Journal of Nutrition Health & Aging最新文献

{"title":"From the molecular to the functional level: the aging continuum through blood pressure trajectories","authors":"","doi":"10.1016/j.jnha.2024.100320","DOIUrl":"10.1016/j.jnha.2024.100320","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S127977072400407X/pdfft?md5=8eacb29920447de77693f618c4218052&pid=1-s2.0-S127977072400407X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships between sarcopenia, depressive symptoms, and the risk of all-cause mortality in the Chinese population","authors":"","doi":"10.1016/j.jnha.2024.100316","DOIUrl":"10.1016/j.jnha.2024.100316","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004032/pdfft?md5=f4d92f66f5644487629cc0b7fc85ca44&pid=1-s2.0-S1279770724004032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity of BNT162b2 as a first booster after a ChAdOx1 primary series in a Thai geriatric population living with frailty","authors":"","doi":"10.1016/j.jnha.2024.100315","DOIUrl":"10.1016/j.jnha.2024.100315","url":null,"abstract":"<div><h3>Objectives</h3><p>Impact of frailty towards immunogenicity and reactogenicity of BNT162b2 boosters administered via intramuscular or intradermal routes in a Thai geriatric population</p></div><div><h3>Design</h3><p>Prospective, randomized, open-labeled.</p></div><div><h3>Setting</h3><p>Siriraj Hospital, Thailand.</p></div><div><h3>Participants</h3><p>Geriatric adults aged ≥65 years.</p></div><div><h3>Intervention</h3><p>10 μg intradermal or 30 μg intramuscular BNT162b2 (Pfizer-BioNTech).</p></div><div><h3>Measurements</h3><p>Anti-SARS-CoV-2 receptor binding domain IgG, neutralizing antibodies (NAb), and interferon-gamma producing cells against Wuhan and Omicron BA.4/5. Analyses were stratified based on participants’ Clinical Frailty Scale.</p></div><div><h3>Results</h3><p>A total of 139 participants were included in the analysis. Two-four weeks post-booster administration, NAb titers against Wuhan but not Omicron BA.4/5 were significantly lower among frail participants than non-frail participants who received intramuscular administration. Spike-specific T cell responses were similar for frail and non-frail participants, regardless of administration route. Frail participants who received intradermal BNT162b2 had fewer local adverse events (AEs), but higher systemic AEs than non-frail participants.</p></div><div><h3>Conclusion</h3><p>Similar immune responses across vaccine routes warrants further evaluation of intradermal BNT162b2 in frail geriatric populations. Frail participants may be more sensitive to reporting systemic AEs.</p></div><div><h3>Registration of clinical trials</h3><p>The parent study was registered under the Thai Clinical Trials Registry (TCTR20220112002).</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004020/pdfft?md5=608a02641f6454280eea7645977239b6&pid=1-s2.0-S1279770724004020-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of information and communication technology-based smart care services for physical and cognitive functions in older adults living alone: A quasi-experimental study","authors":"","doi":"10.1016/j.jnha.2024.100318","DOIUrl":"10.1016/j.jnha.2024.100318","url":null,"abstract":"<div><h3>Background</h3><p>As the global population ages and the number of older adults living alone increases, societies face the responsibility of building new support systems and providing novel forms of care to ensure the independence and happiness of sick or frail older individuals. This quasi-experimental study examined the association between information and communication technology-based smart care services and the physical and cognitive functions of older individuals living alone.</p></div><div><h3>Methods</h3><p>This study used a suite of smart technologies (artificial intelligence speaker, radar sensor, and personalized exercise App.) and interventions tailored to the initial physical functional scores of the participants. A total of 176 participants were recruited and assigned, with 88 participants in the intervention group and 88 in the control group. The short physical performance battery (SPPB), the digit span test (DST), and the Korean mini-mental state examination (K-MMSE) were used to assess participants before and after 12 weeks.</p></div><div><h3>Results</h3><p>No significant differences in gender, age, or educational levels were observed between the intervention and control groups. After adjusting for baseline performance, analysis of covariance revealed that the intervention group exhibited better outcomes in the SPPB five-time chair stand score (adjusted score difference: 0.329; <em>P</em> = 0.044) and the backward DST (adjusted score difference: 0.472; <em>P</em> = 0.007), but had lower score of K-MMSE (adjusted score difference: −0.935; <em>P</em> = 0.021), indicating enhanced lower limb muscle strength and cognitive function in working memory.</p></div><div><h3>Conclusion</h3><p>ICT-based smart care services, combined with personalized exercise interventions, significantly support the physical and cognitive health of solitary older individuals. This approach highlights the potential of integrating smart technology and targeted physical activity to foster the well-being of the aging population living alone.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004056/pdfft?md5=ca19092e698f97b628db6ecaf8545c4c&pid=1-s2.0-S1279770724004056-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141637253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns and intrinsic capacity in older adults: a 6-year prospective cohort study","authors":"Jinhee Kim ,&nbsp;Yunhwan Lee ,&nbsp;Miji Kim ,&nbsp;Chang Won Won ,&nbsp;Mi Kyung Kim ,&nbsp;Jee-Seon Shim","doi":"10.1016/j.jnha.2024.100314","DOIUrl":"10.1016/j.jnha.2024.100314","url":null,"abstract":"<div><h3>Objectives</h3><p>Only a few studies have investigated dietary patterns and intrinsic capacity (IC). This study examined the prospective associations between dietary patterns, IC, and IC sub-domains over 6 years in community-dwelling Korean older adults.</p></div><div><h3>Design</h3><p>A prospective cohort study.</p></div><div><h3>Setting and participants</h3><p>Data were obtained from participants aged 70–84 years in the Korean Frailty and Aging Cohort Study (2016–2022). The study population included 665 enrollees at baseline who completed IC and dietary data.</p></div><div><h3>Methods</h3><p>Dietary data were obtained from baseline surveys of the nutritional sub-cohort using two nonconsecutive 24‐hour dietary recalls, and dietary patterns were derived using cluster analysis. IC was constructed by measuring cognitive, locomotor, vitality, sensory, and psychological domains. A generalized estimating equation was used to analyze the longitudinal associations between dietary patterns, IC, and IC sub-domain scores.</p></div><div><h3>Results</h3><p>In total, 665 enrollees were included in the analysis. After adjusting for confounders, in older men, the dietary pattern of cluster 1 (variety of healthy foods and alcohols) compared to that of cluster 2 (rice and kimchi) was positively associated with changes in the IC score (<em>ß</em> = 0.41, 95% confidence interval [CI] = 0.04−0.78). In older women, the dietary pattern of cluster 1 (variety of healthy foods) was positively associated with changes in the IC score (<em>ß</em> = 0.30, 95% CI = 0.02–0.58), IC score group (<em>ß</em> = 0.11, 95% CI = 0.02–0.20), and psychological domain (<em>ß</em> = 0.25, 95% CI = 0.11–0.38) compared to that of cluster 3 (rice, vegetables, and kimchi).</p></div><div><h3>Conclusions</h3><p>Dietary patterns (variety of healthy foods) were positively associated with changes in IC scores and their sub-domains in older adults.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004019/pdfft?md5=1b5089bc69387679fb35b806d7574e33&pid=1-s2.0-S1279770724004019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age, sex, and APOE gene-specific associations between dynapenic obesity and dementia in a large cohort","authors":"Zhao Yao ,&nbsp;Jie Wang ,&nbsp;Tianfang Zhang ,&nbsp;Hongjing Ai ,&nbsp;Zeinab Abdelrahman ,&nbsp;Xiaohong Wu ,&nbsp;Daming Wang ,&nbsp;Fenfen Chen ,&nbsp;Ziwei Zhang ,&nbsp;Xiaosheng Wang ,&nbsp;Zuyun Liu ,&nbsp;Zuobing Chen","doi":"10.1016/j.jnha.2024.100313","DOIUrl":"10.1016/j.jnha.2024.100313","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the associations between dynapenic obesity and the risk of dementia, and the modifying effects of age, sex, and the APOE gene, using a large population-based cohort.</p></div><div><h3>Methods</h3><p>279,884 participants aged 55 and above from the UK Biobank were included. The participants were classified into four categories based on body mass index and hand grip strength: healthy, obesity, dynapenia, and dynapenic obesity. The incident dementia was identified based on linked hospital records and death register data. Cox proportional hazards regression models were used to estimate the associations, followed by age-, sex-, and apolipoprotein E (APOE) gene-stratified analyses.</p></div><div><h3>Results</h3><p>During the median follow-up of 12.4 years, 5,170 (1.8%) participants developed dementia. Compared with the healthy group, participants with dynapenic obesity had 67% higher dementia risk (hazard ratio [HR]: 1.67, 95% confidence interval [CI]: 1.44–1.94). Compared with the healthy group, higher risks of dementia in participants with dynapenic obesity were respectively observed in male (HR: 2.03, 95% CI: 1.65–2.50), younger (&lt;65 years, HR: 1.97, 95% CI: 1.55–2.50), and non-ε4-carrier (HR: 1.97, 95% CI: 1.60–2.44) (all P for interaction &lt;0.05). In participants under 65 years and non-ε4-carrier, those with dynapenic obesity had the highest risk of dementia (HR: 2.63, 95% CI: 1.91–3.62), compared with the healthy group (P for second order interaction = 0.026).</p></div><div><h3>Conclusions</h3><p>Dynapenic obesity is associated with increased risks of dementia, especially in participants under 65 years and non-ε4-carrier, suggesting the importance of managing dynapenic obesity in the prevention of cognition-related disorders.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004007/pdfft?md5=aad5846282599b28d0b6cb1691c3c72a&pid=1-s2.0-S1279770724004007-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential interplay between multimorbidity patterns and frailty and their mutual mediation effect on mortality in old age","authors":"Rui She ,&nbsp;Davide Liborio Vetrano ,&nbsp;Maria Kwan Wa Leung ,&nbsp;Hui Jiang ,&nbsp;Chengxuan Qiu","doi":"10.1016/j.jnha.2024.100305","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100305","url":null,"abstract":"<div><h3>Background</h3><p>Multimorbidity and frailty often concurrently occur among older adults.</p></div><div><h3>Objectives</h3><p>To assess the reciprocal association between multimorbidity (condition count and patterns) and frailty and examine the mutual mediation effect of multimorbidity and frailty in their associations with mortality among Chinese older adults.</p></div><div><h3>Methods</h3><p>This nationwide population-based longitudinal study included 16,563 participants aged ≥65 years in the Chinese Longitudinal Healthy Longevity Survey who were surveyed in 2008 and followed up in 2011, 2014, and 2018. Frailty phenotype was assessed by the modified Fried criteria and vital status was ascertained from family members. Cross-lagged panel model (CLPM) was used to test bidirectional associations between multimorbidity and frailty. The direct and indirect effects of multimorbidity and frailty on mortality were evaluated using the combined CLPM with survival analysis.</p></div><div><h3>Results</h3><p>Three multimorbidity patterns were identified: cardiometabolic diseases, cognitive-sensory disorder, and arthritis-digestive-respiratory diseases. The number of chronic conditions and cognitive-sensory disease pattern showed bidirectional associations with frailty across waves (range for <em>β</em>: 0.046−0.109; all <em>P</em> &lt; 0.001), while cardiometabolic and arthritis-digestive-respiratory patterns unidirectionally predicted frailty change. Furthermore, frailty mediated 23%–27% of the association between multimorbidity and mortality. Only the number of conditions and cognitive-sensory disease pattern were significant mediators in the association between frailty and mortality, with the proportion of mediation ranging 4%–12%.</p></div><div><h3>Conclusions</h3><p>Multimorbidity measures including condition count and cognitive-sensory disease pattern are bi-directionally associated with frailty in older adults. These multimorbidity measures and frailty partially mediated each other’s association with mortality, with frailty acting as a more prominent pathway in the association between multimorbidity and mortality.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003920/pdfft?md5=059441de6aed25d790b9933f8da35a8d&pid=1-s2.0-S1279770724003920-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional and longitudinal associations of adherence to WCRF/AICR cancer prevention recommendations with health-related quality of life in breast cancer survivors. Health-EpiGEICAM study","authors":"Virginia Lope ,&nbsp;Ángel Guerrero-Zotano ,&nbsp;Nerea Fernández de Larrea-Baz ,&nbsp;Silvia Antolín ,&nbsp;Marta Benavent Viñuales ,&nbsp;Begoña Bermejo ,&nbsp;Emma Ruiz-Moreno ,&nbsp;José Manuel Baena-Cañada ,&nbsp;Lorena París ,&nbsp;Antonio Antón ,&nbsp;José Ignacio Chacón ,&nbsp;Montserrat Muñoz ,&nbsp;José Angel García-Sáenz ,&nbsp;Clara Olier ,&nbsp;Pedro Sánchez Rovira ,&nbsp;Angels Arcusa Lanza ,&nbsp;Sonia González ,&nbsp;Joan Brunet ,&nbsp;Amparo Oltra ,&nbsp;Susana Bezares ,&nbsp;Marina Pollán","doi":"10.1016/j.jnha.2024.100312","DOIUrl":"https://doi.org/10.1016/j.jnha.2024.100312","url":null,"abstract":"<div><h3>Objectives</h3><p>Adherence to healthy lifestyle recommendations has been reported to improve health-related quality of life (HRQL) in breast cancer (BC) patients, but the influence of long-term behavioral changes remains unknown. We evaluated the association between adherence to the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations and HRQL both, at BC diagnosis and the change 7−12 years later.</p></div><div><h3>Design</h3><p>Prospective cohort study.</p></div><div><h3>Settings and participants</h3><p>A total of 406 breast cancer survivors, from the EpiGEICAM study, were recruited in 16 Spanish hospitals.</p></div><div><h3>Measurements</h3><p>Epidemiological, clinical, dietary, physical activity and HRQL information was collected both at recruitment and 7−12 years later. A 7-item score to measure compliance with recommendations was assessed according to the 2018 WCRF/AICR scoring criteria. HRQL was evaluated using SF-36 questionnaire. Linear mixed models for longitudinal data were used to assess the cross-sectional and longitudinal association between adherence score and the physical and mental component summary scores.</p></div><div><h3>Results</h3><p>At diagnosis, for each unit increase in WCRF/AICR score adherence, the HRQL physical domain increased 0.78 points (95%CI: −0.04 to 1.60; <em>P</em> trend:0.06). The mean change in physical HRQL from diagnosis to follow-up per unit increase in within-subject adherence score was 0.73 points (95%CI: −0.18 to 1.65; <em>P</em> trend: 0.12). For the mental domain, no association was observed with compliance with the recommendations at diagnosis, nor with changes in adherence over time.</p></div><div><h3>Conclusions</h3><p>Our results suggest that Increased adherence to WCRF/AICR cancer prevention recommendations over time could contribute to slightly improved long-term physical HRQoL in BC survivors.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003993/pdfft?md5=d8ebf1b1c1422e787d11032afed3fe3b&pid=1-s2.0-S1279770724003993-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141542378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ketogenic diet on cognitive function of patients with Alzheimer's disease: a systematic review and meta-analysis","authors":"Liyang Rong ,&nbsp;Yating Peng ,&nbsp;Qi Shen ,&nbsp;Keying Chen ,&nbsp;Bangjiang Fang ,&nbsp;Weirong Li","doi":"10.1016/j.jnha.2024.100306","DOIUrl":"10.1016/j.jnha.2024.100306","url":null,"abstract":"<div><h3>Background</h3><p>Ketogenic diets (KD) have shown remarkable effects in many disease areas. It has been demonstrated in numerous animal experiments that KD is effective in the treatment of Alzheimer's disease (AD). But the clinical effect of treating AD is uncertain.</p></div><div><h3>Objective</h3><p>To systematically review the impact of KD on cognitive function in AD.</p></div><div><h3>Methods</h3><p>We conducted a search of three international databases—PubMed, Cochrane Library, and Embase—to retrieve RCTs on the KD intervention for AD from the inception of the databases through October 2023. Two reviewers searched and screened the literature, extracted and checked relevant data independently, and assessed the risk of bias of the included studies. The meta-analysis was carried out utilizing RevMan 5.3 software.</p></div><div><h3>Results</h3><p>A total of 10 RCTS involving 691 patients with AD were included. There were 357 participants in the intervention group and 334 participants in the control group. The duration of the KD intervention ranged from a minimum of 3 months to a maximum of 15 months. Meta-analysis results showed that KD could effectively improve the mental state of the elderly (NM scale) [MD = 7.56, 95%CI (3.02, 12.10), <em>P</em> = 0.001], MMSE [MD = 1.25, 95%CI (0.46, 2.04), <em>P</em> = 0.002], and ADAS-Cog [MD = −3.43, 95%CI (−5.98, −0.88), <em>P</em> = 0.008]. The elevation of ketone body (β-hydroxybutyric) [MD = 118.84, 95%CI (15.20, 222.48), <em>P</em> = 0.02] may also lead to the elevation of triglyceride [MD = 0.19, 95%CI (0.03, 0.35), <em>P</em> = 0.02] and low density lipoprotein [MD = 0.31, 95%CI (0.04, 0.58), <em>P</em> = 0.02].</p></div><div><h3>Conclusion</h3><p>Research conducted has indicated that the KD can enhance the mental state and cognitive function of those with AD, albeit potentially leading to an elevation in blood lipid levels. In summary, the good intervention effect and safety of KD are worthy of promotion and application in clinical treatment of AD.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003932/pdfft?md5=f335c2bd4d995643e4d44892ba4bc46e&pid=1-s2.0-S1279770724003932-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of intrinsic capacity and medication non-adherence among older adults with non-communicable diseases in Taiwan","authors":"Chiachi Bonnie Lee ,&nbsp;Li-Jung Elizabeth Ku ,&nbsp;Yu-Tsung Chou ,&nbsp;Hung-Yu Chen ,&nbsp;Hui-Chen Su ,&nbsp;Yi-Lin Wu ,&nbsp;Yu-Tai Lo ,&nbsp;Yi-Ching Yang ,&nbsp;Chung-Yi Li","doi":"10.1016/j.jnha.2024.100303","DOIUrl":"10.1016/j.jnha.2024.100303","url":null,"abstract":"<div><h3>Objectives</h3><p>Medication non-adherence among older adults with non-communicable diseases (NCDs) remains prevalent worldwide, which causes hospitalization and mortality. Our study aimed to examine the association of medication non-adherence with level of overall intrinsic capacity (IC), pattern of IC, and specific IC component among older adults with NCDs.</p></div><div><h3>Methods</h3><p>A cross-sectional questionnaire-based survey of 1268 older adults aged 60 years and above was conducted in 2022 in southern Taiwan. Among them, 894 suffered from 1 more NCD were included in this study. The Integrated Care for Older People Screening Tool for Taiwanese and the Adherence to Refills and Medication Scale were used to assess IC and medication non-adherence, respectively. Latent class analysis (LCA) was used to identify patterns of IC impairment, and binary logistic regression was used to assess the association between medication non-adherence and IC.</p></div><div><h3>Results</h3><p>Older adults in the moderate (score: 1–2) or low (score≧3) overall IC groups were more likely to experience medication non-adherence (moderate: adjusted odds ratio (aOR) 1.57 [95% CI: 1.05–2.36]; low: 2.26 [1.40–3.67]). The “physical and nutritional impairments accompanied by depressive symptoms” group was associated with statistically higher odds of medication non-adherence (aOR 1.66 [1.01–2.73]). Older adults with cognitive impairment, hearing loss, or depressive symptoms showed greater likelihood of medication non-adherence (cognitive impairment: aOR 1.53 [1.03–2.27]; hearing loss: aOR 1.57 [1.03–2.37]; depressive symptoms: aOR 1.81 [1.17–2.80]).</p></div><div><h3>Conclusions</h3><p>Intervention for improving medication non-adherence among older adults with NCDs should consider IC.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724003907/pdfft?md5=1a097aa09d7e5eef9e58a6c66a3ef4bb&pid=1-s2.0-S1279770724003907-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141472780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}