Journal of Nutrition Health & Aging最新文献

{"title":"Self-reported motoric cognitive risk syndrome predicts long-term mortality in older adults","authors":"Yiwen Xing ,&nbsp;Li Zhang ,&nbsp;Pan Liu ,&nbsp;Yiming Pan ,&nbsp;Zhe Tang ,&nbsp;Lina Ma","doi":"10.1016/j.jnha.2025.100578","DOIUrl":"10.1016/j.jnha.2025.100578","url":null,"abstract":"<div><h3>Objectives</h3><div>Motoric cognitive risk syndrome (MCR) is a pre-dementia syndrome characterized by slow gait and subjective cognitive decline, increasing the risk of adverse clinical events such as dementia and falls in older adults. However, whether self-reported MCR (sMCR) predicts long-term mortality in Chinese older adults remains unknown. This study aimed to explore the role of sMCR in 8-year mortality in community-dwelling older adults.</div></div><div><h3>Design</h3><div>Longitudinal cohort study.</div></div><div><h3>Setting</h3><div>Data were sourced from the Beijing Longitudinal Study of Aging.</div></div><div><h3>Participants</h3><div>A total of 1,683 community-dwelling individuals aged 65 years and older who were free from disability and dementia at baseline were included.</div></div><div><h3>Measurements</h3><div>sMCR was defined based on the presence of subjective cognitive decline and self-reported slow gait. Mortality data were tracked over the 8-year follow-up period. Cox regression models were used to analyze the association between sMCR and 8-year mortality.</div></div><div><h3>Results</h3><div>A total of 113 (6.71%) community-dwelling individuals had sMCR. sMCR was associated with female sex, older age, no spouse, living in rural areas, low education level, low monthly income, no work, no tea intake, poor sleep quality, inactivity, poor physical performance, chronic diseases, and frailty. Participants with sMCR had a higher 8-year mortality compared to those without (70.80% vs. 34.52%). Cox regression analysis showed that sMCR predicted 8-year mortality (hazard ratio [HR] = 2.859, 95% confidence interval [CI] 2.260–3.619). This association remained significant even after adjusting for sex, age, area, education level, marital status, chronic diseases, and lifestyle factors (HR = 1.540, 95% CI 1.169–2.028).</div></div><div><h3>Conclusions</h3><div>sMCR is a predictor of 8-year mortality in Chinese community-dwelling older adults, which highlights the importance of early identification and intervention for sMCR to reduce adverse clinical outcomes in the aging population.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100578"},"PeriodicalIF":4.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the methodology of clinical trials in older people: A scoping review with global perspective","authors":"Matteo Cesari ,&nbsp;Marco Canevelli ,&nbsp;Wei Zhang ,&nbsp;Jotheeswaran Amuthavalli Thiyagarajan ,&nbsp;Domenico Azzolino ,&nbsp;Antonio Cherubini ,&nbsp;Jagadish K Chhetri ,&nbsp;Amit Dias ,&nbsp;Eduardo Ferriolli ,&nbsp;Susanna Gentili ,&nbsp;Celia L Gregson ,&nbsp;Hyobum Jang ,&nbsp;Sebastiana Kalula ,&nbsp;Peter Lloyd-Sherlock ,&nbsp;Radmila Matijevic ,&nbsp;Federica Quarata ,&nbsp;Ritu Sadana ,&nbsp;Anshu Banerjee ,&nbsp;Vasee Moorthy","doi":"10.1016/j.jnha.2025.100582","DOIUrl":"10.1016/j.jnha.2025.100582","url":null,"abstract":"<div><div>As people age, they are more likely to develop chronic diseases, experience physical and mental impairments, and face social issues. This complexity makes traditional research protocols challenging, leading to the exclusion of older individuals in clinical trials (CTs) and limiting the applicability of evidence-based medicine, especially in low- and middle-income countries (LMICs).</div><div>A scoping review of the literature (based on PubMed, Embase, and Scopus) was conducted to identify recommendations to improve the methodology of CTs involving older persons. The findings were then shared with a panel of researchers with expertise in older adult research in LMICs, who assessed and refined the recommendations for implementation in low-resource settings.</div><div>After screening more than 4,700 articles, 80 were retained as relevant, providing 1,119 inputs on the design and conduct of CTs in older persons. These inputs were homogenised into 120 recommendations and organised into 13 clusters representing different phases and aspects of a CT. Key recommendations, enriched from experts’ input, indicate the importance of addressing various barriers that hinder older persons' participation in CTs in LMICs, such as poor funding, inadequate age-friendly facilities, ageism, transportation issues, and the need for standardised terminology and culturally sensitive assessment tools.</div><div>CTs involving older individuals face unique challenges. Effective methodologies and innovative approaches are essential for generating scientific evidence that informs clinical practice and promotes healthy ageing. The present work highlights the need for practical, inclusive strategies to navigate the complexities of conducting CTs in older adults.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100582"},"PeriodicalIF":4.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of geriatric nutritional risk index in predicting survival of type B aortic dissection patients after thoracic endovascular aortic repair","authors":"Kaiwen Zhao ,&nbsp;Jinzhu Niu ,&nbsp;Yuzhen He ,&nbsp;Lingxu Kong ,&nbsp;Wenyao Zhao ,&nbsp;Qingsheng Lu ,&nbsp;Shuangshuang Li ,&nbsp;Jian Zhou","doi":"10.1016/j.jnha.2025.100572","DOIUrl":"10.1016/j.jnha.2025.100572","url":null,"abstract":"<div><h3>Background</h3><div>The geriatric nutritional risk index (GNRI) is a reliable indicator of patients’ nutrition status and has been shown to be valuable in predicting the outcome of patients with various cardiovascular diseases. This study explored the association between perioperative GNRI and the prognosis of type B aortic dissection (TBAD) patients receiving thoracic endovascular aortic repair (TEVAR).</div></div><div><h3>Methods</h3><div>A total of 1,157 consecutive patients who underwent TEVAR between January 2007 and August 2019 were included, with data from 789 patients analyzed. The GNRI was used to measure nutritional status. Patients were categorized into five groups based on the GNRI quintile. The study's endpoints included all-cause mortality, aortic-related adverse events (ARAEs), and major adverse cardiovascular and cerebrovascular events (MACCEs) at 30 days, 1 year, and 5 years. The univariate and multivariate Cox regression analyses the effect of GNRI on the endpoints. Kaplan–Meier survival analysis was conducted to assess the incidence of these endpoints across the five groups, and restricted cubic spline (RCS) analysis was used to examine the non-linear relationship between GNRI and all-cause mortality.</div></div><div><h3>Results</h3><div>The Kaplan-Meier survival analyses revealed that the risk of 1-year and 5-year all-cause mortality was highest in the Q1 group among the five groups (P = 0.009 and P = 0.002, respectively). However, there was no significant difference in 1-year and 5-year ARAEs and MACCEs (all P &gt; 0.05). Multivariate Cox analysis showed that continuous GNRI was independently associated with 5-year all-cause death (HR = 0.97, 95% CI: 0.95–1.00; P = 0.027). Compared with the Q1 group, the Q2 (HR = 0.22, 95% CI: 0.06−0.80; P = 0.021) and Q4 groups (HR = 0.26, 95% CI: 0.08−0.81; P = 0.020) had lower risks of 1-year all-cause mortality. The Q2 group (HR = 0.38, 95% CI: 0.18−0.83; P = 0.015) and Q3 group (HR = 0.46, 95% CI: 0.22−0.96; P = 0.039) were also observed to have a lower risk of 5-year all-cause mortality than the Q1 group. In the subgroup analyses, chronic kidney disease (CKD) showed significant interaction (P-interaction &lt; 0.001). Besides, the RCS analysis identified a “U”-shaped relationship between GNRI and all-cause mortality of TBAD patients following TEAVR.</div></div><div><h3>Conclusions</h3><div>TBAD patients undergoing TEVAR showed a strong correlation between perioperative low GNRI and higher risks of 1-year and 5-year all-cause mortalities. TBAD patients with a too low GNRI should receive particular attention.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100572"},"PeriodicalIF":4.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The relationship between serum uric acid and accelerated aging in middle-aged and older adults: a prospective cohort study based on CHARLS” [J Nutr Health Aging 29 (2025) 100488]","authors":"Weiyi Shi,&nbsp;Zihong Cai,&nbsp;Xiaoxu Ren,&nbsp;Juehan Wang,&nbsp;Hang Zhou,&nbsp;Zuobing Chen","doi":"10.1016/j.jnha.2025.100581","DOIUrl":"10.1016/j.jnha.2025.100581","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100581"},"PeriodicalIF":4.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A non-fasting marker of metabolic syndrome in a high-risk population","authors":"Sabrina Cancelliere ,&nbsp;Tracy Heung ,&nbsp;Christina Blagojevic ,&nbsp;Sarah Malecki ,&nbsp;Satya Dash ,&nbsp;Anne S. Bassett","doi":"10.1016/j.jnha.2025.100573","DOIUrl":"10.1016/j.jnha.2025.100573","url":null,"abstract":"<div><h3>Objective</h3><div>The rising prevalence of metabolic syndrome among young adults has prompted studies of fasting triglyceride-glucose (TyG) index as a marker of insulin resistance. We aimed to evaluate metabolic syndrome in young adults using non-fasting TyG index and a high-risk genetic model, 22q11.2 microdeletion.</div></div><div><h3>Methods</h3><div>We assessed metabolic syndrome and its components in 350 adults (50.6% female) aged 18–59 (median 27.7, IQR 22.5–38.1) years with typical 22q11.2 microdeletions. We used multivariable logistic regression and receiver operating characteristic (ROC) curves to evaluate the association of non-fasting TyG index with metabolic syndrome.</div></div><div><h3>Results</h3><div>Non-fasting TyG index was significantly associated with metabolic syndrome (OR 3.23, 95% CI 2.27–4.59, p &lt; 0.0001), independent of age, sex, BMI, and hypothyroidism. Non-fasting TyG index was positively correlated with number of metabolic syndrome components per individual. In this high-risk population, prevalence of metabolic syndrome was 21.7% (60/277) among young adults (18−39 years), and 45.2% (33/73, p &lt; 0.0001) among middle-aged adults (40−59 years). Non-fasting TyG index ≥4.81 was an effective indicator of prevalent metabolic syndrome, with an area under the ROC curve of 0.83 (95% CI 0.78−0.88).</div></div><div><h3>Conclusions</h3><div>The results support non-fasting TyG index as a practical marker of metabolic syndrome, and by extension insulin resistance, encouraging future studies evaluating non-fasting TyG index in young adults as a predictor of cardiovascular disease later in life. The high prevalence of metabolic syndrome at a young age in 22q11.2 microdeletion demonstrates the potential value of this genetic high-risk population for future prospective studies, with animal and cellular models available.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100573"},"PeriodicalIF":4.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal relationship between malnutrition and oral function impairment in older adults with dysphagia: A cross-lagged panel model","authors":"Hiroyasu Furuya ,&nbsp;Takeshi Kikutani ,&nbsp;Yuri Yokota ,&nbsp;Maiko Ozeki ,&nbsp;Fumiyo Tamura","doi":"10.1016/j.jnha.2025.100577","DOIUrl":"10.1016/j.jnha.2025.100577","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to longitudinally investigate the temporal relationship between tongue pressure and malnutrition in older adults with dysphagia and to determine the antecedent factors.</div></div><div><h3>Design</h3><div>This is a retrospective cohort study.</div></div><div><h3>Setting and Participants</h3><div>In total, 177 participants aged ≥65 years with dysphagia who visited a specialized dysphagia rehabilitation clinic between 2014 and 2018 were enrolled.</div></div><div><h3>Measurements</h3><div>Malnutrition was assessed based on the phenotypic criteria (unintentional weight loss, low body mass index, and reduced skeletal muscle mass) from the Global Leadership Initiative on Malnutrition framework. Tongue pressure was measured using a tongue pressure measuring device. The bidirectional association between tongue pressure and malnutrition was examined, adjusting for age, sex, cognitive function, occlusal support status, and comorbidities.</div></div><div><h3>Results</h3><div>In the Cross-Lagged Panel Model, a significant cross-lagged effect was observed from tongue pressure to malnutrition at 6 months (β = −0.135, p &lt; 0.001) and 12 months (β = −0.112, p = 0.028). However, the pathway from malnutrition to tongue pressure was not significant. Logistic regression analysis also revealed that baseline tongue pressure was significantly associated with malnutrition at 6 months (odds ratio [OR] = 0.91, 95% confidence interval [CI]: 0.86–0.95) and 12 months (OR = 0.89, 95% CI: 0.84–0.94). During the follow-up period, tongue pressure improved; however, the prevalence of malnutrition increased.</div></div><div><h3>Conclusions</h3><div>Decreased tongue pressure may precede malnutrition in older adults with dysphagia; however, a reverse relationship was not observed. The findings suggest the importance of incorporating oral function assessment as part of the risk assessment for malnutrition.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100577"},"PeriodicalIF":4.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative stress and inflammation mediate the association between Life's Crucial 9 and biological ageing: A secondary analysis of two observational studies","authors":"Haoran Wang ,&nbsp;Jingwen Zhang ,&nbsp;Jiaxin Ning ,&nbsp;Yating Cui ,&nbsp;Huimin Hou ,&nbsp;Ming Liu ,&nbsp;Jianyong Liu ,&nbsp;Runhua Tang ,&nbsp;Jianye Wang","doi":"10.1016/j.jnha.2025.100575","DOIUrl":"10.1016/j.jnha.2025.100575","url":null,"abstract":"<div><h3>Background</h3><div>Life’s Essential 8 (LE8) is known to have a negative correlation with biological aging, while the relationship between the Life’s Crucial 9 (LC9) score, which includes mental health, and biological aging remains to be further investigated.</div></div><div><h3>Methods</h3><div>We obtained data from two national cohorts, the UK Biobank and National Health and Nutrition Examination Survey (NHANES), to analyze the association between LC9 and biological aging. Biological aging was assessed using PhenoAge and KDMAge, with gender, race, and other indicators included as covariates. We applied linear regression models and restricted cubic splines (RCS) to analyze and describe the relationship. Furthermore, we explored the mediating role of oxidative stress and inflammation in the association between LC9 and biological aging. Subgroup analyses were conducted using multiple linear regression models, and differences between subgroups were assessed through interaction p-value tests. Sensitivity analyses were subsequently performed, followed by an exploration of the underlying mechanisms.</div></div><div><h3>Results</h3><div>In this study, the UK Biobank cohort included 46,599 participants, with 44,973 participants having complete data for all covariates, LC9, and the necessary calculations for PhenoAge and KDMage. In the NHANES cohort, these numbers were 11,726 and 5,936, respectively. In the UK Biobank cohort, a significant association was found between the LC9 score and PhenoAge (β = −2.484, p &lt; 0.001), with similar results observed for KDMage (β = −7.987, p &lt; 0.001). Similar findings were observed in the NHANES cohort, with significant associations between the LC9 score and both PhenoAge (β = −5.327, p &lt; 0.001) and KDMAge (β = 11.826, p &lt; 0.001). These findings align with previous research suggesting that higher LC9 scores are associated with slower biological aging. After multivariable adjustment, an \"inverse L-shaped\" relationship was observed (non-linear P &lt; 0.001). In the mediation analysis, oxidative stress and inflammation showed significant mediating effects between LC9 and both PhenoAge and KDMage (p &lt; 0.001 for both). In the subgroup analysis, the LC9 score showed broad applicability, particularly among male participants aged over 60 years.</div></div><div><h3>Conclusion</h3><div>This cohort study suggests that higher LC9 scores are associated with slower biological aging. In addition to emphasizing diet and lifestyle habits, the role of mental health in biological aging should not be overlooked.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100575"},"PeriodicalIF":4.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of phenotypic aging, lifestyle, and genetic risk with incidence of atrial fibrillation: A large prospective cohort study in the UK Biobank","authors":"Tingting Lin ,&nbsp;Ximin Fan ,&nbsp;Liangtang Zeng ,&nbsp;Qiang Li ,&nbsp;Feilong Wang ,&nbsp;Hao Lu","doi":"10.1016/j.jnha.2025.100562","DOIUrl":"10.1016/j.jnha.2025.100562","url":null,"abstract":"<div><h3>Objectives</h3><div>Our study aimed to investigate the association of phenotypic aging, lifestyle, and genetic risk with the risk of incident atrial fibrillation (AF).</div></div><div><h3>Design</h3><div>A large prospective cohort study.</div></div><div><h3>Setting and participants</h3><div>This study included 327,122 participants from the UK Biobank.</div></div><div><h3>Methods</h3><div>PhenoAge acceleration (PhenoAgeAccel) was calculated by regressing phenotypic age (PhenoAge) on chronological age. Two key stratification tools were derived from previous research: the Healthy Lifestyle Score (HLS) based on smoking, body mass index (BMI), physical activity, and diet, to assess participants' lifestyles; and the polygenic risk score (PRS) based on 104 AF-associated SNPs and their effect sizes identified in a GWAS to evaluate genetic risk. Cox proportional hazards models were employed to assess both independent and combined effects of PhenoAgeAccel, HLS, and PRS with AF risk.</div></div><div><h3>Results</h3><div>At a median follow-up of 10.84 (10.08–11.56) years, 15,997 cases of AF were identified. Each standard deviation (SD) increase in PhenoAgeAccel was associated with a 30% higher AF risk (HR 1.30, 95% CI 1.28–1.31). Participants biologically older (PhenoAgeAccel&gt;0) had a significantly higher risk of AF (HR 1.47, 95% CI 1.42−1.51) compared to those biologically younger (PhenoAgeAccel≤0), whereas ideal HLS was significantly associated with a lower risk of AF (HR 0.52, 95% CI 0.49−0.56 vs. poor HLS), and high genetic risk was significantly associated with a higher risk of AF (HR 2.30, 95% CI 2.21−2.39 vs. low genetic risk). Joint effects and multiplicative/additive interactions were noted between PhenoAgeAccel and HLS (or genetic risk). When combined PhenoAgeAccel and genetic risk, participants biologically older and in high genetic risk had the highest AF risk (HR 3.52, 95% CI 3.31–3.74). When combined PhenoAgeAccel and HLS, participants who were biologically older and had a poor lifestyle had the highest AF risk (HR 2.42, 95% CI 2.23–2.62). Further analysis categorized PhenoAgeAccel into quartiles based on its population distribution, and the associations remained consistent.</div></div><div><h3>Conclusions</h3><div>Increased PhenoAgeAccel is significantly associated with increased risk of AF. When combined with a poor lifestyle or high genetic risk, the risk is further increased. These findings highlight the importance of integrating phenotypic aging, genetic risk, and lifestyle factors into AF prevention strategies.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143908150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of calcium supplement with risk of incident arrhythmia","authors":"Ru Chen ,&nbsp;Duqiu Liu ,&nbsp;Chenxing Yang ,&nbsp;Tianyu Guo ,&nbsp;Sen Liu ,&nbsp;Yi Guo ,&nbsp;Jinjie Xiong ,&nbsp;Shan Deng","doi":"10.1016/j.jnha.2025.100565","DOIUrl":"10.1016/j.jnha.2025.100565","url":null,"abstract":"<div><h3>Background and aims</h3><div>Calcium plays a crucial role in cardiac electrophysiology, but the association between calcium supplement and the risk of incident arrhythmia remains unclear.</div></div><div><h3>Objective</h3><div>To investigate the relationship between habitual calcium supplement and incident risk of cardiac arrhythmia.</div></div><div><h3>Methods</h3><div>We conducted a prospective study of 480,972 participants from the UK Biobank. Habitual calcium supplement was treated as the main exposure. The primary outcome was the incidence of arrhythmias, including atrial fibrillation/flutter (AF/AFL), ventricular arrhythmia (VA), and bradyarrhythmia. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>After a median follow-up of 11.69 years, 46,609 incident arrhythmia cases were documented, including 36,406 AF/AFL, 5,370 VA, and 14,226 bradyarrhythmia. After multivariable adjustment, calcium supplement was associated with an increased risk of total arrhythmias (HR 1.11, 95% CI 1.05–1.19), AF/AFL (HR 1.20, 95% CI 1.12–1.28), VA (HR 1.14, 95% CI 1.07–1.21), and bradyarrhythmia (HR 1.18, 95% CI 1.11–1.26). Significant interactions were observed between calcium supplement and estimated glomerular filtration rate, diabetes, cardiovascular disease, and polygenic risk score for AF (all p for interaction &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Calcium supplement was associated with an increased risk of incident arrhythmia. Careful evaluation of the potential arrhythmic risk is warranted when considering calcium supplement in individuals with clinical indications.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100565"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Mediterranean, high-quality, and anti-inflammatory diet with dementia in UK Biobank cohort","authors":"Ji-eun Youn ,&nbsp;Yu-Jin Kwon ,&nbsp;Yae-Ji Lee ,&nbsp;Seok-Jae Heo ,&nbsp;Ji-Won Lee","doi":"10.1016/j.jnha.2025.100564","DOIUrl":"10.1016/j.jnha.2025.100564","url":null,"abstract":"<div><h3>Background</h3><div>This study examined the relationship between adherence to the Mediterranean diet, MIND diet, Recommended Food Score (RFS), Alternative Healthy Eating Index (AHEI), and Energy-adjusted Dietary Inflammatory Index (EDII) and dementia risk in a large UK population cohort.</div></div><div><h3>Methods</h3><div>We analyzed data from 131,209 participants in the UK Biobank, aged 40–69 years, with no prior diagnosis of dementia at baseline. Dietary intake was assessed using the validated Oxford WebQ tool, and adherence to each dietary pattern was calculated. Dementia incidence was identified using algorithmically defined outcomes based on ICD codes. Fine–Gray subdistribution hazard models adjusted for sociodemographic, genetic, and lifestyle factors were applied to examine the association between dietary indices and dementia risk. Subgroup analyses were conducted based on age, sex, obesity status, and ApoEε4 status.</div></div><div><h3>Results</h3><div>Over a median follow-up of 13.5 years, 1453 dementia cases were identified. Higher adherence to the MEDAS, MIND diet, RFS, and AHEI was significantly associated with reduced dementia risk (HRs: 0.79, 0.73, 0.72, and 0.77, respectively). Conversely, higher EDII scores, indicating pro-inflammatory diets, were linked to an increased dementia risk (HR: 1.3). These associations were more pronounced in older adults (≥60 years), women, non-obese individuals, and ApoEε4 non-carriers. Subgroup analyses revealed differential impacts of dietary patterns based on demographic and health-related factors.</div></div><div><h3>Conclusion</h3><div>Greater adherence to Mediterranean, MIND, and high-quality diets is associated with a lower risk of dementia, while pro-inflammatory diets increase the risk. High-quality anti-inflammatory diets play a significant role in reducing the risk of dementia, with stronger effects observed in specific subgroups.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100564"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}