unpacking vitality for healthy aging—A call for multidimensional assessment and social integration","authors":"Hidenori Arai","doi":"10.1016/j.jnha.2025.100617","DOIUrl":"10.1016/j.jnha.2025.100617","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100617"},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of time spent in sedentary behavior, physical activity, and sleep are associated with cognitive decline among CLSA participants: A latent class analysis","authors":"R.A. Palazuelos-González ,&nbsp;R.C. Oude-Voshaar ,&nbsp;N. Smidt ,&nbsp;A.C. Liefbroer","doi":"10.1016/j.jnha.2025.100619","DOIUrl":"10.1016/j.jnha.2025.100619","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify latent classes of time spent in movement activities (leisure sitting, physical activities, and sleep), characterize them, and assess their association with changes in memory, executive functioning, and overall cognition among middle aged and older adults.</div></div><div><h3>Design</h3><div>Longitudinal cohort study with a 3-year follow-up.</div></div><div><h3>Setting</h3><div>Non-institutionalized middle aged and older adults from the general population.</div></div><div><h3>Participants</h3><div>12,212 adults aged 45–86 years from the Canadian Longitudinal Study on Aging.</div></div><div><h3>Measurements</h3><div>Latent Class Analysis was performed to identify groups of participants with comparable movement activities based on self-reported time spent in leisure sitting, walking, moderate and vigorous physical activity (assessed using the Physical Activity Scale for the Elderly), and sleep at baseline. Multivariable linear regression models were used to examine the associations between the identified groups and reliable change in memory, executive functioning and overall cognition, measured by a validated neuropsychological battery including 6 different cognitive tests.</div></div><div><h3>Results</h3><div>Three groups were identified: Sedentary/Disturbed Sleep (SedDS, 53.9%), Intermediately Active/Normal Sleep (IntNS, 34.6%), and Active/Normal Sleep (ActNS, 11.5%). The SedDS group showed greater cognitive decline after 3 year follow-up across all cognitive domains (memory β = −0.061, 95%CI −0.100, −0.021; executive functioning β = −0.049, 95%CI −0.090, −0.008; overall cognition β = −0.067, 95%CI −0.106, −0.027) compared to IntNS. Interestingly, ActNS showed a greater cognitive decline (memory β = −0.065, 95% CI −0.124, −0.005; overall cognition β = −0.062, 95% CI −0.123, −0.002) relative to IntNS.</div></div><div><h3>Conclusion</h3><div>In mid- and later life, sleep disturbances primarily coincide with a sedentary lifestyle. For optimal cognitive ageing, moderate physical activity seems more beneficial than either sedentary behavior or excessive physical activity to delay accelerated cognitive ageing.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100619"},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144490212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tooth loss, diet quality, and cognitive decline: A 15-year longitudinal study","authors":"Lewis Winning ,&nbsp;Danielle Logan ,&nbsp;Claire T. McEvoy ,&nbsp;Dominic Farsi ,&nbsp;Gareth J. McKay ,&nbsp;Christopher C. Patterson ,&nbsp;Peter Passmore ,&nbsp;Clive Holmes ,&nbsp;Gerard J. Linden ,&nbsp;Bernadette McGuinness","doi":"10.1016/j.jnha.2025.100620","DOIUrl":"10.1016/j.jnha.2025.100620","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the association between tooth loss and the incidence of mild cognitive impairment (MCI) and dementia, focusing on diet quality as a potential mediator.</div></div><div><h3>Design</h3><div>Prospective cohort study.</div></div><div><h3>Setting and participants</h3><div>Community-dwelling older men enrolled in the Northern Ireland PRIME study (Prospective Epidemiological Study of Myocardial Infarction).</div></div><div><h3>Measurements</h3><div>A group of men, aged 58–71 years, underwent dental examinations in 2001–2003. Surviving participants were invited to attend a cognitive rescreening in 2016–2020, which included a food frequency questionnaire. Cognitive outcomes were categorised as normal, MCI or dementia, based on standardised neurocognitive tests. Dietary diversity scores (DDS) were calculated based on the frequency of intake of food groups. Analyses included multiple logistic regression to evaluate the associations between tooth loss, defined as &lt;20 remaining natural teeth, and MCI/dementia incidence adjusting for potential confounders. Mediation analysis assessed the role of diet quality in this relationship.</div></div><div><h3>Results</h3><div>A total of 628 men were included, with a mean baseline age of 63.2 years (SD 2.8) and a median follow-up of 15.0 years (IQR 14.2–17.0). At rescreening, 485 (77.2%) were cognitively normal, 112 (17.8%) had MCI, and 31 (4.9%) had dementia. In fully adjusted models, tooth loss was significantly associated with MCI/dementia (OR = 2.06, 95% CI 1.20–3.55, <em>p</em> &lt; 0.01). DDS partially mediated this relationship, explaining approximately 23% of the total effect.</div></div><div><h3>Conclusion</h3><div>In this cohort of older men, tooth loss was associated with incidence of MCI/dementia over 15 years, and diet diversity partially mediated this association. These findings highlight an important pathway connecting oral health, dietary quality, and cognitive outcomes.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100620"},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green tea consumption and dementia risk in community-dwelling Japanese people aged 40–74 years: A 12-year cohort study","authors":"Rikuto Kaise ,&nbsp;Kaori Kitamura ,&nbsp;Yumi Watanabe ,&nbsp;Keiko Kabasawa ,&nbsp;Akemi Takahashi ,&nbsp;Toshiko Saito ,&nbsp;Ryosaku Kobayashi ,&nbsp;Rieko Oshiki ,&nbsp;Osamu Yamazaki ,&nbsp;Kei Watanabe ,&nbsp;Ribeka Takachi ,&nbsp;Shoichiro Tsugane ,&nbsp;Kazutoshi Nakamura","doi":"10.1016/j.jnha.2025.100615","DOIUrl":"10.1016/j.jnha.2025.100615","url":null,"abstract":"<div><h3>Objective</h3><div>Green tea, like coffee, has been suggested to protect against dementia, but supporting evidence is lacking. The present study aimed to determine independent associations of green tea consumption with, and interactions of green tea and coffee consumption on, dementia risk in middle-aged and older people.</div></div><div><h3>Methods</h3><div>The present study is a 12-year follow-up of the Murakami cohort study on age-related diseases. Participants were 13,660 (men, 6,573 [48.1%]; mean age, 59.0 (SD = 9.3) years) community-dwelling residents aged 40–74 years. The baseline survey was conducted between 2011−2013. A self-administered questionnaire obtained information on predictors, including sex, age, marital status, education, occupation, body size, physical activity, smoking, alcohol, tea and coffee consumption, energy intake, and medical history. Green tea consumption was quantitatively determined with a validated questionnaire. Cases of incident dementia were identified using the long-term care insurance database.</div></div><div><h3>Results</h3><div>Higher green tea consumption was associated with lower hazard ratios (HRs) for dementia (multivariable P for trend = 0.0178), with the highest quartile having a lower HR (adjusted HR = 0.75) than the lowest quartile. The adjusted HR for dementia by cup-based green tea consumption (1 cup = 150 mL) was 0.952 (95%CI:0.92−0.99), corresponding to a 4.8% reduction per 1 cup increase. High consumption of both green tea and coffee was not associated with low dementia risk (P for interaction = 0.0210).</div></div><div><h3>Conclusion</h3><div>Higher consumption of green tea is independently associated with a lower risk of dementia. Although green tea was found to be beneficial, excessive consumption of both green tea and coffee is not recommended for the prevention of dementia.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100615"},"PeriodicalIF":4.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144366225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular-kidney-metabolic overlaps, clinical outcomes, and quality of life in patients with acute heart failure","authors":"Jingkuo Li ,&nbsp;Lubi Lei ,&nbsp;Lihua Zhang ,&nbsp;Yuanlin Guo ,&nbsp;Xin Yuan","doi":"10.1016/j.jnha.2025.100613","DOIUrl":"10.1016/j.jnha.2025.100613","url":null,"abstract":"<div><h3>Background</h3><div>The impact of cardiovascular-kidney-metabolic (CKM) multimorbidity on outcomes in heart failure (HF) patients from China is not well-characterized.</div></div><div><h3>Objectives</h3><div>To evaluate the influence of CKM multimorbidity on short-term and long-term clinical outcomes and health-related quality of life.</div></div><div><h3>Methods</h3><div>Using data from a multicenter prospective cohort in China, we classified patients hospitalized for HF according to numbers or combinations of CKM conditions (atherosclerotic cardiovascular disease [ASCVD]), chronic kidney disease [CKD], and type 2 diabetes [T2D]). Cox regression models assessed associations of CKM multimorbidity with 1-year major adverse cardiovascular events (MACE), all-cause death, cardiovascular (CV) death, all-cause rehospitalization, HF rehospitalization, and 4-year mortality outcomes. Generalized linear models evaluated CKM multimorbidity’s impact on 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ-12) scores at 1, 6, and 12 months post-discharge.</div></div><div><h3>Results</h3><div>Among 4875 patients, 68.2% had at least one CKM condition, and 8.0% had all three. Having three CKM conditions significantly increased 1-year MACE (adjusted hazard ratio [aHR] 1.87), all-cause death (aHR 1.78), CV death (aHR 1.78), all-cause rehospitalization (aHR 1.70), HF rehospitalization (aHR 1.76), 4-year all-cause death (aHR 1.95), and CV death (aHR 1.78). Patients with three CKM conditions had a 12-month KCCQ-12 score difference of −6.35 compared to those with no CKM conditions.</div></div><div><h3>Conclusions</h3><div>CKM multimorbidity is common in Chinese patients hospitalized for HF and is associated with a higher risk of clinical outcomes and lower health-related quality of life.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100613"},"PeriodicalIF":4.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}