Journal of Nutrition Health & Aging最新文献

{"title":"Normative data of ultrasound quadriceps rectus femoris geometric values. The ECOSARC-2 Study","authors":"Ester López Jiménez ,&nbsp;Paola Reinoso Párraga ,&nbsp;Alfonso González Ramírez ,&nbsp;Marta Neira Álvarez ,&nbsp;Adriana Abizanda Saro ,&nbsp;Marisa Fernández González de la Riva ,&nbsp;Cristina Alonso Bouzón ,&nbsp;Victoriano Chavero Carrasco ,&nbsp;Gema Montemayor Galán ,&nbsp;Juan Rodríguez Solís ,&nbsp;Rubén Alcantud Córcoles ,&nbsp;Raquel Ramírez Martín ,&nbsp;Carmen de Pablos Hernández ,&nbsp;Fabricio Zambom-Ferraresi ,&nbsp;Brian Dax Vásquez ,&nbsp;Pedro Luis Sagüillo González ,&nbsp;Ignacio Morón Merchante ,&nbsp;Rafael García Molina ,&nbsp;Rocío Menéndez Colino ,&nbsp;Nicolás Martínez Velilla ,&nbsp;Pedro Abizanda","doi":"10.1016/j.jnha.2025.100608","DOIUrl":"10.1016/j.jnha.2025.100608","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe geometric muscle ultrasound normative values of Quadriceps Rectus Femoris (QRF) at mid-thigh in Spanish community-dwelling older adults. Secondary objectives included evaluating the associations between ultrasound measurements and physical function, muscle strength, frailty, and dependency in basic activities of daily living.</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Setting</h3><div>Outpatient clinics of Geriatric Departments at seven University Hospitals and three Primary care settings of Spain.</div></div><div><h3>Participants</h3><div>424 community-dwelling persons ≥70 years old.</div></div><div><h3>Measurements</h3><div>Ultrasound measurements were acquired using a Clarius® L7 HD3 probe. QRF thickness (QRFT), QRF area (QRFA), subcutaneous adipose thickness (SAT), total mid-thigh thickness (TTT), and pennation angle (PA) were calculated. Normative values are provided, and associations with comorbidity, dependency, strength, frailty and physical function are described.</div></div><div><h3>Results</h3><div>Mean age was 81.5 years (range 70−99), 66.7% were female. Mean Barthel index was 93 (SD 11), and mean FRAIL score was 1.1 (1.2). Mean SPPB was 8.7 (SD 2.9) and mean grip strength was 20.7 (8.0). Median values of QRFT, QRFA, SAT, TTT, and PA for women and men were 14.2 / 16.1 mm, 5.4 / 6.4 cm<span><span>²</span></span>, 15.1 / 9.2 mm, 41.1 / 40.1, and 10.0 / 10.6 respectively. Functional variables were strongly associated with QRFT, QRFA, and TTT in men, and PA with SPPB in both sexes.</div></div><div><h3>Conclusions</h3><div>The ECOSARC-2 study provides normative values of geometric mid-thigh muscle ultrasound parameters in community-dwelling older adults. These values are essential for determining sex-specific cut-off points for conditions such as sarcopenia, frailty, malnutrition, and for predicting relevant outcomes.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100608"},"PeriodicalIF":4.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma biomarkers for monitoring muscle function and physical performance decline in older adults: A 2-year longitudinal study","authors":"Tae-Hwan Gil ,&nbsp;Ji Yeon Kim ,&nbsp;Ji-Won Shin ,&nbsp;Dong-Hyun Jang ,&nbsp;Seung Shin Park ,&nbsp;Sang Wan Kim ,&nbsp;Chan Soo Shin ,&nbsp;Ok Hee Jeon ,&nbsp;Sung Hye Kong","doi":"10.1016/j.jnha.2025.100607","DOIUrl":"10.1016/j.jnha.2025.100607","url":null,"abstract":"<div><h3>Background</h3><div>Reliable biomarkers for diagnosing and monitoring sarcopenia remain limited, especially those reflecting longitudinal changes in muscle health. This study aimed to evaluate associations between plasma biomarkers and both cross-sectional and 2-year longitudinal changes in muscle mass, strength, and physical performance in older adults.</div></div><div><h3>Methods</h3><div>We analyzed plasma biomarkers in 93 participants (mean age: 74.3 years; 88% female) from a hospital-based longitudinal cohort. Biomarkers were quantified using ELISA, and multivariable regression analyses were conducted for sarcopenia components such as muscle mass, function, and performance, adjusting for age, sex, and body mass index (BMI).</div></div><div><h3>Results</h3><div>Leptin levels were negatively associated with both baseline and 2-year changes in appendicular lean mass indexed by ALM/height² and ALM/BMI after adjustments. DHEAS positively correlated with the baseline ALM/BMI, and IL-6 negatively correlated with a change in ALM/BMI. Regarding muscle function, higher baseline grip strength was associated with myostatin, DHEAS, and negatively with leptin and GDF-15. For physical performance, DHEAS and IGF-1 were positively associated with SPPB scores at the baseline, while IL-6 and GDF-15 were negatively associated with these. Notably, IL-6 was also positively associated with 2-year SPPB change.</div></div><div><h3>Conclusion</h3><div>These findings highlight the potential of specific plasma biomarkers to identify individuals at risk of sarcopenia-related functional decline and to serve as practical tools for monitoring sarcopenia progression in older adults.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100607"},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited association between multimorbidity and high-sensitive C-reactive protein or gait speed in community-dwelling octogenarians – findings from the BUTTERFLY study","authors":"Aziz Debain ,&nbsp;Veerle Knoop ,&nbsp;Axelle Costenoble ,&nbsp;Mirko Petrovic ,&nbsp;Ivan Bautmans","doi":"10.1016/j.jnha.2025.100603","DOIUrl":"10.1016/j.jnha.2025.100603","url":null,"abstract":"<div><h3>Background</h3><div>Biological age is a key determinant of disease progression and increased morbidity. However, it is unclear whether multimorbidity is associated with low-grade inflammation or gait speed in octogenarians.</div></div><div><h3>Aim</h3><div>To examine cross-sectional associations between commonly used comorbidity indices and either elevated high-sensitivity C-reactive protein (hsCRP) or reduced gait speed in community-dwelling non-frail adults aged 80 and older.</div></div><div><h3>Methods</h3><div>a total of 404 community-dwelling older adults (mean age: 83 ± 3 years) were assessed for multimorbidity, gait speed, and hscrp. five comorbidity indices were calculated: charlson comorbidity index, cumulative illness rating scale for geriatrics, elixhauser comorbidity index (eci), rockwood frailty index, and a weighted modified disease count. binary logistic regression was used to analyze associations with elevated hscrp (&gt;3.0 mg/l) and reduced gait speed (&lt;0.8 m/s).</div></div><div><h3>Results</h3><div>Of the indices evaluated, only the ECI showed a significant association with elevated hsCRP (adjusted odds ratio [aOR] = 1.18, 95% CI: 1.03–1.35; p = 0.020). When stratified by gender, this association remained significant in men (aOR = 1.29, 95% CI: 1.053–1.59; p = 0.014), but not in women. Furthermore, none of the comorbidity indices were significantly associated with low gait speed.</div></div><div><h3>Conclusion</h3><div>Among the comorbidity indices assessed, only the ECI demonstrated a modest yet significant association with hsCRP levels in individuals aged 80 years and older. In contrast, no significant associations were observed between any of the comorbidity indices and reduced gait speed in this population. This highlights the importance of comprehensive care, including individualized lifestyle interventions, nutritional support, and timely pharmacological adjustments for effective chronic disease management.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100603"},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulation and atrial fibrillation in prognostic models for type B aortic dissection","authors":"Amir Reza Akbari ,&nbsp;Benyamin Alam","doi":"10.1016/j.jnha.2025.100612","DOIUrl":"10.1016/j.jnha.2025.100612","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100612"},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional association between brain-derived neurotrophic factor and intrinsic capacity in older adults: The mediating role of oxidative stress","authors":"Chi Zhang ,&nbsp;Ping Zeng ,&nbsp;Yushan Zhang ,&nbsp;Yuting Kang ,&nbsp;Jie Zhang ,&nbsp;Jing Li ,&nbsp;Hong Shi ,&nbsp;Shiwei Liu ,&nbsp;Ji Shen","doi":"10.1016/j.jnha.2025.100599","DOIUrl":"10.1016/j.jnha.2025.100599","url":null,"abstract":"<div><h3>Objectives</h3><div>Brain-derived neurotrophic factor (BDNF) is a key indicator in the brain-muscle axis. This study aimed to investigate the association of plasma BDNF and intrinsic capacity (IC) in older people, and to examine the mediating role of inflammation and oxidative stress.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 658 community-dwelling older adults (70.38 ± 6.06 years, 59.42% female). Intrinsic capacity including five domains was evaluated according to the World Health Organization recommendation. Plasma BDNF, high sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-a), Interleukin-1 beta (IL-1β), Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), and Glutathione reductase (GR)were measured by enzyme-linked immunosorbent assay methods. Restricted cubic spline and multivariate logistic regression were conducted to explore the association of BDNF with IC impairment. Mediation analyses were used to explore the potential mechanisms. Demographic characteristics, health behaviors, and comorbidities were included as covariates.</div></div><div><h3>Results</h3><div>247(37.54%) participants had IC impairment. Older individuals with impaired IC had lower levels of BDNF, IL-1β, SOD, and GR, while showed higher levels of hs-CRP and MDA compared to the normal group. There was an L-shaped negative correlation between BDNF levels and the odds of IC impairment (<em>P</em>-nonlinear &lt;0.001). After adjusting for all confounders, the odds for IC impairment in the medium and high BDNF tertiles were significantly lower than in the low BDNF tertile, with ORs of 0.43(95% CI: 0.26−0.89, <em>P</em> = 0.004) and 0.38(95% CI: 0.20−0.71, <em>P</em> = 0.007), respectively. Plasma SOD and GR mediated 4.13% (95% CI: 1.15, 7.16) and 7.82% (95% CI: 3.24, 12.48) of the total effect of BDNF on IC.</div></div><div><h3>Conclusion</h3><div>High levels of circulatory BDNF may be related to lower odds of IC impairment. Oxidative stress status partially explains the mechanisms underlying the association.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100599"},"PeriodicalIF":4.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic clocks as mediators of health behaviors and mortality in middle-aged and older adults","authors":"Xing-Ling Chen ,&nbsp;Qiang-Qiang Zhao ,&nbsp;Sheng-Rong Lin ,&nbsp;Xing-Ling He ,&nbsp;Xiao-Jiao Zhang ,&nbsp;Si-Jing Li ,&nbsp;Zi-Ru Li ,&nbsp;Jia-Hui Chen ,&nbsp;Hua Zhang ,&nbsp;Xiao-Fang Li ,&nbsp;Yue-Hui Zhou ,&nbsp;Hui-Li Liao ,&nbsp;Shu-Ning Sun ,&nbsp;Zhong-Qi Yang ,&nbsp;Shi-Hao Ni ,&nbsp;Lu Lu","doi":"10.1016/j.jnha.2025.100602","DOIUrl":"10.1016/j.jnha.2025.100602","url":null,"abstract":"<div><h3>Background</h3><div>The impact of healthy lifestyles on epigenetic age acceleration (EAA) and mortality in middle-aged/ senior populations remains unclear. This study investigates associations between lifestyle factors, EAA biomarkers, and mortality risk.</div></div><div><h3>Method</h3><div>The 2532 adults of 50 years or older that registered in NHANES between 1999–2002.This study evaluated compares first- to third-generation epigenetic clocks (HannumAge, HorvathAge, PhenoAge, GrimAge2, DunedinPoAm) in predicting mortality risk associations between five lifestyle domains (diet, abdominal adiposity, physical activity, smoking, alcohol) and EAA were analyzed via multivariable regression, with mediation models testing EAA’s role in lifestyle-mortality relationships.</div></div><div><h3>Results</h3><div>Survival curves results identified DunedinPoAm, GrimAge2AA, and PhenoAgeAA as robust biomarkers of accelerated biological aging, independent of chronological age. In multivariable linear regression models, full adherence to healthy behaviors reduced GrimAge2AA by β = −5.55 years, PhenoAgeAA by β = −2.64 years, and DunedinPoAm by β = −0.06 SD, with smoking cessation demonstrating the strongest GrimAge2AA attenuation (10.17 years). Stratified analyses revealed pronounced benefits: cancer patients adhering to healthy diets (β = −0.04 SD, P for interaction = 0.01) and hypertensive individuals reducing smoking (β = −0.05 SD, <em>P</em> for interaction = 0.04) showed significant EAA mitigation. The sensitivity analysis is consistent with the original results. Mediation analyses indicated GrimAge2AA accounted for 63.58% of lifestyle-survival associations, DunedinPoAm (44.63%) and PhenoAgeAA (28.45%).</div></div><div><h3>Conclusions</h3><div>These findings suggest that comprehensive adherence to healthy lifestyle behaviors is associated with reduced epigenetic aging, supporting their potential utility as targets for mortality risk mitigation. And emphasize the utility of epigenetic clocks in precision gerontology.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100602"},"PeriodicalIF":4.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor concerning ‘Association between sarcopenia index and the risk of second hip fracture in older adults’","authors":"Li Liu","doi":"10.1016/j.jnha.2025.100601","DOIUrl":"10.1016/j.jnha.2025.100601","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100601"},"PeriodicalIF":4.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial","authors":"Meina Li ,&nbsp;Qi Zhang ,&nbsp;Wen Zhao ,&nbsp;Juan Chen ,&nbsp;Yinghua Liu ,&nbsp;Limian Zhou ,&nbsp;Yihui Liu ,&nbsp;Langrun Wang ,&nbsp;Yiran Guan ,&nbsp;Jian He ,&nbsp;Qiuyue Jiang ,&nbsp;Zhaozhong Zeng ,&nbsp;Xinmei Guo ,&nbsp;Can Liu ,&nbsp;Liwei Zhang ,&nbsp;Yong Zhang ,&nbsp;Jie Luo ,&nbsp;Wei-Lian Hung ,&nbsp;Jingjing He ,&nbsp;Ran Wang","doi":"10.1016/j.jnha.2025.100598","DOIUrl":"10.1016/j.jnha.2025.100598","url":null,"abstract":"<div><div>Research on effects of synbiotics in older adults with functional constipation (FC) is limited. This randomized, double-blind, placebo-controlled trial evaluated a 4-week synbiotic (<em>Bifidobacterium animalis</em> subsp. <em>lactis</em> BL-99 and fructooligosaccharides [FOS]) intervention in 67 participants ≥60 years old meeting Rome IV FC criteria. Compared to placebo, the synbiotic group showed significant improvements in weekly spontaneous bowel movements (Least squares mean ± standard error: 4.94 ± 0.25 vs. 3.00 ± 0.26, <em>P</em> &lt; 0.001) and whole gut transit time (37.13 ± 3.78 vs. 50.64 ± 4.22 h, <em>P</em> = 0.019), with benefits sustained 2 weeks post-intervention. It also reduced time per toilet attempt and alleviated rectal discomfort symptoms more effectively than placebo. Fecal microbiome analysis revealed increased abundance of beneficial <em>Bifidobacterium</em> species, correlating with symptom improvement (<em>P</em> &lt; 0.05). These findings demonstrate that BL-99/FOS supplementation ameliorates FC symptoms in older adults, with effects sustained post-discontinuation, potentially mediated through gut microbiota modulation. Further mechanistic investigation is warranted.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100598"},"PeriodicalIF":4.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor concerning \"Association between sarcopenia index and the risk of second hip fracture in older adults\" by Liu et al","authors":"Longqing Yu ,&nbsp;Zhaohui Ma ,&nbsp;Qiuping Zhang ,&nbsp;Kexin Pan ,&nbsp;Fupeng Liu ,&nbsp;Ping Li ,&nbsp;Mei Zhang","doi":"10.1016/j.jnha.2025.100600","DOIUrl":"10.1016/j.jnha.2025.100600","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100600"},"PeriodicalIF":4.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global roadmap for inclusive clinical trials in older adults","authors":"Jorge G. Ruiz","doi":"10.1016/j.jnha.2025.100591","DOIUrl":"10.1016/j.jnha.2025.100591","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100591"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}