Journal of Nutrition Health & Aging最新文献

{"title":"Differential associations of dietary inflammatory potential, antioxidant capacity, and Mediterranean diet adherence with biological aging: A UK Biobank study","authors":"Cong Zhang , Ren-Fang Han , Song Yin , Yue-Qing Huang","doi":"10.1016/j.jnha.2025.100638","DOIUrl":"10.1016/j.jnha.2025.100638","url":null,"abstract":"<div><h3>Background</h3><div>Biological aging, distinct from chronological age, significantly impacts chronic disease risk and is a crucial target for health interventions. While diet is hypothesized to influence aging through inflammatory and oxidative pathways, systematic evidence from large populations remains limited. To address this gap, we used UK Biobank data with complementary dietary indices assessing inflammatory and antioxidant properties, providing comprehensive insights into diet-aging links.</div></div><div><h3>Methods</h3><div>We analyzed data from 46,755 UK Biobank participants in this cross-sectional study. Dietary inflammatory potential, antioxidant capacity, and Mediterranean diet adherence were assessed using the Dietary Inflammatory Index (DII), Composite Dietary Antioxidant Index (CDAI), and Alternative Mediterranean Diet (aMED) scores, respectively, derived from 24-h food consumption reports. Biological age acceleration was quantified by Klemera-Doubal method biological age (KDM-BA) and phenotypic age (PhenoAge). Multivariate linear and logistic regressions, restricted cubic spline models, and mediation analyses were performed, adjusting for extensive confounders.</div></div><div><h3>Results</h3><div>Pro-inflammatory diets (higher DII scores) were significantly associated with increased biological age acceleration (KDM-BA: β = 0.39; PhenoAge: β = 0.96, all <em>P</em> < 0.001), whereas antioxidant-rich diets (higher CDAI scores) and Mediterranean diets (higher aMED scores) showed inverse associations (CDAI: β= −0.33 to −0.50; aMED: β = −0.31 to −0.60, all <em>P</em> < 0.001). Logistic regressions confirmed that aMED adherence reduced odds of biological age acceleration (OR: 0.68–0.69, <em>P</em> < 0.001). Dose-response analyses revealed nonlinear positive associations between DII and PhenoAge acceleration (<em>P</em><sub>nonlinear</sub> < 0.001), nonlinear negative associations for CDAI (<em>P</em><sub>nonlinear</sub> ≤ 0.016), and near-linear negative trends for aMED (<em>P</em><sub>nonlinear</sub> ≤ 0.035). Mediation analyses indicated that DII and CDAI accounted for 15.7%–50.4% and 15.0%–20.2%, respectively, of the association between aMED and biological age acceleration, highlighting anti-inflammatory and antioxidant mechanisms in delaying aging.</div></div><div><h3>Conclusion</h3><div>This study provides robust evidence that dietary pro-inflammatory potential, antioxidant capacity, and Mediterranean diet adherence exhibit independent and differential associations with biological aging. Pro-inflammatory diets are associated with accelerated aging, whereas antioxidant-rich and Mediterranean diets are associated with decelerated biological aging. Mediation analyses reveal that the Mediterranean diet’s benefits are partially mediated by its anti-inflammatory and antioxidant properties. Future research should employ longitudinal designs to establish causation and clarify mechanisms, positioning diet as a key modi","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100638"},"PeriodicalIF":4.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capturing vitality: Toward a multidimensional lens for intrinsic capacity and healthy aging","authors":"Hussein Samhat , Gustavo Duque","doi":"10.1016/j.jnha.2025.100636","DOIUrl":"10.1016/j.jnha.2025.100636","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100636"},"PeriodicalIF":4.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Geroscience Research – A Scoping Review of Regulatory Environments for Gerotherapeutics","authors":"John Muscedere ,&nbsp;Carrie L. Shorey ,&nbsp;Gustavo Duque ,&nbsp;Perry Kim ,&nbsp;Amanda L. Lorbergs ,&nbsp;Chris McGlory ,&nbsp;Reshma A. Merchant ,&nbsp;John C. Newman ,&nbsp;Yves Rolland ,&nbsp;Bruno Vellas","doi":"10.1016/j.jnha.2025.100637","DOIUrl":"10.1016/j.jnha.2025.100637","url":null,"abstract":"<div><h3>Background</h3><div>Globally, older adults are living longer but often in poorer health with multiple chronic conditions straining healthcare systems. Gerotherapeutics, which target the biological mechanisms of aging, could reduce this burden by extending healthspan. However, before therapies can be adopted, they must undergo rigorous study and regulatory approval; existing regulatory frameworks and the barriers to their development are unknown.</div></div><div><h3>Objective</h3><div>We conducted a scoping review of geroscience regulatory frameworks and identified barriers to their development.</div></div><div><h3>Methods</h3><div>A comprehensive government, academic, and grey literature search in the United States, Europe, Canada, and other regions including Medline and EMBASE (via OVID), Google Scholar, CINAHL, and CADTH Grey Matters was conducted. For inclusion of only recent literature, searches were limited to English-language publications from 2014 to 2024.</div></div><div><h3>Results</h3><div>In 3,780 publications screened for inclusion, no regulatory frameworks for gerotherapeutics were found. In the 34 included publications, 4 major barriers were identified: 1) lack of recognition of the biological processes of aging as targets for medical intervention; 2) absence of clear regulatory pathways to evaluate aging-focused therapies; 3) economic uncertainties, including high development costs and limited incentives due to unclear regulatory environments; and 4) insufficient public and policy engagement.</div></div><div><h3>Conclusion</h3><div>We did not identify any geroscience specific regulatory frameworks but identified barriers to their development. For biological aging to advance as a therapeutic target, stakeholders must develop comprehensive regulatory guidelines, incentivize research and conduct public education. Global collaboration is crucial to harmonize regulatory efforts and ensure equitable adoption of therapies, ultimately enhancing healthspan worldwide.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100637"},"PeriodicalIF":4.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of muscle strength and power in the short physical performance battery for predicting negative outcomes in older adults with mobility limitations","authors":"Hélio José Coelho-Júnior ,&nbsp;Alejandro Álvarez-Bustos ,&nbsp;Leocadio Rodriguez-Mañas ,&nbsp;Francesco Landi ,&nbsp;Emanuele Marzetti","doi":"10.1016/j.jnha.2025.100631","DOIUrl":"10.1016/j.jnha.2025.100631","url":null,"abstract":"<div><h3>Objectives</h3><div>The present study examined sex-specific associations between Short Physical Performance Battery (SPPB) indexes operationalized according to lower limb muscle strength and power and the occurrence of negative events in older adults with mobility limitations.</div></div><div><h3>Design</h3><div>Secondary longitudinal analysis of a randomized controlled trial</div></div><div><h3>Setting</h3><div>Community-Dwellers.</div></div><div><h3>Participants</h3><div>Older adults (70+ years) with mobility limitations.</div></div><div><h3>Methods</h3><div>Participants completed the SPPB under standardized conditions. Muscle power measures were estimated according to results of the 5-time sit-to-stand (5STS) test using validated equations. Then, four SPPB indexes were created by replacing 5STS test results with muscle power measures. Outcomes were assessed after 24 months of randomization and included mobility disability, hospitalization, and death.</div></div><div><h3>Results</h3><div>Data from 1,422 participants were analyzed. Cox regression models revealed sex-specific associations between SPPB variants and adverse outcomes. SPPB indexes incorporating muscle strength or power were significantly associated with mobility disability in both sexes, and with hospitalization and death in women. According to Akaike’s Information Criterion, muscle power-based SPPB indexes provided the best fit for predicting negative outcomes.</div></div><div><h3>Conclusions</h3><div>Sex-specific associations exist between modified SPPB indexes and adverse outcomes in older adults with mobility limitations. Notably, SPPB variants incorporating muscle power measures demonstrated the best fit for adverse outcomes in comparison to traditional SPPB.</div></div><div><h3>Trial registration</h3><div>ClinicalTrials.gov identifier: NCT02582138 (registration date: 2015-10-08).</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100631"},"PeriodicalIF":4.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the MIND diet and cognitive health in middle-aged and older adults: A systematic review","authors":"Jenny Hiu Wai Tse ,&nbsp;Queenie Pui Sze Law ,&nbsp;Jenny Tsun Yee Tsang ,&nbsp;Lorna Kwai Ping Suen ,&nbsp;Stefanos Tyrovolas ,&nbsp;Rick Yiu Cho Kwan","doi":"10.1016/j.jnha.2025.100630","DOIUrl":"10.1016/j.jnha.2025.100630","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Cognitive decline, a natural aspect of aging, is linked to negative outcomes like increased mortality and social isolation. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, blending the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH) diet elements, aims to slow cognitive decline and reduce dementia risk. Secondary analyses of population studies and randomized controlled trials (RCTs) show mixed results on the MIND diet's effectiveness in improving cognitive health. Existing reviews have explored the MIND diet's impact on cognitive health, though their focus can be broad or narrow. Our review offers an updated perspective by specifically targeting dementia risk and clinical cognitive function, integrating new studies for enhanced insights into clinical practice and research.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 and the Synthesis Without Meta-analysis (SWiM) guidelines and was registered in PROSPERO (CRD42023391972). We included quantitative studies on middle-aged and older adults (mean age &gt;40 years) examining MIND diet adherence and cognitive health, excluding non-original research. A systematic search was conducted in five databases from March 2023 to March 2024 using relevant search terms. Data were extracted and assessed for bias by multiple reviewers using Joanna Briggs Institute (JBI) tools. Heterogeneous data were synthesized using SWiM guidelines, focusing on cognitive function outcomes, with results presented in tables and figures.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The search over five databases identified 898 articles, with 26 meeting the inclusion criteria. A hand search added 13 more, totaling 39 articles from 14 countries, including cohorts, cross-sectional, RCTs, and case-control studies. Most studies were conducted in the United States of America (USA), published between 2015 and 2024. Participant numbers ranged from 37 to 120,661, with follow-ups from 3 months to 24 years. Some studies explored more than one correlation. Of the studies, 14 out of 19 articles explored MIND diet adherence and global cognitive function, showing positive results. 10 out of 11 studies investigated MIND diet adherence and dementia/Alzheimer’s risk, showing positive associations. 16 out of 18 articles examined the MIND diet's effect on domain-specific cognitive functions, with favorable outcomes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;This systematic review reveals the significant promise of the MIND diet in enhancing cognitive health, specifically in global cognition, memory, and executive function. While observational studies strongly advocate for its inclusion in clinical guidelines to prevent and manage Alzheimer's disease (AD) and dementia, results from RCTs are mixed, suggesting further investigation is needed. The use of PRISMA and SWiM guidelines ensures ","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100630"},"PeriodicalIF":4.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory index and the risk of cardiovascular disease and mortality: A prospective cohort study of Chinese community-dwelling older adults","authors":"Shu-Yi Li ,&nbsp;Zhi-Hui Lu ,&nbsp;Jason C.S. Leung ,&nbsp;Yi Su ,&nbsp;Blanche W.M. Yu ,&nbsp;Timothy C.Y. Kwok","doi":"10.1016/j.jnha.2025.100624","DOIUrl":"10.1016/j.jnha.2025.100624","url":null,"abstract":"<div><h3>Objectives</h3><div>Inflammation is a contributory factor for cardiovascular disease (CVD), and diet can modulate inflammation. This study aimed to investigate the association between dietary inflammatory index (DII) and CVD outcomes, and the mediating roles of cardiovascular risk factors.</div></div><div><h3>Design</h3><div>A prospective cohort study.</div></div><div><h3>Setting and participants</h3><div>A total of 3,013 Chinese community-dwelling older adults aged ≥65 years without CVD were included between 2001 and 2003 in Hong Kong.</div></div><div><h3>Measurements</h3><div>DII was calculated using a 280-item validated food frequency questionnaire. CVD outcomes included incident CVD, coronary heart disease (CHD), stroke, and CVD mortality, which were obtained from official records. Cox proportional hazards models examined the association between tertiles of DII and CVD outcomes. Mediation analysis explored the mediating roles of cardiovascular risk factors, including inflammatory biomarkers, impaired renal function, abnormal ankle-brachial index (ABI), obesity, central obesity, diabetes mellitus, and hypertension.</div></div><div><h3>Results</h3><div>There were 263 CVD cases, 147 CHD cases, and 130 strokes during a median follow-up of 5.7 years. There were 277 CVD deaths during a median follow-up of 16.8 years. The highest tertile of DII was associated with increased risks of CVD incidence (HR: 1.43, 95% CI: 1.05–1.96) and CVD mortality (HR: 1.45, 95% CI: 1.03–2.03) compared with the lowest tertile. No significant associations were found for CHD and stroke. Impaired renal function, abnormal ABI, and hyperhomocysteinemia mediated the effects of a pro-inflammatory diet on CVD risk, with mediated proportions ranging from 3.68% to 7.78%.</div></div><div><h3>Conclusion</h3><div>A pro-inflammatory diet increased the risks of CVD incidence and mortality, mediated by impaired renal function, abnormal ABI, and hyperhomocysteinemia.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100624"},"PeriodicalIF":4.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition risk as a predictor of quality of life and skeletal muscle depletion following upper gastrointestinal cancer diagnosis: A longitudinal analysis","authors":"Lauren Hanna ,&nbsp;Kay Nguo ,&nbsp;Judi Porter ,&nbsp;Daniel Croagh ,&nbsp;Catherine E Huggins","doi":"10.1016/j.jnha.2025.100623","DOIUrl":"10.1016/j.jnha.2025.100623","url":null,"abstract":"<div><h3>Objectives</h3><div>Low skeletal muscle index (SMI) and radiodensity (SMD) are established prognostic indicators in cancer. This study investigated risk factors for low and decreasing SMI and low SMD in upper gastrointestinal cancer and examined the influence of malnutrition risk on the association between SMI and health-related quality of life (HRQOL).</div></div><div><h3>Design</h3><div>Longitudinal analysis of randomised controlled trial outcome data.</div></div><div><h3>Setting</h3><div>Three health services in Victoria, Australia.</div></div><div><h3>Participants</h3><div>Adults newly diagnosed with oesophageal, gastric or pancreatic cancer.</div></div><div><h3>Measurements</h3><div>Outcomes assessed at diagnosis, and three- and six-month follow-up. SMI and SMD were assessed via computed tomography imaging analysis, with low values determined using established sex-specific thresholds. Malnutrition risk was assessed using the Patient Generated Subjective Global Assessment (Short Form), and HRQOL with the EORTC QLQ-C30. Multiple logistic regression identified risk factors for low SMI and low SMD at baseline, and SMI decline (≥5%) from baseline to 3 months. Associations between SMI and HRQOL were examined using multiple linear regression, adjusting for malnutrition risk.</div></div><div><h3>Results</h3><div>Among 105 participants (43% oesophageal, 20% gastric, 37% pancreatic cancer), older age predicted low SMI and low SMD. Low SMI risk was higher in females and lower with higher BMI. At three months, 57% (37/65) experienced ≥5% SMI loss, associated with higher malnutrition risk, higher baseline SMI, and post-diagnosis weight loss. Malnutrition risk was a strong independent predictor of poorer HRQOL score at all timepoints. Lower or decreasing SMI (≥5%) was also independently associated with poorer HRQOL on some scales.</div></div><div><h3>Conclusion</h3><div>Malnutrition risk independently predicted lower HRQOL and muscle loss, and may confound the relationship between SMI and HRQOL. As a modifiable factor, addressing malnutrition risk could improve HROQL and preserve muscle in upper gastrointestinal cancer.</div></div><div><h3>Trial registration</h3><div>Australian New Zealand Clinical Trials Registry, 27 January 2017 (12617000152325).</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100623"},"PeriodicalIF":4.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum klotho is inversely associated with girth in older women but is not associated with falls or musculoskeletal measures in either sex","authors":"Bess Dawson-Hughes ,&nbsp;Elsa M. Konieczynski ,&nbsp;Lisa Ceglia","doi":"10.1016/j.jnha.2025.100618","DOIUrl":"10.1016/j.jnha.2025.100618","url":null,"abstract":"<div><h3>Objective</h3><div>Serum klotho, a biomarker of aging, has been associated with cardiovascular disease, kidney disease, and osteoarthritis, but information on an association with muscle and bone aging is limited. We assessed serum klotho as a potential biomarker of age-related changes in body composition, odds of falling, muscle strength and bone mineral density (BMD) in older adults.</div></div><div><h3>Design</h3><div>Exploratory analysis within the STOP IT clinical trial.</div></div><div><h3>Setting</h3><div>USDA Human Nutrition Research Center on Aging at Tufts University.</div></div><div><h3>Participants</h3><div>Healthy adults (178 men; 209 women) age ≥65 years treated daily for 3 years with either 700 IU of vitamin D₃ plus 500 mg of calcium or placebo.</div></div><div><h3>Methods</h3><div>We examined associations of serum klotho (at 6 or 12 months) with odds of falling, and with baseline and 3-year changes in body composition, grip strength and spine and hip BMD by dual-energy X-ray absorptiometry (DXA).</div></div><div><h3>Results</h3><div>Serum klotho levels did not differ significantly in the two treatment arms. In the arms combined, klotho was inversely associated with waist circumference (β= -0.007, p = 0.01) in the women but not in the men, after adjustment for age, physical activity, treatment assignment, kidney function, season and time of klotho measurement. Serum klotho was not associated with odds of falling or with proportion of body fat or lean mass, grip strength, or spine or hip BMD or their 3-year changes in men or women.</div></div><div><h3>Conclusion</h3><div>Serum klotho is inversely related to waist circumference in healthy older women but not men. Serum klotho does not appear to be a useful biomarker of musculoskeletal status in older women or men.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100618"},"PeriodicalIF":4.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of n-3 fatty acid intake with muscle mass and strength in older adults: A cross-sectional analysis of the UK biobank data","authors":"Maha Timraz ,&nbsp;Marion Guerrero Wyss ,&nbsp;Terry J. Quinn ,&nbsp;Emilie Combet ,&nbsp;Carlos Celis-Morales ,&nbsp;Stuart R. Gray","doi":"10.1016/j.jnha.2025.100622","DOIUrl":"10.1016/j.jnha.2025.100622","url":null,"abstract":"<div><h3>Objectives</h3><div>The main aim was to investigate the association of n-3 fatty acid intake and the n-6/n-3 fatty acid intake ratio with muscle mass and strength in older adults.</div></div><div><h3>Methods</h3><div>This study included 61,381 individuals (28,187 men and 33,194 women) aged ≥60 years. Grip strength and muscle mass index were assessed and n-3 and n-6 fatty acid intake were determined. Regression models adjusted for age, deprivation index, ethnicity, month of assessment, total energy intake, multimorbidity, lifestyle factors and physical activity. A sensitivity analysis was conducted in participants aged ≥65 years and in people with sarcopenia.</div></div><div><h3>Results</h3><div>Data are presented as trend for quintiles from fully adjusted models. Higher n-3 fatty acid intake was associated with a higher grip strength in both men (0.114 kg; 95% CI: 0.02 to 0.21) and women (0.115 kg; 95% CI: 0.05 to 0.18). Similar results were reported for grip strength index, with no associations observed for muscle mass index. No associations were seen in people ≥65 years. In people with sarcopenia no associations of n-3 fatty acid intake with grip strength or grip strength index were seen, but a positive association with muscle mass index was noted in men (0.197 kg/m²; 95% CI: 0.05 to 0.33). The n-6/n-3 fatty acid intake ratio was associated with grip strength in women (0.081 kg; 95% CI: −0.16 to 0.000) and with muscle mass index in men (−0.016 kg/m²; 95% CI: −0.02 to 0.00), no other associations were observed. No associations were seen in people with sarcopenia or people ≥65 years.</div></div><div><h3>Conclusion</h3><div>Higher n-3 fatty acid intake, with no consistent association with the n-6/n-3 fatty acid intake, was modestly associated with grip strength, with effects varying by sex and age, suggesting limited benefit for sarcopenia prevention at typical intake levels in older adults.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100622"},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unpacking vitality for healthy aging—A call for multidimensional assessment and social integration","authors":"Hidenori Arai","doi":"10.1016/j.jnha.2025.100617","DOIUrl":"10.1016/j.jnha.2025.100617","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100617"},"PeriodicalIF":4.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}