Journal of Nutrition Health & Aging最新文献

{"title":"Letter to the Editor regarding “The role of nutritional supplement on post-stroke fatigue: A pilot randomized controlled trial”","authors":"Xinjie Wang , Hui Ma","doi":"10.1016/j.jnha.2024.100288","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100288","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003750/pdfft?md5=b5a42582e184dd7e5c6df50cf08abee9&pid=1-s2.0-S1279770724003750-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141303972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention","authors":"Cristina Galarregui ,&nbsp;Santiago Navas-Carretero ,&nbsp;M. Angeles Zulet ,&nbsp;Carlos J. González-Navarro ,&nbsp;J. Alfredo Martínez ,&nbsp;Begoña de Cuevillas ,&nbsp;Helena Marcos-Pasero ,&nbsp;Elena Aguilar-Aguilar ,&nbsp;Guillermo Reglero ,&nbsp;Ana Ramirez de Molina ,&nbsp;Paloma Chausa ,&nbsp;Jose M. Iniesta ,&nbsp;M. Elena Hernando ,&nbsp;Enrique J. Gómez ,&nbsp;Alejandro Garcia-Rudolph ,&nbsp;Alberto García-Molina ,&nbsp;Viviana Loria-Kohen ,&nbsp;Itziar Abete","doi":"10.1016/j.jnha.2024.100289","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100289","url":null,"abstract":"<div><h3>Objectives</h3><p>Innovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adults with overweight or obesity.</p></div><div><h3>Methods</h3><p>127 men and women aged between 50 and 80 years with overweight/obesity participated in the study—between January 2020 and September 2020 at the Center for Nutrition Research-University of Navarra and IMDEA-ALIMENTACIÓN—and were randomly assigned to a usual-care group (standard recommendations) or precision group (precision nutrition strategy based on the inclusion of individualised foods and a mobile application). Anthropometry, body fat percentage, biochemical parameters, diet, and quality of life (SF-36 Health Survey) were assessed at baseline and after 3 months.</p></div><div><h3>Results</h3><p>Both strategies were found to improve overall metabolic health; however, the precision approach demonstrated significantly better outcomes. The precision strategy reduced body weight at 3 months (−4.3 kg; p &lt; 0.001) with significant improvements in body fat percentage, blood pressure and general metabolic health (glycated haemoglobin; alanine aminotransferase; aspartate aminotransferase; hepatic steatosis index) in comparison with the standard recommendations. The precision approach significantly enhanced the quality of life (SF-36) of individuals, with additional improvements in emotional well-being (p = 0.024) and vitality (p = 0.008). Adherence to the Mediterranean diet was significantly associated with a higher quality of life and vitality.</p></div><div><h3>Conclusion</h3><p>These results support the benefit of precision nutrition approaches for promoting healthy aging and emotional well-being, enhancing the quality of life in aging populations, during the COVID-19 pandemic.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003762/pdfft?md5=6f1f90d42e3eb1a8c8be4a3c8dd9a8a2&pid=1-s2.0-S1279770724003762-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary evaluation of home-delivered meals for reducing frailty in older adults at risk for mal-nutrition","authors":"Lisa A. Juckett ,&nbsp;Melica Nikahd ,&nbsp;J. Madison Hyer ,&nbsp;Jared N. Klaus ,&nbsp;Melinda L. Rowe ,&nbsp;Leah E. Bunck ,&nbsp;Govind Hariharan","doi":"10.1016/j.jnha.2024.100283","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100283","url":null,"abstract":"<div><h3>Objective</h3><p>To examine the potential benefit of home-delivered meals for reducing frailty levels among community-dwelling older adults at risk for malnutrition.</p></div><div><h3>Design</h3><p>A retrospective, single-group observational approach.</p></div><div><h3>Setting</h3><p>One large home-delivered meal agency in the Midwest United States.</p></div><div><h3>Participants</h3><p>1090 community-dwelling older adults who received home-delivered meal services, funded through the Older Americans Act, between June 2020 and December 2021.</p></div><div><h3>Measurement</h3><p>Frailty status was measured by the Home Care Frailty Scale (HCFS) which was routinely administered by agency staff to home-delivered meal clients as part of a quality improvement project. The HCFS was administered at the start of meal services, 3-months after meals began, and 6-months after meals began.</p></div><div><h3>Results</h3><p>At baseline, 55.4% of clients were found to be at high risk for malnutrition. While there was a significant and consistent decline in HCFS throughout the follow-up period for both high and low nutritional risk groups, the reduction in frailty from baseline to 6-months was greater for the high nutritional risk group (Δ = −1.9; 95% CI: [−2.7, −1.1]; <em>p</em> &lt; 0.001) compared to those with low nutritional risk (Δ = −1.5; 95% CI: [−2.3, −0.7]; <em>p</em> &lt; 0.001). Compared to those who lived alone, clients who lived with other individuals presented with higher levels of frailty at baseline and 3-month follow-up for both low and high malnutrition risk groups.</p></div><div><h3>Conclusion</h3><p>Home-delivered meal clients are commonly at risk for both frailty and malnutrition. Home-delivered meal programs, which are intended to reduce malnutrition among older adults, may serve as a promising solution for reducing frailty in the vulnerable aging population.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003701/pdfft?md5=1687cdaac92737faaecb72f070b8f334&pid=1-s2.0-S1279770724003701-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follistatin-respiratory connection predicting all-cause mortality among community-dwelling middle-to-old age individuals: Results from the I-Lan Longitudinal Study","authors":"Hsiao-Chin Shen ,&nbsp;Wei-Ju Lee ,&nbsp;Chuan-Yen Sun ,&nbsp;Wen-Kuang Yu ,&nbsp;Wei-Chih Chen ,&nbsp;Fei-Yuan Hsiao ,&nbsp;Kuang-Yao Yang ,&nbsp;Liang-Kung Chen","doi":"10.1016/j.jnha.2024.100285","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100285","url":null,"abstract":"<div><h3>Objectives</h3><p>The link between aging and pulmonary function decline is well-established, but the underlying mechanisms have yet to be fully revealed. Serum follistatin, a myokine implicated in muscle degeneration, may play a role in age-related pulmonary changes. This study aims to investigate the relationship between serum follistatin levels and pulmonary function decline in community-dwelling older adults, and evaluate their combined association with all-cause mortality.</p></div><div><h3>Research design and methods</h3><p>This longitudinal cohort study utilized data from 751 participants aged ≥50 years in the I-Lan Longitudinal Aging Study between 2018−2019. Serum follistatin levels, spirometry results, demographic and clinical data were retrieved. Participants were stratified based on their follistatin levels. Survival curves and group comparisons based on follistatin levels and decline in peak expiratory flow (PEF) using Kaplan-Meier analysis and log-rank tests. Multivariate Cox proportional hazards models were further used to identify independent predictors of all-cause mortality during the 52-month follow-up.</p></div><div><h3>Results</h3><p>Elevated follistatin levels significantly correlated with worse pulmonary function, particularly decreased PEF (<em>p</em> = 0.030). Kaplan–Meier analysis revealed the combination of elevated follistatin levels and decreased PEF was associated with increased risk of all-cause mortality (Log-rank <em>p</em> = 0.023). Cox proportional hazards models further identified that concurrent presence of higher follistatin levels and decreased PEF predicted higher risk of all-cause mortality (adjusted HR 3.58, 95% CI: 1.22–10.53, <em>p</em> = 0.020).</p></div><div><h3>Conclusion</h3><p>Higher serum follistatin levels correlate with decreased pulmonary function, specifically PEF decline, in community-dwelling older adults. Furthermore, the coexistence of elevated follistatin levels and decreased PEF was associated with risk of all-cause mortality. Follistatin may serve as a biomarker for pulmonary aging and related adverse outcomes.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003725/pdfft?md5=90b85c9d0873db52cd5f2006759f4a10&pid=1-s2.0-S1279770724003725-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of circulating vitamins with 10-year retinal neurodegeneration: the Alienor Study","authors":"Bénédicte MJ Merle ,&nbsp;Cédric Schweitzer ,&nbsp;Marie-Bénédicte Rougier ,&nbsp;Audrey Cougnard-Grégoire ,&nbsp;Laure Gayraud ,&nbsp;Marie-Noëlle Delyfer ,&nbsp;Jean-François Korobelnik ,&nbsp;Cécile Delcourt","doi":"10.1016/j.jnha.2024.100286","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100286","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the associations between circulating vitamins A, D, E, B6, B9, B12 and longitudinal changes in retinal nerve fiber layer (RNFL) thickness.</p></div><div><h3>Methods</h3><p>The Alienor study, a prospective population-based cohort (Bordeaux, France), includes 963 individuals aged 73 years or older at baseline. The present study included 646 participants with complete RNFL measurement and vitamins. Study period is from 2009 to 2020. Peripapillary RNFL thickness was measured using spectral domain optical coherence tomography (SD-OCT). Plasma vitamins A, D and E and, serum vitamins B6, B9 and B12 were measured from blood sample. We performed linear mixed models, adjusted for age, gender, axial length, family history of glaucoma, and alcohol consumption to evaluated associations between vitamins and RNFL thickness changes over time.</p></div><div><h3>Results</h3><p>Individuals having higher concentrations of vitamin E, D and B9 had a slower RNFL thinning during the 10-years of follow-up. Indeed, a 1-standard deviation (SD) increase of vitamin E (10.8 μmol/L), D (17.6 nmol/L) and B9 (11 μmol/L) were associated with slower RNFL thinning by 0.14 μm/year (95% confidence interval (CI), 0.03−0.25, p = 0.01), 0.14 μm/year (95% CI, 0.02−0.27, p = 0.02) and 0.11 μm/year (95% CI: 0.007−0.21, p = 0.04), respectively. No significant associations were observed for vitamins A, B6 and B12 with RNFL thinning.</p></div><div><h3>Conclusions</h3><p>Higher levels of vitamins E, D and B9 were associated with a slower RNFL thickness on SD-OCT over time, suggesting that those vitamins may contribute to the neuroprotection of the retina.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003737/pdfft?md5=394903b285739912456e02105148099a&pid=1-s2.0-S1279770724003737-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of loneliness and social isolation on the benefits of an exercise program with hospitalised older adults","authors":"N. Martínez-Velilla ,&nbsp;ML. Sáez de Asteasu ,&nbsp;F. Zambom-Ferraresi ,&nbsp;A. Galbete ,&nbsp;I. Marín-Epelde ,&nbsp;MC. Ferrara ,&nbsp;J. Yanguas-Lezaún ,&nbsp;M. Izquierdo","doi":"10.1016/j.jnha.2024.100282","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100282","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to assess the prevalence and impact of loneliness (De Jong Gierveld scale) and isolation (Lubben scale) on the effects of a hospital-based exercise programme.</p></div><div><h3>Design</h3><p>Secondary analysis of a randomised clinical trial.</p></div><div><h3>Setting</h3><p>Acute Geriatric Unit of a tertiary hospital in Spain.</p></div><div><h3>Participants</h3><p>103 hospitalised older adults.</p></div><div><h3>Intervention</h3><p>Individualised multicomponent exercise program (20-minute sessions twice a day for 3 consecutive days).</p></div><div><h3>Results</h3><p>Among the 103 randomised patients included in the analysis (both arms included), 58.3% were male, and their mean age was 87.3 (4.5) years. According to the Lubben scale, 15.8% of patients were at risk of isolation, while 62.7% were in a situation of severe or moderate loneliness according to the De Jong Gierveld scale. In the non-isolated group, training showed a substantial positive impact on Geriatric Depression Scale (B = −1.25, 95% CI = −0.24 to −0.27). In the isolated group, all outcomes improved, but only the Quality of Life showed significant changes (B = 35, 95% CI = 4.96–35.8). The SPPB test (B = 1.62, 95% CI = 0.19–3.04) and Quality of Life, (B = 17.1, 95% CI = 1.84–32.3) showed a significant improvement in the non-loneliness exercise group while no differences were found in the loneliness group.</p></div><div><h3>Conclusion</h3><p>Despite the high prevalence of loneliness and social isolation, individualised exercise programs provide significant benefits to hospitalised patients, especially in quality of life.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003695/pdfft?md5=c1e2ef957eb74ce033cd33d81c2ce4a9&pid=1-s2.0-S1279770724003695-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between anemia and all-cause mortality among Chinese older people: The evidence from CHARLS","authors":"Xiao-Ming Zhang ,&nbsp;Lei-E Li ,&nbsp;Cong- Hua Wang ,&nbsp;Qing-Li Dou ,&nbsp;Yun- Zhi Yang","doi":"10.1016/j.jnha.2024.100281","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100281","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003683/pdfft?md5=d65432992ee425aa3bcb7c6357f7ba65&pid=1-s2.0-S1279770724003683-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141241193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transitions in intrinsic capacity among community-dwelling older people and their associated factors: a multistate modelling analysis","authors":"Ruby Yu,&nbsp;Derek Lai,&nbsp;Grace Leung,&nbsp;Lok-Yan Tam,&nbsp;Clara Cheng,&nbsp;Sara Kong,&nbsp;Cecilia Tong,&nbsp;Jean Woo","doi":"10.1016/j.jnha.2024.100273","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100273","url":null,"abstract":"<div><h3>Objectives</h3><p>Trajectory of intrinsic capacity (IC) can be non-linear and discontinuous, which traditional linear models may not be able to handle. This study thus aimed to model the trajectory of IC as transitions between different IC states and examine their associated factors.</p></div><div><h3>Methods</h3><p>Longitudinal data from a sample of community-dwelling older people aged 60 years or above (<em>n</em> = 1,588) was analysed. A set of 14 self-reported items representing different domains of IC were administered annually to measure IC at four time points. Based on the number of impaired IC domains (i.e., cognitive, locomotor, vitality, sensory, and psychological), participants at each time point were classified into one of three IC states, namely state 1 (0 impaired domain), state 2 (1–2 impaired domains), and state 3 (3–5 impaired domains). Multistate modelling was used to identify factors associated with the transitions from one state to another.</p></div><div><h3>Results</h3><p>The mean age of participants was 75.0 years, and 77.4% of them were female. At baseline, 12.4% were in state 1, 51.8% were in state 2, and 35.8% were in state 3. 62.8% of participants experienced at least one transition between states, among which 12% experienced a transition every year. The transitions occurred mostly between adjacent IC states and could take place back and forth. Age, sex, marital status, perceived financial adequacy, number of chronic diseases, and self-rated health were the factors associated with the transitions.</p></div><div><h3>Conclusion</h3><p>Findings may serve as a valuable reference for guiding future policies to optimize IC and promote healthy ageing using a person-centred approach.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003609/pdfft?md5=1b2a7677ede0824375e659e7d9cba417&pid=1-s2.0-S1279770724003609-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction effect of metals exposure and dietary habit on cognitive function in Chinese older adult cohort","authors":"Peiyi Liu ,&nbsp;Jiahui Wang ,&nbsp;Pengcheng Mei ,&nbsp;Junyu Li ,&nbsp;Benhong Xu ,&nbsp;Xiaohu Ren ,&nbsp;Xiao Chen ,&nbsp;Desheng Wu ,&nbsp;Feiqi Zhu ,&nbsp;Xifei Yang ,&nbsp;Meian He ,&nbsp;Jianjun Liu ,&nbsp;Haiyan Huang","doi":"10.1016/j.jnha.2024.100284","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100284","url":null,"abstract":"<div><h3>Background</h3><p>As the important factors in cognitive function, dietary habits and metal exposures are interactive with each other. However, fewer studies have investigated the interaction effect of them on cognitive dysfunction in older adults.</p></div><div><h3>Methods</h3><p>2,445 registered citizens aged 60–85 years from 51 community health centers in Luohu District, Shenzhen, were recruited in this study based on the Chinese older adult cohort. All subjects underwent physical examination and Mini-cognitive assessment scale. A semi quantitative food frequency questionnaire was used to obtain their food intake frequency, and 21 metal concentrations in their urine were measured.</p></div><div><h3>Results</h3><p>Elastic-net regression model, a machine learning technique, identified six variables that were significantly associated with cognitive dysfunction in older adults. These variables included education level, gender, urinary concentration of arsenic (As) and cadmium (Cd), and the frequency of monthly intake of egg and bean products. After adjusting for multiple factors, As and Cd concentrations were positively associated with increased risk of mild cognitive impairment (MCI) in the older people, with OR values of 1.19 (95% CI: 1.05–1.42) and 1.32 (95% CI: 1.01–1.74), respectively. In addition, older adults with high frequency of egg intake (≥30 times/month) and bean products intake (≥8 times/month) had a reduced risk of MCI than those with low protein egg intake (&lt;30 times/month) and low bean products intake (&lt;8 times/month), respectively. Furthermore, additive interaction were observed between the As exposure and egg products intake, as well as bean products. Cd exposure also showed additive interactions with egg and bean products intake.</p></div><div><h3>Conclusions</h3><p>The consumption of eggs and bean products, as well as the levels of exposure to the heavy metals Cd and As, have been shown to have a substantial influence on cognitive impairment in the elderly population.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003713/pdfft?md5=7b75d452ced827bd9fed7e9a6595c3b4&pid=1-s2.0-S1279770724003713-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex difference in skeletal muscle mass in relation to metabolic dysfunction-associated steatotic liver disease: a propensity score matching study","authors":"Da-Hye Son ,&nbsp;Yu-Jin Kwon ,&nbsp;Jun-Hyuk Lee","doi":"10.1016/j.jnha.2024.100270","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100270","url":null,"abstract":"<div><h3>Background</h3><p>While low muscle mass is considered a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), whether the relationship is independent of fat mass remains unclear.</p></div><div><h3>Objectives</h3><p>This study aims to clarify the association between the sex-specific height-adjusted low skeletal muscle mass index (LSMI) and MASLD.</p></div><div><h3>Methods</h3><p>Data from the 2008–2010 Korean National Health and Nutrition Examination Survey were analyzed. LSMI was defined using the 2019 Asian Working Group for Sarcopenia. The non-alcoholic fatty liver disease-liver fat score was used to assess MASLD. Gender-specific 1:1 propensity score matching (PSM) was performed to mitigate the confounding effects of anthropometric variables and lifestyles. Conditional logistic analysis was used on the dataset after PSM to estimate the odds ratio (OR) with a 95% confidence interval (CI).</p></div><div><h3>Results</h3><p>After PSM, the prevalence of MASLD was significantly higher in men with LSMI than in those without LSMI (37.4% vs. 29.6%). No significant difference was observed in the prevalence of MASLD between groups after PSM in women (20.4% vs. 20.3%). Conditional logistic analysis revealed that the odds of having MASLD were significantly higher in men with LSMI compared to those without LSMI (OR = 1.38, 95% CI: 1.09–1.75), while no significant association was found in women with LSMI (OR = 1.10, 95% CI: 0.87–1.40).</p></div><div><h3>Conclusion</h3><p>Height-adjusted LSMI is an independent factor associated with MASLD in the condition of the same level of fat mass in men. Further prospective studies in diverse populations are needed to confirm our findings.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003579/pdfft?md5=11d1ac7eeb0587b03a029381d1e64485&pid=1-s2.0-S1279770724003579-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}