Journal of Nutrition Health & Aging最新文献

{"title":"Anticoagulation and atrial fibrillation in prognostic models for type B aortic dissection","authors":"Amir Reza Akbari , Benyamin Alam","doi":"10.1016/j.jnha.2025.100612","DOIUrl":"10.1016/j.jnha.2025.100612","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100612"},"PeriodicalIF":4.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144291122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-sectional association between brain-derived neurotrophic factor and intrinsic capacity in older adults: The mediating role of oxidative stress","authors":"Chi Zhang ,&nbsp;Ping Zeng ,&nbsp;Yushan Zhang ,&nbsp;Yuting Kang ,&nbsp;Jie Zhang ,&nbsp;Jing Li ,&nbsp;Hong Shi ,&nbsp;Shiwei Liu ,&nbsp;Ji Shen","doi":"10.1016/j.jnha.2025.100599","DOIUrl":"10.1016/j.jnha.2025.100599","url":null,"abstract":"<div><h3>Objectives</h3><div>Brain-derived neurotrophic factor (BDNF) is a key indicator in the brain-muscle axis. This study aimed to investigate the association of plasma BDNF and intrinsic capacity (IC) in older people, and to examine the mediating role of inflammation and oxidative stress.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 658 community-dwelling older adults (70.38 ± 6.06 years, 59.42% female). Intrinsic capacity including five domains was evaluated according to the World Health Organization recommendation. Plasma BDNF, high sensitivity C-reactive protein (hs-CRP), Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-a), Interleukin-1 beta (IL-1β), Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px), and Glutathione reductase (GR)were measured by enzyme-linked immunosorbent assay methods. Restricted cubic spline and multivariate logistic regression were conducted to explore the association of BDNF with IC impairment. Mediation analyses were used to explore the potential mechanisms. Demographic characteristics, health behaviors, and comorbidities were included as covariates.</div></div><div><h3>Results</h3><div>247(37.54%) participants had IC impairment. Older individuals with impaired IC had lower levels of BDNF, IL-1β, SOD, and GR, while showed higher levels of hs-CRP and MDA compared to the normal group. There was an L-shaped negative correlation between BDNF levels and the odds of IC impairment (<em>P</em>-nonlinear &lt;0.001). After adjusting for all confounders, the odds for IC impairment in the medium and high BDNF tertiles were significantly lower than in the low BDNF tertile, with ORs of 0.43(95% CI: 0.26−0.89, <em>P</em> = 0.004) and 0.38(95% CI: 0.20−0.71, <em>P</em> = 0.007), respectively. Plasma SOD and GR mediated 4.13% (95% CI: 1.15, 7.16) and 7.82% (95% CI: 3.24, 12.48) of the total effect of BDNF on IC.</div></div><div><h3>Conclusion</h3><div>High levels of circulatory BDNF may be related to lower odds of IC impairment. Oxidative stress status partially explains the mechanisms underlying the association.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100599"},"PeriodicalIF":4.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic clocks as mediators of health behaviors and mortality in middle-aged and older adults","authors":"Xing-Ling Chen ,&nbsp;Qiang-Qiang Zhao ,&nbsp;Sheng-Rong Lin ,&nbsp;Xing-Ling He ,&nbsp;Xiao-Jiao Zhang ,&nbsp;Si-Jing Li ,&nbsp;Zi-Ru Li ,&nbsp;Jia-Hui Chen ,&nbsp;Hua Zhang ,&nbsp;Xiao-Fang Li ,&nbsp;Yue-Hui Zhou ,&nbsp;Hui-Li Liao ,&nbsp;Shu-Ning Sun ,&nbsp;Zhong-Qi Yang ,&nbsp;Shi-Hao Ni ,&nbsp;Lu Lu","doi":"10.1016/j.jnha.2025.100602","DOIUrl":"10.1016/j.jnha.2025.100602","url":null,"abstract":"<div><h3>Background</h3><div>The impact of healthy lifestyles on epigenetic age acceleration (EAA) and mortality in middle-aged/ senior populations remains unclear. This study investigates associations between lifestyle factors, EAA biomarkers, and mortality risk.</div></div><div><h3>Method</h3><div>The 2532 adults of 50 years or older that registered in NHANES between 1999–2002.This study evaluated compares first- to third-generation epigenetic clocks (HannumAge, HorvathAge, PhenoAge, GrimAge2, DunedinPoAm) in predicting mortality risk associations between five lifestyle domains (diet, abdominal adiposity, physical activity, smoking, alcohol) and EAA were analyzed via multivariable regression, with mediation models testing EAA’s role in lifestyle-mortality relationships.</div></div><div><h3>Results</h3><div>Survival curves results identified DunedinPoAm, GrimAge2AA, and PhenoAgeAA as robust biomarkers of accelerated biological aging, independent of chronological age. In multivariable linear regression models, full adherence to healthy behaviors reduced GrimAge2AA by β = −5.55 years, PhenoAgeAA by β = −2.64 years, and DunedinPoAm by β = −0.06 SD, with smoking cessation demonstrating the strongest GrimAge2AA attenuation (10.17 years). Stratified analyses revealed pronounced benefits: cancer patients adhering to healthy diets (β = −0.04 SD, P for interaction = 0.01) and hypertensive individuals reducing smoking (β = −0.05 SD, <em>P</em> for interaction = 0.04) showed significant EAA mitigation. The sensitivity analysis is consistent with the original results. Mediation analyses indicated GrimAge2AA accounted for 63.58% of lifestyle-survival associations, DunedinPoAm (44.63%) and PhenoAgeAA (28.45%).</div></div><div><h3>Conclusions</h3><div>These findings suggest that comprehensive adherence to healthy lifestyle behaviors is associated with reduced epigenetic aging, supporting their potential utility as targets for mortality risk mitigation. And emphasize the utility of epigenetic clocks in precision gerontology.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100602"},"PeriodicalIF":4.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144253581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor concerning ‘Association between sarcopenia index and the risk of second hip fracture in older adults’","authors":"Li Liu","doi":"10.1016/j.jnha.2025.100601","DOIUrl":"10.1016/j.jnha.2025.100601","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100601"},"PeriodicalIF":4.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects and Persistence of Bifidobacterium animalis subsp. lactis BL-99 and Fructooligosaccharides on Older Adults with Functional Constipation: A Randomized, Double-Blind, Placebo-Controlled Trial","authors":"Meina Li ,&nbsp;Qi Zhang ,&nbsp;Wen Zhao ,&nbsp;Juan Chen ,&nbsp;Yinghua Liu ,&nbsp;Limian Zhou ,&nbsp;Yihui Liu ,&nbsp;Langrun Wang ,&nbsp;Yiran Guan ,&nbsp;Jian He ,&nbsp;Qiuyue Jiang ,&nbsp;Zhaozhong Zeng ,&nbsp;Xinmei Guo ,&nbsp;Can Liu ,&nbsp;Liwei Zhang ,&nbsp;Yong Zhang ,&nbsp;Jie Luo ,&nbsp;Wei-Lian Hung ,&nbsp;Jingjing He ,&nbsp;Ran Wang","doi":"10.1016/j.jnha.2025.100598","DOIUrl":"10.1016/j.jnha.2025.100598","url":null,"abstract":"<div><div>Research on effects of synbiotics in older adults with functional constipation (FC) is limited. This randomized, double-blind, placebo-controlled trial evaluated a 4-week synbiotic (<em>Bifidobacterium animalis</em> subsp. <em>lactis</em> BL-99 and fructooligosaccharides [FOS]) intervention in 67 participants ≥60 years old meeting Rome IV FC criteria. Compared to placebo, the synbiotic group showed significant improvements in weekly spontaneous bowel movements (Least squares mean ± standard error: 4.94 ± 0.25 vs. 3.00 ± 0.26, <em>P</em> &lt; 0.001) and whole gut transit time (37.13 ± 3.78 vs. 50.64 ± 4.22 h, <em>P</em> = 0.019), with benefits sustained 2 weeks post-intervention. It also reduced time per toilet attempt and alleviated rectal discomfort symptoms more effectively than placebo. Fecal microbiome analysis revealed increased abundance of beneficial <em>Bifidobacterium</em> species, correlating with symptom improvement (<em>P</em> &lt; 0.05). These findings demonstrate that BL-99/FOS supplementation ameliorates FC symptoms in older adults, with effects sustained post-discontinuation, potentially mediated through gut microbiota modulation. Further mechanistic investigation is warranted.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100598"},"PeriodicalIF":4.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor concerning \"Association between sarcopenia index and the risk of second hip fracture in older adults\" by Liu et al","authors":"Longqing Yu ,&nbsp;Zhaohui Ma ,&nbsp;Qiuping Zhang ,&nbsp;Kexin Pan ,&nbsp;Fupeng Liu ,&nbsp;Ping Li ,&nbsp;Mei Zhang","doi":"10.1016/j.jnha.2025.100600","DOIUrl":"10.1016/j.jnha.2025.100600","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 7","pages":"Article 100600"},"PeriodicalIF":4.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global roadmap for inclusive clinical trials in older adults","authors":"Jorge G. Ruiz","doi":"10.1016/j.jnha.2025.100591","DOIUrl":"10.1016/j.jnha.2025.100591","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100591"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence paradox: Enhancing clinical trials for older adults","authors":"Liang-Kung Chen","doi":"10.1016/j.jnha.2025.100597","DOIUrl":"10.1016/j.jnha.2025.100597","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 6","pages":"Article 100597"},"PeriodicalIF":4.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sensory impairment and cognitive frailty among older people: Evidence from four nationwide cohort studies","authors":"Xiaoming Zhang ,&nbsp;Rui Zeng ,&nbsp;Aizhang Zhu ,&nbsp;Fayi Xie ,&nbsp;Dongmei Ye ,&nbsp;Lihuan Chen ,&nbsp;Yi Xiao ,&nbsp;Ke Zhu ,&nbsp;Tenghui Fan ,&nbsp;Wan Zhu ,&nbsp;Zhigang Wu ,&nbsp;Mengxia Shi ,&nbsp;Yuxu Huang ,&nbsp;Jiahui Bian ,&nbsp;Shixuan Wang ,&nbsp;Ziyun Lv ,&nbsp;Ruzhao Chen ,&nbsp;Yufei Zeng ,&nbsp;Jiang Wang ,&nbsp;Qingli Dou ,&nbsp;Wenwu Zhang","doi":"10.1016/j.jnha.2025.100590","DOIUrl":"10.1016/j.jnha.2025.100590","url":null,"abstract":"<div><h3>Background</h3><div>Sensory impairment, including hearing and vision impairment, are prevalent in older adults and may significantly contribute to cognitive frailty. However, the longitudinal association between sensory impairment and cognitive frailty has not been fully explored. The aim of our study was to examine such associations in four nationally representative cohorts to inform strategies for preventing cognitive frailty and promoting healthy aging.</div></div><div><h3>Methods</h3><div>Data were pooled from four large, longitudinal cohorts: the Health and Retirement Study (HRS), the Chinese Longitudinal Healthy Longevity Survey (CLHLS), the Survey of Health, Ageing and Retirement in Europe (SHARE), and the English Longitudinal Study of Ageing (ELSA). The analysis included 37,076 older adults from these cohorts, with comparable measures of sensory impairment and cognitive frailty across studies. Sensory impairments were assessed via self-reported hearing impairment and vision impairment. The outcome was the incidence of cognitive frailty, assessed using self-reported cognitive function and frailty indicators. Cox regression models were used to evaluate the association between hearing impairments, vision impairments and dual sensory impairment with cognitive frailty risk, adjusting for potential confounders.</div></div><div><h3>Results</h3><div>The cohort had a mean (SD) age of 74.60 (6.61) years for HRS (41.41% male), 81.87 (10.50) years for CLHLS (48.10% male), 72.99 (6.12) years for SHARE (44.27% male), and 73.03 (6.22) years for ELSA (46.59%% male). The prevalence of cognitive frailty was 10.58% for HRS, 6.26% for CLHLS, 12.16% for SHARE, and 5.81% for ELSA. The prevalence of dual sensory impairment was 8.05% for HRS, 3.06% for CLHLS, 10.94% for SHARE, and 4.06% for ELSA. Cox regression revealed a significant synergistic effect between hearing impairment and vision impairment on cognitive frailty risk. Compared to no sensory impairments individuals, those with hearing impairments or vision impairments had a higher risk of cognitive frailty across all cohorts, with individuals with dual sensory impairment exhibiting the highest risk: HRS (Hazard Ratio [HR] = 2.10, 95% CI, 1.71–2.56), CLHLS (HR = 2.08, 95% CI, 1.37–3.15), SHARE (HR = 1.52, 95% CI, 1.35–1.71), and ELSA (HR = 2.77, 95% CI, 1.78–4.31).</div></div><div><h3>Conclusions</h3><div>This study identifies an association between combined hearing and vision impairments and an increased risk of cognitive frailty. These findings suggest that assessing sensory impairments, particularly dual sensory impairment, in older adults may help identify individuals at higher risk of cognitive frailty. Further research, including longitudinal studies and randomized controlled trials, is needed to explore the potential benefits of early sensory interventions for supporting healthy aging.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100590"},"PeriodicalIF":4.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of fear of falling on social engagement among older adults: A nationwide longitudinal panel study","authors":"Jae Hyeok Lim ,&nbsp;Min Jeong Joo ,&nbsp;Jisu Ko ,&nbsp;Dan Bi Kim ,&nbsp;Eun-Cheol Park ,&nbsp;Min Jin Ha","doi":"10.1016/j.jnha.2025.100589","DOIUrl":"10.1016/j.jnha.2025.100589","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Fear of falling (FoF) is characterized by persistent concerns about falling, and empirical investigations are needed to examine the influence of perceived FoF on the broader and more active dimensions of social functioning. This study aims to explore the association between FoF and social participation in older adults, as well as the effects of changes in status over time.</div></div><div><h3>Methods</h3><div>This longitudinal panel study analyzed data from eight waves (2006–2020) of the Korean Longitudinal Study of Aging, comprising 8,632 participants aged 60 years and older (3,735 males and 4,897 females). FoF and activity restriction were assessed, with social engagement defined as involvement in at least one formal social activity, and the frequency of participation was also measured. Additionally, these statuses were categorized to reflect changes from the previous wave. Generalized estimating equation models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs).</div></div><div><h3>Results</h3><div>Over a mean follow-up period of 8.94 years, the average level of social engagement, accounting for variations across all waves, was 73.1% among males and 66.5% among females. Compared to the no FoF group, individuals who had FoF exhibited significantly lower likelihoods of engaging in formal social activity in males (OR: 0.77, CI: 0.67–0.87) and females (OR: 0.84, CI: 0.75–0.94), while those with both FoF and activity restriction exhibited even lower odds of engagement (males, OR: 0.53, CI: 0.44–0.63; females, OR: 0.72, CI: 0.63–0.83). Additionally, FoF is associated with a tendency to impede newly initiated or ongoing social engagements, with more pronounced effects observed in individuals who reported persistent FoF over time.</div></div><div><h3>Conclusions</h3><div>FoF is associated with reduced social engagement in older adults, and therefore, individuals with FoF may require special attention to prevent negative health outcomes resulting from social isolation caused by FoF.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 8","pages":"Article 100589"},"PeriodicalIF":4.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}