Postepy Dermatologii I Alergologii最新文献

{"title":"A case of acquired reactive perforating collagenosis after COVID-19 infection.","authors":"Shaoheng Wang, Xuefen Min, Xi Wang, Lifang Cheng, Liguo Qiu","doi":"10.5114/ada.2024.142575","DOIUrl":"10.5114/ada.2024.142575","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"536-537"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 15% 5-aminolevulinic acid and 10% 5-aminolevulinic acid photodynamic therapy for the treatment of acne vulgaris: a split-face randomized pilot study.","authors":"Natalia Brzezińska, Barbara Bulińska, Natalia Zawadzka, Gustaw Roter, Aneta Szczerkowska-Dobosz","doi":"10.5114/ada.2024.144417","DOIUrl":"10.5114/ada.2024.144417","url":null,"abstract":"<p><strong>Introduction: </strong>Acne vulgaris is a highly prevalent skin disorder, driving the ongoing search for innovative treatment modalities. While numerous studies have demonstrated the effectiveness of photodynamic therapy (PDT) in managing acne vulgaris, there remains a lack of clear guidlines regarding optimal treatment parameters.</p><p><strong>Aim: </strong>To assess the efficacy and safety of 10% concentration 5-aminolevulinic acid-(ALA) in comparison to 15% ALA PDT for treating facial acne vulgaris.</p><p><strong>Material and methods: </strong>A randomized, double-blind, split-face clinical trial was conducted on 25 patients with moderate to severe acne (<i>Leeds grades 2-4</i>). Patients were randomly assigned to two groups with different ALA concentrations applied on one cheek, while a placebo was applied on the other side. After a 1.5-hour incubation, illumination with 633 nm red light from a Light Emitting Diode (LED) lamp (96 J/cm²) was performed in three sessions with 7-10 days' intervals. Treatment effectiveness was assessed by the lesion reduction rate based on lesion counts before the study, after each session, and at 4 and 8 weeks after the last session.</p><p><strong>Results: </strong>Both 15% and 10% ALA-PDT treatments demonstrated significant reductions in inflammatory acne lesion counts compared to the placebo: 10% ALA-PDT showed a reduction of 27.36% versus 12.64% for the placebo (<i>p</i> = 0.04), while 15% ALA-PDT showed a reduction of 40.45% compared to 13.41% (<i>p</i> < 0.01). However, there was no significant difference between ALA-PDT and placebo in treating non-inflammatory lesions. Additionally, there was no difference between the effectiveness of 10% and 15% ALA in reducing any type of acne lesions.</p><p><strong>Conclusions: </strong>ALA-PDT is effective in treating acne vulgaris. However, ALA-PDT provides an advantage over red light only for inflammatory acne lesions. The study indicates that higher concentrations of ALA do not result in more significant reductions in acne lesions.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"479-486"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a correlation between serum and faecal calprotectin levels and the disease severity in patients with moderate-to-severe plaque psoriasis? A pilot study.","authors":"Karina Polak, Tomasz Muszyński, Aleksandra Frątczak, Bartosz Miziołek, Beata Bergler-Czop","doi":"10.5114/ada.2024.142576","DOIUrl":"10.5114/ada.2024.142576","url":null,"abstract":"<p><strong>Introduction: </strong>The role of calprotectin in psoriasis still remains unclear.</p><p><strong>Aim: </strong>To elucidate the associations between the concentrations of serum and faecal calprotectin (CP) and the severity of psoriasis in 20 patients with moderate-to-severe plaque psoriasis and 20 healthy individuals.</p><p><strong>Material and methods: </strong>The CP levels as well as the disease severity including Psoriasis Area and Severity Index (PASI), Body Surface Area (BSA) score and Dermatology Life Quality Index (DLQI) were assessed.</p><p><strong>Results: </strong>The median serum CP level in the psoriasis group was notably higher at 112.24 μg/l (interquartile range, IQR: 81.39-206.82 μg/l) compared to 60.31 μg/l (IQR: 37.41-81.54 μg/l) in the control group (<i>p</i> = 0.001), while the median faecal CP levels were similar between the two groups: 15.00 μg/g (IQR: 6.20-36.13 μg/g) in psoriasis patients and 13.00 μg/g (IQR: 10.26-30.15 μg/g) in controls (<i>p</i> = 0.766). No significant correlations between serum and faecal CP level and the PASI, BSA and DLQI were found.</p><p><strong>Conclusions: </strong>Despite the fact that patients with moderate-to-severe plaque psoriasis seem to present general higher blood calprotectin levels than healthy individuals, they are still within the population cut-off value. The elevated blood calprotectin levels are not conclusively linked to increased severity of psoriasis or to the deterioration in quality of life. Also, in individuals with psoriasis, gastrointestinal inflammation does not differ markedly from healthy controls.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"487-494"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitization to α-gal and omega-5-gliadin in patients with chronic urticaria: clinical implications and need for targeted testing.","authors":"Vesna Vukičević Lazarević, Marina Božan, Ivica Lokner, Alda Ranogajec","doi":"10.5114/ada.2024.144401","DOIUrl":"10.5114/ada.2024.144401","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic urticaria (CU) is defined as the presence of recurring hives and/or angioedema lasting more than 6 weeks. The precise impact of food allergies, particularly to galactose-α-1,3-galactose (α-gal) and omega-5-gliadin (O5G), on the development of CU is not well established.</p><p><strong>Aim: </strong>The study examines the frequency of sensitisation to these allergens and their clinical significance in individuals with CU.</p><p><strong>Material and methods: </strong>We recruited 100 adults newly diagnosed with CU to evaluate the presence of specific immunoglobulin E antibodies and allergies to α-gal and O5G. The patients were categorised into three groups based on their specific IgE levels: those sensitised to α-gal, those sensitised to O5G, and those not sensitised to either. Demographic, clinical, and laboratory variables were compared across the groups.</p><p><strong>Results: </strong>The findings indicated that 5% of the cohort was sensitised to α-gal, and 4% showed sensitivity to O5G, while only 4% of patients had a convincing history of food allergy (two to red meat and two to wheat). The sensitised groups exhibited the greatest levels of total IgE, and had a higher proportion of males. The α-gal group showed higher levels of specific IgE to Ascaris lumbricoides than the group without sensitisation. The groups had similar features in all other assessed aspects.</p><p><strong>Conclusions: </strong>Our CU cohort's sensitivity and convincing food allergy to α-gal and O5G were comparatively modest. While routine screening may not be essential, focused testing of individuals with severe or uncommon symptoms might enhance the accuracy of diagnosis and treatment.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"500-504"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric-onset hidradenitis suppurativa: a case series of 42 patients.","authors":"Aleksandra Górecka, Wioletta Barańska-Rybak, Miłosz Lewandowski, Elżbieta Szymańska, Zuzanna Świerczewska, Irena Walecka","doi":"10.5114/ada.2024.144517","DOIUrl":"10.5114/ada.2024.144517","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa is a chronic, recurring skin condition characterized by inflammation of the terminal hair follicle. It presents as painful, deep-seated, inflamed lesions such as nodules, fistulas, and abscesses. While the mean onset age for hidradenitis suppurativa is typically between 21 and 29 years, the condition can also manifest in childhood.</p><p><strong>Aim: </strong>To review the clinical and demographic characteristics of pediatric-onset hidradenitis suppurativa patients.</p><p><strong>Material and methods: </strong>We present a case series of 42 patients with pediatric-onset hidradenitis suppurativa (onset age 0-18 years) and their management from two tertiary referral centres. Demographic, clinical, and laboratory data were assessed at the Department of Dermatology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland, and the Department of Dermatology, Venereology, and Allergology, Medical University of Gdansk, Poland, from January 2000 to May 2023. This report details the epidemiology, clinical course, and management of the reported pediatric-onset hidradenitis suppurativa cases.</p><p><strong>Results: </strong>The median age of onset in our patients was 14 years (range: 5-17). The cohort comprised 20 (48%) males and 22 (52%) females. The most frequent lesion locations were in the inguinal folds and armpits, with additional occurrences in the buttocks and lower abdomen. Common comorbidities included obesity, hypothyroidism, and affective disorders. The treatment regimen for most patients involved topical clindamycin, systemic antibiotics, oral retinoids, and surgical excisions. Additionally, biologic treatments such as adalimumab, infliximab, and secukinumab were administered.</p><p><strong>Conclusions: </strong>This study affirms that the clinical course and treatment methods in patients with pediatric-onset hidradenitis suppurativa are similar to the adult-onset form. Improved disease awareness enables earlier diagnosis, preventing the deterioration of skin lesions, a decrease in quality of life, and the onset of comorbidities, especially affective disorders, which are prevalent among patients with hidradenitis suppurativa.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"525-529"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LED-emitted blue light improves quality of life and reduces fatigue after COVID-19 infection.","authors":"Daniel Nolberczak, Aleksandra Lesiak, Rafał Czajkowski, Igor Aleksander Bednarski, Joanna Narbutt","doi":"10.5114/ada.2024.144522","DOIUrl":"10.5114/ada.2024.144522","url":null,"abstract":"<p><strong>Introduction: </strong>Despite multiple clinical presentations of long COVID, the most common symptom encountered by the patients is fatigue which significantly impacts daily functioning and quality of life. There are, however, multiple unanswered questions regarding the treatment of fatigue among long COVID patients. Several studies highlighted that repetitive exposure to blue light may alleviate the fatigue in different groups of patients but the studies on the efficacy of blue light therapy in treatment of fatigue in long COVID patients are lacking.</p><p><strong>Aim: </strong>To evaluate the effects of blue light therapy in treatment of fatigue among COVID-19 survivors.</p><p><strong>Material and methods: </strong>The study comprised of 43 adults who underwent COVID-19 infection with a subjective feeling of fatigue 4 weeks after the infection. All participants underwent 10 full-body blue light irradiation for 15 min a day for 5 consecutive days each week. All participants were assessed using the Fatigue Severity Scale (FSS), Short Form 36 Vitality Subscale (SF-36) and Dermatology Life Quality Index (DLQI). Serum samples were taken to measure the levels of tryptophan, kynurenine, kynurenic acid, quinolinic acid and serotonin before and after irradiation.</p><p><strong>Results: </strong>Irradiation with blue light resulted in a significant decrease in FSS and DLQI as well as in an increase in SF-36 and serum levels of tryptophan, kynurenine and serotonin.</p><p><strong>Conclusions: </strong>Our study shows that blue light therapy could be used as adjunctive treatment of fatigue and provide an opportunity for further scientific inquiries.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"515-520"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pruritus prevalence and characteristics in Care and Treatment Facility and Geriatric Outpatient Clinic patients: a cross-sectional study using a standardized pruritus questionnaires.","authors":"Paula Mazan, Aleksandra Lesiak, Małgorzata Skibińska, Monika Rynkowska-Kidawa, Igor Bednarski, Dorota Sobolewska-Sztychny, Marcin Noweta, Joanna Narbutt","doi":"10.5114/ada.2024.144478","DOIUrl":"10.5114/ada.2024.144478","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pruritus is one of the most common symptoms in geriatric patients. Pathogenesis of pruritus is multifactorial.</p><p><strong>Aim: </strong>To evaluate the prevalence and characteristics of pruritus in geriatric patients and to characterise pruritus and explore its possible underlying causes.</p><p><strong>Material and methods: </strong>The study included 132 patients of 65 years of age or older. The intensity of itch was assessed by Visual Analogue Scale (VAS) and Numerical Rating Scale (NRS), xerosis was assessed by overall skin dryness scale (ODS). Patients were asked to complete the 10-Item Pruritus Severity Scale (10-PSS).</p><p><strong>Results: </strong>Patients with pruritus had significantly higher glucose levels and incidence of xerosis compared to those without pruritus. Patients with anaemia had significantly higher 10-PSS scores than those without. A high correlation was found between 10-PSS, NRS and VAS scales. The incidence of pruritus was significantly higher in patients using antihypertensives, antidiabetics and/or statins compared to those who did not use these medications.</p><p><strong>Conclusions: </strong>One of the most common causes of pruritus is xerosis. It is essential to provide appropriate education to patients and caregivers on the use of emollients. Therefore, the development of recommendations would be desirable. Many drugs commonly used in elderly patients may be responsible for pruritus. An in-depth investigation is necessary as pruritus may be the only symptom or it may precede the appearance of typical skin lesions in the course of certain dermatoses for many months.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"463-472"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study between fractional microneedling radiofrequency with systemic isotretinoin and fractional microneedling alone in the treatment of rosacea.","authors":"Anwar Issa Hasan, Kholod A Ali, Tuqa Mohammed Latif","doi":"10.5114/ada.2024.142597","DOIUrl":"10.5114/ada.2024.142597","url":null,"abstract":"<p><strong>Introduction: </strong>Rosacea is a chronic inflammatory disease presenting with facial flushing, non-transient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. The pathogenesis of rosacea is not fully understood, but immune dysfunction, Demodex infection, neurovascular dysregulation, and exposure to ultraviolet radiation represent contributing factors.</p><p><strong>Aim: </strong>To evaluate and compare effectiveness of fractional micro-needling radiofrequency with systemic isotretinoin and micro-needling alone in the treatment of rosacea.</p><p><strong>Material and methods: </strong>A cross-sectional comparative study between fractional microneedling radiofrequency with systemic isotretinoin and micro-needling alone in the treatment of rosacea was carried out in a private outpatient clinic and Al-Yarmouk teaching hospital from January 2022 to June 2023. Group A comprised 25 patients treated with systemic isotretinoin (10 mg/day) for 6 weeks and fractional microneedling radiofrequency for 16 weeks. Patients received a session every 2 weeks during the first 2 months of treatment then one session per month. Group B comprised 25 patients treated with fractional microneedling radiofrequency for 16 weeks. The patients received a session every 2 weeks during the first 2 months of treatment then one session per month. Measurement of baseline serum lipid profile, complete blood count, and liver enzyme levels was done to all patients receiving isotretinoin. All patients in both groups were instructed to use sunscreen and emollients. Follow-up of all patients was carried out for 3 months after treatment. Patients were assessment according to the Grade system of rosacea, patient satisfaction, and relapse rate. Relapse rate: no relapse (0), relapse (1). Patient satisfaction: poor (0), fair (1), and good (2).</p><p><strong>Results: </strong>There was no significant difference in the mean severity score for rosacea between group A and group B, before, after 8 weeks, and after 16 weeks. Patients in group A showed higher good satisfaction (72%) than group B (32%). During the follow-up period the relapse rate was higher in group B (32%) than in group A (16%), the percentage reduction (response rate) of the mean of severity score was 41.37% after 8 weeks and 91.37% after 16 weeks in group A, and 34.48% after 8 weeks and 82.75% after 16 weeks in group B.</p><p><strong>Conclusions: </strong>Fractional microneedling radiofrequency is a safe and effective method in the treatment of rosacea, and so it can be used when there are contraindications to other lines of therapy, when patients are resistant to long-term oral therapy, and when patients (including pregnant women) choose not to take oral or topical drugs.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"495-499"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic cigarettes in dermatology: a systematic review of the literature.","authors":"Paulina Rutecka, Dawid Wolak, Karina Polak, Bartosz Miziołek, Beata Bergler-Czop","doi":"10.5114/ada.2024.144520","DOIUrl":"10.5114/ada.2024.144520","url":null,"abstract":"<p><strong>Introduction: </strong>Electronic cigarettes (e-cigarettes) have been gaining worldwide popularity for several years now, making vaping a major alternative to regular tobacco smoking.</p><p><strong>Aim: </strong>There is still a lack of data on the occurrence of dermatological diseases due to e-cigarettes, so the research was performed.</p><p><strong>Methods: </strong>A systematic review of the literature was performed in Embase and Medline databases. The search included EMTREE and MESH approaches and was conducted according to the PRISMA guidelines.</p><p><strong>Results: </strong>Electronic cigarettes were identified both as an initiating and aggravating factor in several dermatological diseases. Vaping resulted in impaired wound healing and thermal injuries in the healthy skin.</p><p><strong>Conclusions: </strong>Electronic cigarettes have been reported to contribute to the development of various skin diseases and be a source of thermal injury. Lack of data and poor compliance concerning reporting the side effects of vaping make this topic an important issue to monitor.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"446-449"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the expression of Bcl-2 and Ki-67 prognostic markers and apoptotic index with biological behaviour in aggressive and non-aggressive non-melanoma eyelid skin cancer.","authors":"Zuzana Prídavková, Lukáš Plank, Peter Žiak, Juraj Halička, Karolína Benca-Kapitánová, Rastislav Vida, Vladimír Bartoš","doi":"10.5114/ada.2024.144402","DOIUrl":"10.5114/ada.2024.144402","url":null,"abstract":"<p><strong>Introduction: </strong>Prognostic biomarkers facilitate the identification of high-risk tumours.</p><p><strong>Aim: </strong>To evaluate the association of Bcl-2 protein and Ki-67 antigen expression and the apoptotic index with biological behaviour of non-melanoma eyelid tumours.</p><p><strong>Material and methods: </strong>Combined analysis of retrospective and prospective study of data from two centres over a period from 2008 to 2023 on histologically confirmed malignant non-melanoma eyelid tumours without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated.</p><p><strong>Results: </strong>The study cohort included 68 patients with 70 non-melanoma eyelid tumours (<i>n</i> = 70). The basal cell carcinoma was the most frequently present type (97.1%). The median age was 68 years. A tumour size > 5 mm correlates to the aggressive type (<i>p</i> = 0.047). Resection margins < 2 mm were in 33.9%, without any connection to the recurrence rate (<i>p</i> = 0.076). The average value of Bcl-2 expression in non-aggressive types was 82.65% (<i>p</i> < 0.001). The value of Ki-67 expression in patients with non-aggressive tumours was 35.49% (<i>p</i> = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (<i>p</i> = 0.535). No Grade III case was observed in the aggressive types. In 2 cases, the orbital exenteration was carried out (0.03%). In 1 case biological therapy was administered. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 (0.06%) cases.</p><p><strong>Conclusions: </strong>New information on cancer biomarkers in non-melanoma eyelid skin carcinoma contributes to choosing a correct therapy with achieving good aesthetic results and a good survival rate.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"456-462"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}