Journal of Nutrition Health & Aging最新文献

{"title":"Comparison of robustness, resilience and intrinsic capacity including prediction of long-term adverse health outcomes: The KORA-Age study","authors":"Michaela Rippl ,&nbsp;Marie-Theres Huemer ,&nbsp;Lars Schwettmann ,&nbsp;Eva Grill ,&nbsp;Annette Peters ,&nbsp;Michael Drey ,&nbsp;Barbara Thorand","doi":"10.1016/j.jnha.2024.100433","DOIUrl":"10.1016/j.jnha.2024.100433","url":null,"abstract":"<div><h3>Background</h3><div>Frailty, resilience and intrinsic capacity (IC) are concepts to evaluate older person`s health status, but no comparison of their associations with adverse health outcomes exists. We therefore aimed to assess which concept is most useful for determining long-term health of older adults.</div></div><div><h3>Methods</h3><div>Analyses were based on the KORA (Cooperative Health Research in the Region of Augsburg)-Age study (<em>n</em> = 940, 65–93 years). Frailty was evaluated using the physical frailty-phenotype by Fried et al. For comparability to resilience and IC, we chose the protective concept of robustness instead of frailty in the present analysis. Resilience was measured by the 11-item resilience-scale. The IC-score was based on 4 domains (locomotion, cognition, vitality and psychiatric capacities). Associations with falls, disability, and hospitalization at 3-year and 7-year follow-up and with mortality were evaluated by multivariable adjusted logistic and Cox regression. Concept overlaps were illustrated by a Venn-diagram.</div></div><div><h3>Results</h3><div>In the fully adjusted models, robustness showed significant inverse associations with most outcomes (3-year follow-up: OR (95%CI): disability 0.448 (0.300−0.668), 7-year follow-up: falls 0.477 (0.298−0.764), hospitalization 0.547 (0.349−0.856), and all-cause mortality 0.649 (0.460−0.915)) while resilience and IC showed significant inverse associations with disability only (e.g., 7-year-follow-up: resilience: 0.467 (0.304−0.716), IC: 0.510 (0.329−0.793)). 23% of the participants met the criteria for both robustness and IC while 22% met those for robustness and resilience.</div></div><div><h3>Conclusion</h3><div>Robustness was the most useful concept, showing the strongest protective associations for most adverse health outcomes. IC and resilience showed their main strengths in capturing protective associations for disabilities. Robustness overlapped with resilience and IC, supporting the concept of mind-body-interaction.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100433"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between pain, sleep and intrinsic capacity in Chinese older adults: Evidence from CHARLS","authors":"Quan Yuan ,&nbsp;Xiao Yue ,&nbsp;Mei Wang ,&nbsp;Fenghua Yang ,&nbsp;Maoling Fu ,&nbsp;Mengwan Liu ,&nbsp;Cuihuan Hu","doi":"10.1016/j.jnha.2024.100466","DOIUrl":"10.1016/j.jnha.2024.100466","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the relationship between pain, sleep, and intrinsic capacity (IC).</div></div><div><h3>Design</h3><div>A cohort study.</div></div><div><h3>Setting and participants</h3><div>Data were obtained from participants in China Health and Retirement Longitudinal Study (CHARLS) 2011–2015. The study population consisted of older adults who completed assessments on pain, sleep duration, sleep quality and IC at baseline.</div></div><div><h3>Measurements</h3><div>Pain, sleep duration, and sleep quality were assessed through self-reports from participants. The total IC score was derived from five domains: psychological, sensory, cognitive, locomotor, and vitality. The relationships between pain, sleep duration, sleep quality and IC were analyzed using linear mixed models. The relationship between sleep duration and IC was analyzed using quadratic analysis. Stratified analyses by gender and age were also performed.</div></div><div><h3>Results</h3><div>A total of 3517 participants were included in the analysis. After adjusting for all covariates, single-site pain (β = −0.29, 95% confidence interval [CI] = −0.38 to −0.20) and multisite pain (β = −0.41, 95% CI = −0.48 to −0.34) were significantly associated with a decrease in IC compared with older adults without pain; long sleep duration (β = −0.15, 95% CI = −0.24 to −0.06) was significantly associated with a decrease in IC compared with older adults with moderate sleep duration; and poor sleep quality (β = −0.63, 95% CI = −0.71 to −0.55) and fair sleep quality (β = −0.33, 95% CI = −0.40 to −0.27) were significantly associated with a decrease in IC compared with older adults with good sleep quality.</div></div><div><h3>Conclusion</h3><div>To maintain IC, it is important to ensure approximately 7.5 h of sleep duration, improve sleep quality, and manage pain. Interventions should begin as early as possible.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100466"},"PeriodicalIF":4.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary calcium intake with risk of falls in community-dwelling middle-aged and older adults","authors":"Kosuke Asano ,&nbsp;Keiko Kabasawa ,&nbsp;Ribeka Takachi ,&nbsp;Norie Sawada ,&nbsp;Shoichiro Tsugane ,&nbsp;Yumi Ito ,&nbsp;Ichiei Narita ,&nbsp;Kazutoshi Nakamura ,&nbsp;Junta Tanaka","doi":"10.1016/j.jnha.2024.100465","DOIUrl":"10.1016/j.jnha.2024.100465","url":null,"abstract":"<div><h3>Objectives</h3><div>Although calcium supplementation is reported to play a role in preventing falls, few studies have examined the relationship between dietary intake of calcium and falls. Therefore, this study investigated the association of calcium intake with falls in community-dwelling adults.</div></div><div><h3>Design</h3><div>Cross-sectional and longitudinal analyses of a prospective cohort study.</div></div><div><h3>Setting and Participants</h3><div>A 5-year follow-up of a community-based cohort study was conducted with participants aged 40 years or older (mean age, 63.1 years). The cross-sectional and longitudinal analyses included 38,566 and 24,066 participants, respectively.</div></div><div><h3>Measurements</h3><div>Dietary calcium intake was assessed using a validated food frequency questionnaire, with energy adjustment. The outcome was any falls in the preceding year, which were recorded in the self-administered questionnaire. The association of calcium intake with falls was estimated by multivariable logistic regression analysis.</div></div><div><h3>Results</h3><div>The median intake of dietary calcium was 463 mg/day and 577 mg/day in men and women, respectively. In the cross-sectional analysis, lower intake of dietary calcium was associated with falls. The adjusted odds ratio for falls in the lowest quartile versus the highest quartile was found to be 1.29 (95%CI, 1.16, 1.45) in men and 1.12 (95%CI, 1.01, 1.25) in women. The results of the longitudinal analysis were consistent, with the adjusted odds ratio for falls in the lowest quartile versus the highest quartile being 1.20 (95%CI, 1.04, 1.40) in men and 1.23 (95%CI, 1.09, 1.39) in women.</div></div><div><h3>Conclusions</h3><div>Lower intake of dietary calcium was associated with a higher risk of falls. Adequate intake of dietary calcium might help to reduce the occurrence of falls.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100465"},"PeriodicalIF":4.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and risk of postoperative pneumonia: a systematic review and meta-analysis","authors":"Xiaoyu Shu ,&nbsp;Quhong Song ,&nbsp;Xiaoli Huang ,&nbsp;Tianjiao Tang ,&nbsp;Li Huang ,&nbsp;Yanli Zhao ,&nbsp;Taiping Lin ,&nbsp;Ping Xu ,&nbsp;Pingjing Yu ,&nbsp;Jirong Yue","doi":"10.1016/j.jnha.2024.100457","DOIUrl":"10.1016/j.jnha.2024.100457","url":null,"abstract":"<div><h3>Background</h3><div>Identifying patients at risk for postoperative pneumonia and preventing it in advance is crucial for improving the prognoses of patients undergoing surgery. This review aimed to interpret the predictive value of sarcopenia on postoperative pneumonia.</div></div><div><h3>Methods</h3><div>Science Citation Index Expanded (SCIE), Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from inception to August 2nd, 2023 to retrieve eligible studies. The risk of bias was assessed by the Newcastle-Ottawa Scale (NOS). For each study, we computed the odds ratio (OR) and 95% confidence interval (CI) for postoperative pneumonia in patients with and without preoperative sarcopenia, and the I-squared (I²) test was employed to estimate heterogeneity.</div></div><div><h3>Results</h3><div>The search identified 6530 studies, and 32 studies including 114,532 participants were analyzed in this review. In most of the studies included, the risk of bias was moderate. The most reported surgical site was the chest and abdomen, followed by the abdomen, chest, limbs and spine, and head and neck. Overall, patients with preoperative sarcopenia have a 2.62-fold increased risk of developing postoperative pneumonia compared to non-sarcopenic patients [OR 2.62 (I² = 67.5%, 95%CI 2.04–3.37). Subgroup analysis focusing on different surgical sites revealed that sarcopenia has the strongest predictive effect on postoperative pneumonia following abdominal surgery (OR 4.69, I² = 0, 95% CI 3.06–7.19). Subgroup analyses targeting different types of research revealed that sarcopenia has a stronger predictive effect on postoperative pneumonia in prospective studies (OR 5.84 vs. 2.22).</div></div><div><h3>Conclusions</h3><div>Our research findings indicate that preoperative sarcopenia significantly increases the risk of postoperative pneumonia. Future high-quality prospective studies and intervention studies are needed to validate the relationship between sarcopenia and postoperative pneumonia and improve patient outcomes.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100457"},"PeriodicalIF":4.3,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between food insecurity and risk of Parkinson's disease: insights from NHANES data","authors":"Linling Lu","doi":"10.1016/j.jnha.2024.100464","DOIUrl":"10.1016/j.jnha.2024.100464","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100464"},"PeriodicalIF":4.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unhealthful plant-based diet associates with frailty risk predominantly in men with low income from the UK Biobank cohort","authors":"Kerstin Schorr ,&nbsp;Mar Rodriguez-Girondo ,&nbsp;Niels van den Berg ,&nbsp;Lisette CPMG de Groot ,&nbsp;P. Eline Slagboom ,&nbsp;Marian Beekman","doi":"10.1016/j.jnha.2024.100463","DOIUrl":"10.1016/j.jnha.2024.100463","url":null,"abstract":"<div><h3>Objective</h3><div>Plant-based diets (PBD) are generally promoted as beneficial for health. However, whether this is also the case at older ages, when energy deficits, muscle loss and frailty affect health, is unclear. Research has shown that among older adults, particularly in men, a healthful PBD is associated with a lower frailty risk. This relation was however, not studied in the context of socio-economic status (SES), a major factor influencing the risk of frailty. Therefore, we aim to assess whether plant-based diets associate with frailty risk at older ages and whether this association is moderated by sex and income in a large population-based dataset.</div></div><div><h3>Methods</h3><div>We investigated baseline data from the UK Biobank cohort study (UKB) cross-sectionally (n = 73 180, mean age = 55.48 ± 7.87). We applied a plant-based diet index [range 17−85], differentiating between a healthful (hPDI) and unhealthful plant-based diet (uPDI). Frailty was assessed by the Fried frailty phenotype and categorized into 0–4 symptoms of frailty. Average annual household income was divided into three categories: low (&lt;18.000 £), medium (18.000–52.000 £) and high (&gt;52.000 £). We applied an ordinal logistic regression model with frailty as the categorical outcome and PDI as continuous predictor while adjusting for age, sex, ethnicity, education, BMI and UKB assessment center. Secondly, we included an interaction term (PDI*sex*income). To identify subgroups driving any interactions, we stratified by sex and subsequently by income group to determine the effect of PDI in subgroups while additionally adjusting for lifestyle factors.</div></div><div><h3>Results</h3><div>A 10-unit increase in hPDI was associated with 3.4% lower odds for frailty (OR = 0.966, 95%CI [0.946, 0.987]), whereas a 10-unit increase in uPDI was associated with 7.7% greater odds for frailty (OR = 1.077, 95%CI [1.054, 1.101]). The association between uPDI and frailty was moderated by income and sex (uPDI*income*sex, p = 0.002), whereas no such moderation was found for hPDI (p = 0.602). Subsequent stratification reveals a significant effect of uPDI on frailty particularly among men with low income (OR = 1.177, 95% CI [1.069, 1.298]), but not for women. This association in men largely persisted after adjustment for additional lifestyle factors (OR = 1.119, 95%CI [0.995, 1.258]).</div></div><div><h3>Conclusion</h3><div>We observed that adherence to an unhealthful plant-based diet was associated with a higher risk for frailty. This relation was especially observed for men with lower incomes and not explained by other lifestyle factors. While future research may investigate more specific determinants of health and diet behavior in men of low household income, this group in particular may profit from diet intervention improving diet quality</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100463"},"PeriodicalIF":4.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical inactivity, depressive symptoms, and progression to sarcopenia in older adults: a 4-year longitudinal study","authors":"Ryo Yamaguchi ,&nbsp;Keitaro Makino ,&nbsp;Osamu Katayama ,&nbsp;Daiki Yamagiwa ,&nbsp;Hiroyuki Shimada","doi":"10.1016/j.jnha.2024.100452","DOIUrl":"10.1016/j.jnha.2024.100452","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine the combined association of physical inactivity and depressive symptoms with the progression to sarcopenia in community-dwelling older adults.</div></div><div><h3>Design</h3><div>A 4-year follow-up longitudinal study.</div></div><div><h3>Setting</h3><div>Community-dwelling older adults living in Japan, who were not sarcopenic at baseline.</div></div><div><h3>Participants</h3><div>The participants were 2,538 community-dwelling older adults and with a mean age of 70.9 ± 4.6 years, of whom 1,327 (52.3%) were women.</div></div><div><h3>Measurements</h3><div>Sarcopenia, defined according to the European Working Group on Sarcopenia in Older People 2, was assessed at baseline and at the 4-year follow-up. Participants were divided into four groups according to their inactivity and depressive symptoms. Physical inactivity was assessed using two face–to–face questions regarding the frequency of regular exercise, sports, and light exercise per week. Depressive symptoms were defined as a score of six or higher on the Geriatric Depression Scale 15-item version. Logistic regression analysis was used to determine whether inactivity and depressive symptoms were associated with progression to sarcopenia 4 years later. For participants who could not be followed and participants with missing data in the follow-up assessment, the data at the follow-up assessment were imputed using the multiple imputations.</div></div><div><h3>Results</h3><div>After 4 years, 518 participants (20.4%) with complete data progressed to sarcopenia. The rate of progression to sarcopenia after multiple imputations was 23.4%. Logistic regression analysis after multiple imputations showed that the group with both factors was significantly associated with the progression to sarcopenia [Odds ratio, 1.64 (95% Confidence interval 1.11–2.44), p = 0.014]. By contrast, no significant association was found for either inactivity or depressive symptoms alone.</div></div><div><h3>Conclusion</h3><div>This study indicates that the coexistence of physical inactivity and depressive symptoms may contribute to the progression of sarcopenia. Addressing both physical and mental factors, rather than limiting the problem to a single factor, may be essential for preventing sarcopenia.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 3","pages":"Article 100452"},"PeriodicalIF":4.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional associations between dietary intake of polyunsaturated fatty acids, physical function, and sarcopenia in community-dwelling older adults","authors":"Hélio José Coelho-Júnior ,&nbsp;Alejandro Álvarez-Bustos ,&nbsp;Anna Picca ,&nbsp;Riccardo Calvani ,&nbsp;Leocadio Rodriguez-Mañas ,&nbsp;Francesco Landi ,&nbsp;Emanuele Marzetti","doi":"10.1016/j.jnha.2024.100423","DOIUrl":"10.1016/j.jnha.2024.100423","url":null,"abstract":"<div><h3>Objectives</h3><div>The present study examined the associations between the dietary intake of polyunsaturated fatty acids (PUFAs), physical function, and the prevalence of sarcopenia in Italian community-dwelling older adults.</div></div><div><h3>Design</h3><div>Cross-sectional study.</div></div><div><h3>Setting</h3><div>Unconventional settings across Italy (e.g., exhibitions, health promotion campaigns).</div></div><div><h3>Participants</h3><div>Older adults (65+ years) who provided a written informed consent.</div></div><div><h3>Methods</h3><div>Physical function was evaluated according to isometric handgrip strength (IHG) and 5-time sit-to-stand (5STS) performances. Muscle power parameters were estimated based on 5STS values. Sarcopenia was operationalized according to the presence of low physical function (IHG or 5STS) plus low appendicular skeletal muscle mass (ASM), estimated according to calf circumference. A 12-item food questionary was used to estimate the dietary intake of PUFAs, which included omega-3 (α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid) and omega-6 fatty acids.</div></div><div><h3>Results</h3><div>Multiple linear regression results indicate negative and significant associations between the dietary intake of α-linolenic acid and muscle power, and between docosahexaenoic acid consumption and ASM. No significant associations were found between PUFAs-related variables and sarcopenia.</div></div><div><h3>Conclusions</h3><div>Results of the present study indicate that PUFAs-related variables were negatively and significantly associated with physical function and body composition in older adults. Nevertheless, no significant associations were found with sarcopenia. These findings suggest that a more detailed analysis of covariates should be conducted in future investigations that aim to examine the associations between the dietary intake of PUFAs and sarcopenia-related parameters.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100423"},"PeriodicalIF":4.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor clinical outcomes associated to multimorbidity, frailty and malnutrition in patients with atrial fibrillation","authors":"Eva Soler-Espejo ,&nbsp;Beatriz Ángela Zazo-Luengo ,&nbsp;José Miguel Rivera-Caravaca ,&nbsp;Raquel López-Gávez ,&nbsp;María Asunción Esteve-Pastor ,&nbsp;Gregory Y.H. Lip ,&nbsp;Francisco Marín ,&nbsp;Vanessa Roldán","doi":"10.1016/j.jnha.2024.100430","DOIUrl":"10.1016/j.jnha.2024.100430","url":null,"abstract":"<div><h3>Background</h3><div>Atrial fibrillation (AF) patients often present with a higher prevalence of comorbidities, frailty, and malnutrition. We investigated if multimorbidity, frailty and malnutrition were associated with clinical outcomes in patients with AF starting vitamin K antagonist (VKA) therapy.</div></div><div><h3>Methods</h3><div>Prospective observational cohort study including AF outpatients starting VKAs from July 2016 to June 2018. Multimorbidity was assessed by the number of comorbidities, frailty was evaluated using the Clinical Frailty Scale (CFS), and nutritional status was appraised using the Controlling Nutritional Status (CONUT). During 2-years of follow-up, ischemic strokes/transient ischemic attacks (TIA), major bleeds, and all-cause deaths, were recorded.</div></div><div><h3>Results</h3><div>1050 AF patients (51.4% female; median age 77 years, IQR 70–83) were included. Of these, 912 (86.9%) had multimorbidity (≥2 comorbidities additional to AF), 186 (17.7%) exhibited any frailty degree (CFS ≥ 5), and 76 (7.2%) had moderate-to-severe malnutrition (CONUT ≥ 5). The crude number of comorbidities and the CFS were significantly associated with major bleeds, whereas the CFS and the CONUT score were related to all-cause mortality. After adjustment, any frailty degree was associated with higher risks of major bleeding (aHR 3.04, 95% CI 1.67−5.52) and death (aHR 2.04, 95% CI 1.39−3.01). Moderate-to-severe malnutrition increased risk for ischemic stroke/TIA (aHR 2.25, 95% CI 1.11−4.56) and all-cause mortality (aHR 3.21, 95% CI 2.14−4.83).</div></div><div><h3>Conclusions</h3><div>In this real-world prospective cohort of AF taking VKAs, most patients had multiple comorbidities, frailty and malnutrition. Frailty and malnutrition were important risk factors for bleeding, stroke, and mortality in these patients.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100430"},"PeriodicalIF":4.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-trajectories of intrinsic capacity and their effect on higher-level functional capacity, life satisfaction, and self-esteem in community-dwelling older adults: the NILS-LSA","authors":"Shu Zhang ,&nbsp;Chikako Tange ,&nbsp;Shih-Tsung Huang ,&nbsp;Sayaka Kubota ,&nbsp;Hiroshi Shimokata ,&nbsp;Yukiko Nishita ,&nbsp;Rei Otsuka","doi":"10.1016/j.jnha.2024.100432","DOIUrl":"10.1016/j.jnha.2024.100432","url":null,"abstract":"<div><h3>Objectives</h3><div>Variability in intrinsic capacity (IC) changes among community-dwelling older adults and their effect on health outcomes remain understudied. We examined the variability in IC trajectories and their impact on higher-level functional capacity (HLFC), life satisfaction, and self-esteem.</div></div><div><h3>Design</h3><div>Longitudinal study.</div></div><div><h3>Setting</h3><div>Data from the second to seventh waves (2000–2012) of the National Institute for Longevity Sciences–Longitudinal Study of Aging project.</div></div><div><h3>Participants</h3><div>934 community dwellers (aged ≥60).</div></div><div><h3>Measurements</h3><div>We used group-based multi-trajectory modeling to obtain IC trajectories across six domains: cognition, locomotion, vitality, vision, hearing, and psychological well-being. We employed multivariable regression to investigate the associations between IC trajectories and a decline in HLFC (assessed using the Tokyo Metropolitan Institute of Gerontology Index of Competence [TMIG-IC]; baseline TMIG-IC - follow-up TMIG-IC ≥ 2; logistic regression model), life satisfaction (assessed using the Life Satisfaction Index-K [LSI-K]; linear mixed model), and self-esteem (assessed using the Rosenberg Self-Esteem Scale [RSES]; linear mixed model).</div></div><div><h3>Results</h3><div>We identified four IC trajectories: the “healthy aging group” (63.7%), the “hearing decline group” (15.1%), the “vision and cognitive decline group” (12.7%), and the “comprehensive deterioration group” (8.5%). Compared to the healthy aging group, the vision and cognitive decline group and the comprehensive deterioration group displayed a significantly greater risk of a decline in the TMIG-IC score (multivariable-adjusted odds ratio [aOR], 95% confidence interval [CI] = 2.05 [1.11, 3.79], 2.74 [1.41, 5.30], respectively), the LSI-K score (multivariable-adjusted <em>β</em> [standard error] = −0.46 [0.08], −0.52 [0.10], respectively), and the RSES score (multivariable-adjusted <em>β</em> [standard error] = −0.85 [0.16], −0.66 [0.20], respectively). The “hearing decline group” did not show a significantly increased risk for these outcomes.</div></div><div><h3>Conclusion</h3><div>Older adults with different IC trajectories may differ in HLFC, life satisfaction, and self-esteem. Public health officials should be aware of this and provide targeted interventions.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 1","pages":"Article 100432"},"PeriodicalIF":4.3,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}