握力-瘦体重指数（GSLMI）作为诊断癌症患者肌肉疏松症和生存预后的重要工具：一项全国性多中心队列研究。

IF 4.3 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2024-11-11 DOI:10.1016/j.jnha.2024.100409

Zhenyu Huo , Feifei Chong , Siyu Luo , Na Li , Ning Tong , Zongliang Lu , Jing Guo , Ling Zhang , Xin Lin , Mengyuan Zhang , Hongmei Zhang , Muli Shi , Xiumei He , Jie Liu , Chunhua Song , Hanping Shi , Hongxia Xu

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引用次数: 0

摘要

目的确定握力-肌肉-质量指数（GSLMI）是否能在临床环境中精确诊断肌少症并预测癌症患者的预后：环境和参与者：8831 名年龄在 18 岁及以上、组织学诊断为癌症并正在接受抗癌治疗的住院患者：GSLMI是手部握力（HGS）除以瘦体重（LM）的比率，计算公式为GSLMI = HGS（公斤）/ LM（公斤）。研究采用 Kaplan-Meier 曲线和 Cox 模型来估算 GSLMI 与存活率之间的关系：共有 3,071 名男性（48.40%）和 3,274 名女性（51.60%）患者参与了研究。GLIS定义的肌肉疏松症发病率为2,646人（41.70%）。研究确定了最佳的性别特异性阈值，该阈值具有最佳的诊断性能，可识别出较低的 GSLMI：GSLMI 可作为一种新型诊断工具，用于识别肌肉疏松症，并可能对癌症患者的预后具有价值。使用 GSLMI 是更好地管理癌症患者健康的一个可行且有前景的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Grip-Strength-Lean-Mass Index (GSLMI) as a valuable tool for sarcopenia diagnosis and survival prognosis in cancer patients: a nationwide multicenter cohort study

Objectives

To identify whether the Grip-Strength-Lean-Mass Index (GSLMI) can precisely diagnose sarcopenia and predict prognosis for cancer patients in clinical settings.

Design

A nationwide multicenter cohort study.

Setting and participants

8,831 inpatients aged 18 years and older, histologically diagnosed with cancer and receiving anti-cancer therapy.

Measurements

The GSLMI is the ratio of hand grip strength (HGS) divided by lean mass (LM), calculated by the formula: GSLMI = HGS (kg) / LM (kg). Kaplan-Meier curves and Cox models were used to estimate the association between the GSLMI and survival.

Results

A total of 3,071 (48.40%) male and 3,274 (51.60%) female patients were enrolled in the study. The prevalence of GLIS-defined sarcopenia was 2,646 (41.70%). The optimal sex-specific thresholds with the best diagnostic performance to identify a low GSLMI were determined to be <0.61 for males and <0.47 for females based on the ROC curves. According to Kaplan-Meier curves, patients with a high GSLMI exhibited better overall survival than those with a low GSLMI (HR = 0.664, 95%CI = 0.604−0.729, log-rank P < 0.001). Multivariable survival analysis revealed that the GSLMI showed an independent association with a lower hazard of death as a continuous variable (HR = 0.70, 95% CI = 0.51−0.96).

Conclusions

The GSLMI may serve as a novel diagnostic tool for identifying sarcopenia and may have prognostic value for cancer patients. Using the GSLMI represents a feasible and promising option for better managing the health of patients with cancer.

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.