Association of circadian syndrome with functional disability among middle-aged and older adults in China

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-07-01 DOI:10.1016/j.jnha.2025.100621

Yuhan Huang , Kaiyuan Wang , Yue He, Wenjing Wang, Chengxiang Hu, Kexin Jiang, Jiaqi Zhang, Yuchun Tao , Lina Jin

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引用次数: 0

Abstract

Background

Circadian syndrome (CircS) is a complex syndrome involving disorders of biological rhythms and multidimensional health risks. The objective of this research is to explore the association between CircS and functional disability.

Methods

This research utilized data from CHARLS, spanning the years 2011–2015. In the cross-sectional study, data from 12,758 Chinese adults aged 45 years and above in 2011 were used, and logistic regression models were employed to explore the association of CircS and its components with functional disability. A total of 8538 eligible subjects participated in the longitudinal study, and Cox regression models were used to analyze the longitudinal association and subgroup analysis.

Results

The cross-sectional analysis revealed positive associations of CircS with both ADL disability (OR = 1.68, 95% CI: 1.41, 2.00, p < 0.001) and IADL disability (OR = 1.74, 95% CI: 1.49, 2.04, p < 0.001). Longitudinal analysis also indicated that CircS was significantly associated with an elevated risk of developing both ADL disability (HR = 1.57, 95% CI: 1.33, 1.86, p < 0.001) and IADL disability (HR = 1.22, 95% CI: 1.05, 1.43, p = 0.012). Subgroup analysis found that the association between CircS and ADL disability had significant interactions with gender (p for interaction = 0.046) and smoking status (p for interaction < 0.001).

Conclusion

Our findings find a positive association between CircS and functional disability, and the importance of gender and smoking status in these associations are emphasized.

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中国中老年人昼夜节律综合征与功能障碍的关系

背景：昼夜节律综合征（CircS）是一种涉及生物节律紊乱和多维健康风险的复杂综合征。本研究的目的是探讨CircS与功能障碍之间的关系。方法本研究利用CHARLS 2011-2015年的数据。在横断面研究中，采用2011年12758名45岁及以上中国成年人的数据，采用logistic回归模型探讨CircS及其成分与功能障碍的关系。共有8538名符合条件的受试者参与纵向研究，采用Cox回归模型进行纵向关联分析和亚组分析。结果横断面分析显示CircS与ADL残疾呈正相关(OR = 1.68, 95% CI: 1.41, 2.00, p <；0.001)和IADL功能障碍(OR = 1.74, 95% CI: 1.49, 2.04, p <；0.001)。纵向分析还表明，CircS与发生ADL残疾的风险升高显著相关(HR = 1.57, 95% CI: 1.33, 1.86, p <；0.001)和IADL残疾（HR = 1.22, 95% CI: 1.05, 1.43, p = 0.012）。亚组分析发现CircS与ADL残疾之间的关联与性别（相互作用p = 0.046）和吸烟状况(相互作用p <；0.001)。结论CircS与功能障碍之间存在正相关关系，性别和吸烟状况在这些关系中具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.