Laura Piejko, Małgorzata Glenc-Ambroży, Jan Juszczyk, Joanna Czajkowska, Monika Bugdol, Mikołaj Łanocha, Beata Bergler-Czop, Anna Polak
{"title":"TCA化学去皮作为绝经后妇女面部抗衰老疗法:一项随机临床研究。","authors":"Laura Piejko, Małgorzata Glenc-Ambroży, Jan Juszczyk, Joanna Czajkowska, Monika Bugdol, Mikołaj Łanocha, Beata Bergler-Czop, Anna Polak","doi":"10.5114/ada.2024.144161","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>A randomised controlled clinical trial involving a novel trichloroacetic acid (TCA) peel was performed. The experimental group, the placebo group, the staff administering treatments, the persons evaluating intervention results, and the statistical analyst were all blinded.</p><p><strong>Aim: </strong>To assess the efficacy of a novel TCA peel containing urea peroxide 5%, coenzyme Q10 5%, and kojic acid 10% as anti-aging skin therapy for postmenopausal women.</p><p><strong>Material and methods: </strong>Forty-six postmenopausal women at a mean age of 60.63 ±2.6 years were equally and randomly divided into an experimental group (EG; <i>n</i> = 23) and a control group (CG; <i>n</i> = 23), which received facial skin treatments with a TCA peel and a placebo solution, respectively. Treatment sessions were performed once weekly for 4 consecutive weeks. Between the sessions, the participants were required to apply the same post-peel cream in the morning and evening. Skin-aging parameters - hydration, elasticity, and sebum levels - were measured using the MC 750 B2 (Courage + Khazaka electronic GmbH, Cologne, Germany), wrinkle appearance was assessed based on photographs taken with the Fujifilm XT-1 camera, and the Wrinkle Severity Rating Scale and skin aesthetic improvement was rated using the Patient's Aesthetic Improvement Scale and the Global Aesthetic Improvement Scale. All assessments were carried out pre- and post-intervention and at months 1 and 3 of follow-up.</p><p><strong>Results: </strong>Skin hydration and participants' satisfaction with treatment results measured post-treatment and at month 3 of follow-up were greater in the EG than in the CG.</p><p><strong>Conclusions: </strong>The TCA chemical peel improved facial skin hydration in postmenopausal women, but not skin elasticity. The results of the treatments were rated by the participants as satisfying.Trial Registration no: ISRCTN41899475; doi.org/10.1186/ISRCTN41899475.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"28-41"},"PeriodicalIF":1.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921928/pdf/","citationCount":"0","resultStr":"{\"title\":\"TCA chemical peel as facial anti-aging therapy for postmenopausal women: a randomised clinical study.\",\"authors\":\"Laura Piejko, Małgorzata Glenc-Ambroży, Jan Juszczyk, Joanna Czajkowska, Monika Bugdol, Mikołaj Łanocha, Beata Bergler-Czop, Anna Polak\",\"doi\":\"10.5114/ada.2024.144161\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>A randomised controlled clinical trial involving a novel trichloroacetic acid (TCA) peel was performed. The experimental group, the placebo group, the staff administering treatments, the persons evaluating intervention results, and the statistical analyst were all blinded.</p><p><strong>Aim: </strong>To assess the efficacy of a novel TCA peel containing urea peroxide 5%, coenzyme Q10 5%, and kojic acid 10% as anti-aging skin therapy for postmenopausal women.</p><p><strong>Material and methods: </strong>Forty-six postmenopausal women at a mean age of 60.63 ±2.6 years were equally and randomly divided into an experimental group (EG; <i>n</i> = 23) and a control group (CG; <i>n</i> = 23), which received facial skin treatments with a TCA peel and a placebo solution, respectively. Treatment sessions were performed once weekly for 4 consecutive weeks. Between the sessions, the participants were required to apply the same post-peel cream in the morning and evening. Skin-aging parameters - hydration, elasticity, and sebum levels - were measured using the MC 750 B2 (Courage + Khazaka electronic GmbH, Cologne, Germany), wrinkle appearance was assessed based on photographs taken with the Fujifilm XT-1 camera, and the Wrinkle Severity Rating Scale and skin aesthetic improvement was rated using the Patient's Aesthetic Improvement Scale and the Global Aesthetic Improvement Scale. All assessments were carried out pre- and post-intervention and at months 1 and 3 of follow-up.</p><p><strong>Results: </strong>Skin hydration and participants' satisfaction with treatment results measured post-treatment and at month 3 of follow-up were greater in the EG than in the CG.</p><p><strong>Conclusions: </strong>The TCA chemical peel improved facial skin hydration in postmenopausal women, but not skin elasticity. The results of the treatments were rated by the participants as satisfying.Trial Registration no: ISRCTN41899475; doi.org/10.1186/ISRCTN41899475.</p>\",\"PeriodicalId\":54595,\"journal\":{\"name\":\"Postepy Dermatologii I Alergologii\",\"volume\":\"42 1\",\"pages\":\"28-41\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921928/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Postepy Dermatologii I Alergologii\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/ada.2024.144161\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/10/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Postepy Dermatologii I Alergologii","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/ada.2024.144161","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/10/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
TCA chemical peel as facial anti-aging therapy for postmenopausal women: a randomised clinical study.
Introduction: A randomised controlled clinical trial involving a novel trichloroacetic acid (TCA) peel was performed. The experimental group, the placebo group, the staff administering treatments, the persons evaluating intervention results, and the statistical analyst were all blinded.
Aim: To assess the efficacy of a novel TCA peel containing urea peroxide 5%, coenzyme Q10 5%, and kojic acid 10% as anti-aging skin therapy for postmenopausal women.
Material and methods: Forty-six postmenopausal women at a mean age of 60.63 ±2.6 years were equally and randomly divided into an experimental group (EG; n = 23) and a control group (CG; n = 23), which received facial skin treatments with a TCA peel and a placebo solution, respectively. Treatment sessions were performed once weekly for 4 consecutive weeks. Between the sessions, the participants were required to apply the same post-peel cream in the morning and evening. Skin-aging parameters - hydration, elasticity, and sebum levels - were measured using the MC 750 B2 (Courage + Khazaka electronic GmbH, Cologne, Germany), wrinkle appearance was assessed based on photographs taken with the Fujifilm XT-1 camera, and the Wrinkle Severity Rating Scale and skin aesthetic improvement was rated using the Patient's Aesthetic Improvement Scale and the Global Aesthetic Improvement Scale. All assessments were carried out pre- and post-intervention and at months 1 and 3 of follow-up.
Results: Skin hydration and participants' satisfaction with treatment results measured post-treatment and at month 3 of follow-up were greater in the EG than in the CG.
Conclusions: The TCA chemical peel improved facial skin hydration in postmenopausal women, but not skin elasticity. The results of the treatments were rated by the participants as satisfying.Trial Registration no: ISRCTN41899475; doi.org/10.1186/ISRCTN41899475.