Journal of Nutrition Health & Aging最新文献

{"title":"Association between temporalis muscle thickness and functional outcomes in acute stroke: A meta-analysis and GRADE approach","authors":"Yao-Chung Yang ,&nbsp;Chun-Hao Yin ,&nbsp;Pei-Chin Lin ,&nbsp;Yow-Ling Shiue","doi":"10.1016/j.jnha.2025.100614","DOIUrl":"10.1016/j.jnha.2025.100614","url":null,"abstract":"<div><h3>Background</h3><div>Sarcopenia is associated with poor prognosis in patients with acute stroke. While temporalis muscle thickness (TMT) and area (TMA) have been studied in various conditions, their association with stroke prognosis remains unclear.</div></div><div><h3>Methods</h3><div>To investigate the validity of TMT and TMA as poststroke outcome predictors, we performed a comprehensive search of the PubMed, CENTRAL, and Embase databases to identify pertinent studies published up to October 31, 2024. A meta-analysis of the pooled estimates of the temporalis muscle predictors was conducted, and the evidence quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.</div></div><div><h3>Results</h3><div>This meta-analysis included 15 studies and revealed that both TMT and TMA were associated with functional outcomes and dysphagia risk in patients with stroke. Specifically, patients with better functional outcome had higher TMT value (mean difference [MD] = 0.84 mm, 95% confidence interval [CI] = 0.55–1.13, <em>I</em>² = 45%). Likewise, patients with better functional outcomes had larger TMA values (MD = 65.99 mm², 95% CI = 0.41–1.06, <em>I</em>² = 85%). A lower TMT value at stroke onset was associated with increased dysphagia risk (MD = 1.63 mm, 95% CI = 0.74–2.52, <em>I</em>² = 50%). Subgroup analyses showed that the association between TMT and functional outcome was more evident in individuals aged 50 years or older and in Asian populations, with no significant differences observed between sexes. The certainty of evidence according to GRADE assessment ranged from low to moderate.</div></div><div><h3>Conclusions</h3><div>TMT and TMA measurements obtained from routine neuroimaging may serve as useful reference markers for functional prognosis in stroke patients.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100614"},"PeriodicalIF":4.3,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific associations of DXA-measured visceral and subcutaneous fat with serum α-Klotho in middle-aged adults","authors":"Shuimei Sun ,&nbsp;Yun Wan ,&nbsp;Yang Jian ,&nbsp;Cailin Tang ,&nbsp;Qi Chen ,&nbsp;Kai Wei","doi":"10.1016/j.jnha.2025.100616","DOIUrl":"10.1016/j.jnha.2025.100616","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100616"},"PeriodicalIF":4.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144329980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of seafood consumption with sleep quality according to high sensitivity C-reactive protein levels in Korean adults","authors":"Yeongeun Jeong ,&nbsp;Minji Kim ,&nbsp;Seungyoun Jung ,&nbsp;Yangha Kim","doi":"10.1016/j.jnha.2025.100611","DOIUrl":"10.1016/j.jnha.2025.100611","url":null,"abstract":"<div><h3>Objective</h3><div>The consumption of seafood, which is major sources of <em>n</em>-3 polyunsaturated fatty acids, such as docosahexaenoic and eicosapentaenoic acids, has been associated with sleep quality. Seafood and its bioactive components may enhance sleep quality by regulating systemic inflammation and neuroendocrine pathways. However, longitudinal studies examining the interplay between seafood consumption, sleep quality, and inflammatory status are lacking. Therefore, in this cohort study of 2332 participants from the Korean Genome and Epidemiology Study, we investigated the potential modulatory role of inflammatory status for the association between seafood consumption and the risk of poor sleep quality.</div></div><div><h3>Methods and measurements</h3><div>Dietary intake was assessed using a validated 106-item food frequency questionnaire. High-sensitivity C-reactive protein (hs-CRP) levels were assessed as a marker of systematic inflammatory status. Sleep quality was assessed using Pittsburgh Sleep Quality Index. The hazard ratio (HR) and 95% confidence interval (CI) for the risk of poor sleep quality was estimated using Cox proportional hazards model.</div></div><div><h3>Results</h3><div>After 6 years of follow-up, 118 and 192 cases of poor sleep quality were documented among men and women, respectively. The greater seafood consumption was significantly associated with lower risk of poor sleep quality. The multivariable-adjusted HR (95% CI) comparing the highest with the lowest tertile of seafood consumption was 0.66 (0.45–0.98) (<em>p-</em>trend = 0.032). This inverse association appeared to be limited to participants with lower levels of hs-CRP.</div></div><div><h3>Conclusion</h3><div>Our results suggested that the favorable effects of seafood consumption on sleep quality could vary by inflammatory status. Larger cohort studies are warranted to replicate our findings.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100611"},"PeriodicalIF":4.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary spermidine intake with biological age acceleration and the mediating role of insulin-like growth factor 1 in the UK Biobank","authors":"Xiaofeng Ma ,&nbsp;Pan-Pan Zhu ,&nbsp;Jia-Dong Ning ,&nbsp;Yu-Xiang Long ,&nbsp;Yi-Ming Tao ,&nbsp;Chun-Quan Ou ,&nbsp;Qian Zhou ,&nbsp;Li Li","doi":"10.1016/j.jnha.2025.100610","DOIUrl":"10.1016/j.jnha.2025.100610","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100610"},"PeriodicalIF":4.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the oxidative balance score and spinal pain among older adults","authors":"Jinfeng Huang ,&nbsp;Haitao Guan ,&nbsp;Zihong Ji ,&nbsp;Zhichen Jiang ,&nbsp;Jiangwei Zhu ,&nbsp;Chenyu Wu ,&nbsp;Jiajia Chen ,&nbsp;Zijian Yan","doi":"10.1016/j.jnha.2025.100609","DOIUrl":"10.1016/j.jnha.2025.100609","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100609"},"PeriodicalIF":4.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital frailty risk score in predicting outcomes after simultaneous colon and liver resection for colorectal cancer liver metastasis in older adults: Evidence from the Nationwide Inpatient Sample 2015–2018","authors":"Haohao Huang ,&nbsp;Weidong Jin ,&nbsp;Huiling Sun ,&nbsp;Bo Diao ,&nbsp;Ping Wang ,&nbsp;Jiankun Jia ,&nbsp;Dandan Ma ,&nbsp;Yi Zhang","doi":"10.1016/j.jnha.2025.100606","DOIUrl":"10.1016/j.jnha.2025.100606","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigated the impact of clinical frailty on short-term outcomes of simultaneous colorectal cancer (CRC) and colorectal cancer liver metastasis (CRLM) resections.</div></div><div><h3>Setting and participants</h3><div>Data of older patients ≥ 60 years old undergoing simultaneous CRC/CRLM resections between 2005 and 2018 were identified in the United States (US) Nationwide Inpatient Sample (NIS) database.</div></div><div><h3>Methods</h3><div>Frailty was determined using the Hospital Frailty Risk Score (HFRS) according to the International Classification of Diseases Ninth and Tenth (ICD-9 and ICD-10) codes. Study outcomes included mortality, prolonged hospital stay (LOS), non-routine discharge, and complications.</div></div><div><h3>Results</h3><div>Data of 4514 patients were analyzed. Frailty was significantly associated with increased risks of in-hospital mortality (adjusted odds ratio [aOR] = 3.65, 95% confidence interval [CI]: 2.52, 5.28), non-routine discharge (aOR = 2.44, 95% CI: 2.08, 2.87), prolonged LOS (aOR = 3.07, 95% CI: 2.60, 3.61), overall complications (aOR = 3.47, 95% CI: 3.03, 3.97), sepsis (aOR = 13.73, 95% CI: 9.76, 19.31), respiratory failure (aOR = 4.99, 95% CI: 3.80, 6.57), acute kidney injury (AKI) (aOR = 6.42, 95% CI: 4.83, 8.52), and acute liver failure (aOR = 2.10, 95% CI: 1.38, 3.21), as well as 32.69 thousand USD higher total hospital costs (95% CI: 28.41, 36.97) than no frailty. Incorporating frailty with traditional demographic and clinical risk factors improved in-hospital mortality prediction (area under ROC curve [AUC]: 0.765 to 0.799).</div></div><div><h3>Conclusions</h3><div>In older patients aged ≥ 60 years undergoing simultaneous CRC and CRLM resection, HFRS-defined frailty is a significant predictor of adverse in-hospital outcomes. The addition of HFRS-defined frailty to demographic and clinical variables in predictive models improved the AUC for mortality prediction. Incorporating frailty assessment into the preoperative risk stratification and decision-making process for these patients may support surgeons in delivering more personalized and effective care.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100606"},"PeriodicalIF":4.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144308190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative data of ultrasound quadriceps rectus femoris geometric values. The ECOSARC-2 Study","authors":"Ester López Jiménez ,&nbsp;Paola Reinoso Párraga ,&nbsp;Alfonso González Ramírez ,&nbsp;Marta Neira Álvarez ,&nbsp;Adriana Abizanda Saro ,&nbsp;Marisa Fernández González de la Riva ,&nbsp;Cristina Alonso Bouzón ,&nbsp;Victoriano Chavero Carrasco ,&nbsp;Gema Montemayor Galán ,&nbsp;Juan Rodríguez Solís ,&nbsp;Rubén Alcantud Córcoles ,&nbsp;Raquel Ramírez Martín ,&nbsp;Carmen de Pablos Hernández ,&nbsp;Fabricio Zambom-Ferraresi ,&nbsp;Brian Dax Vásquez ,&nbsp;Pedro Luis Sagüillo González ,&nbsp;Ignacio Morón Merchante ,&nbsp;Rafael García Molina ,&nbsp;Rocío Menéndez Colino ,&nbsp;Nicolás Martínez Velilla ,&nbsp;Pedro Abizanda","doi":"10.1016/j.jnha.2025.100608","DOIUrl":"10.1016/j.jnha.2025.100608","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe geometric muscle ultrasound normative values of Quadriceps Rectus Femoris (QRF) at mid-thigh in Spanish community-dwelling older adults. Secondary objectives included evaluating the associations between ultrasound measurements and physical function, muscle strength, frailty, and dependency in basic activities of daily living.</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Setting</h3><div>Outpatient clinics of Geriatric Departments at seven University Hospitals and three Primary care settings of Spain.</div></div><div><h3>Participants</h3><div>424 community-dwelling persons ≥70 years old.</div></div><div><h3>Measurements</h3><div>Ultrasound measurements were acquired using a Clarius® L7 HD3 probe. QRF thickness (QRFT), QRF area (QRFA), subcutaneous adipose thickness (SAT), total mid-thigh thickness (TTT), and pennation angle (PA) were calculated. Normative values are provided, and associations with comorbidity, dependency, strength, frailty and physical function are described.</div></div><div><h3>Results</h3><div>Mean age was 81.5 years (range 70−99), 66.7% were female. Mean Barthel index was 93 (SD 11), and mean FRAIL score was 1.1 (1.2). Mean SPPB was 8.7 (SD 2.9) and mean grip strength was 20.7 (8.0). Median values of QRFT, QRFA, SAT, TTT, and PA for women and men were 14.2 / 16.1 mm, 5.4 / 6.4 cm<span><span>²</span></span>, 15.1 / 9.2 mm, 41.1 / 40.1, and 10.0 / 10.6 respectively. Functional variables were strongly associated with QRFT, QRFA, and TTT in men, and PA with SPPB in both sexes.</div></div><div><h3>Conclusions</h3><div>The ECOSARC-2 study provides normative values of geometric mid-thigh muscle ultrasound parameters in community-dwelling older adults. These values are essential for determining sex-specific cut-off points for conditions such as sarcopenia, frailty, malnutrition, and for predicting relevant outcomes.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100608"},"PeriodicalIF":4.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma biomarkers for monitoring muscle function and physical performance decline in older adults: A 2-year longitudinal study","authors":"Tae-Hwan Gil ,&nbsp;Ji Yeon Kim ,&nbsp;Ji-Won Shin ,&nbsp;Dong-Hyun Jang ,&nbsp;Seung Shin Park ,&nbsp;Sang Wan Kim ,&nbsp;Chan Soo Shin ,&nbsp;Ok Hee Jeon ,&nbsp;Sung Hye Kong","doi":"10.1016/j.jnha.2025.100607","DOIUrl":"10.1016/j.jnha.2025.100607","url":null,"abstract":"<div><h3>Background</h3><div>Reliable biomarkers for diagnosing and monitoring sarcopenia remain limited, especially those reflecting longitudinal changes in muscle health. This study aimed to evaluate associations between plasma biomarkers and both cross-sectional and 2-year longitudinal changes in muscle mass, strength, and physical performance in older adults.</div></div><div><h3>Methods</h3><div>We analyzed plasma biomarkers in 93 participants (mean age: 74.3 years; 88% female) from a hospital-based longitudinal cohort. Biomarkers were quantified using ELISA, and multivariable regression analyses were conducted for sarcopenia components such as muscle mass, function, and performance, adjusting for age, sex, and body mass index (BMI).</div></div><div><h3>Results</h3><div>Leptin levels were negatively associated with both baseline and 2-year changes in appendicular lean mass indexed by ALM/height² and ALM/BMI after adjustments. DHEAS positively correlated with the baseline ALM/BMI, and IL-6 negatively correlated with a change in ALM/BMI. Regarding muscle function, higher baseline grip strength was associated with myostatin, DHEAS, and negatively with leptin and GDF-15. For physical performance, DHEAS and IGF-1 were positively associated with SPPB scores at the baseline, while IL-6 and GDF-15 were negatively associated with these. Notably, IL-6 was also positively associated with 2-year SPPB change.</div></div><div><h3>Conclusion</h3><div>These findings highlight the potential of specific plasma biomarkers to identify individuals at risk of sarcopenia-related functional decline and to serve as practical tools for monitoring sarcopenia progression in older adults.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100607"},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited association between multimorbidity and high-sensitive C-reactive protein or gait speed in community-dwelling octogenarians – findings from the BUTTERFLY study","authors":"Aziz Debain ,&nbsp;Veerle Knoop ,&nbsp;Axelle Costenoble ,&nbsp;Mirko Petrovic ,&nbsp;Ivan Bautmans","doi":"10.1016/j.jnha.2025.100603","DOIUrl":"10.1016/j.jnha.2025.100603","url":null,"abstract":"<div><h3>Background</h3><div>Biological age is a key determinant of disease progression and increased morbidity. However, it is unclear whether multimorbidity is associated with low-grade inflammation or gait speed in octogenarians.</div></div><div><h3>Aim</h3><div>To examine cross-sectional associations between commonly used comorbidity indices and either elevated high-sensitivity C-reactive protein (hsCRP) or reduced gait speed in community-dwelling non-frail adults aged 80 and older.</div></div><div><h3>Methods</h3><div>a total of 404 community-dwelling older adults (mean age: 83 ± 3 years) were assessed for multimorbidity, gait speed, and hscrp. five comorbidity indices were calculated: charlson comorbidity index, cumulative illness rating scale for geriatrics, elixhauser comorbidity index (eci), rockwood frailty index, and a weighted modified disease count. binary logistic regression was used to analyze associations with elevated hscrp (&gt;3.0 mg/l) and reduced gait speed (&lt;0.8 m/s).</div></div><div><h3>Results</h3><div>Of the indices evaluated, only the ECI showed a significant association with elevated hsCRP (adjusted odds ratio [aOR] = 1.18, 95% CI: 1.03–1.35; p = 0.020). When stratified by gender, this association remained significant in men (aOR = 1.29, 95% CI: 1.053–1.59; p = 0.014), but not in women. Furthermore, none of the comorbidity indices were significantly associated with low gait speed.</div></div><div><h3>Conclusion</h3><div>Among the comorbidity indices assessed, only the ECI demonstrated a modest yet significant association with hsCRP levels in individuals aged 80 years and older. In contrast, no significant associations were observed between any of the comorbidity indices and reduced gait speed in this population. This highlights the importance of comprehensive care, including individualized lifestyle interventions, nutritional support, and timely pharmacological adjustments for effective chronic disease management.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100603"},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulation and atrial fibrillation in prognostic models for type B aortic dissection","authors":"Amir Reza Akbari ,&nbsp;Benyamin Alam","doi":"10.1016/j.jnha.2025.100612","DOIUrl":"10.1016/j.jnha.2025.100612","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100612"},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}