Journal of Nutrition Health & Aging最新文献

{"title":"Decreased muscle strength and thigh muscle area assessed with CT imaging in older Chinese adults with long duration of type 2 diabetes","authors":"Yi Yuan ,&nbsp;Sidong Li ,&nbsp;Lu Yin ,&nbsp;Yongbin Su ,&nbsp;Zhe Guo ,&nbsp;Yandong Liu ,&nbsp;Glen M. Blake ,&nbsp;Ling Wang ,&nbsp;Yajun Liu ,&nbsp;Xiaoguang Cheng ,&nbsp;Klaus Engelke ,&nbsp;Annegreet G. Vlug","doi":"10.1016/j.jnha.2025.100506","DOIUrl":"10.1016/j.jnha.2025.100506","url":null,"abstract":"<div><h3>Objective</h3><div>We aimed to compare muscle strength, physical performance, and muscle parameters in non-diabetic and type 2 diabetes mellitus (T2DM) older adults and to determine the association of the duration of diabetes with these outcomes.</div></div><div><h3>Design</h3><div>A cross-sectional study.</div></div><div><h3>Setting</h3><div>The China Action on Spine and Hip Status study (CASH).</div></div><div><h3>Participants</h3><div>301 participants enrolled from a subcohort of CASH, of which 114 were diagnosed with well-controlled type 2 diabetes mellitus,</div></div><div><h3>Measurements</h3><div>We measured physical performance and muscle strength with the timed up-and-go test (TUG) and handgrip strength (HGS) and measured the area and density of the thigh, gluteus and trunk muscles (core muscles) using quantitative CT scans.</div></div><div><h3>Results</h3><div>Participants with long-term (≥10 years) diabetes had a longer TUG (β coefficient: 0.64 [95% CI, 0.06, 1.22]; <em>P</em> = 0.030) and a lower HGS (−2.29 [−4.48, −0.10]; <em>P</em> = 0.041) as well as a lower muscle area of the thigh (−7.10 [−13.44, −0.76]; <em>P</em> = 0.028). The lower HGS among patients with long-term (≥10 years) diabetes was largely mediated by muscle area of the thigh (compared with non-diabetic controls: percentage mediated, 38.3%; <em>P</em> = 0.023; compared with &lt;10 years diabetes: percentage mediated, 51.8%; <em>P</em> = 0.039).</div></div><div><h3>Conclusions</h3><div>Older adults with long-term (≥10 years) diabetes had lower TUG and HGS than either non-diabetic participants, and the difference in HGS was largely mediated by a decrease in muscle area of the thigh muscles. Our finding suggested that long duration of diabetes, even in well-controlled subjects, may be associated with poor physical functions.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100506"},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study","authors":"Olga Laosa ,&nbsp;Eva Topinkova ,&nbsp;Isabelle Bourdel-Marchasson ,&nbsp;Bruno Vellas ,&nbsp;Mikel Izquierdo ,&nbsp;Giusseppe Paolisso ,&nbsp;Timothy Hardman ,&nbsp;Andrej Zeyfang ,&nbsp;Laura Pedraza ,&nbsp;Jose A. Carnicero ,&nbsp;Leocadio Rodriguez-Mañas ,&nbsp;Alan J. Sinclair ,&nbsp;on behalf of the MIDFRAIL consortium","doi":"10.1016/j.jnha.2025.100512","DOIUrl":"10.1016/j.jnha.2025.100512","url":null,"abstract":"<div><h3>Aims</h3><div>Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after ≥18 months of intervention.</div></div><div><h3>Methods</h3><div>298 community-dwelling older adults (&gt;70 years) participating in MIDFRAIL followed-up for 18–24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341).</div></div><div><h3>Results</h3><div>Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried’s frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3–5.4; p = 0.009 and OR 1.9; 95%CI 1.1−3.1; p = 0.02, respectively). IG participants more frequently improved ≥1 point in SPPB score (OR 1.85; 95%CI 1.09–3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants.</div></div><div><h3>Conclusions</h3><div>The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100512"},"PeriodicalIF":4.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticholinergic drug exposure is associated with prevalence, worsening and incidence of dysphagia among hospitalized older adults","authors":"Lucia Muglia ,&nbsp;Alessia Beccacece ,&nbsp;Luca Soraci ,&nbsp;Ramona Caloiero ,&nbsp;Franco Arturi ,&nbsp;Paolo Fabbietti ,&nbsp;Mirko Di Rosa ,&nbsp;Jacopo Sabbatinelli ,&nbsp;Giada Ida Greco ,&nbsp;Elvira Filicetti ,&nbsp;Mara Volpentesta ,&nbsp;Alberto Montesanto ,&nbsp;Ersilia Paparazzo ,&nbsp;Antonio Cherubini ,&nbsp;Massimiliano Fedecostante ,&nbsp;Chiara Chinigò ,&nbsp;Maria Capalbo ,&nbsp;Andrea Corsonello ,&nbsp;Fabrizia Lattanzio","doi":"10.1016/j.jnha.2025.100507","DOIUrl":"10.1016/j.jnha.2025.100507","url":null,"abstract":"<div><h3>Objectives</h3><div>In this study, we aimed at evaluating the association between anticholinergic drug exposure and prevalence, worsening, and incidence of dysphagia among hospitalized older individuals.</div></div><div><h3>Design and setting</h3><div>We used data from the REPORT-Age project, a multicenter cohort study including patients aged 65 years or more, admitted to acute care hospitals of the Italian National Institute for Health and Sciences on Aging (INRCA-IRCCS) between 2011 and 2019.</div></div><div><h3>Participants</h3><div>4,005 older patients aged 84.7 (SD = 6.6) years underwent comprehensive geriatric examination according to the interRAI minimum dataset for acute care (MDS-AC), at both hospital admission and discharge.</div></div><div><h3>Measurements</h3><div>Both prevalence and severity of dysphagia were assessed through items of subjective evaluation included in the section K3 of MDS-AC questionnaire; the anticholinergic drug exposure was measured by means of CRIDECO Anticholinergic Load Scale (CALS) and Anticholinergic Cognitive Burden (ACB) scales. Next, we used logistic regression models to evaluate the association between anticholinergic burden and prevalence of dysphagia at hospital admission; Kaplan Meier cumulative probability curves and cox proportional hazard models were used to analyze the association between anticholinergic burden at hospital admission and worsening or incidence of dysphagia during hospital stay.</div></div><div><h3>Results</h3><div>Out of 4,005 patients included, 1,070 (30%) presented dysphagia at hospital admission. High anticholinergic burden was associated with increased prevalence of dysphagia at hospital admission (<em>p</em> &lt; 0.001). Moreover, patients with high anticholinergic burden (ACB and CALS ≥ 2) were at increased risk of dysphagia worsening during hospital stay (HR, 95%CI: 1.14, 1.06−1.22 and 1.12, 1.03−1.23 for ACB and CALS respectively). Among the 2,935 patients with normal swallowing function at hospital admission, high anticholinergic burden was associated with the incidence of dysphagia at hospital discharge (HR, 95% CI: 1.89, 1.21−2.96 and 1.86, 1.14−3.06 for ACB and CALS respectively). Development of dysphagia during hospital stay was associated with a reduced prescription of anticholinergic medications (ORs, 95% CI 1.13 (1.07–1.20) and 1.08 (1.01–1.15) for ACB and CALS, respectively).</div></div><div><h3>Conclusions</h3><div>Increased anticholinergic burden was associated with the prevalence, worsening, and incidence of dysphagia among older hospitalized patients.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100507"},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Protein-enriched oral nutritional supplements on muscle function in middle-aged and elderly women: A randomized controlled trial","authors":"Minji Kang ,&nbsp;Hyunkyung Rho ,&nbsp;Minhui Kim ,&nbsp;Miji Lee ,&nbsp;Yunsook Lim ,&nbsp;Jinmann Chon ,&nbsp;Hyunjung Lim","doi":"10.1016/j.jnha.2025.100508","DOIUrl":"10.1016/j.jnha.2025.100508","url":null,"abstract":"<div><h3>Objectives</h3><div>This study evaluated the effects of protein-enriched oral nutritional supplementation (ONS) consumption for 12 weeks on muscle mass, muscular strength, and function in middle-aged and elderly women.</div></div><div><h3>Design</h3><div>A single-center, double-blind, randomized controlled trial</div></div><div><h3>Participants</h3><div>This study was conducted with 70 healthy female participants aged 50–80.</div></div><div><h3>Intervention and measurements</h3><div>Participants were instructed to incorporate two daily packs of either the test ONS (Nucare Active, Daesang Wellife Corp., Seoul, Republic of Korea; 200 kcal/pack, 23 g carbohydrate, 6 g fat, and 15 g protein including branched chain amino acids or placebo ONS (200 kcal/pack, 33 g carbohydrate, 8 g fat, and 1 g protein) into their routine for 12 weeks while maintaining their regular lifestyle. The primary outcome was lean body mass (LBM), while secondary outcomes included muscular strength, physical performance ability, inflammatory markers, and body fat mass (FM).</div></div><div><h3>Results</h3><div>Sixty-four participants (33 in the test group, 31 in the placebo group; mean ± SD age, [test] 63.06 ± 5.51 years, [placebo] 63.29 ± 3.28 years, <em>p</em> = 0.839) completed the 12-week protocol. The test group exhibited a higher percentage change in LBM than the placebo group (0.26 % [95%CI: −0.27, 0.78] vs. −0.47 % [95%CI: −0.81, −0.13]; <em>p</em> = 0.020). The placebo group experienced a significant increase in FM (38.15 % [95%CI: 36.62, 39.69] to 38.67 % [95%CI: 37.14, 40.21]; <em>p</em> &lt; 0.01). The difference in the changes in LBM/BMI and FM/BMI between the two groups was also visually distinct. There were no significant differences between the two groups in terms of muscular strength, physical performance ability, or inflammatory markers.</div></div><div><h3>Conclusions</h3><div>Protein-enriched ONS helped maintain LBM and prevent FM gain in middle-aged and elderly females. This suggests its potential role in preventing frailty and musculoskeletal disorders associated with female aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 5","pages":"Article 100508"},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of cardiovascular–kidney–metabolic syndrome stages with premature mortality and the role of social determinants of health","authors":"Ruixin Zhu ,&nbsp;Ran Wang ,&nbsp;Jingjing He ,&nbsp;Langrun Wang ,&nbsp;Huiyu Chen ,&nbsp;Yifan Wang ,&nbsp;Peng An ,&nbsp;Keji Li ,&nbsp;Fazheng Ren ,&nbsp;Weili Xu ,&nbsp;J. Alfredo Martinez ,&nbsp;Anne Raben ,&nbsp;Jie Guo","doi":"10.1016/j.jnha.2025.100504","DOIUrl":"10.1016/j.jnha.2025.100504","url":null,"abstract":"<div><h3>Objectives</h3><div>The American Heart Association defined cardiovascular–kidney–metabolic (CKM) syndrome as a novel multi-stage disorder. We examined the associations of CKM stages with premature mortality and the role of social determinants of health (SDOHs).</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting and participants</h3><div>A nationally representative sample of US adults from NHANES 1999–2018.</div></div><div><h3>Measurements</h3><div>CKM included 5 stages (stages 0–4), reflecting progressive pathophysiology. Premature mortality (deaths before 75 years) were ascertained via linkage to the National Death Index with follow-up until 2019. Cox proportional-hazards models adjusted for age, sex, race/ethnicity, medical history, and other confounding factors were used to calculate the hazard ratios (HR) and 95% CIs for CKM-mortality associations.</div></div><div><h3>Results</h3><div>Among 27,909 participants (mean age 49.7 years, 49.0% females), 1762 premature deaths occurred over a median follow-up of 8.3 years. Compared with stage 0, the adjusted HRs for all-cause premature mortality at CKM stages 1–4 were 0.88 (95% CI 0.66–1.17), 1.31 (0.99–1.73), 1.94 (1.31–2.87), and 2.19 (1.61–2.98), respectively. For CVD premature mortality, the adjusted HRs for CKM stages 1–4 were 1.12 (0.46–2.72), 1.74 (0.71–4.28), 3.93 (1.53–10.12), and 6.48 (2.95–14.20), respectively. Among adults at CKM stages 3–4, unfavorable SDOHs, particularly not living with a partner, low family income, lack of private health insurance, unemployment, or ≥2 cumulative SDOHs (4.16, 95% CI 3.35–5.18) were associated with increased all-cause premature mortality. Among those at CKM stages 0–2, unfavorable SDOHs were also related to increased premature mortality.</div></div><div><h3>Conclusion</h3><div>CKM stages 3–4, but not stages 1–2, were associated with increased risks of premature mortality compared with stage 0. The risks were increased by unfavorable SDOHs across CKM stages.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100504"},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition to retirement impact on food consumption frequency: results from a longitudinal analysis within the Survey of Health, Ageing and Retirement in Europe (SHARE)","authors":"Giacomo Pietro Vigezzi ,&nbsp;Paola Bertuccio ,&nbsp;Marialaura Bonaccio ,&nbsp;Lucia Palandri ,&nbsp;Augusto Di Castelnuovo ,&nbsp;Elena Righi ,&nbsp;Licia Iacoviello ,&nbsp;Mariangela Rondanelli ,&nbsp;Marco Vinceti ,&nbsp;Anna Odone","doi":"10.1016/j.jnha.2025.100503","DOIUrl":"10.1016/j.jnha.2025.100503","url":null,"abstract":"<div><h3>Objectives</h3><div>It has been suggested that major life course transitions, such as retirement, can greatly impact lifestyles. However, the evidence is scant and inconclusive, especially with reference to the effects on dietary habits. We investigated the long-term effects of retirement on the frequency of food consumption using data from the Survey of Health, Ageing, and Retirement in Europe (SHARE).</div></div><div><h3>Design and participants</h3><div>We used data from a SHARE-based cohort, including European individuals from 28 countries aged 50 and older who were employed at baseline and retired during follow-up time (2004–2020).</div></div><div><h3>Measurements</h3><div>Dietary habits were assessed through self-reported frequencies of consumption for fruit and vegetables, dairy products, meat and fish, legumes and eggs. A dietary score (dichotomised as ≥5 or &lt;5) was also estimated. Generalised estimating equation models calculated relative risks (RR) of daily (for fruit, vegetables and dairy products) and 3−6 times per week (for meat, fish, legumes and eggs) consumptions before and after retirement, adjusting for selected variables.</div></div><div><h3>Results</h3><div>The cohort included 8,998 individuals with a mean follow-up time of 9 years. Baseline daily consumption frequencies were 73.7% for fruit and vegetables and 65.9% for dairy products, while 3−6 times per week frequencies were 39.8% for meat and fish and 26.1% for legumes and eggs. An increase in 3−6 times a week consumption of meat and fish (RR 1.07, 95% CI 1.01–1.13) and legumes and eggs (RR 1.09, 95% CI 1.01–1.17) was observed 10 or more years post-retirement. Daily consumption of fruit and vegetables, and dairy products remained stable. The RR of a dietary score ≥5 post-retirement was 1.11 (95% CI 1.06–1.16, 10 or more years after).</div></div><div><h3>Conclusions</h3><div>Retirement positively appears to influence overall dietary habits, particularly by improving the consumption frequency of protein-rich foods, while the stability in fruit, vegetables, and dairy consumption suggests that well-established habits persist despite life transitions.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100503"},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated biological aging and risk of inflammatory bowel disease: A prospective study from 401,013 participants","authors":"Baolong Cao ,&nbsp;Xiaoke Zhao ,&nbsp;Zhixi Lu ,&nbsp;Hongmei Zhang","doi":"10.1016/j.jnha.2025.100505","DOIUrl":"10.1016/j.jnha.2025.100505","url":null,"abstract":"<div><h3>Objectives</h3><div>Relationship between biological aging and inflammatory bowel disease (IBD) remains unclear. We aimed to explore the associations of biological age and genetic predisposition with IBD and the predictive ability.</div></div><div><h3>Methods</h3><div>Biological age and genetic predisposition were measured by PhenoAge and the polygenic risk score (PRS), respectively. The hazard ratio (HR) and 95% confidence interval (CI) of PhenoAge and combined PRS for Crohn’s disease (CD) and ulcerative colitis (UC) were evaluated by Cox proportional hazards models. Additive interactions were examined to evaluate the joint effect. C statistic was employed to assess the predictive ability.</div></div><div><h3>Results</h3><div>During the follow-up period of 5,320,311 person-years of 401,013 participants, 2467 patients with UC and 1262 patients with CD were observed. PhenoAge showed a significant association with an increased risk of incident IBD. Each standard deviation of PhenoAge acceleration correlated with a 38% (95% CI: 34%–41%), 35% (95% CI: 30%–38%), and 46% (95% CI: 41%–51%) increased risk of IBD, UC, and CD, respectively. Joint effects and additive interactions were noted between PhenoAge and the PRS. Individuals with a high PRS and the highest PhenoAge acceleration had the highest risk for UC (HR: 9.16, 95% CI: 7.08–11.85) and CD (7.72, 6.05–9.86), respectively. Incorporating PhenoAge and the PRS could enhance the accuracy of predicting IBD, with a highest C statistic of 0.71 for UC and 0.72 for CD.</div></div><div><h3>Conclusion</h3><div>Accelerated biological aging is associated with an increased risk of IBD, particularly in individuals with high genetic predisposition. Identifying individuals with accelerated biological aging has significant implications for reducing IBD risk.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100505"},"PeriodicalIF":4.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Growth Differentiation Factor 15 is Negatively Associated with Leukocyte Telomere Length","authors":"Jie Yu,&nbsp;Yiwen Liu,&nbsp;Huabing Zhang,&nbsp;Fan Ping,&nbsp;Wei Li,&nbsp;Lingling Xu,&nbsp;Yuxiu Li","doi":"10.1016/j.jnha.2025.100493","DOIUrl":"10.1016/j.jnha.2025.100493","url":null,"abstract":"<div><h3>Background</h3><div>Telomere length(TL)and mitochondrial DNA copy number(mtDNAcn) are classic biomarker of aging. Recently, growth differentiation factor 15(GDF15) has attracted considerable attention as a vital component in the aging process.</div></div><div><h3>Methods</h3><div>The present study aimed to study the relationship between GDF15 and telomere length and mtDNAcn.This was a cross-sectional analysis nested in a longitudinal cohort study conducted in Changping District, Beijing, from 2014 to 2021. Serum GDF15,leukocyte lelomere length(LTL) and mtDNAcn were determined in 802 subjects.LTL and mtDNAcn was quantified by real-time PCR assay. Multivariate linear regression and restricted cubic spline diagram were used for statistical analysis.</div></div><div><h3>Results</h3><div>Subjects with higher GDF15 were older,had larger waist circumference, higher systolic blood pressure and glycated hemoglobin A1c (HbA1c),shorter LTL and tended to had less mtDNAcn. In correlation analysis, GDF15 was positively correlated with age, while LTL and mtDNAcn were negatively correlated with age.After adjusting for confounding factors,GDF15 was negatively associated with LTL (β = −0.120, 95%CI [−0.197, −0.042], p = 0.003) and the association was linear(p for nonlinear = 0.645), while the negative association between GDF15 and mtDNAcn did not reach significance.In the stratified analyses,the negative associations between GDF15 and LTL were more prominent in women, overweight individuals, or subjects with abnormal glucose tolerance (AGT), but similar results were observed in younger and older subjects.</div></div><div><h3>Conclusions</h3><div>This study found a linear negative association between GDF 15 and LTL,which was more prominent in women, overweight or AGT subjects.These results supported that GDF15 might be a reliable biomarker of aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 4","pages":"Article 100493"},"PeriodicalIF":4.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143133178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes on the progression of Alzheimer’s disease via trajectories of amyloid–tau–neurodegeneration (ATN) biomarkers","authors":"Eun Woo Kim ,&nbsp;Keun You Kim ,&nbsp;Eosu Kim ,&nbsp;for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.jnha.2024.100444","DOIUrl":"10.1016/j.jnha.2024.100444","url":null,"abstract":"<div><h3>Background</h3><div>Alzheimer’s disease (AD) is characterized by the accumulation of abnormal proteins, such as β-amyloid and tau, in the brain, which precedes cognitive impairment. Although diabetes mellitus (DM) is a well-established risk factor for AD, few studies have investigated how the presence of DM affects the sequential pathogenesis of AD, specifically within the amyloid-tau-neurodegeneration (ATN) and cognition framework.</div></div><div><h3>Objectives</h3><div>This study aims to investigate the trajectories of ATN biomarkers in relation to the presence of DM in the preclinical and prodromal stages of AD.</div></div><div><h3>Design</h3><div>Participants with normal cognition (CN) or mild cognitive impairment (MCI) at baseline were included. Subjects were followed for 12–192 months, with neuroimaging and cognitive assessments conducted at every 12 or 24 months.</div></div><div><h3>Setting</h3><div>This study utilized data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database.</div></div><div><h3>Participants</h3><div>A total of 603 participants aged 55–90 years were included, comprising 284 CN (25 with DM, 259 without DM) and 319 MCI (39 with DM, 280 without DM) individuals.</div></div><div><h3>Measurements</h3><div>ATN biomarkers were identified using florbetapir positron emission tomography (PET), flortaucipir PET, and magnetic resonance imaging (MRI), respectively. Cognition was assessed using the Clinical Dementia Rating-Sum of Boxes (CDR-SB) and Mini-Mental State Examination (MMSE). Moderation analysis was conducted to investigate the effect of DM on the association between ATN biomarkers of AD.</div></div><div><h3>Results</h3><div>Elevated amyloid standardized uptake value ratios (SUVRs) were associated with increased tau levels in the hippocampus, and this association was significantly enhanced by the presence of DM in MCI participants (p = 0.021). DM also strengthened the association between increased tau SUVR levels and neurodegeneration (indicated by decreased entorhinal cortical volumes; p = 0.005) in those with MCI. Furthermore, DM enhanced the association of decreased entorhinal (p = 0.012) and middle temporal cortex (p = 0.031) volumes with increased (worsened) CDR-SB scores in MCI participants. However, DM did not predict significant longitudinal changes in ATN pathology or cognitive decline in CN participants.</div></div><div><h3>Conclusions</h3><div>Our study suggests that DM may increase the risk of AD by accelerating each step of the A-T-N cascade in the prodromal stage of AD, underscoring the importance of DM management in preventing the MCI conversion to AD.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100444"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal association between ADL disability and depression in middle-aged and elderly: national cohort study","authors":"Siru Wang ,&nbsp;Minglan Yu ,&nbsp;Wenyi Huang ,&nbsp;Tingting Wang ,&nbsp;Kezhi Liu ,&nbsp;Bo Xiang","doi":"10.1016/j.jnha.2024.100450","DOIUrl":"10.1016/j.jnha.2024.100450","url":null,"abstract":"<div><h3>Background</h3><div>The decline in daily living abilities (ADL) among older adults is a notable predictor of depressive symptoms and the occurrence of disease. However, the effects of changes in ADL disability on the progression of depression have not been extensively studied.</div></div><div><h3>Objective</h3><div>This research aims to examine the relationship between current ADL disability and depression in individuals aged 45 and older, as well as to explore how ADL disability influences the progression of depression in later life within China.</div></div><div><h3>Methods</h3><div>This study analyzed 7-year data from the China Health and Retirement Longitudinal Study (CHARLS), involving 2,205 middle-aged and older adults. The ADL disability (BADL: such as eating, dressing; IADL: such as shopping, cooking) were obtained using ADL scale (scores 0–12, lower is better), and depression was measured by the Center for Epidemiologic Studies Depression Scale (scores 0–30, lower is better). The latent growth curve and cross-lagged models were analyzed after adjusting relevant control variables to study the effect of ADL disability on the progression of depression.</div></div><div><h3>Results</h3><div>The mean values for depression, basic activities of daily living (BADL), and instrumental activities of daily living (IADL) varied from 9.44 to 11.08, 6.45 to 6.81, and 6.86 to 7.29, respectively. The analysis indicated a potential association between depression and ADL. Specifically, the trajectory of BADL was a significant predictor of both initial depression (<em>β</em> = 0.138, 95%CI = 0.039−0.237) and its trajectory (<em>β</em> = 0.579, 95%CI = 0.403−0.754). Although IADL did not significantly predict the trajectory of depression, it was a significant predictor of initial depression (<em>β</em> = 0.471, 95%CI = 0.404−0.538). Additionally, cross-lag regression analysis provided further support for the relationship between depression and BADL disability.</div></div><div><h3>Conclusions</h3><div>This research highlights how ADL disability can forecast future depression in Chinese middle-aged and older adults. The findings indicate a significant connection between ADL disability and both changes in and future instances of depression in this group. Therefore, it is crucial for the Chinese government to prioritize interventions that enhance physical functioning in the elderly, as such measures can effectively mitigate the worsening of depression and promote positive aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 2","pages":"Article 100450"},"PeriodicalIF":4.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}