老年急性缺血性脑卒中患者血管内治疗后的术前虚弱状态及短期和长期死亡风险

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-09-04 DOI:10.1016/j.jnha.2025.100673

Weiwei Gao , Xingyu Chen , Arslan Annadurdyyev , Lijuan Cai , Lingfeng Yu , Ziqu Xu , Renjing Zhu

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引用次数: 0

摘要

目的评价实验室虚弱指数（FI-LAB）对老年大血管闭塞急性缺血性脑卒中（LVO-AIS）患者血管内治疗（EVT）后死亡率的预测价值。方法回顾性研究纳入382例年龄≥60岁的EVT患者。FI-LAB采用44项术前实验室参数构建。主要终点为12个月全因死亡率；次要终点为14天死亡率。Cox比例风险模型评估了fi - lab与死亡率的关系。结果382例患者中，68.8%表现出不同程度的虚弱。在完全调整的模型中，与健康患者相比，体弱患者14天死亡风险增加1.82倍（P = 0.012）， 12个月死亡风险增加2.61倍（P < 0.001）。FI-LAB每增加0.1个单位，14天死亡风险增加51% (P = 0.001)， 12个月死亡风险增加63% （P < 0.001）。结论fi - lab可独立预测老年脑卒中EVT术后短期和长期死亡率，为临床决策提供客观的风险分层。

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Preprocedural frailty status and short- and long-term mortality risk after endovascular therapy in elderly acute ischemic stroke patients

Objectives

To evaluate the Laboratory-based Frailty Index (FI-LAB) for predicting mortality following endovascular therapy (EVT) in elderly patients with large vessel occlusion acute ischemic stroke (LVO-AIS).

Methods

This retrospective study enrolled 382 patients aged ≥60 years undergoing EVT. FI-LAB was constructed using 44 preprocedural laboratory parameters. Primary endpoint was 12-month all-cause mortality; secondary endpoint was 14-day mortality. Cox proportional hazards models assessed FI-LAB-mortality associations.

Results

Among 382 patients, 68.8% exhibited varying degrees of frailty. In fully adjusted models, compared with robust patients, frail patients demonstrated a 1.82-fold increase in 14-day mortality risk (P = 0.012) and a 2.61-fold increase in 12-month mortality risk (P < 0.001). Each 0.1-unit increase in FI-LAB was associated with a 51% increase in 14-day mortality risk (P = 0.001) and a 63% increase in 12-month mortality risk (P < 0.001).

Conclusions

FI-LAB independently predicts short-term and long-term mortality following EVT in elderly stroke patients, offering objective risk stratification for clinical decision-making.

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.