Journal of Nutrition Health & Aging最新文献

{"title":"Dietary inflammatory index, mediating biomarkers and incident frailty in Chinese community-dwelling older adults","authors":"Shu-Yi Li ,&nbsp;Zhi-Hui Lu ,&nbsp;Yi Su ,&nbsp;Jason C.S. Leung ,&nbsp;Timothy C.Y. Kwok","doi":"10.1016/j.jnha.2024.100304","DOIUrl":"10.1016/j.jnha.2024.100304","url":null,"abstract":"<div><h3>Objectives</h3><p>Diet can modulate systemic inflammation, while inflammation is a critical contributory factor of frailty. However, longitudinal data on the association between dietary inflammatory index (DII) and frailty are limited, and the intermediate mechanisms remain unclear. This study aimed to examine the association between DII and incident frailty and the potential mediating roles of frailty-related biomarkers.</p></div><div><h3>Design</h3><p>Prospective cohort study.</p></div><div><h3>Setting</h3><p>The Mr. OS and Ms. OS (Hong Kong) study.</p></div><div><h3>Participants</h3><p>A total of 3,035 community-dwelling men and women aged above 65 years without frailty at baseline were included.</p></div><div><h3>Measurements</h3><p>DII scores were calculated using the locally validated food frequency questionnaire. Incident frailty at year four was defined using the Fried frailty phenotype. Logistic regression was used to examine the association between DII and frailty onset. Mediation analysis was used to explore the mediating roles of frailty-related biomarkers in the DII-frailty association.</p></div><div><h3>Results</h3><p>During four years of follow-up, 208 individuals developed frailty. Compared with the lowest tertile of DII, the highest tertile was associated with an increased risk of incident frailty (OR: 1.82; 95% CI: 1.17–2.82; <em>p</em> = 0.008) after adjustment for relevant confounders. The DII-frailty association was significant in men but not in women. Furthermore, increasing serum homocysteine, decreasing serum folate, and reducing estimated glomerular filtration rate (eGFR) mediated 11.6%, 7.1%, and 9.6 % of the total relation between DII and frailty onset, respectively.</p></div><div><h3>Conclusion</h3><p>In this cohort study, a pro-inflammatory diet was associated with a higher risk of frailty onset, mediated by homocysteine, folate, and renal function.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003919/pdfft?md5=4eceacc70a850fecc32540d2832b186f&pid=1-s2.0-S1279770724003919-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of cannabinoids in managing cancer-related anorexia in older adults: a systematic review of the literature","authors":"Chiara Ceolin ,&nbsp;Marina De Rui ,&nbsp;Adele Ravelli ,&nbsp;Mario Virgilio Papa ,&nbsp;Maria Devita ,&nbsp;Giuseppe Sergi ,&nbsp;Alessandra Coin","doi":"10.1016/j.jnha.2024.100299","DOIUrl":"10.1016/j.jnha.2024.100299","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Anorexia of aging (AoA) is a prevalent geriatric syndrome characterized by a multifactorial decline in appetite and reduced food intake associated with the aging process. This systematic review aims to investigate the use and outcomes of cannabinoids in addressing AoA, with the goal of providing a comprehensive understanding and discussing their potential integration into daily clinical practice.</p></div><div><h3>Methods</h3><p>A thorough search of databases (Embase Ovid, Scopus, PubMed, Cochrane Library, and Web of Science) identified 6100 studies. After eliminating duplicates and screening titles and abstracts, 25 studies underwent full appraisal. Two reviewers assessed inclusion suitability, and study methodologies were evaluated using the Newcastle-Ottawa Scale (NOS) for observational studies and the modified Jadad Scoring Scale for randomized controlled trials. Ultimately, six studies published between 2002 and 2019, involving 869 participants, were included in the review.</p></div><div><h3>Results</h3><p>Out of the 6 fin. l papers selected, 5 were randomized trials, and 1 was a prospective study. Megestrol acetate (800 mg/d) proved to be more effective than dronabinol 2.5 mg twice a day in increasing appetite. Nabilone (at a dosage of 0.5 mg per day) did not show superiority over placebo in alleviating symptoms such as pain, nausea, loss of appetite, and weight. However, with a double dosage followed by 1.0 mg/6 weeks, after eight weeks of treatment, patients recorded a significant increase in calorie intake and carbohydrate consumption compared to the placebo group, with some patients also experiencing substantial weight gain. Regarding delta-9-tetrahydrocannabinol (THC), a weight increase of ≥10% was observed in 17.6% of patients with doses of 5 mg or 10 mg capsules daily, without significant side effects. Additionally, patients treated with THC 2.5 mg reported improved chemosensory perception and increased appetite before meals compared to placebo. No significant side effects were reported in older adults taking cannabinoids.</p></div><div><h3>Conclusions</h3><p>Cannabinoids offer promise in enhancing the quality of life for older individuals with active neoplastic disease. However, to establish comprehensive guidelines, further research with larger sample sizes is essential. Only through this approach can we fully grasp the potential and application of cannabinoids in addressing the nutritional concerns associated with neoplastic diseases.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003865/pdfft?md5=ee49281a797497475423169e311f754b&pid=1-s2.0-S1279770724003865-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using cardiorespiratory fitness to operationalize vitality: a path analysis on the hierarchical structure of intrinsic capacity","authors":"Ruby Yu,&nbsp;Derek Lai,&nbsp;Grace Leung,&nbsp;Cecilia Tong,&nbsp;Jean Woo","doi":"10.1016/j.jnha.2024.100300","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100300","url":null,"abstract":"<div><h3>Background</h3><p>There is a lack of consensus about the operationalization of vitality, which is one of the intrinsic capacity (IC) domains. In particular, no study has investigated whether cardiorespiratory fitness (CRF) can be considered a vitality indicator.</p></div><div><h3>Objective</h3><p>To examine whether vitality is the upstream domain of IC, and establish the validity of CRF as a vitality indicator, using maximal oxygen consumption (VO₂ max) as a representative.</p></div><div><h3>Methods</h3><p>561 older adults from a longitudinal cohort study were included. Variables under consideration were VO₂ max, other IC domains, instrumental activities of daily living (IADL), and handgrip strength, which was considered an already validated indicator of vitality. Using handgrip strength as the reference point, path analyses were performed to examine whether VO₂ max followed a similar hierarchical structure in predicting change in IADL difficulty through other IC domains.</p></div><div><h3>Results</h3><p>The mean age of the participants was 75.5 years. The path model in which vitality was measured by VO₂ max demonstrated adequate fit, which was similar to the model in which vitality was measured by handgrip strength. Regarding the path coefficients, the model using VO₂ max demonstrated significant total and indirect effects. Notably, the indirect effect was due to the locomotor domain (standardized coefficient = −0.148, <em>p</em> &lt; .001), but not the cognitive or psychological domain.</p></div><div><h3>Conclusion</h3><p>Vitality is the upstream domain of IC. VO₂ max can be considered an indicator to operationalize the vitality concept.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003877/pdfft?md5=5170761316765cfdbd92b02e47809fbd&pid=1-s2.0-S1279770724003877-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial","authors":"Sonja Baltic ,&nbsp;David Nedeljkovic ,&nbsp;Nikola Todorovic ,&nbsp;Marijana Ranisavljev ,&nbsp;Darinka Korovljev ,&nbsp;Jelena Cvejic ,&nbsp;Jelena Ostojic ,&nbsp;Tyler W. LeBaron ,&nbsp;Judi Timmcke ,&nbsp;Valdemar Stajer ,&nbsp;Sergej M. Ostojic","doi":"10.1016/j.jnha.2024.100287","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100287","url":null,"abstract":"<div><h3>Objectives</h3><p>To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment.</p></div><div><h3>Design</h3><p>A parallel-group, randomized, placebo-controlled, double-blind experimental design, maintaining a 1:1 allocation ratio between the experimental group (receiving the dihydrogen-producing minerals and PQQ) and the control group (receiving the placebo) throughout the trial.</p></div><div><h3>Setting and participants</h3><p>Thirty-four elderly individuals with mild cognitive impairment (mean age 71.9 ± 3.8 years; 28 females) voluntarily provided written consent to participate in this trial. Participants were assigned in a double-blind parallel-group design to receive either a dihydrogen-PQQ mixture (Alpha Hope®, CalerieLife, Irvine, CA) or placebo twice daily for a 6-week intervention period.</p></div><div><h3>Methods</h3><p>The primary endpoint was the change in serum brain-derived neurotrophic factor (BDNF) from baseline to the 6-week follow-up; secondary outcomes included cognitive function indices, specific metabolites in brain tissue, brain oxygenation, and the prevalence and severity of side effects. Interaction effects (time vs. intervention) were evaluated using two-way ANOVA with repeated measures and Friedman’s 2-way ANOVA by ranks, for normally distributed data with homogeneous variances and non-homogeneous variances, respectively.</p></div><div><h3>Results</h3><p>Dihydrogen-PQQ resulted in a significant elevation in serum BDNF levels at the six-week follow-up (<em>P</em> = 0.01); conversely, no changes in BDNF levels were observed in the placebo group throughout the study duration (<em>P</em> = 0.27). A non-significant trend in the impact of interventions on BDNF levels was observed (treatment vs. time interaction, <em>P</em> = 0.14), suggesting a tendency for dihydrogen-PQQ to upregulate BDNF levels compared to the placebo. A significant interaction effect was observed for the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) scores in the orientation domain (<em>P</em> = 0.03), indicating the superiority of dihydrogen-PQQ over placebo in enhancing this cognitive aspect. Cerebral oxygenation saturation exhibited a significant increase following the administration of the dihydrogen-PQQ mixture, from 48.4 ± 7.2% at baseline to 52.8 ± 6.6% at 6-week post-administration (<em>P</em> = 0.005). In addition, brain <em>N</em>-acetyl aspartate levels significantly increased at seven out of thirteen locations post-intervention in participants receiving the mixture (<em>P</em> ≤ 0.05).</p></div><div><h3>Conclusions</h3><p>Despite the limited number of participants included in the study for interpreting clinical parameters, the dihydrogen-PQQ mixture blend shows promise as a potential dietary intervention for enhancing mental orientation and brain met","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003749/pdfft?md5=a038db077af87d7099748e0f0d51cc89&pid=1-s2.0-S1279770724003749-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic perspectives of pre-, pro-, post-biotics in the treatment of sarcopenia","authors":"Yves Rolland ,&nbsp;Andrea Ticinesi ,&nbsp;Harry Sokol ,&nbsp;Philipe De Souto Barreto","doi":"10.1016/j.jnha.2024.100298","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100298","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003853/pdfft?md5=81aedef8abadc07de4ac1647623e5909&pid=1-s2.0-S1279770724003853-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141439267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simplified definition of sarcopenia: muscle mass/body weight","authors":"William J. Evans ,&nbsp;Luigi Ferrucci","doi":"10.1016/j.jnha.2024.100302","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100302","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003890/pdfft?md5=5d09a67263b68c602e372144323f6ee3&pid=1-s2.0-S1279770724003890-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141439268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic value of calf circumference for sarcopenia in community-dwelling older adults","authors":"Alejandro Álvarez-Bustos ,&nbsp;Jose Antonio Carnicero ,&nbsp;Helio José Coelho-Junior ,&nbsp;Riccardo Calvani ,&nbsp;Francisco José García-García ,&nbsp;Emanuele Marzetti ,&nbsp;Francesco Landi ,&nbsp;Leocadio Rodriguez-Mañas","doi":"10.1016/j.jnha.2024.100290","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100290","url":null,"abstract":"<div><h3>Background</h3><p>An age-dependent normative values of calf circumference (CC) has been recently proposed as an accessible proxy for muscle mass. However, its usefulness to estimate sarcopenia has not been assessed. The objectives of the present study were to determine if the substitution of the classical way to assess muscle mass by these values have enough diagnostic accuracy and prognostic value among older adults living in the community.</p></div><div><h3>Methods</h3><p>Data from the Toledo Study of Healthy Ageing (TSHA) were used. CC was measured using an anthropometric tape. We used two age-groups CC cut-off points: the TSHA CC median and the one proposed in the Longevity Check-up 7+ (Lookup 7+) project. Sarcopenia was defined based on the European Working Group on Sarcopenia in Older People (EWGSOP2), the Foundation for the National Institutes of Health (FNIH), and FNIH criteria standardized for our population (sFNIH). Frailty (according to the Frailty Phenotype and the Frailty Trait Scale-5) and disability (Katz index) were assessed at baseline and follow-up. Mortality and first hospitalization were also recorded. Logistic (incident frailty and worsening disability) and Cox (mortality and hospitalization) regressions were performed. Diagnostic accuracy was assessed through Kappa index, AUCs, positive and negative predictive values. Predictive ability was assessed through AUCs and integrated AUCs (IAUCs).</p></div><div><h3>Results</h3><p>1531 participants (74.8 ± 5.8 years; 45.6% men) were included in the analysis. Prevalence rates of sarcopenia were 22.7% (sFNIH), 15.0% (FNIH), and 13.9% (EWGSOP2). Using TSHA-based cut-points of CC, the prevalence of sarcopenia was 16.8% (sFNIH), 11.0% (FNIH), and 11.5% (EWGSOP2). According to LC7+-based CC cut-off points, sarcopenia prevalence was 17.6% (sFNIH), 11.9% (FNIH), and 12.4% (EWGSOP2). CC cut-off points showed low-to-moderate agreement (Kappa Index values between 0.49 and 0.69) with appendicular lean mass for the evaluation of sarcopenia. Sarcopenia identified by Lookup 7+ and TSHA CC cut-off points was associated with the adverse events examined, with similar AUCs and IAUCs than original sarcopenia definitions, and were lost after adjustment by baseline frailty, except when the original EWGSOP2 definition was used.</p></div><div><h3>Conclusions</h3><p>Using normalized values of CC as a criteria of muscle mass shows moderate agreement with classical criteria for diagnosing sarcopenia and offer similar predictive value in community-dwelling older adults.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003774/pdfft?md5=f74e480672789cf9466d1569dd4880e0&pid=1-s2.0-S1279770724003774-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of oxidative balance score with all-cause mortality among older adults in the United States: evidence from NHANES 2007–2018","authors":"Shanshan Jia,&nbsp;Xingwei Huo,&nbsp;Lirong Sun,&nbsp;Xiaoping Chen","doi":"10.1016/j.jnha.2024.100297","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100297","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003841/pdfft?md5=10341207908ea967544ad7dde7360100&pid=1-s2.0-S1279770724003841-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In response to: Letter to the Editor regarding “The role of nutritional supplement on post-stroke fatigue: a pilot randomized controlled trial”","authors":"Silvia Giovannini ,&nbsp;Chiara Iacovelli ,&nbsp;Claudia Loreti ,&nbsp;Giovanni Frisullo ,&nbsp;Letizia Castelli","doi":"10.1016/j.jnha.2024.100301","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100301","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003889/pdfft?md5=949a616cd3c3aa69d4a46b5b1ca767ee&pid=1-s2.0-S1279770724003889-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of non-severe COVID-19 infection and progression to frailty among robust older veterans","authors":"Natasha M. Resendes ,&nbsp;Jerry Bradley ,&nbsp;Fei Tang ,&nbsp;Iriana S. Hammel ,&nbsp;Jorge G. Ruiz","doi":"10.1016/j.jnha.2024.100296","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100296","url":null,"abstract":"<div><h3>Background</h3><p>Studies have shown that frailty was increased in hospitalized COVID-19 patients. However, it is not clear whether non-severe COVID-19 increases the risk for pre-frailty and frailty development. Our study aimed to determine the risk of developing frailty and pre-frailty in robust veterans who contracted non-severe COVID-19.</p></div><div><h3>Methods</h3><p>We conducted a retrospective cohort study to assess the association of SARS-CoV-2 infection with the development of pre-frailty and frailty status among robust U.S. veterans using VA COVID-19 Shared Data Resource. We included patients 55 years and older who had at least one SARS-CoV-2 testing between March 15, 2020, and November 30, 2020, had been active patients in the past 12 months, and had a VA frailty index of zero (robust status) at the time of testing. Cox proportional hazard model was used to assess the association between COVID-19 infection and developing frailty or pre-frailty and frailty. We also assessed the association by patients’ age groups, sex, and race.</p></div><div><h3>Findings</h3><p>We identified 82070 veterans mean age 68.3 ± 7.8, 74738 (91.1%) male, 53899 (65.7%) white, 7557 (9.2%) with mild COVID-19 infection. Over the follow up period of 36 months, testing positive for COVID-19 was associated with a 66% increase in the hazard of becoming frail (adjusted HR = 1.66, 95%CI: 1.32–2.08), and a 68% increase in the hazard of becoming pre-frail (adjusted HR = 1.68, 95%CI: 1.45–1.94). Among male patients, mild COVID-19 infection was associated with a 54% increase in the hazard of becoming frail (adjusted HR = 1.54, 95% CI: 1.21−1.96), while among female patients there was a 330% increase (adjusted HR = 4.30, 95% CI: 2.13−8.64).</p></div><div><h3>Conclusions and relevance</h3><p>Non-severe COVID-19 infection that occurred in robust older adults increased the risk of developing frailty. Further multi-center prospective cohort studies evaluating the mechanism of action and clinical trials of treatment options for post-COVID frailty are indicated in Veterans to support clinical care.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":5.8,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S127977072400383X/pdfft?md5=194553d50fc8a19a68fa8d205e809bcf&pid=1-s2.0-S127977072400383X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}