Comparison of muscle strength and power in the short physical performance battery for predicting negative outcomes in older adults with mobility limitations

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-07-15 DOI:10.1016/j.jnha.2025.100631

Hélio José Coelho-Júnior , Alejandro Álvarez-Bustos , Leocadio Rodriguez-Mañas , Francesco Landi , Emanuele Marzetti

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引用次数: 0

Abstract

Objectives

The present study examined sex-specific associations between Short Physical Performance Battery (SPPB) indexes operationalized according to lower limb muscle strength and power and the occurrence of negative events in older adults with mobility limitations.

Design

Secondary longitudinal analysis of a randomized controlled trial

Setting

Community-Dwellers.

Participants

Older adults (70+ years) with mobility limitations.

Methods

Participants completed the SPPB under standardized conditions. Muscle power measures were estimated according to results of the 5-time sit-to-stand (5STS) test using validated equations. Then, four SPPB indexes were created by replacing 5STS test results with muscle power measures. Outcomes were assessed after 24 months of randomization and included mobility disability, hospitalization, and death.

Results

Data from 1,422 participants were analyzed. Cox regression models revealed sex-specific associations between SPPB variants and adverse outcomes. SPPB indexes incorporating muscle strength or power were significantly associated with mobility disability in both sexes, and with hospitalization and death in women. According to Akaike’s Information Criterion, muscle power-based SPPB indexes provided the best fit for predicting negative outcomes.

Conclusions

Sex-specific associations exist between modified SPPB indexes and adverse outcomes in older adults with mobility limitations. Notably, SPPB variants incorporating muscle power measures demonstrated the best fit for adverse outcomes in comparison to traditional SPPB.

Trial registration

ClinicalTrials.gov identifier: NCT02582138 (registration date: 2015-10-08).

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短期体能表现电池中肌肉力量和能量预测老年人活动受限的负面结果的比较

目的研究基于下肢肌肉力量和力量的短体能性能电池（SPPB）指数与老年人活动受限的负面事件发生之间的性别特异性关联。设计一项随机对照试验的二次纵向分析。参与者为行动不便的70岁以上成年人。方法在标准化条件下完成SPPB。肌肉力量测量根据5次坐立（5STS）测试的结果，使用验证的方程进行估计。然后用肌力测量代替5STS测试结果，生成4个SPPB指标。结果在随机化24个月后进行评估，包括活动障碍、住院和死亡。结果对1422名参与者的数据进行了分析。Cox回归模型显示SPPB变异与不良结局之间存在性别特异性关联。包含肌肉力量或力量的SPPB指数与两性的行动障碍以及女性的住院和死亡显著相关。根据赤池信息准则，以肌力为基础的SPPB指标最适合预测阴性结果。结论修改后的SPPB指数与老年人活动受限的不良结局存在性别特异性关联。值得注意的是，与传统的SPPB相比，结合肌肉力量测量的SPPB变体显示出最适合不良结果。临床试验注册：clinicaltrials .gov编号：NCT02582138（注册日期：2015-10-08）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.