Journal of Nutrition Health & Aging最新文献

{"title":"Pain trajectories in relation to incident functional limitation among older adults: A prospective cohort study","authors":"Qiao Xiang ,&nbsp;Yuxiao Li ,&nbsp;Ziyi Zhong ,&nbsp;Wei Huang ,&nbsp;Jielei Chu ,&nbsp;Taiping Lin ,&nbsp;Birong Dong ,&nbsp;Jirong Yue ,&nbsp;Masoud Isanejad","doi":"10.1016/j.jnha.2025.100704","DOIUrl":"10.1016/j.jnha.2025.100704","url":null,"abstract":"<div><h3>Objectives</h3><div>We aimed to identify pain trajectories and examine their associations with incident functional limitation in older adults, including activities of daily living (ADL) and instrumental ADL (IADL).</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting</h3><div>Community-based setting in western China.</div></div><div><h3>Participants</h3><div>We included participants with pain score information during 2018–2022, no prevalent functional limitation by 2022, and sufficient follow-up data for functional limitation assessment during 2023–2024.</div></div><div><h3>Measurements</h3><div>Group-based trajectory modeling was applied to identify pain trajectories based on the Numeric Rating Scale pain scores. Multivariate logistic regression models were used to assess the association between pain trajectories and incident ADL and IADL limitation. Sensitivity analyses were conducted using generalized estimating equations. Subgroup analyses were performed to assess potential interaction effects.</div></div><div><h3>Results</h3><div>A total of 887 older adults (all aged ≥60 years) were finally included in the analytic sample, of whom 139 (15.7%) and 198 (22.3%) individuals developed incident ADL and IADL limitation during the two-year follow-up, respectively. Four pain trajectories were identified: ‘<em>Persistently Pain-Free</em>’ (43.0%), ‘<em>Pain Remission</em>’ (16.7%), ‘<em>Developing Mild Pain</em>’ (21.9%), and ‘<em>Persistent Mild-to-Moderate Pain</em>’ (18.5%). Compared to the ‘<em>Persistently Pain-Free</em>’ group, only participants in the ‘<em>Persistent Mild-to-Moderate Pain</em>’ group had a significantly higher risk of developing ADL limitation (adjusted odds ratio = 2.19, 95% CI 1.32–3.63). No significant associations were found between any pain trajectory and the risk of incident IADL limitation. No significant interactions were observed in the subgroup analyses for either ADL or IADL (P for interaction &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Persistent pain, even at mild-to-moderate levels, independently predicts incident limitation in ADL rather than IADL in older adults, while achieving pain remission may help prevent functional decline in ADL. These findings underscore the importance of early identification and management of persistent pain to help maintain functional independence.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100704"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of standard dietary inflammatory index with diabetic retinopathy in diabetes: A prospective cohort study","authors":"Zihan Xu ,&nbsp;Feipeng Jiang ,&nbsp;Yun Zhang ,&nbsp;Jier Ma ,&nbsp;Jianjun Ren ,&nbsp;Meixia Zhang","doi":"10.1016/j.jnha.2025.100694","DOIUrl":"10.1016/j.jnha.2025.100694","url":null,"abstract":"<div><h3>Background and aims</h3><div>Diabetic retinopathy (DR) is a major cause of vision impairment, and its development is linked to chronic inflammation. Investigating the role of dietary patterns, specifically the standard dietary inflammatory index (DII), may provide insights into modifiable risk factors for DR.</div></div><div><h3>Objective</h3><div>To quantify the impact of dietary inflammatory potential (assessed via the standard DII) on both risk of DR and structural alterations across individual retinal layers.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study using data from the UK Biobank. Cox proportional hazards models and restricted cubic splines were used to examine the correlation between the standard DII and DR in three adjusted models. Sensitivity analyses were performed to test the robustness of the outcomes. Linear regression models were employed to explore the associations between the standard DII and retinal structural parameters.</div></div><div><h3>Results</h3><div>Data from 16,224 participants with diabetes from the UK Biobank were analyzed, including 1,257 (7.75%) who developed DR during the follow-up period. Higher standard DII scores were associated with an increased risk of DR in all adjusted models [Model 3: HR = 1.51, 95% CI: (1.15, 1.99), p = 0.003]. A J-shaped association between standard DII scores and DR was observed, and the relationship was significant only when the standard DII score was greater than −2.5 [HR = 1.59, 95% CI: (1.44, 2.04), p = 0.002]. Subgroup analyses revealed consistent results across different stratified groups, indicating increased DR risk. Image analysis revealed that standard DII scores were associated with the thinning of the retinal pigment epithelium layer.</div></div><div><h3>Conclusions</h3><div>Our findings suggest a J-shaped association between standard DII score and DR risk in a multiracial sample from the UK Biobank. These findings indicate that an anti-inflammatory diet may be promising for mitigating the onset of DR.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100694"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Egg intake and cognitive function in healthy adults: A systematic review of the literature","authors":"Nessmah Sultan ,&nbsp;Nicole J. Kellow ,&nbsp;Caroline J. Tuck ,&nbsp;Edellyne Cheng ,&nbsp;Clare MacMahon ,&nbsp;Jessica R. Biesiekierski","doi":"10.1016/j.jnha.2025.100696","DOIUrl":"10.1016/j.jnha.2025.100696","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive decline is a growing public health concern, particularly in aging populations. Eggs are a widely consumed, nutrient-dense food containing choline, phospholipids, tryptophan, and omega-3 fatty acids, which individually support cognitive processes such as memory, attention, and neurogenesis. While these individual nutrients have demonstrated benefits in supplementation studies, the cognitive effects of whole egg consumption are not well established. This systematic review aimed to evaluate the association between whole egg consumption and cognitive function in healthy adults.</div></div><div><h3>Methods</h3><div>A systematic search of five electronic databases (Medline, Embase, CINAHL Plus, SCOPUS, and PsychInfo) was conducted from database inception through February 2025. Studies were included if they investigated whole egg intake in relation to cognitive outcomes in healthy adults. Risk of bias was assessed using tools appropriate to study design. Due to heterogeneity in study methods, outcomes were synthesised narratively. Cognitive outcomes were categorised into domains including global cognitive function, memory, executive function, language, processing speed, and dementia risk.</div></div><div><h3>Results</h3><div>Eleven studies met the inclusion criteria: one pre-post intervention study, six prospective cohort studies, three cross-sectional studies, and one case-control study. Study populations were predominantly older adults and included &gt;38,000 participants. Two studies reported a reduced risk of dementia or cognitive impairment associated with moderate egg consumption (approximately 0.5–1 egg per day), while one study found increased risk at high intake levels (Over 1 egg per day). Several studies showed improvements in memory, verbal fluency, or processing speed with moderate—but not high—egg intake. The pre-post study reported improved reaction time following eight weeks of daily egg consumption (2 eggs per day). Heterogeneity in exposure measurement and cognitive testing methods limited direct comparisons across studies.</div></div><div><h3>Discussion</h3><div>Moderate whole egg consumption may be associated with improvements in cognitive outcomes in healthy adults, including reduced dementia risk and better memory performance. However, findings are inconsistent and limited by differences in study design, dietary assessment, and cognitive testing. Further well-controlled intervention studies are needed to determine optimal intake levels, explore mechanisms, and assess whether eggs can be integrated meaningfully into dietary strategies to support cognitive aging. (PROSPERO registration: 408532).</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100696"},"PeriodicalIF":4.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of appetite using health-care-professional-reported SNAQ","authors":"Jérémy Raffin ,&nbsp;Stéphane Gerard ,&nbsp;Morgane Naudy ,&nbsp;Marion Meras ,&nbsp;Yves Rolland","doi":"10.1016/j.jnha.2025.100693","DOIUrl":"10.1016/j.jnha.2025.100693","url":null,"abstract":"<div><h3>Background</h3><div>Appetite loss is a major concern in various clinical contexts but the self-assessment of appetite might be compromised in some populations such as in individuals with dementia. The use of surrogate responders might be useful but no study so far has investigated whether hetero-administrated questionnaires might be valid tools to assess appetite.</div></div><div><h3>Methods</h3><div>Forty men and women aged 66–97 years, without dementia, were recruited from the Medical care and Rehabilitation Unit of the Toulouse University Hospital, France. Within the same day, patients’ appetite was assessed using the SNAQ, a 4-answers questionnaire that was administrated separately to the patients as well as to two certified nursing assistant (CNA) surrogate responders answering on behalf of the patients. Intraclass correlation coefficients (ICC) as well as Kappa’s and Gwet’s AC1 coefficients were computed to test the agreement between the patients and each surrogate assessor and between the two surrogate assessors.</div></div><div><h3>Results</h3><div>When comparing patients versus surrogate responders’ SNAQ scores, ICC (95% Confidence Interval (CI)) showed weak to moderate correlations, ranging from 0.087 (−0.224, 0.384) to 0.519 (0.254, 0.713). The rate of correct categorization was 65.0–67.5 % and Kappa’s and Gwet’s coefficients ranged from 0.300 (0.006, 0.594) to 0.360 (0.082, 0.638), indicating poor agreements between patient and surrogates. When comparing the surrogate responders with each other, the percentage of similar diagnosis was 82.5% with corresponding Kappa’s and Gwet’s coefficients of 0.650 (0.417, 0.883) and 0.652 (0.406, 0.898), indicating good agreements among surrogate raters.</div></div><div><h3>Conclusion</h3><div>We found weak-to-moderate coefficients for the SNAQ used as a hetero-administrated questionnaire. Further investigation across diverse clinical settings and using larger samples are needed to provide further insights to our preliminary observations.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100693"},"PeriodicalIF":4.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the BFR-7211 on lower limb muscle strength in older adults: A randomized controlled trial","authors":"Yejun Kim ,&nbsp;Soojung Kang ,&nbsp;Minseo Kim ,&nbsp;Janghyeon Kim ,&nbsp;Bo-Young Youn","doi":"10.1016/j.jnha.2025.100692","DOIUrl":"10.1016/j.jnha.2025.100692","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To evaluate the efficacy of a proprioceptive neuromuscular facilitation (PNF) stretching program integrated into a massage chair (BFR-7211) on lower limb strength, balance, and functional mobility in older adults, as a potential intervention for preventing sarcopenia and enhancing musculoskeletal health.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Design&lt;/h3&gt;&lt;div&gt;A randomized controlled trial with a 4-week follow-up (12 visits) and 1:1 allocation ratio, conducted without blinding due to the nature of the interventions.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Setting and participants&lt;/h3&gt;&lt;div&gt;Sixty-two community-dwelling older adults, 65 years and older, from a senior welfare center were randomized into an experimental group (massage chair with PNF stretching) or a control group (standard trunk exercise program) three times per week for a 4-week intervention period.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;The experimental group received mechanical massage therapy utilizing the PNF stretching mode (XM module, level 2) of the massage chair for 20 min, three times weekly over four weeks. The control group performed a standard trunk exercise program consisting of trunk curl-ups, diagonal trunk curls, and single-legged extensions for 30 min per session. The primary outcome was measured by the Short Physical Performance Battery (SPPB). Secondary outcomes included maximal hamstring strength, body composition, depressive symptoms (GDS-K), fear of falling (KFES), and quality of life (K-CASP-16). Adverse events were monitored throughout the study. Outcomes were measured at baseline, 6th visit, and the final visit (visit 12). Within-group changes were assessed using paired t-tests, while between-group differences were analyzed with Welch’s t-tests and a prespecified ANCOVA adjusting for baseline SPPB, age, and sex. Adjusted mean differences with 95% CIs and p-values are reported, and a sensitivity analysis using a linear mixed model accounted for repeated measures at visits 6 and 12 with baseline SPPB as a covariate.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The experimental group showed significant improvements in SPPB total score (from 9.42 ± 2.38 to 11.58 ± 0.67, &lt;em&gt;p&lt;/em&gt; &lt; 0.001), chair-stand, balance, and gait speed, while the control group showed minimal or negative changes. Hamstring muscle strength increased significantly in the experimental group for both legs, whereas the control group experienced a decline. The experimental group also demonstrated a slight increase in soft lean mass, which is also statistically significant. The experimental group also demonstrated a significant reduction in fear of falling (KFES: −3.00, &lt;em&gt;p&lt;/em&gt; = 0.045) and improved quality of life (K-CASP-16: +2.32, &lt;em&gt;p&lt;/em&gt; = 0.032), with no significant change in depressive symptoms or body composition. No serious adverse events were reported.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;A four-week massage chair-based PNF stretching program significantly improved lower limb strength, physical fun","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 12","pages":"Article 100692"},"PeriodicalIF":4.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-specific associations between intrinsic capacity impairments and self-rated health in community-dwelling adults: Insights from Taiwan longitudinal study on aging","authors":"Sheng-Ping Chu ,&nbsp;Chi-Yun Wu ,&nbsp;Hsi-Yu Lai ,&nbsp;I-Tzu Chen ,&nbsp;Lin-Chieh Meng ,&nbsp;Chih-Kuang Liang ,&nbsp;Ming-Yueh Chou ,&nbsp;Wei-Ju Lee ,&nbsp;Liang-Kung Chen ,&nbsp;Fei-Yuan Hsiao","doi":"10.1016/j.jnha.2025.100688","DOIUrl":"10.1016/j.jnha.2025.100688","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization's Integrated Care for Older People framework emphasizes intrinsic capacity (IC) assessment, yet the relationship between specific intrinsic capacity impairments and self-rated health (SRH) across different age groups remains inadequately characterized.</div></div><div><h3>Objectives</h3><div>To analyze age-specific associations between six IC domains and self-rated health using Taiwan Longitudinal Study on Aging data, adjusting for demographic, socioeconomic, and health factors.</div></div><div><h3>Methods</h3><div>We extracted 3,330 participants with good or poor self-rated health, stratified into three age groups: 55−64 years (n = 1,278), 65−74 years (n = 1,011), and 75+ years (n = 1,041). Five sequential logistic regression models assessed associations between IC impairments (locomotor capacity, vitality, vision, hearing, cognition, psychological capacity) and self-rated health, adjusting for sex, education, marital status, employment, economic satisfaction, chronic conditions, smoking, drinking, physical exercise, and sleep quality.</div></div><div><h3>Results</h3><div>IC impairment prevalence increased with age: 17.2% (55−64), 38.2% (65−74), and 61.5% (75+). After adjustment, age-specific patterns of IC impairments associated with poor self-rated health emerged. In middle-aged adults (55−64), locomotor capacity showed the strongest association with poor self-rated health (OR = 14.61, 95% CI: 3.50–61.01), though the wide confidence interval reflects the low prevalence of impairment. Psychological capacity (OR = 5.96, 95% CI: 3.32–10.69) could thus be the most dominant IC impairment that is linked to poor self-rated health in this age group. For young-old adults (65−74), locomotor capacity had the greatest impact (OR = 4.19, 95% CI: 2.02–8.67), followed by psychological capacity (OR = 3.68, 95% CI: 2.33–5.82) and vitality (OR = 2.14, 95% CI: 1.11–4.16). In the oldest adults (75+), vitality became particularly important (OR = 4.17, 95% CI: 2.22–7.84), alongside with psychological capacity (OR = 3.15, 95% CI: 2.18–4.56) and locomotor capacity (OR = 2.20, 95% CI: 1.52–3.17).</div></div><div><h3>Conclusions</h3><div>Age-specific patterns suggest targeted interventions: mental health support for middle-aged adults, mobility preservation for young-old adults, and vitality enhancement for the oldest adults. These findings provide guidance for age-tailored ICOPE strategies.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100688"},"PeriodicalIF":4.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to the Japanese Diet is Associated with Lower Risk of Geriatric Depression: A Prospective-Cohort Study Based on the New Integrated Suburban Seniority Investigation (NISSIN) Project","authors":"Ho Chen ,&nbsp;Eri Maeda ,&nbsp;Wen Hao ,&nbsp;Kenji Wakai ,&nbsp;Satoe Okabayashi ,&nbsp;Shigekazu Ukawa ,&nbsp;Akiko Tamakoshi","doi":"10.1016/j.jnha.2025.100689","DOIUrl":"10.1016/j.jnha.2025.100689","url":null,"abstract":"<div><h3>Objectives</h3><div>Geriatric depression is an increasingly important public health issue in an aging society. However, while Japan boasts one of the world’s highest and healthiest life expectancies at birth, there was no prospective cohort study dedicated to the specific association between the Japanese diet and geriatric depression. Thus, we aimed to examine this relationship and assess whether such association extends beyond better physical health secondary to higher diet quality.</div></div><div><h3>Design, setting, participants, and measurements</h3><div>Our study utilized the New Integrated Suburban Seniority Investigation (NISSIN) Project, which is an age-specific prospective cohort study that recruited residents of Nisshin City, Japan who were about to reach 65 years of age between 1996 and 2005. We measured the adherence to the Japanese diet of 1620 elderly Japanese individuals (827 male and 793 female) with a modified version of the Japanese Diet Index (JDI) and assessed the development of geriatric depression with the Geriatric Depression Scale 15 items questionnaire when they reached 70 years of age.</div></div><div><h3>Results</h3><div>A total of 135 individuals developed geriatric depression at 70 years of age. After adjusting for major confounding factors, those within the highest group of adherence to the Japanese diet had significantly reduced risk of developing geriatric depression (adjusted odds ratio [aOR] = 0.525, 95% confidence interval [CI]: 0.286 – 0.962) when compared to those with the lowest adherence, and each point received on the JDI was also associated with reduced risk of geriatric depression (aOR = 0.900, 95% CI: 0.816−0.992). Dietary item-wise analyses showed that fish and shellfish (p = 0.024), green-yellow vegetable (p = 0.003), and soybean-derived products (p = 0.001) were significantly associated with lower risk of geriatric depression.</div></div><div><h3>Conclusion</h3><div>Adherence to the Japanese diet, especially those rich in green-yellow vegetables, soybean-derived products, and fish and shellfish, may be protective against geriatric depression.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100689"},"PeriodicalIF":4.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic determinants of sarcopenia incidence: A 14-year prospective study of 33,797 participants","authors":"Ha-Na Kim ,&nbsp;John C. Newman ,&nbsp;Ji Hyun Lee ,&nbsp;Yun-Ah Lee ,&nbsp;Yuji Jeong ,&nbsp;Se-Hong Kim","doi":"10.1016/j.jnha.2025.100668","DOIUrl":"10.1016/j.jnha.2025.100668","url":null,"abstract":"<div><h3>Objectives</h3><div>Sarcopenia, an age-related loss of skeletal muscle mass and strength, increases the risk of adverse health outcomes and socioeconomic burden; however, the metabolic causes of sarcopenia are unclear. This study investigated the association between plasma metabolites and incident sarcopenia and evaluated their predictive value for the incidence of sarcopenia.</div></div><div><h3>Methods</h3><div>This prospective cohort study included 33,797 participants aged 40–69 years from the UK Biobank who were free of sarcopenia and had plasma metabolomic data available. Plasma metabolite levels, including amino acids, fatty acids, lipid/lipoprotein subclasses, creatinine, and glycoprotein acetyls, were measured using nuclear magnetic resonance-based profiling. Incident sarcopenia was defined using the ICD-10 codes or criteria for low skeletal muscle mass and muscle strength.</div></div><div><h3>Results</h3><div>During a follow-up period of over 14 years, 829 participants developed sarcopenia. Of the 249 metabolites tested, 38 were significantly associated with the incidence of sarcopenia. The area under the ROC curve (AUC) of sarcopenia incidence for the 38 metabolites was 0.696 (95% CI: 0.666–0.726), and the AUC for conventional risk factors was 0.738–0.892, according to the models. The combined model, which integrated conventional risk factors and metabolites, significantly improved prediction (AUC: 0.779–0.898).</div></div><div><h3>Conclusions</h3><div>This study identified 38 plasma metabolites associated with incident sarcopenia. Incorporating these metabolites into models with conventional risk factors yielded statistically significant improvements in prediction beyond that of conventional factors alone; however, the gain was modest, and its clinical relevance remains to be determined. These findings suggest that although the clinical utility of these metabolites for predicting sarcopenia incidence has not yet been fully established, they may nevertheless provide insights into underlying biological pathways and could contribute to the development of preventive or therapeutic strategies in geriatric care.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100668"},"PeriodicalIF":4.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition for Healthy Longevity","authors":"Natasha Grande de França ,&nbsp;João Valentini Neto","doi":"10.1016/j.jnha.2025.100691","DOIUrl":"10.1016/j.jnha.2025.100691","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100691"},"PeriodicalIF":4.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145157754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faecalibacterium prausnitzii Indicates Healthspan and Lifespan in Nonhuman Primates","authors":"Kylie Kavanagh ,&nbsp;Taylor Sheridan ,&nbsp;Ravichandra Vemuri ,&nbsp;Aleaya Bowie ,&nbsp;Darla DeStephanis ,&nbsp;Shannon Kraniak ,&nbsp;Elizabeth Burner ,&nbsp;McKinley Santiago","doi":"10.1016/j.jnha.2025.100690","DOIUrl":"10.1016/j.jnha.2025.100690","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the relationship between fecal <em>Faecalibacterium prausnitzii</em> and health resiliency.</div></div><div><h3>Design</h3><div>Cohorts of nonhuman primates were evaluated prior to disease development for fecal abundances of <em>Faecalibacterium prausnitzii.</em></div></div><div><h3>Setting</h3><div>Radiation-induced and spontaneously arising age-induced morbidity and mortality, including high rates of Type 2 diabetes.</div></div><div><h3>Participants</h3><div>Old world male and female nonhuman primates.</div></div><div><h3>Measurements</h3><div>Age, weight, glycemic indices, fecal total microbial loads and specific detection <em>Faecalibacterium prausnitzii</em> levels as measured by whole genome sequencing or polymerase chain reaction.</div></div><div><h3>Results</h3><div>Higher levels of fecal <em>Faecalibacterium prausnitzii</em> was observed in nonhuman primates that survived whole body irradiation, had longer lifespans, and were protected from future Type 2 diabetes diagnoses. Type 2 diabetes development further lowered <em>Faecalibacterium prausnitzii</em> levels. The mean effect size for differences in fecal abundance was 1.76 (95% confidence interval 0.03–3.50).</div></div><div><h3>Conclusion</h3><div>The abundance of the intestinal microbial species <em>Faecalibacterium prausnitzii</em> appears to be a strong candidate biomarker species for a preferred microbiome that predicts superior health resiliency and associated lifespan.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100690"},"PeriodicalIF":4.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}