Journal of Nutrition Health & Aging最新文献

{"title":"Effects of an individualised exercise program in hospitalised older adults with cancer: A randomised clinical trial","authors":"M.C. Ferrara ,&nbsp;F. Zambom-Ferraresi ,&nbsp;A. Castillo ,&nbsp;M. Delgado ,&nbsp;A. Galbete ,&nbsp;V. Arrazubi ,&nbsp;I. Morilla ,&nbsp;F. Zambom-Ferraresi ,&nbsp;M.L. Fernández González de la Riva ,&nbsp;R. Vera Garcìa ,&nbsp;N. Martínez-Velilla","doi":"10.1016/j.jnha.2024.100424","DOIUrl":"10.1016/j.jnha.2024.100424","url":null,"abstract":"<div><div>We aimed to examine the effects of an individualised multicomponent exercise program on functional outcomes in hospitalised older patients with cancer. Patients aged ≥ 65 were recruited upon admission to a Medical Oncology Department and randomly allocated to receive a multicomponent exercise training program twice daily for five days or standard hospital care. The primary outcome measure was the change in functional status using the Short Physical Performance Battery. This study allocated 30 patients in the Control group and 28 in the intervention group. The mean age was 74.4 years. The intervention group (<em>n</em> = 14) showed significant improvements vs the Control group (<em>n</em> = 20) in the Short Physical Performance Battery (SPPB) (between-group difference, 1.92; 95% CI = 0.80,3.07), knee extension strength (between-group difference 7.72; 95% CI = 1.83,13.8), as well as a significant reduction in fatigue (between-group difference −26.5; 95% CI = −38.6,−13.9). This individualised exercise program appears to have contributed to improving functional abilities and reducing fatigue in hospitalised older cancer patients.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100424"},"PeriodicalIF":4.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated pace of frailty in patients with schizophrenia","authors":"Shun Yao ,&nbsp;Lijun Wang ,&nbsp;Zhiying Yang ,&nbsp;Yichong Xu ,&nbsp;Xiaoqing Zhang ,&nbsp;Yuan Shi ,&nbsp;Donghong Cui","doi":"10.1016/j.jnha.2024.100412","DOIUrl":"10.1016/j.jnha.2024.100412","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia is associated with an increased risk of mortality and physical comorbidities, indicating a potentially accelerated frailty process in affected individuals. This study aimed to test association between schizophrenia and frailty using the frailty index based on laboratory markers (FI-Lab).</div></div><div><h3>Methods</h3><div>A total of 600 patients with schizophrenia and 518 healthy controls, aged between 20 and 69 years were included in the present study. Frailty was assessed using the FI-Lab, incorporating routine laboratory markers, body mass index, and blood pressure measurements. FI-Lab for patients with schizophrenia and healthy controls was compared, with stratification by age group and sex. In addition, robust was defined as FI-Lab ≤ 0.12, pre-frail as 0.12–0.25, and frail as &gt;0.25. Multiple linear regression analysis was used to test the association between schizophrenia and FI-Lab. Multinomial logistic regression was used to test the association between schizophrenia and frailty status. Spearman correlation analysis was performed to assess the relationship between the Positive and Negative Syndrome Scale (PANSS) scores and FI-Lab in schizophrenia patients.</div></div><div><h3>Results</h3><div>Schizophrenia patients exhibited significantly higher FI-Lab than healthy controls across all age groups, indicating accelerated pace of frailty in schizophrenia patients. Schizophrenia was significantly associated with FI-Lab (β = 0.044, p = 0.004) in the adjusted model. Schizophrenia was significantly associated with both pre-frail status (OR = 2.26, 95% CI = 1.40−3.68, p = 0.001) and frail status (OR = 10.33, 95% CI = 5.65−19.93, p = 0.007) compared to robust status in the adjusted model. Additionally, a positive correlation between FI-Lab and PANSS scores suggests that more severe schizophrenia symptoms correlate with higher degree of frailty.</div></div><div><h3>Conclusion</h3><div>These findings suggest that schizophrenia contributes to an increased risk of frailty. The FI-Lab provides a quantitative measure of frailty. This underscores the importance of integrating frailty considerations into the treatment and management of schizophrenia.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100412"},"PeriodicalIF":4.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex moderates diet quality differences in integrated collaborative care for comorbid obesity and depression: Post-hoc analysis of the RAINBOW RCT","authors":"Nan Lv ,&nbsp;Sydney W. Chin ,&nbsp;Lan Xiao ,&nbsp;Zhengxin Tang ,&nbsp;Aanika Parikh ,&nbsp;Jun Ma","doi":"10.1016/j.jnha.2024.100426","DOIUrl":"10.1016/j.jnha.2024.100426","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate (1) whether an evidence-based behavioral weight loss intervention was associated with improved diet quality in adults with obesity and depression compared with usual care; and (2) whether the associations were modified by sex.</div></div><div><h3>Design</h3><div>In the RAINBOW RCT, 409 participants were randomized in 1:1 ratio to receive a 12-month intervention integrating a Diabetes Prevention Program-based behavioral weight loss treatment with problem-solving therapy for depression (n = 204) or usual care (n = 205). Participants completed 24-h dietary recalls at baseline, 6, 12, 18, and 24 months. Dietary outcomes included the DASH score as the composite measure of diet quality and its components. Between-group differences in dietary outcomes were examined among all participants and by sex, using repeated-measures mixed-effects linear models.</div></div><div><h3>Results</h3><div>Intervention group had mean age 50.9 (SD 12.2) years and 71% women, while control had 51.0 (11.9) years and 70% women. Changes in DASH scores did not differ between the intervention and usual care control groups through 24 months in both females and males. Compared with controls, males in the intervention group had decreased nut, seed, and legume intake at 6 (mean difference, −1.1; 95% CI, −1.9, −0.3 servings/day; P = 0.01; P_ajd = 0.73) and 12 months (−1.0; −2.0, −0.0 servings/day; P = 0.048; P_ajd = 0.73). Compared with controls, females in the intervention group had decreased fruit and vegetable intake at 18 (−1.8; −2.9, −0.6 servings/day; P = 0.002; P_ajd = 0.08) and 24 months (−1.1; −2.2, −0.1 servings/day; P = 0.03; P_ajd = 0.25), and whole grain intake at 24 months (−0.5; −0.9, −0.1 servings/day; P = 0.03; P_ajd = 0.25), but increased percent calories from fat at 24 months (3.6; 0.6, 6.5; P = 0.02; P_ajd = 0.25).</div></div><div><h3>Conclusion</h3><div>Diet quality not only did not improve in an effective behavioral weight loss intervention but deteriorated in females, in particular. These post-hoc findings warrant confirmation and may suggest sex-tailored behavior change techniques specifically targeting diet quality are needed in behavioral weight loss interventions aside from caloric reductions.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov#NCT02246413 (<span><span>https://clinicaltrials.gov/ct2/show/NCT02246413</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100426"},"PeriodicalIF":4.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling aging muscle loss throughout lesser mealworm protein supplementation","authors":"Bruno Remigio Cavalcante ,&nbsp;Mariana Ferreira de Souza","doi":"10.1016/j.jnha.2024.100407","DOIUrl":"10.1016/j.jnha.2024.100407","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100407"},"PeriodicalIF":4.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grip-Strength-Lean-Mass Index (GSLMI) as a valuable tool for sarcopenia diagnosis and survival prognosis in cancer patients: a nationwide multicenter cohort study","authors":"Zhenyu Huo ,&nbsp;Feifei Chong ,&nbsp;Siyu Luo ,&nbsp;Na Li ,&nbsp;Ning Tong ,&nbsp;Zongliang Lu ,&nbsp;Jing Guo ,&nbsp;Ling Zhang ,&nbsp;Xin Lin ,&nbsp;Mengyuan Zhang ,&nbsp;Hongmei Zhang ,&nbsp;Muli Shi ,&nbsp;Xiumei He ,&nbsp;Jie Liu ,&nbsp;Chunhua Song ,&nbsp;Hanping Shi ,&nbsp;Hongxia Xu","doi":"10.1016/j.jnha.2024.100409","DOIUrl":"10.1016/j.jnha.2024.100409","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify whether the Grip-Strength-Lean-Mass Index (GSLMI) can precisely diagnose sarcopenia and predict prognosis for cancer patients in clinical settings.</div></div><div><h3>Design</h3><div>A nationwide multicenter cohort study.</div></div><div><h3>Setting and participants</h3><div>8,831 inpatients aged 18 years and older, histologically diagnosed with cancer and receiving anti-cancer therapy.</div></div><div><h3>Measurements</h3><div>The GSLMI is the ratio of hand grip strength (HGS) divided by lean mass (LM), calculated by the formula: GSLMI = HGS (kg) / LM (kg). Kaplan-Meier curves and Cox models were used to estimate the association between the GSLMI and survival.</div></div><div><h3>Results</h3><div>A total of 3,071 (48.40%) male and 3,274 (51.60%) female patients were enrolled in the study. The prevalence of GLIS-defined sarcopenia was 2,646 (41.70%). The optimal sex-specific thresholds with the best diagnostic performance to identify a low GSLMI were determined to be &lt;0.61 for males and &lt;0.47 for females based on the ROC curves. According to Kaplan-Meier curves, patients with a high GSLMI exhibited better overall survival than those with a low GSLMI (HR = 0.664, 95%CI = 0.604−0.729, log-rank P &lt; 0.001). Multivariable survival analysis revealed that the GSLMI showed an independent association with a lower hazard of death as a continuous variable (HR = 0.70, 95% CI = 0.51−0.96).</div></div><div><h3>Conclusions</h3><div>The GSLMI may serve as a novel diagnostic tool for identifying sarcopenia and may have prognostic value for cancer patients. Using the GSLMI represents a feasible and promising option for better managing the health of patients with cancer.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100409"},"PeriodicalIF":4.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between peak expiratory flow rate and all-cause mortality among Chinese stroke survivors","authors":"Yue-Ying Feng ,&nbsp;Conghua Wang ,&nbsp;Yuan-Mei Lan ,&nbsp;Tian-Chao Chen ,&nbsp;Hao-Qi Wu ,&nbsp;Xin-Yi Liu ,&nbsp;Xin-Juan Wu ,&nbsp;Xiao-Ming Zhang","doi":"10.1016/j.jnha.2024.100410","DOIUrl":"10.1016/j.jnha.2024.100410","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100410"},"PeriodicalIF":4.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial quality control measures, systemic inflammation, and lower-limb muscle power in older adults: a PROMPT secondary analysis","authors":"Helio José Coelho-Junior ,&nbsp;Emanuele Marzetti ,&nbsp;Casey L. Sexton ,&nbsp;Kevin Wu ,&nbsp;Robert Mankowski ,&nbsp;Stephen D. Anton ,&nbsp;Christiaan Leeuwenburgh ,&nbsp;Anna Picca","doi":"10.1016/j.jnha.2024.100408","DOIUrl":"10.1016/j.jnha.2024.100408","url":null,"abstract":"<div><h3>Objectives</h3><div>The study was conducted to explore associations between markers of mitochondrial quality control (MQC) from vastus lateralis muscle biopsies, serum inflammatory markers, and measures of muscle power assessed by two different tools in a sample of older adults.</div></div><div><h3>Design</h3><div>Secondary analysis of data collected in the PeppeR develOpMental ProjecT (PROMPT) at the University of Florida (Gainesville, FL, USA).</div></div><div><h3>Methods</h3><div>Forty-three older adults (n = 20 women) were included in the study. Muscle volume of the calf and thigh was quantified by three-dimensional magnetic resonance imaging. Lower-limb muscle power was estimated using 5-time sit-to-stand (5STS) muscle power equations and isokinetic test. Protein markers of MQC were measured in muscle samples by Western immoblotting (n = 12–23), while type I and II fiber cross-sectional area (CSA) and their proportion were quantified using immunohistochemistry (n = 12). Cytochrome C oxidase enzyme activity was measured spectrophotometrically. Finally, inflammatory markers were quantified in the serum using a multiplex immunoassay (n = 39).</div></div><div><h3>Results</h3><div>Mean age of participants was 78.1 ± 5.5 years, and the average body mass index was 26.2 ± 4.5 kg/m². Markers of mitochondrial biogenesis (i.e., PGC-1α), mitochondrial import proteins (i.e., cHsp70 and mtHsp70), and type I fiber CSA were significantly associated with muscle power estimated via both 5STS muscle power equations and isokinetic test (p &lt; 0.05). Specific associations were also found according to the muscle power assessment method. 5STS muscle power measures were negatively correlated with ClvCasp3, P-AMPK, T-AMPK, P-p38, GM-CSF, INF-γ, IL1b, IL6, IL8, and TNF-α, whereas positive associations were found with BAX (p &lt; 0.05). In contrast, isokinetic measures were significantly and positively correlated with RIP140, Hsp60, and type II muscle fiber CSA (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Markers of mitochondrial biogenesis (PGC-1α), mitochondrial import proteins (cHsp70 and mtHsp70), and type I muscle fiber CSA were significantly linked to lower-limb muscle power in older adults. These results suggest that muscle power is influenced by mitochondrial signaling. We also found that the relationship between mitochondrial mediators, inflammatory markers, and muscle power varied according to the assessment tool used.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100408"},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breakfast energy intake and dietary quality and trajectories of cardiometabolic risk factors in older adults","authors":"Karla-Alejandra Pérez-Vega ,&nbsp;Camille Lassale ,&nbsp;María-Dolores Zomeño ,&nbsp;Olga Castañer ,&nbsp;Jordi Salas-Salvadó ,&nbsp;F. Javier Basterra-Gortari ,&nbsp;Dolores Corella ,&nbsp;Ramón Estruch ,&nbsp;Emilio Ros ,&nbsp;Francisco J. Tinahones ,&nbsp;Gemma Blanchart ,&nbsp;Mireia Malcampo ,&nbsp;Daniel Muñoz-Aguayo ,&nbsp;Helmut Schröder ,&nbsp;Montserrat Fitó ,&nbsp;Álvaro Hernáez","doi":"10.1016/j.jnha.2024.100406","DOIUrl":"10.1016/j.jnha.2024.100406","url":null,"abstract":"<div><h3>Objectives</h3><div>Not skipping breakfast is associated with a better overall diet quality and lower cardiometabolic risk. However, the impact of calorie intake and dietary quality of breakfast on cardiovascular health remains unexplored. We aimed to study the associations between breakfast energy intake and quality and time trajectories of cardiometabolic traits in high cardiovascular risk participants.</div></div><div><h3>Design</h3><div>Prospective observational exploratory study with repeated measurements.</div></div><div><h3>Setting</h3><div>Spanish older adults.</div></div><div><h3>Participants</h3><div>383 participants aged 55–75 with metabolic syndrome from PREDIMED-Plus, a clinical trial involving a weight-loss lifestyle intervention based on the Mediterranean diet.</div></div><div><h3>Measurements</h3><div>Participants were followed for 36 months. Longitudinal averages of breakfast energy intake and quality were calculated. Three categories were defined for energy intake: 20−30% (reference), &lt;20% (low), and &gt;30% (high). Quality was estimated using the Meal Balance Index; categories were above (reference) or below the median score (low). Natural cubic spline mixed effects regressions described trajectories of cardiometabolic indicators (anthropometry, blood pressure, lipids, glucose, glycated hemoglobin, and kidney function) in breakfast groups. Inter-group differences in predicted values were estimated by linear regressions. Analyses were adjusted for age, sex, PREDIMED-Plus intervention group, education, smoking, physical activity, and total daily kilocalorie intake. Lipid profile analyses were further adjusted for baseline hypercholesterolemia, blood pressure analyses for baseline hypertension, and glucose/glycated hemoglobin analyses for baseline diabetes. Breakfast energy intake analyses were adjusted for breakfast quality, and vice versa.</div></div><div><h3>Results</h3><div>At 36 months, compared to the reference, low- or high-energy breakfasts were associated with differences in body mass index (low: 0.61 kg/m² [95% confidence interval: 0.19; 1.02]; high: 1.18 kg/m² [0.71; 1.65]), waist circumference (low: 2.22 cm [0.96; 3.48]; high: 4.57 cm [3.13; 6.01]), triglycerides (low: 13.8 mg/dL [10.8; 16.8]; high: 28.1 cm [24.7; 31.6]), and HDL cholesterol (low: −2.13 mg/dL [−3.41; −0.85]; high: −4.56 mg/dL [−6.04; −3.09]). At 36 months, low-quality breakfast was associated with higher waist circumference (1.50 cm [0.53; 2.46]), and triglycerides (5.81 mg/dL [3.50; 8.12]) and less HDL cholesterol (−1.66 mg/dL [−2.63; −0.69]) and estimated glomerular filtration rate (−1.22 mL/min/1.73m² [−2.02; −0.41]).</div></div><div><h3>Conclusions</h3><div>Low- or high-energy and low-quality breakfasts were associated with higher adiposity and triglycerides, and lower HDL cholesterol in high-risk older adults. Low-quality breakfasts were also linked to poorer kidney function.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100406"},"PeriodicalIF":4.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of phenotypic age and accelerated aging with severity and disability in patients with acute ischemic stroke","authors":"Yongkang Liu ,&nbsp;Jiangchuan Wang ,&nbsp;Zicheng Wei ,&nbsp;Yu Wang ,&nbsp;Minghua Wu ,&nbsp;Jianhua Wang ,&nbsp;Xiao Chen ,&nbsp;Rong Chen","doi":"10.1016/j.jnha.2024.100405","DOIUrl":"10.1016/j.jnha.2024.100405","url":null,"abstract":"<div><h3>Objective</h3><div>Biological age may be more accurate than chronological age in determining chronic health outcomes. However, few studies have shown the association between biological age and acute ischemic stroke (AIS). In this study we showed the association between phenotypic age (PhenoAge) or accelerated aging and severity and disability in patients with AIS.</div></div><div><h3>Design</h3><div>Retrospective study.</div></div><div><h3>Setting and subjects</h3><div>936 patients with AIS during January 2019 to July 2021 and 512 patients during June 2022 to July 2023 for a validation.</div></div><div><h3>Methods</h3><div>Stroke severity was evaluated based on the National Institute of Health stroke scale (NIHSS) questionnaire scale. Disability was evaluated by modified Rankin Scale. PhenoAge was calculated based on chronological age and 9 clinical chemistry biomarkers. Logistic regression analyses were applied to estimate the relationship between PhenoAge and the severity and disability.</div></div><div><h3>Results</h3><div>PhenoAge (odds ratio [OR] = 1.03, 95% confidence interval [CI]: 1.0–1.04, for NIHSS ≥ 5; OR = 1.05, 95%CI: 1.03−1.07, for NIHSS ≥ 10) was independently associated with stroke severity. The probability of NIHSS ≥ 5 or NIHSS ≥ 10 was significantly increased in individuals with accelerated ageing versus individuals with no accelerated aging (age gap: OR = 1.79, 95%CI: 1.18−2.72; OR = 3.53, 95%CI: 1.60−7.77; phenotypically older vs. phenotypically younger: OR = 2.01, 95%CI: 1.21−3.35; OR = 3.69, 95%CI: 1.36−10.0). Similar trends was observed when accelerated aging was defined by residual discrepancies between PhenoAge and chronological age (OR = 1.02, 95%CI: 1.01−1.04, for NIHSS ≥ 5; OR = 1.05, 95%CI: 1.02−1.08, for NIHSS ≥ 10). The area under the curve of PhenoAge was higher than that of chronological age in identifying patients with NIHSS ≥ 5 (0.66, 95%CI:0.62−0.70 vs. 0.61, 95%CI: 0.58−0.65, p &lt; 0.01) and NIHSS ≥ 10 (0.69, 95%CI:0.60−0.77 vs. 0.63, 95%CI: 0.55−0.72, p = 0.05). The probability of severe disability was significantly increased in individuals with accelerated aging versus individuals with no accelerated aging (age gap: OR = 2.87, 95%CI: 1.09−7.53; phenotypically older vs. phenotypically younger: 4.88 (1.20−19.88). Similar results were observed in the validation population.</div></div><div><h3>Conclusion</h3><div>PhenoAge or accelerated aging is associated with stroke severity and disability even after adjusting for chronological age.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100405"},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between edentulism and cardiometabolic multimorbidity in US middle-aged and older adults","authors":"Xiaoming Zhang ,&nbsp;Rui Zeng ,&nbsp;Fayi Xie ,&nbsp;Jiang Wang ,&nbsp;Dongmei Ye ,&nbsp;Aizhang Zhu ,&nbsp;Lihuan Chen ,&nbsp;Wan Zhu ,&nbsp;Ke Zhu ,&nbsp;Tenghui Fan ,&nbsp;Qingli Dou ,&nbsp;Wenwu Zhang","doi":"10.1016/j.jnha.2024.100404","DOIUrl":"10.1016/j.jnha.2024.100404","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 12","pages":"Article 100404"},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}