因COVID-19住院的老年患者3个月死亡率与离子钙水平的关系

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-08-28 DOI:10.1016/j.jnha.2025.100661

Audrey Boudaille , Alexis Bourgeais , Mathieu Corvaisier , Olivier Brière , Jennifer Gautier , Cédric Annweiler , on behalf of the GERIA-COVID study group

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引用次数: 0

摘要

目的本研究的目的是确定老年人群感染Covid-19后3个月离子化钙（CaI）水平与死亡率之间的关系。设计：观察性回顾性队列研究。环境和参与者纳入了在昂热大学医院老年急症护理部住院的179名患者。新冠肺炎患者专用病房开放时间为2020年3月1日至2020年6月30日和2020年10月1日至2021年3月29日。考虑的协变量包括：年龄、性别、等资源组（GIR）评分≤3、甲状旁腺激素（PTH）、c反应蛋白（CRP）、严重营养不良（白蛋白≤30g /L）、癌症史、心肌病史、严重慢性肾功能衰竭（清净≤30ml /min）、临床改善顺序量表（OSCI）评分、使用全身皮质类固醇和常规补充维生素D。直接电位法也被用作协变量。以血清CaI浓度（>；1.22和≤1.22 mmol/L）定义各组，采用Cox模型计算生存曲线，观察诊断为COVID-19至死亡的时间。结果在Cox模型中，血钙浓度超过1.22 mmol/l与3个月死亡率显著相关（HR 2.40 [1.34-4.31], p = 0.003）。结论老年COVID-19住院患者的CaI与3个月死亡率存在相关性。

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Association between ionized calcium levels and 3-months mortality in geriatric patients hospitalized for COVID-19

Objectives

The aim of this study was to determine an association between ionized calcium (CaI) levels and mortality 3 months after Covid-19 infection in geriatric population.

Design

Observational retrospective cohort study.

Setting and participants

One hundred and seventy-nine patients hospitalized in the geriatric acute care unit of Angers University Hospital were included. This specific unit specifically dedicated to COVID-19 patients was opened for 2 periods : from March 1, 2020 to June 30, 2020 and from October 1, 2020 to March 29, 2021. Covariates considered were: age, sex, Iso-Resources Groups (GIR) score ≤ 3, Parathyroid hormone (PTH), C-Reactive Protein (CRP), severe undernutrition defined as albumin < 30 g/L, history of cancer, history of cardiomyopathy, severe chronic renal failure (defined as clearance < 30 ml/min), Ordinal Scale for Clinical Improvement (OSCI) score, use of systemic corticosteroids and usual vitamin D supplementation. Direct potentiometry was also used as a covariate.

Measurements

The time elapsed between the diagnosis of COVID-19 and death was studied by survival curves calculated using Cox model in each group defined by serum CaI concentration (>1.22 and ≤1.22 mmol/L).

Results

In the Cox model, a significant association was found between CaI over 1.22 mmol/l and 3-months mortality, analyzed in an adjusted model (HR 2.40 [1.34–4.31], p = 0.003).

Conclusion

There is an association between CaI and 3 months mortality in geriatric patients hospitalized for COVID-19.

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.