Journal of Nutrition Health & Aging最新文献

{"title":"Evidence paradox: Enhancing clinical trials for older adults","authors":"Liang-Kung Chen","doi":"10.1016/j.jnha.2025.100597","DOIUrl":"10.1016/j.jnha.2025.100597","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100597"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sensory impairment and cognitive frailty among older people: Evidence from four nationwide cohort studies","authors":"Xiaoming Zhang ,&nbsp;Rui Zeng ,&nbsp;Aizhang Zhu ,&nbsp;Fayi Xie ,&nbsp;Dongmei Ye ,&nbsp;Lihuan Chen ,&nbsp;Yi Xiao ,&nbsp;Ke Zhu ,&nbsp;Tenghui Fan ,&nbsp;Wan Zhu ,&nbsp;Zhigang Wu ,&nbsp;Mengxia Shi ,&nbsp;Yuxu Huang ,&nbsp;Jiahui Bian ,&nbsp;Shixuan Wang ,&nbsp;Ziyun Lv ,&nbsp;Ruzhao Chen ,&nbsp;Yufei Zeng ,&nbsp;Jiang Wang ,&nbsp;Qingli Dou ,&nbsp;Wenwu Zhang","doi":"10.1016/j.jnha.2025.100590","DOIUrl":"10.1016/j.jnha.2025.100590","url":null,"abstract":"<div><h3>Background</h3><div>Sensory impairment, including hearing and vision impairment, are prevalent in older adults and may significantly contribute to cognitive frailty. However, the longitudinal association between sensory impairment and cognitive frailty has not been fully explored. The aim of our study was to examine such associations in four nationally representative cohorts to inform strategies for preventing cognitive frailty and promoting healthy aging.</div></div><div><h3>Methods</h3><div>Data were pooled from four large, longitudinal cohorts: the Health and Retirement Study (HRS), the Chinese Longitudinal Healthy Longevity Survey (CLHLS), the Survey of Health, Ageing and Retirement in Europe (SHARE), and the English Longitudinal Study of Ageing (ELSA). The analysis included 37,076 older adults from these cohorts, with comparable measures of sensory impairment and cognitive frailty across studies. Sensory impairments were assessed via self-reported hearing impairment and vision impairment. The outcome was the incidence of cognitive frailty, assessed using self-reported cognitive function and frailty indicators. Cox regression models were used to evaluate the association between hearing impairments, vision impairments and dual sensory impairment with cognitive frailty risk, adjusting for potential confounders.</div></div><div><h3>Results</h3><div>The cohort had a mean (SD) age of 74.60 (6.61) years for HRS (41.41% male), 81.87 (10.50) years for CLHLS (48.10% male), 72.99 (6.12) years for SHARE (44.27% male), and 73.03 (6.22) years for ELSA (46.59%% male). The prevalence of cognitive frailty was 10.58% for HRS, 6.26% for CLHLS, 12.16% for SHARE, and 5.81% for ELSA. The prevalence of dual sensory impairment was 8.05% for HRS, 3.06% for CLHLS, 10.94% for SHARE, and 4.06% for ELSA. Cox regression revealed a significant synergistic effect between hearing impairment and vision impairment on cognitive frailty risk. Compared to no sensory impairments individuals, those with hearing impairments or vision impairments had a higher risk of cognitive frailty across all cohorts, with individuals with dual sensory impairment exhibiting the highest risk: HRS (Hazard Ratio [HR] = 2.10, 95% CI, 1.71–2.56), CLHLS (HR = 2.08, 95% CI, 1.37–3.15), SHARE (HR = 1.52, 95% CI, 1.35–1.71), and ELSA (HR = 2.77, 95% CI, 1.78–4.31).</div></div><div><h3>Conclusions</h3><div>This study identifies an association between combined hearing and vision impairments and an increased risk of cognitive frailty. These findings suggest that assessing sensory impairments, particularly dual sensory impairment, in older adults may help identify individuals at higher risk of cognitive frailty. Further research, including longitudinal studies and randomized controlled trials, is needed to explore the potential benefits of early sensory interventions for supporting healthy aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100590"},"PeriodicalIF":4.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fear of falling on social engagement among older adults: A nationwide longitudinal panel study","authors":"Jae Hyeok Lim ,&nbsp;Min Jeong Joo ,&nbsp;Jisu Ko ,&nbsp;Dan Bi Kim ,&nbsp;Eun-Cheol Park ,&nbsp;Min Jin Ha","doi":"10.1016/j.jnha.2025.100589","DOIUrl":"10.1016/j.jnha.2025.100589","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Fear of falling (FoF) is characterized by persistent concerns about falling, and empirical investigations are needed to examine the influence of perceived FoF on the broader and more active dimensions of social functioning. This study aims to explore the association between FoF and social participation in older adults, as well as the effects of changes in status over time.</div></div><div><h3>Methods</h3><div>This longitudinal panel study analyzed data from eight waves (2006–2020) of the Korean Longitudinal Study of Aging, comprising 8,632 participants aged 60 years and older (3,735 males and 4,897 females). FoF and activity restriction were assessed, with social engagement defined as involvement in at least one formal social activity, and the frequency of participation was also measured. Additionally, these statuses were categorized to reflect changes from the previous wave. Generalized estimating equation models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Over a mean follow-up period of 8.94 years, the average level of social engagement, accounting for variations across all waves, was 73.1% among males and 66.5% among females. Compared to the no FoF group, individuals who had FoF exhibited significantly lower likelihoods of engaging in formal social activity in males (OR: 0.77, CI: 0.67–0.87) and females (OR: 0.84, CI: 0.75–0.94), while those with both FoF and activity restriction exhibited even lower odds of engagement (males, OR: 0.53, CI: 0.44–0.63; females, OR: 0.72, CI: 0.63–0.83). Additionally, FoF is associated with a tendency to impede newly initiated or ongoing social engagements, with more pronounced effects observed in individuals who reported persistent FoF over time.</div></div><div><h3>Conclusions</h3><div>FoF is associated with reduced social engagement in older adults, and therefore, individuals with FoF may require special attention to prevent negative health outcomes resulting from social isolation caused by FoF.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100589"},"PeriodicalIF":4.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations regarding biomarker selection in the CHARLS-based study of serum uric acid and accelerated aging","authors":"Qingyi Zhou ,&nbsp;Xiaoqi Ma ,&nbsp;Peiyu Zhu ,&nbsp;Liang Chu","doi":"10.1016/j.jnha.2025.100588","DOIUrl":"10.1016/j.jnha.2025.100588","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100588"},"PeriodicalIF":4.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between accelerometer-measured physical activity and mortality in cancer survivors: A prospective cohort study from UK Biobank","authors":"Zhihan Jiang ,&nbsp;Bingyan Wang ,&nbsp;Yifei Zhao ,&nbsp;Jing Weng ,&nbsp;Jiaojiao Liao ,&nbsp;Liyuan Tao ,&nbsp;Kui Sun ,&nbsp;Zhipeng Zhang ,&nbsp;Xin Zhou ,&nbsp;Wei Fu","doi":"10.1016/j.jnha.2025.100586","DOIUrl":"10.1016/j.jnha.2025.100586","url":null,"abstract":"<div><h3>Objectives</h3><div>Postdiagnosis physical activity is an important component of healthy lifestyle in cancer survivors. In this study, we aimed to explore the association between intensity and duration of physical activity measured by wearable accelerometers and mortality among pan-cancer survivors.</div></div><div><h3>Methods</h3><div>A prospective cohort study involving cancer survivors (<em>n</em> = 11,708) from UK Biobank was performed. All participants had thorough physical activity data that was measured by wrist-worn accelerometers. Restricted cubic splines and multivariate Cox proportional hazards models were employed to assess the dose-response associations between physical activity time at varying intensities and both all-cause and cancer-specific mortality.</div></div><div><h3>Results</h3><div>During a median follow-up of 8.9 years, a total of 983 deaths occurred, including 656 cancer-related deaths. Multivariate models identified significant dose-response associations between moderate to vigorous-intensity physical activity (MVPA) time and mortality. Hazard ratios (HRs) for all-cause mortality were 0.64 (95% CI, 0.54–0.76), 0.61 (95% CI, 0.51–0.74) and 0.52 (95% CI, 0.42–0.66) in participants with MVPA time of 272–407, 407–579 and ≥579 min per week, respectively. HRs for cancer-specific mortality were 0.71 (95% CI, 0.58–0.88), 0.69 (95%CI, 0.55–0.87) and 0.61 (95%CI, 0.47–0.81) for the aforementioned groups. Similar patterns were observed for moderate-intensity physical activity but not for light-intensity physical activity. Survival benefits of active physical activity were pronounced in cancers from multiple organs.</div></div><div><h3>Conclusions</h3><div>Active physical activity substantially reduced all-cause mortality in pan-cancer survivors and cancer-specific mortality in cancer survivors of specific sites. However, the benefits were significant only when intensity of physical activity reached moderate to vigorous level.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100586"},"PeriodicalIF":4.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the methodology of clinical trials for aging populations: A call to innovation, inclusion, and global relevance","authors":"Emanuele Marzetti ,&nbsp;Riccardo Calvani ,&nbsp;Hélio Jose Coelho-Junior","doi":"10.1016/j.jnha.2025.100587","DOIUrl":"10.1016/j.jnha.2025.100587","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100587"},"PeriodicalIF":4.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effect of nutritional support in geriatric inpatients classified by the GLIM criteria","authors":"Shan Jiang ,&nbsp;Xiling Chen ,&nbsp;Lan Ma ,&nbsp;Qihao Guo ,&nbsp;Lan Luo ,&nbsp;Yuehui Wang ,&nbsp;Xuan Qu ,&nbsp;Jiaojiao Li ,&nbsp;Liping An ,&nbsp;Wei Huang ,&nbsp;Yonghua Wu ,&nbsp;Hongyu Zhang ,&nbsp;Cuntai Zhang ,&nbsp;Yun Fan ,&nbsp;Songbai Zheng ,&nbsp;Jian Cao ,&nbsp;Xiaohong Liu","doi":"10.1016/j.jnha.2025.100585","DOIUrl":"10.1016/j.jnha.2025.100585","url":null,"abstract":"<div><h3>Objectives</h3><div>In this study, we aimed to explore the impact of nutrition therapy on clinical outcomes for patients classified according to the Global Leadership Initiative on Malnutrition (GLIM) criteria.</div></div><div><h3>Design</h3><div>Prospective, multicenter cohort study.</div></div><div><h3>Setting</h3><div>This study was conducted from September 2020 to December 2022 across 28 geriatric centers in China.</div></div><div><h3>Participants</h3><div>A total of 862 patients aged ≥65 years were included.</div></div><div><h3>Intervention</h3><div>All participating physicians completed a 6-h training on nutritional support, following international guidelines before the study. Patients had a nutritional risk screening 2002 score ≥3 points within 48 h of admission. Physicians determined specific nutritional support regimens.</div></div><div><h3>Measurements</h3><div>GLIM assessments were conducted after enrollment. Nutritional and functional statuses were evaluated at baseline and 90 days after admission. Clinical outcomes—mortality, readmission, new infections, and falls—were documented after 90 days.</div></div><div><h3>Results</h3><div>Compared to 108 patients without malnutrition per the GLIM criteria, 754 malnourished patients showed lower weight, body mass index (BMI), and Mini Nutritional Assessment-Short Form (MNA-SF) scores and significant reductions in grip strength, calf circumference, and Barthel activities of daily living (ADLs) index. The percentage of patients with adequate caloric intake at the 90-day follow-up was 70.7% (<em>n</em> = 533) and 67.6% (<em>n</em> = 73) in the malnutrition and non-malnutrition groups (<em>p</em> = 0.51) and that of patients with adequate protein intake was 65.9% (<em>n</em> = 497) and 58.3% (<em>n</em> = 63), respectively (<em>p</em> = 0.12). Moreover, malnourished patients showed significant improvements in body weight, BMI, MNA-SF scores, calf circumference, and Barthel ADL index compared to those without malnutrition. Malnourished patients also had lower risks of readmission and falls at follow-up.</div></div><div><h3>Conclusion</h3><div>Among older inpatients at nutritional risk, those with malnutrition classified according to the GLIM criteria benefited from nutritional support, demonstrating improved BMI, MNA-SF scores, calf circumference, and Barthel ADL index, as well as reduced readmission rates and incidence of falls.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100585"},"PeriodicalIF":4.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social isolation, healthy lifestyle, and intrinsic capacity among older adults in China: A longitudinal study","authors":"Xiao Yue ,&nbsp;Quan Yuan ,&nbsp;Rong Zhou ,&nbsp;Mei Wang","doi":"10.1016/j.jnha.2025.100583","DOIUrl":"10.1016/j.jnha.2025.100583","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate the independent and interactive associations of social isolation and a healthy lifestyle on intrinsic capacity (IC) among older adults in China.</div></div><div><h3>Design and setting</h3><div>A longitudinal cohort study was conducted using data from the China Health and Retirement Longitudinal Study (CHARLS), spanning three waves (2011, 2013, and 2015) and involving adults aged 60 years and older.</div></div><div><h3>Participants</h3><div>A total of 4495 older adults with complete data on IC, social isolation, healthy lifestyle, and relevant covariates at baseline were included in the final analysis.</div></div><div><h3>Measurements</h3><div>IC was assessed using a composite score across five domains: locomotor, cognitive, sensory, vitality, and psychological. Social isolation was measured using an index based on living arrangements, marital status, contact with children, and social participation. A healthy lifestyle was defined based on five factors: smoking, alcohol consumption, physical activity, sleep duration, and body mass index (BMI). Multiple linear regression and linear mixed-effects models were used to examine cross-sectional and longitudinal associations. Interactive terms between social isolation and a healthy lifestyle were analyzed. Sensitivity analyses were performed by stratifying participants by age and gender.</div></div><div><h3>Results</h3><div>At baseline, 31.0%, 62.3%, and 6.7% of participants had social isolation scores of 0, 1−2, and 3−4, respectively, while 28.5%, 37.0%, and 34.6% had healthy lifestyle scores of 0−2, 3, and 4−5, respectively. Compared to participants with no social isolation (score = 0), the IC scores decreased for participants with social isolation scores of 1−2 and 3−4 (β = −0.36, 95% confidence interval [CI]: −0.42 to −0.30) and (β = −0.65, 95% CI: −0.77 to −0.53), respectively. In contrast, adherence to a healthy lifestyle was associated with improved IC (β = 0.27, 95% CI: 0.20 to 0.34 for score 3; β = 0.54, 95% CI: 0.47 to 0.60 for score 4−5). Interactive analysis showed that a healthy lifestyle mitigated the adverse associations of social isolation on IC, but this protective effect weakened as social isolation increased. Sensitivity analyses confirmed the robustness of these findings.</div></div><div><h3>Conclusion</h3><div>This study identified significant associations between social isolation, healthy lifestyle, and intrinsic capacity in older Chinese adults. Social isolation was negatively associated with IC, while a healthy lifestyle was positively associated with IC. The observed interaction between social isolation and healthy lifestyle highlights the importance of integrated interventions targeting both social engagement and health behaviors in supporting IC during aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100583"},"PeriodicalIF":4.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culture-sensitive lifestyle intervention tailored to non-Western migrant older adults improves physical performance: A randomized controlled trial","authors":"Esmée J.M. Biersteker ,&nbsp;Jantine van den Helder ,&nbsp;Nannette van der Spek ,&nbsp;Mieke Holwerda ,&nbsp;Hinke Kruizenga ,&nbsp;Peter J.M. Weijs ,&nbsp;Michael Tieland","doi":"10.1016/j.jnha.2025.100584","DOIUrl":"10.1016/j.jnha.2025.100584","url":null,"abstract":"<div><h3>Objectives</h3><div>To counteract sarcopenia in non-Western migrant older adults, lifestyle interventions with increased physical activity and adequate dietary protein intake are promising. However, regular community-based lifestyle interventions often lack a culture-sensitive approach. The aim of this study was to assess the effects of a newly developed culture-sensitive lifestyle intervention on physical performance in non-Western Surinamese older adults.</div></div><div><h3>Design</h3><div>A randomized controlled trial.</div></div><div><h3>Participants</h3><div>This study was conducted with 65 non-Western migrant participants (Surinamese, 65 ± 7 y, 91% female, 82% overweight or obese).</div></div><div><h3>Intervention</h3><div>The participants were allocated to the culture-sensitive lifestyle intervention (n = 35) or control group (n = 30). The six-month intervention consisted of an exercise training program and a nutritional program, both adapted to the cultural and personal needs of the participants.</div></div><div><h3>Measurements</h3><div>The primary outcome was physical performance, measured by 6-minute walking test. Secondary outcomes were timed-up-and-go, 30-seconds chair stand, knee-extension strength, single leg stand tests, appendicular lean soft tissue mass, fat mass, protein intake and daily physical activity. Linear mixed models were performed to assess intervention effects with significance set at p &lt; 0.05.</div></div><div><h3>Results</h3><div>The intervention group improved physical performance by 12% from baseline 440 ± 62 m to 6 months 492 ± 73 m compared to 8% in control group from 438 ± 93 m to 471 ± 66 m (+25.5 m, 95%CI (3.2;47.9), p = 0.027). Knee-extension strength was significantly better maintained in the intervention group from 273 ± 71 N to 270 ± 70 N, whereas the control group decreased knee-extension strength by 8% at six months from 262 ± 78 N to 240 ± 87 N (+19 N, 95%CI (1–38), p = 0.040). The intervention group significantly increased protein intake more (from 63 ± 21 to 78 ± 38 g/day) compared to the control group (from 72 ± 25 to 78 ± 29 g/day) at three months (+15 g/day, 95%CI (1;28), p = 0.035). No difference between groups was found for physical activity or the other secondary outcomes.</div></div><div><h3>Conclusions</h3><div>In non-Western migrant Surinamese older adults, a culture-sensitive lifestyle intervention improved physical performance, protein intake, and maintained muscle strength, presenting a promising approach to manage sarcopenia risk in this population.</div></div><div><h3>Trial registration</h3><div>Clinicaltrials.gov (NCT06407583).</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100584"},"PeriodicalIF":4.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute high-fat high-sugar diet rapidly increases blood-brain barrier permeability in mice","authors":"Este Leidmaa ,&nbsp;Andreas Zimmer ,&nbsp;Valentin Stein ,&nbsp;Anne-Kathrin Gellner","doi":"10.1016/j.jnha.2025.100574","DOIUrl":"10.1016/j.jnha.2025.100574","url":null,"abstract":"<div><div>The blood-brain barrier (BBB) maintains brain homeostasis by protecting the brain from pathological stimuli and controlling the entry of physiological substances from the periphery. Consequently, alterations in BBB permeability may pose a threat to brain health. Long-term consumption of a high-fat high-sugar/Western diet (HFD) is known to induce BBB dysfunction. However, nothing is known about the immediate effects of acute HFD consumption on the BBB. Using spectrophotometry and <em>in vivo</em> 2-photon microscopy in mice, we demonstrate region-specific BBB leakage already after 1 h of HFD for low- and high-molecular-weight tracers. Acute HFD also significantly increased BBB permeability to the anticancer drug doxorubicin. These previously unknown effects of acute HFD in mice may have far-reaching implications for the clinical use of drugs depending on the dietary habits of the patient, and might inform future studies on drug transport to the brain.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100574"},"PeriodicalIF":4.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}