Journal of Nutrition Health & Aging最新文献

{"title":"Associations of Physical Frailty, Social Deficits, and Cognitive Impairment with Risk of 45 Incident Non-Communicable Diseases: The Mediating Role of Accelerated Biological Aging—A Prospective Cohort Study","authors":"Bing Pei ,&nbsp;Yue Yu ,&nbsp;Xinyuan Shen ,&nbsp;Yanjie Jia ,&nbsp;Jianping Wang ,&nbsp;Yihan Zhang ,&nbsp;Ying Shi ,&nbsp;Wenjing Wang ,&nbsp;Fulan Hu ,&nbsp;Fan Wang","doi":"10.1016/j.jnha.2025.100672","DOIUrl":"10.1016/j.jnha.2025.100672","url":null,"abstract":"<div><h3>Objectives</h3><div>Frailty extends beyond a physical construct to encompass cognitive and social functioning. We aimed to assess the associations of these impairments, individually and in combination, with the risk of 45 non-communicable diseases (NCDs), and explore the role of accelerated biological aging.</div></div><div><h3>Design and setting</h3><div>A prospective cohort study was conducted using data from the UK Biobank.</div></div><div><h3>Participants</h3><div>A total of 427,026 participants with physical data, 171,269 with social data, and 49,820 with cognitive data were included in analysis.</div></div><div><h3>Measurements</h3><div>Physical frailty, social deficits, and cognitive impairment were assessed using self-reported data and anthropometric measurements, while biological age was calculated based on blood chemistry and clinical data. Hazard ratios (HRs) and population attributable fractions were calculated to assess their associations with NCDs risk. The role of accelerated biological aging in these associations were investigated by mediation analysis.</div></div><div><h3>Results</h3><div>Physical frailty, high social deficits, and cognitive impairment were associated with an increased risk of 27, 17, and 7 NCDs, respectively (HR &gt; 1, <em>P</em>_adjusted&lt;0.05). Pre-physical frailty and moderate-social deficits were also associated with numerous NCDs risk. Compared to participants with single impairment, those with impairment in multiple domains had a higher risk of NCDs (<em>P</em> &lt; 0.05). In addition, physical frailty and high social deficits had a greater impact on NCDs in younger individuals (&lt;60 years old) and females (<em>P</em>_interaction&lt;0.05). These function impairments accelerated biological aging (<em>P</em>_trend&lt;0.05), and mediation analysis revealed that accelerated biological aging explained 3.205%–50.296% of their associations with NCDs.</div></div><div><h3>Conclusions</h3><div>Impairments in physical, social, and cognitive functions were associated with an increased risk of numerous NCDs, with accelerated biological aging partially mediating these associations, highlighting the importance of systematically assessing frailty and biological aging and implementing interventions to prevent NCDs.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100672"},"PeriodicalIF":4.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preprocedural frailty status and short- and long-term mortality risk after endovascular therapy in elderly acute ischemic stroke patients","authors":"Weiwei Gao ,&nbsp;Xingyu Chen ,&nbsp;Arslan Annadurdyyev ,&nbsp;Lijuan Cai ,&nbsp;Lingfeng Yu ,&nbsp;Ziqu Xu ,&nbsp;Renjing Zhu","doi":"10.1016/j.jnha.2025.100673","DOIUrl":"10.1016/j.jnha.2025.100673","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the Laboratory-based Frailty Index (FI-LAB) for predicting mortality following endovascular therapy (EVT) in elderly patients with large vessel occlusion acute ischemic stroke (LVO-AIS).</div></div><div><h3>Methods</h3><div>This retrospective study enrolled 382 patients aged ≥60 years undergoing EVT. FI-LAB was constructed using 44 preprocedural laboratory parameters. Primary endpoint was 12-month all-cause mortality; secondary endpoint was 14-day mortality. Cox proportional hazards models assessed FI-LAB-mortality associations.</div></div><div><h3>Results</h3><div>Among 382 patients, 68.8% exhibited varying degrees of frailty. In fully adjusted models, compared with robust patients, frail patients demonstrated a 1.82-fold increase in 14-day mortality risk (P = 0.012) and a 2.61-fold increase in 12-month mortality risk (P &lt; 0.001). Each 0.1-unit increase in FI-LAB was associated with a 51% increase in 14-day mortality risk (P = 0.001) and a 63% increase in 12-month mortality risk (P &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>FI-LAB independently predicts short-term and long-term mortality following EVT in elderly stroke patients, offering objective risk stratification for clinical decision-making.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100673"},"PeriodicalIF":4.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gut–liver axis in progressive steatotic liver disease: A focus on bile acid dysregulation","authors":"Panayiotis Louca ,&nbsp;Juan M. Pericàs ,&nbsp;Yu Lin ,&nbsp;Afroditi Kouraki ,&nbsp;Olga Estévez-Vázquez ,&nbsp;María Martínez-Gómez ,&nbsp;M. Serra Cusidó ,&nbsp;Joanna P. Simpson ,&nbsp;Francisco Javier Cubero ,&nbsp;Natalie Z.M. Homer ,&nbsp;Ana M. Valdes ,&nbsp;Cristina Menni","doi":"10.1016/j.jnha.2025.100671","DOIUrl":"10.1016/j.jnha.2025.100671","url":null,"abstract":"<div><h3>Introduction</h3><div>The gut–liver axis regulates metabolic homeostasis, with bile acids (BAs) serving as key signalling molecules. BA dysregulation is implicated in metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction- and alcohol-associated liver disease (MetALD), yet consistent identification of BA markers and their mechanistic roles across different stages of these diseases remain elusive.</div></div><div><h3>Methods</h3><div>We integrated three complementary studies to examine BA dysregulation: a population-based cohort (1522 females from TwinsUK with serum BA and liver biomarker data), a clinical cohort (30 patients with steatotic liver disease, fibrosis stages F0-F4, and 4 controls), and rodent models (20 rats with MASLD/MetALD vs. 9 controls). BA profiles were quantified via LC–MS.</div></div><div><h3>Results</h3><div>The primary bile acid taurocholate was consistently correlated with liver pathology: in TwinsUK, it associated with ALT (β [95%CI] 1.81 [1.27, 2.36], FDR &lt; 0.05) both overall and when stratifying for age (&lt;65 years, <em>n</em> = 923; ≥65 years, <em>n</em> = 599); in the clinical cohort, it was associated with F3 fibrosis (OR [95%CI] 8.56 × 10⁻¹⁰ [3.80 × 10⁻¹³, 1.93 × 10⁻⁶], FDR &lt; 0.05); and in rodents, it was associated with MASLD/MetALD (OR [95%CI] 2.86 [1.17, 9.51], FDR &lt; 0.05). The secondary bile acid taurochenodeoxycholate was associated with both early (F0, OR [95%CI] 13.63 [1.04, 179.17], <em>p</em> &lt; 0.05) and advanced stages of disease (rodents, OR [95%CI] 15.41 [2.94, 311.82], FDR &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Taurocholate and taurochenodeoxycholate emerge as consistent BA markers across liver disease stages, suggesting BA metabolism as potential therapeutic targets. This multi-model study bridges knowledge gaps in BA-driven mechanisms, informing personalised strategies for SLD management.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100671"},"PeriodicalIF":4.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear Dose-Response and Calcium-Magnesium Interactions of Dietary Minerals with Cognitive Function in Older Adults","authors":"Xingchen He ,&nbsp;Yaxuan Yan ,&nbsp;Jiawen Wang ,&nbsp;Yijia Lin ,&nbsp;Xinyi Wu ,&nbsp;Min Li ,&nbsp;Tianyu Zhong ,&nbsp;Xuliang Weng","doi":"10.1016/j.jnha.2025.100669","DOIUrl":"10.1016/j.jnha.2025.100669","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100669"},"PeriodicalIF":4.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breakfast consumption behavior was positively associated with cognitive function in Chinese adults aged 55 years and above","authors":"Xiaoyun Song ,&nbsp;Xiaofang Jia ,&nbsp;Bing Zhang ,&nbsp;Huijun Wang","doi":"10.1016/j.jnha.2025.100662","DOIUrl":"10.1016/j.jnha.2025.100662","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aims to investigate the relationship between breakfast consumption behavior and cognitive function in Chinese adults aged 55 years and above, and the mediating effect of diet quality.</div></div><div><h3>Methods</h3><div>Data were drawn from the China Health and Nutrition Survey (CHNS) 1997, 2000, 2004, 2006, 2015, and 2018. Participants aged 55 years and above who had at least two waves of completed data on dietary measures and cognitive assessments were eligible. Breakfast consumption behavior was counted during the 3-day 24-h survey period and classified into breakfast skipping and breakfast consumption. Cognitive function was examined using part items of the Telephone Interview for Cognitive Status-modified. Three-level linear mixed-effects models were performed to examine the relationship between breakfast consumption behavior and cognitive function due to the repeated-measured data. The Mediating effect of diet quality, indicated by the China Elderly Dietary Guidelines Index 2022 (CDGI 2022-E), was explored.</div></div><div><h3>Results</h3><div>A total of 5462 participants were included. Significant associations between breakfast consumption behavior and global cognitive score (breakfast skipping vs. consumption: β = −0.77, 95%CI: −1.23, −0.31) as well as global cognitive composite z-score (breakfast skipping vs. consumption: β = −0.22, 95%CI: −0.30, −0.15) were observed in total participants. Similar significant associations were found in participants stratified by age at baseline or gender. Overall diet quality assessed by CDGI 2022-E played a modest mediating role between breakfast consumption behavior and cognitive score.</div></div><div><h3>Conclusions</h3><div>Habitual breakfast consumption may have the advantage of improving cognitive function in the Chinese older population, in which overall diet quality exerted a mediating effect.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100662"},"PeriodicalIF":4.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centenarian athletes: The paradigm of healthy longevity?","authors":"Ángel Buendía-Romero ,&nbsp;Enrique Higueras-Liébana ,&nbsp;Luis M. Alegre ,&nbsp;Ignacio Ara ,&nbsp;Pedro L. Valenzuela","doi":"10.1016/j.jnha.2025.100665","DOIUrl":"10.1016/j.jnha.2025.100665","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100665"},"PeriodicalIF":4.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144912913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Letter to the editor on: Tooth loss, diet quality, and cognitive decline: A 15-year longitudinal study”","authors":"Lewis Winning ,&nbsp;Gerard J. Linden","doi":"10.1016/j.jnha.2025.100667","DOIUrl":"10.1016/j.jnha.2025.100667","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100667"},"PeriodicalIF":4.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor on: “Tooth loss, diet quality, and cognitive decline: A 15-year longitudinal study”","authors":"Jinyu Wu ,&nbsp;Wen Wang ,&nbsp;Kuncheng Yang","doi":"10.1016/j.jnha.2025.100666","DOIUrl":"10.1016/j.jnha.2025.100666","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100666"},"PeriodicalIF":4.0,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ionized calcium levels and 3-months mortality in geriatric patients hospitalized for COVID-19","authors":"Audrey Boudaille ,&nbsp;Alexis Bourgeais ,&nbsp;Mathieu Corvaisier ,&nbsp;Olivier Brière ,&nbsp;Jennifer Gautier ,&nbsp;Cédric Annweiler ,&nbsp;on behalf of the GERIA-COVID study group","doi":"10.1016/j.jnha.2025.100661","DOIUrl":"10.1016/j.jnha.2025.100661","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to determine an association between ionized calcium (CaI) levels and mortality 3 months after Covid-19 infection in geriatric population.</div></div><div><h3>Design</h3><div>Observational retrospective cohort study.</div></div><div><h3>Setting and participants</h3><div>One hundred and seventy-nine patients hospitalized in the geriatric acute care unit of Angers University Hospital were included. This specific unit specifically dedicated to COVID-19 patients was opened for 2 periods : from March 1, 2020 to June 30, 2020 and from October 1, 2020 to March 29, 2021. Covariates considered were: age, sex, Iso-Resources Groups (GIR) score ≤ 3, Parathyroid hormone (PTH), C-Reactive Protein (CRP), severe undernutrition defined as albumin &lt; 30 g/L, history of cancer, history of cardiomyopathy, severe chronic renal failure (defined as clearance &lt; 30 ml/min), Ordinal Scale for Clinical Improvement (OSCI) score, use of systemic corticosteroids and usual vitamin D supplementation. Direct potentiometry was also used as a covariate.</div></div><div><h3>Measurements</h3><div>The time elapsed between the diagnosis of COVID-19 and death was studied by survival curves calculated using Cox model in each group defined by serum CaI concentration (&gt;1.22 and ≤1.22 mmol/L).</div></div><div><h3>Results</h3><div>In the Cox model, a significant association was found between CaI over 1.22 mmol/l and 3-months mortality, analyzed in an adjusted model (HR 2.40 [1.34–4.31], <em>p</em> = 0.003).</div></div><div><h3>Conclusion</h3><div>There is an association between CaI and 3 months mortality in geriatric patients hospitalized for COVID-19.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 9","pages":"Article 100661"},"PeriodicalIF":4.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144907360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor concerning ‘Creatinine and cystatin C-based indices for predicting sarcopenia, frailty and disability in older community-dwelling adults’","authors":"Longqing Yu","doi":"10.1016/j.jnha.2025.100664","DOIUrl":"10.1016/j.jnha.2025.100664","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100664"},"PeriodicalIF":4.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144904121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}