Association between long-term burden of sarcopenia and cardiorespiratory multimorbidity

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging Pub Date : 2025-09-09 DOI:10.1016/j.jnha.2025.100670

Zuolin Lu , Yunyuan Kong , Weihao Shao , Jiawen Ke , Yachen Wang , Xiaoxia Wei , Yabing Hou , Ruitai Shao

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引用次数: 0

Abstract

Background

Sarcopenia, the progressive loss of muscle mass and function, is a common condition in older adults and has been linked to both cardiovascular disease (CVD) and chronic respiratory diseases (CRD). However, the association between long-term changes of sarcopenia and cardiorespiratory multimorbidity remains underexplored. This study aims to investigate how changes in sarcopenia burden over time relate to cardiorespiratory multimorbidity in Chinese adults.

Methods

Data from the China Health and Retirement Longitudinal Study (CHARLS) were used, including 5186 participants aged 45 and older. Sarcopenia was assessed using criteria for muscle mass, strength, and physical performance. Sarcopenia trajectories were identified using group-based trajectory modeling, and associations with cardiorespiratory multimorbidity (CVD and CRD) were assessed using multivariable-adjusted logistic regression models.

Results

The study included 5186 participants with mean age of 58.2 ± 8.4 years. A total of 301 (5.8%) participants experienced cardiorespiratory multimorbidity. Four distinct sarcopenia trajectory groups were identified: persistently low, moderate-to-low, low-to-high, and persistently high burden. Compared to the reference (persistently low group), the low-to-high trajectory of sarcopenia burden had the strongest association with cardiorespiratory multimorbidity (OR: 2.64, 95% CI: 1.73–4.04), followed by the persistently high group (OR: 2.05, 95% CI: 1.46–2.89) and moderate-to-low group (OR: 1.90; 95% CI: 1.38–2.60).

Conclusions

Changes in sarcopenia burden are significantly associated with cardiorespiratory multimorbidity, with a rapid increase in sarcopenia burden (low-to-high trajectory) being particularly detrimental. Monitoring sarcopenia progression and early intervention may be crucial in preventing cardiorespiratory multimorbidity. Further research is needed to explore underlying mechanisms and evaluate interventions.

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肌肉减少症的长期负担与心肺多病之间的关系

骨骼肌减少症是一种肌肉质量和功能的进行性损失，是老年人的一种常见疾病，与心血管疾病（CVD）和慢性呼吸系统疾病（CRD）有关。然而，肌肉减少症的长期变化与心肺多病之间的关系仍未得到充分探讨。本研究旨在探讨中国成人骨骼肌减少症负担随时间变化与心肺多病的关系。方法采用中国健康与退休纵向研究（CHARLS）的数据，纳入5186名年龄在45岁及以上的参与者。使用肌肉质量、力量和身体表现的标准评估肌肉减少症。使用基于组的轨迹模型确定了肌肉减少症的轨迹，并使用多变量调整的逻辑回归模型评估了与心肺多病（CVD和CRD）的关联。结果纳入5186例，平均年龄58.2±8.4岁。共有301名（5.8%）参与者经历了心肺多重疾病。确定了四种不同的肌肉减少轨迹组：持续低负荷、中等到低负荷、低到高负荷和持续高负荷。与参考组（持续低组）相比，从低到高的肌肉减少负荷轨迹与心肺多病的相关性最强（OR: 2.64, 95% CI: 1.73-4.04），其次是持续高组（OR: 2.05, 95% CI: 1.46-2.89）和中到低组（OR: 1.90, 95% CI: 1.38-2.60）。结论骨骼肌减少负荷的变化与心肺多病显著相关，骨骼肌减少负荷的快速增加（从低到高的轨迹）尤其有害。监测肌肉减少症的进展和早期干预可能是预防心肺多病的关键。需要进一步的研究来探索潜在的机制和评估干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition Health & Aging 医学-老年医学

CiteScore

7.80

自引率

3.40%

发文量

136

审稿时长

4-8 weeks

期刊介绍： There is increasing scientific and clinical interest in the interactions of nutrition and health as part of the aging process. This interest is due to the important role that nutrition plays throughout the life span. This role affects the growth and development of the body during childhood, affects the risk of acute and chronic diseases, the maintenance of physiological processes and the biological process of aging. A major aim of "The Journal of Nutrition, Health & Aging" is to contribute to the improvement of knowledge regarding the relationships between nutrition and the aging process from birth to old age.