Journal of Nutrition Health & Aging最新文献

{"title":"Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length","authors":"Jie Yu,&nbsp;Yiwen Liu,&nbsp;Huabing Zhang,&nbsp;Fan Ping,&nbsp;Wei Li,&nbsp;Lingling Xu,&nbsp;Yuxiu Li","doi":"10.1016/j.jnha.2025.100493","DOIUrl":"10.1016/j.jnha.2025.100493","url":null,"abstract":"<div><h3>Background</h3><div>Telomere length(TL)and mitochondrial DNA copy number(mtDNAcn) are classic biomarker of aging. Recently, growth differentiation factor 15(GDF15) has attracted considerable attention as a vital component in the aging process.</div></div><div><h3>Methods</h3><div>The present study aimed to study the relationship between GDF15 and telomere length and mtDNAcn.This was a cross-sectional analysis nested in a longitudinal cohort study conducted in Changping District, Beijing, from 2014 to 2021. Serum GDF15,leukocyte lelomere length(LTL) and mtDNAcn were determined in 802 subjects.LTL and mtDNAcn was quantified by real-time PCR assay. Multivariate linear regression and restricted cubic spline diagram were used for statistical analysis.</div></div><div><h3>Results</h3><div>Subjects with higher GDF15 were older,had larger waist circumference, higher systolic blood pressure and glycated hemoglobin A1c (HbA1c),shorter LTL and tended to had less mtDNAcn. In correlation analysis, GDF15 was positively correlated with age, while LTL and mtDNAcn were negatively correlated with age.After adjusting for confounding factors,GDF15 was negatively associated with LTL (β = −0.120, 95%CI [−0.197, −0.042], p = 0.003) and the association was linear(p for nonlinear = 0.645), while the negative association between GDF15 and mtDNAcn did not reach significance.In the stratified analyses,the negative associations between GDF15 and LTL were more prominent in women, overweight individuals, or subjects with abnormal glucose tolerance (AGT), but similar results were observed in younger and older subjects.</div></div><div><h3>Conclusions</h3><div>This study found a linear negative association between GDF 15 and LTL,which was more prominent in women, overweight or AGT subjects.These results supported that GDF15 might be a reliable biomarker of aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100493"},"PeriodicalIF":4.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes on the progression of Alzheimer’s disease via trajectories of amyloid–tau–neurodegeneration (ATN) biomarkers","authors":"Eun Woo Kim ,&nbsp;Keun You Kim ,&nbsp;Eosu Kim ,&nbsp;for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.jnha.2024.100444","DOIUrl":"10.1016/j.jnha.2024.100444","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer’s disease (AD) is characterized by the accumulation of abnormal proteins, such as β-amyloid and tau, in the brain, which precedes cognitive impairment. Although diabetes mellitus (DM) is a well-established risk factor for AD, few studies have investigated how the presence of DM affects the sequential pathogenesis of AD, specifically within the amyloid-tau-neurodegeneration (ATN) and cognition framework.</div></div><div><h3>Objectives</h3><div>This study aims to investigate the trajectories of ATN biomarkers in relation to the presence of DM in the preclinical and prodromal stages of AD.</div></div><div><h3>Design</h3><div>Participants with normal cognition (CN) or mild cognitive impairment (MCI) at baseline were included. Subjects were followed for 12–192 months, with neuroimaging and cognitive assessments conducted at every 12 or 24 months.</div></div><div><h3>Setting</h3><div>This study utilized data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database.</div></div><div><h3>Participants</h3><div>A total of 603 participants aged 55–90 years were included, comprising 284 CN (25 with DM, 259 without DM) and 319 MCI (39 with DM, 280 without DM) individuals.</div></div><div><h3>Measurements</h3><div>ATN biomarkers were identified using florbetapir positron emission tomography (PET), flortaucipir PET, and magnetic resonance imaging (MRI), respectively. Cognition was assessed using the Clinical Dementia Rating-Sum of Boxes (CDR-SB) and Mini-Mental State Examination (MMSE). Moderation analysis was conducted to investigate the effect of DM on the association between ATN biomarkers of AD.</div></div><div><h3>Results</h3><div>Elevated amyloid standardized uptake value ratios (SUVRs) were associated with increased tau levels in the hippocampus, and this association was significantly enhanced by the presence of DM in MCI participants (p = 0.021). DM also strengthened the association between increased tau SUVR levels and neurodegeneration (indicated by decreased entorhinal cortical volumes; p = 0.005) in those with MCI. Furthermore, DM enhanced the association of decreased entorhinal (p = 0.012) and middle temporal cortex (p = 0.031) volumes with increased (worsened) CDR-SB scores in MCI participants. However, DM did not predict significant longitudinal changes in ATN pathology or cognitive decline in CN participants.</div></div><div><h3>Conclusions</h3><div>Our study suggests that DM may increase the risk of AD by accelerating each step of the A-T-N cascade in the prodromal stage of AD, underscoring the importance of DM management in preventing the MCI conversion to AD.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100444"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between ADL disability and depression in middle-aged and elderly: national cohort study","authors":"Siru Wang ,&nbsp;Minglan Yu ,&nbsp;Wenyi Huang ,&nbsp;Tingting Wang ,&nbsp;Kezhi Liu ,&nbsp;Bo Xiang","doi":"10.1016/j.jnha.2024.100450","DOIUrl":"10.1016/j.jnha.2024.100450","url":null,"abstract":"<div><h3>Background</h3><div>The decline in daily living abilities (ADL) among older adults is a notable predictor of depressive symptoms and the occurrence of disease. However, the effects of changes in ADL disability on the progression of depression have not been extensively studied.</div></div><div><h3>Objective</h3><div>This research aims to examine the relationship between current ADL disability and depression in individuals aged 45 and older, as well as to explore how ADL disability influences the progression of depression in later life within China.</div></div><div><h3>Methods</h3><div>This study analyzed 7-year data from the China Health and Retirement Longitudinal Study (CHARLS), involving 2,205 middle-aged and older adults. The ADL disability (BADL: such as eating, dressing; IADL: such as shopping, cooking) were obtained using ADL scale (scores 0–12, lower is better), and depression was measured by the Center for Epidemiologic Studies Depression Scale (scores 0–30, lower is better). The latent growth curve and cross-lagged models were analyzed after adjusting relevant control variables to study the effect of ADL disability on the progression of depression.</div></div><div><h3>Results</h3><div>The mean values for depression, basic activities of daily living (BADL), and instrumental activities of daily living (IADL) varied from 9.44 to 11.08, 6.45 to 6.81, and 6.86 to 7.29, respectively. The analysis indicated a potential association between depression and ADL. Specifically, the trajectory of BADL was a significant predictor of both initial depression (<em>β</em> = 0.138, 95%CI = 0.039−0.237) and its trajectory (<em>β</em> = 0.579, 95%CI = 0.403−0.754). Although IADL did not significantly predict the trajectory of depression, it was a significant predictor of initial depression (<em>β</em> = 0.471, 95%CI = 0.404−0.538). Additionally, cross-lag regression analysis provided further support for the relationship between depression and BADL disability.</div></div><div><h3>Conclusions</h3><div>This research highlights how ADL disability can forecast future depression in Chinese middle-aged and older adults. The findings indicate a significant connection between ADL disability and both changes in and future instances of depression in this group. Therefore, it is crucial for the Chinese government to prioritize interventions that enhance physical functioning in the elderly, as such measures can effectively mitigate the worsening of depression and promote positive aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100450"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of short-term and long-term ketogenic diet on gene expression in the aging mouse brain","authors":"Matthew S. Stratton ,&nbsp;José Alberto López-Domínguez ,&nbsp;Alessandro Canella ,&nbsp;Jon J. Ramsey ,&nbsp;Gino A. Cortopassi","doi":"10.1016/j.jnha.2024.100427","DOIUrl":"10.1016/j.jnha.2024.100427","url":null,"abstract":"<div><h3>Background</h3><div>Aging is associated with multiple neurodegenerative conditions that severely limit quality of life and can shorten lifespan. Studies in rodents indicate that in addition to extending lifespan, the ketogenic diet (KD) improves cognitive function in aged animals, yet long term adherence to KD in Humans is poor.</div></div><div><h3>Objectives</h3><div>To broadly investigate what mechanisms might be activated in the brain in response to ketogenic diet.</div></div><div><h3>Methods</h3><div>We conducted transcriptome wide analysis on whole brain samples from 13-month-old mice, 13-month-old mice fed a ketogenic diet for 1 month, 26-month-old mice, and 26-month-old mice fed a ketogenic diet for 14 months.</div></div><div><h3>Results</h3><div>As expected, analysis of differently expressed genes between the old (26 month) vs younger mice (13 month) showed clear activation of inflammation and complement system pathways with aging. Analysis between the 26-month-old animals fed ketogenic diet for 14 months with 26-month-old animals fed control diet indicate that long-term KD resulted in activation of LRP, TCF7L2 (WNT pathway), and IGF1 signaling. There was also a significant increase in the expression of SOX2-dependent oligodendrocyte/myelination markers, though TCF7L2 and SOX2 dependent gene sets were largely overlapping. Remarkably, the effect of 1 month of ketogenic diet was minimal and there was no congruence between gene expression effects of short-term KD vs long-term KD.</div></div><div><h3>Conclusions</h3><div>This work informs target identification efforts for aging and neurodegenerative disorder therapeutics discovery while also establishing differential effects of short-term vs long-term KD on gene expression in the brain.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100427"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Mediterranean diet adherence and Parkinson's disease: a systematic review and meta-analysis","authors":"Jiarui Zhao ,&nbsp;Yuan Peng ,&nbsp;Zhenfang Lin ,&nbsp;Yulai Gong","doi":"10.1016/j.jnha.2024.100451","DOIUrl":"10.1016/j.jnha.2024.100451","url":null,"abstract":"<div><h3>Background and aims</h3><div>Parkinson's disease (PD) is a chronic neurodegenerative disorder, and past research suggests that adherence to the Mediterranean diet (MD) may influence the risk of PD. However, there are varying conclusions among different studies regarding the correlation between long-term adherence to the MD and the occurrence of PD. This meta-analysis aimed to investigate the association between MD adherence and PD incidence.</div></div><div><h3>Methods</h3><div>This meta-analysis was registered on PROSPERO (CRD42024520410). We searched PubMed, Embase, Web of Science, and Cochrane databases to identify observational studies, including prospective cohorts, case-control, and cross-sectional studies, up to February 2024. Studies reported on MD adherence were included, with MD adherence categorized through a quantifying score or index. The pool odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for the highest versus the lowest categories of MD score in relation to PD risk, using random-effects models. Additionally, bias assessment, heterogeneity assessment, sensitivity analysis, and subgroup analysis were performed. A total of 12 studies were included in the meta-analysis.</div></div><div><h3>Results</h3><div>The overall effect size of PD risk was as follows: compared to the lowest adherence to the MD, the highest adherence to MD showed a significant negative correlation with the incidence of PD, with an overall OR of 0.75 (95% CI: 0.66, 0.84). Specifically, in studies diagnosing PD, the overall OR was 0.83 (95% CI: 0.74, 0.94), while in studies diagnosing prodromal Parkinson's disease (pPD), the overall OR was 0.67 (95%CI: 0.59, 0.76). For individuals aged &lt;60 years, the overall OR was 0.70 (95%CI: 0.62, 0.78), whereas, for those aged ≥60 years, the overall OR was 0.86 (95%CI: 0.74, 0.99).</div></div><div><h3>Conclusions</h3><div>The evidence from this meta-analysis demonstrates a significant negative correlation between adherence to MD patterns and the risk of PD, suggesting that the MD may serve as a protective factor for PD. This dietary pattern may be particularly beneficial in reducing the risk of pPD.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100451"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive function differs across healthy lifestyle behavior profiles: a 10-year population-based prospective cohort study","authors":"Huixiu Hu ,&nbsp;Yajie Zhao ,&nbsp;Di Guo ,&nbsp;Ying Deng ,&nbsp;Huanhuan Luo ,&nbsp;Yuqing Hao ,&nbsp;Chao Sun ,&nbsp;Kang Yu","doi":"10.1016/j.jnha.2025.100487","DOIUrl":"10.1016/j.jnha.2025.100487","url":null,"abstract":"<div><h3>Background</h3><div>Modifiable lifestyle behaviors significantly influence the risk of cognitive impairment. However, the cumulative effects of multidimensional lifestyle profiles on cognitive function remain poorly understood, as most studies examine individual lifestyle behaviors in isolation. This study aimed to identify distinct profiles of individuals based on healthy lifestyle behaviors and to examine associations between these profiles and cognitive function in older Chinese adults.</div></div><div><h3>Methods</h3><div>We used a prospective cohort, including 5381 participants of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) between 2008 and 2018, aged 65 years and older with normal cognition at baseline. Questionnaires were used to collect self-reported data on healthy diet, sleep quality, physical activities, cognitive activities, and social activities. Repeated measures of the Mini-Mental State Examination (MMSE) were utilized to assess cognitive function. Latent Profile Analysis (LPA) was conducted to identify profiles characterized by similar characteristics of lifestyle behaviors. The resultant profiles, were then used to further explore associations with cognitive function using cox proportional hazard regression and linear mixed models.</div></div><div><h3>Results</h3><div>During a 10-year follow-up period, 2017 (37.5%) out of 5381 participants developed cognitive impairment. Three latent profiles were identified: (1) “active engagement” (n = 347, 6.4%); (2) “moderate engagement” (n = 627, 11.7%); and (3) “negative engagement” (n = 4407, 81.9%). Compared to negative engagement, the active profile had the lower risk of cognitive impairment (HR = 0.693, 95% CI: 0.553−0.868), longer years to develop cognitive impairment (mean = 7.818, range: 6.701, 8.935) and slower rate of annual cognitive decline (0.407 points per year). Similarly, the moderate engagement profile had the lower risk of cognitive impairment (HR = 0.781, 95% CI: 0.664−0.919), longer years to develop cognitive impairment (mean = 7.541, 95%CI: 6.464, 8.619) and slower rate of annual cognitive decline (0.297 points per year) compared to negative profile. Subgroup analysis revealed that there were no significant differences observed across any of the subgroups, including age, gender, year of schooling, marital status, residence, live alone, family economic status.</div></div><div><h3>Conclusions</h3><div>These findings imply the likelihood of an inverse correlation between the levels of engagement in healthy lifestyle behavior and the risk of cognitive impairment. Even adopting a few healthy lifestyle habits is superior to none at all, underscoring the value of lifestyle modifications for cognitive health.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100487"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on: The impact of dietary acid load on super-agers with exceptional cognitive abilities: A propensity score analysis of national health and nutrition examination survey (NHANES) 2011–2014","authors":"Maximilian Andreas Storz ,&nbsp;Alvaro Luis Ronco","doi":"10.1016/j.jnha.2024.100441","DOIUrl":"10.1016/j.jnha.2024.100441","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100441"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions between vitamin D deficiency and inflammation on diabetes risk: data from 336,500 UK Biobank adults","authors":"Jatupol Kositsawat ,&nbsp;Shangshu Zhao ,&nbsp;George A. Kuchel ,&nbsp;Lisa C. Barry ,&nbsp;Richard H. Fortinsky ,&nbsp;Ben Kirk ,&nbsp;Gustavo Duque ,&nbsp;Chia-Ling Kuo","doi":"10.1016/j.jnha.2024.100446","DOIUrl":"10.1016/j.jnha.2024.100446","url":null,"abstract":"<div><h3>Objectives</h3><div>Findings regarding the effects of vitamin D supplementation on diabetes risk are inconclusive. Because inflammation and vitamin D levels are interconnected, we hypothesized that higher inflammation levels moderate the effects of vitamin D deficiency on diabetes risk.</div></div><div><h3>Design, setting, participants, and measurements</h3><div>UK Biobank participants without pre-existing diabetes at baseline were included (N = 336,500). We first linked vitamin D and C-reactive protein (CRP; inflammation measure) levels with incident diabetes during a mean follow-up of 13.5 years (SD = 1.9). Then, we investigated the moderation effect of CRP on the associations between vitamin D deficiency (&lt;10 ng/mL) and incident diabetes and performed subgroup analyses according to age (&lt;60 vs. <span><math><mo>≥</mo></math></span>60 years) and frailty status (frail; pre-frail; non-frail). Multivariate analyses were conducted using restricted cubic spline Cox proportional hazards regression models.</div></div><div><h3>Results</h3><div>Lower vitamin D and higher CRP levels were significantly associated with an increased risk of diabetes during follow-up. There was a significant interaction between vitamin D deficiency and CRP on incident diabetes (p &lt; 0.001). In participants with higher levels of CRP, the hazard ratio of developing diabetes comparing participants who had vitamin D deficiency to those who did not was lower than that in participants with lower levels of CRP. The moderation effect of CRP was similar between younger and older adults but was stronger in frail or pre-frail older adults than in non-frail older adults.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that the effect of vitamin D deficiency on incident diabetes may be affected by inflammation. This finding may explain the inconsistent results from vitamin D supplementation trials. Vitamin D supplementation without considering the potential impact of inflammation might prove unsatisfactory.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100446"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns in the context of ageing and cognitive and physical functions","authors":"Natasha A. Grande de França,&nbsp;Kelly Virecoulon Giudici","doi":"10.1016/j.jnha.2025.100481","DOIUrl":"10.1016/j.jnha.2025.100481","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100481"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life famine exposure, genetic susceptibility and risk of MAFLD in adulthood","authors":"Yuying Wang ,&nbsp;Kun Zhang ,&nbsp;Bin Wang ,&nbsp;Bowei Yu ,&nbsp;Ziteng Zhang ,&nbsp;Yuetian Yu ,&nbsp;Yuefeng Yu ,&nbsp;Ying Sun ,&nbsp;Yi Chen ,&nbsp;Wen Zhang ,&nbsp;Yan Cai ,&nbsp;Qian Xiang ,&nbsp;Fangzhen Xia ,&nbsp;Ningjian Wang ,&nbsp;Yingli Lu","doi":"10.1016/j.jnha.2024.100443","DOIUrl":"10.1016/j.jnha.2024.100443","url":null,"abstract":"<div><h3>Objectives</h3><div>Early-famine exposure was reported to be associated with metabolic associated fatty liver disease (MAFLD); however, it has not been fully elucidated whether the gene-famine interaction exist in this association. We aimed to investigate the association between early-life famine exposure in different genetic risk stratifications and the risk of MAFLD in adulthood.</div></div><div><h3>Design, setting, participants, and measurements</h3><div>The study included 8213 participants from the SPECT-China study. Famine exposure subgroups was defined according to the birth year. A genetic risk score (GRS) was constructed with single nucleotide polymorphisms associated with MAFLD in East Asians. Logistic models were used to examine the association of famine exposure and GRS with MAFLD.</div></div><div><h3>Results</h3><div>Early-life famine exposure was positively associated with MAFLD after adjusting for multiple confounders (OR (95% CI): fetal-exposure 1.3(1.11−1.53), childhood exposure 1.12(1−1.25)). Meanwhile, with per SD increment of GRS (2.49 points), the OR(95%CI) of MAFLD was 1.1(1.04−1.16). In high GRS group, fetal-exposure was positively associated with 45% higher risk of MAFLD (1.45(1.15–1.83)). In men, neither in low or high GRS subgroups observed an association between early-life famine exposure and MAFLD. But in women with high GRS of MAFLD, fetal-exposure was positively associated with even higher risk of MAFLD (1.64(1.22–2.22)).</div></div><div><h3>Conclusion</h3><div>The positive association between early-life famine exposure and MAFLD is intensified by high genetic susceptibility of MAFLD in women and in general population in China; while this association does not exist in men or in those with low genetic risk scores.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100443"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}