Postepy Dermatologii I Alergologii最新文献

{"title":"Atopic dermatitis and prematurity - a prospective study with analysis of the cytokine profile and thymus growth: a preliminary report.","authors":"Aleksandra Kowalik, Kazimierz Wêglarczyk, Małgorzata Klimek, Zofia Goliñska, Barbara Malinowska, Maciej Siedlar, Przemko Kwinta","doi":"10.5114/ada.2025.153589","DOIUrl":"10.5114/ada.2025.153589","url":null,"abstract":"<p><strong>Introduction: </strong>Preterm children suffer from atopic dermatitis (AD) less frequently than term children do. The reason for this phenomenon has not yet been identified. Hypotheses include changes in the T-helper 1 (Th1)/T-helper 2 (Th2) balance or altered development of the thymus.</p><p><strong>Aim: </strong>This study was designed to compare the Th1/Th2 cytokine balance and thymus size in preterm and term children and investigate the associations between these results and a possible diagnosis of AD in the second year of life.</p><p><strong>Material and methods: </strong>The population comprised 28 preterm and 19 term children. During the first week of life, Th1/Th2/Th17 cytokine levels in the blood were assessed, and the thymus was measured via ultrasound. In the second year of life, 30 children were examined to determine whether AD was present, and the abovementioned procedures were repeated.</p><p><strong>Results: </strong>AD was diagnosed in 3 out of 18 (16.7%) preterm children and 1 out of 12 (8.3%) term children (OR = 2.2; 95% CI: 0.201-24.086). For all patients, the thymus/weight index was lower, and there was a significant decrease in the level of IL-2 and increases in the levels of IL-4 and IL-17 in the second year of life compared with those after birth. There were no differences in cytokine levels or thymus size in the second year of life between the preterm/term and AD/non-AD subgroups.</p><p><strong>Conclusions: </strong>The observed associations may indicate that the immunological status of preterm children in the second year of life may not vastly differ from that of term children.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"414-422"},"PeriodicalIF":1.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small intestine bacterial overgrowth in patients diagnosed with allergic disease: preliminary findings.","authors":"Marcelina Bartuzi-Lepczynska, Natalia Ukleja-Sokolowska","doi":"10.5114/ada.2025.153546","DOIUrl":"10.5114/ada.2025.153546","url":null,"abstract":"<p><strong>Introduction: </strong>The gastrointestinal microbiota is thought to play a role in the pathogenesis of food allergies. One potential contributing factor is small intestinal bacterial overgrowth (SIBO).</p><p><strong>Aim: </strong>This study aims to investigate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with diagnosed allergic diseases and to assess potential associations between SIBO and allergy burden.</p><p><strong>Material and methods: </strong>This study included 44 patients aged 21-73 years, who were evaluated for suspected food hypersensitivity of various origin. A medical history was collected, followed by a physical examination, point-of-care skin tests and a breath test for SIBO. Patients with celiac disease, known autoimmune or malignant disorders, or those receiving medications that could influence study outcomes were excluded. Additionally, patients who had recently undergone endoscopy or abdominal surgery, were experiencing an exacerbation of a chronic illness, or had an acute infection were not included in the study.</p><p><strong>Results: </strong>A positive breath test for SIBO was found in 85.7% of patients with a history of food allergy and 78.3% of patients without confirmed allergy; however, the difference was not statistically significant.</p><p><strong>Conclusions: </strong>This pilot study did not confirm a higher prevalence of SIBO in patients with food allergies compared to those without. Further studies with larger sample sizes and more comprehensive allergological diagnostics are needed to definitively assess the potential link between SIBO and food allergies.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"407-413"},"PeriodicalIF":1.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear IgA bullous dermatosis in a child after the second dose of inactivated COVID-19 vaccine.","authors":"Xinrui Li, Jiliang Lu, Yongxia Liu, Baoqi Yang","doi":"10.5114/ada.2025.153502","DOIUrl":"10.5114/ada.2025.153502","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"429-431"},"PeriodicalIF":1.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of direct immunofluorescence for diagnosing autoimmune bullous diseases: data from the Central European referral department.","authors":"Magdalena Jałowska, Bogusz Falkowski, Monika Bowszyc-Dmochowska, Maria Raptis-Bolwach, Justyna Gornowicz-Porowska, Agnieszka Seraszek-Jaros, Marian Dmochowski","doi":"10.5114/ada.2025.153492","DOIUrl":"10.5114/ada.2025.153492","url":null,"abstract":"<p><strong>Introduction: </strong>Autoimmune bullous disorders (AIBD) are a heterogeneous group of diseases resulting from autoantibodies production. Nowadays, direct immunofluorescence (DIF) is the basic diagnostic tool for diagnosing AIBD.</p><p><strong>Aim: </strong>This study was performed to assess the percentages of positive and negative DIF tests performed in individuals clinically suspected to suffer from AIBD in a single Central European referral department laboratory and to propose ways to improve the effectiveness of DIF in AIBD imaging diagnostics.</p><p><strong>Material and methods: </strong>A total of 1985 consecutive tests were collected during 9 consecutive years (2016-2024). We analysed the total number of results, the percentages of positive and negative results year by year, and according to the unit that sent material for testing.</p><p><strong>Results: </strong>We found that almost one-third of the tests were positive (30.88% overall, over 9 years). The percentage of positive results has varied from year to year (from 26.22% in 2016 to 38.89% in 2023). The percentage of positive results was higher in outpatient clinics than in hospital wards (33.7% vs. 22.9%; <i>p</i> < 0.0001; χ² test).</p><p><strong>Conclusions: </strong>DIF should be performed thoughtfully at both clinical and laboratory levels, and approximately 31% of positive results should be regarded as a good outcome. To increase this percentage, specialised units should be maintained to keep up with the constant development of knowledge and experience in AIBD. Negative DIF results could also be useful in differential diagnostics of AIBD, but their percentage should be minimized.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"373-377"},"PeriodicalIF":1.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentrin/SUMO-specific protease 1 contributes to drug resistance in melanoma by mediating the deSUMOylation of Yes-associated protein.","authors":"Bei Zhao, Yinghua Liu, Xuemei Tang, Shi Cheng","doi":"10.5114/ada.2025.153499","DOIUrl":"10.5114/ada.2025.153499","url":null,"abstract":"<p><strong>Introduction: </strong>The effectiveness of chemotherapy in treating melanoma is limited due to drug resistance. Previous studies have shown that SENP1 (Sentrin/SUMO-specific protease 1) is related to the tumour hypoxic microenvironment, tumorigenesis and metastasis.</p><p><strong>Aim: </strong>This study aimed to investigate its roles in drug resistance of melanoma.</p><p><strong>Material and methods: </strong>Originally, a concentration of 2 μg/ml dacarbazine (DTIC) was employed in the treatment of A375 and M14 cell lines for a duration of 24 h. Subsequently, the cells were transferred to fresh medium and allowed to proliferate until reaching 80% of their maximum density. This treatment cycle was then repeated for a total of 10 days, following which the DTIC concentration was doubled. The establishment of drug-resistant cell lines for both A375 and M14 occurred after 8 months of sustained and continuous treatment. The expression level of SENP1 was monitored monthly using real-time reverse transcriptase-polymerase chain reaction (RT-qPCR), with a fold change above 1.5 compared to the untreated condition considered as significant.</p><p><strong>Results: </strong>Finally, the study found that SENP1 was up-regulated by about 2.2-1.7 times in the drug-resistant cells. In addition, overexpression of SENP1 in normal A375 cells improved cell viability against DTIC. The study also found that Yes-associated protein (YAP) could form protein condensates in the cytoplasm while its expression was enhanced by SENP1-mediated deSUMOylation.</p><p><strong>Conclusions: </strong>This study suggests that there is a positive correlation between the ubiquitin-specific protease SENP1 and drug resistance in melanoma. Its up-regulation may lead to changes in the deSUMOylation of YAP, activate the Hippo signalling pathway, and increase the resistance of melanoma to DTIC.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"398-406"},"PeriodicalIF":1.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of bullous eosinophilic annular erythema.","authors":"Xuan Long, Guiying Zhang, Shuaihantian Luo","doi":"10.5114/ada.2025.153501","DOIUrl":"10.5114/ada.2025.153501","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"423-424"},"PeriodicalIF":1.4,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of antioxidant-anti-inflammatory therapy on skin rejuvenation and repair. The clinical case series study.","authors":"Dorota Sobolewska-Sztychny, Magdalena Ciążyńska, Joanna Narbutt, Natalia Bień, Aleksandra Lesiak","doi":"10.5114/ada.2025.153318","DOIUrl":"10.5114/ada.2025.153318","url":null,"abstract":"<p><strong>Introduction: </strong>Reactive oxygen species (ROS) and oxidative stress play a crucial role in both intrinsic and extrinsic skin aging. Antioxidants act as powerful ROS scavengers, mitigating skin aging by neutralizing already-formed ROS and restoring skin oxygen homeostasis, thereby indirectly protecting DNA integrity.</p><p><strong>Aim: </strong>This study aimed to assess the efficacy of a combined therapy involving antioxidants, peels, growth factors, mesopeptide cocktails, and microneedling on selected skin parameters.</p><p><strong>Material and methods: </strong>Twenty Caucasian female participants with skin phototypes II to IV and signs of aging were included. Each participant underwent a three-step treatment regimen consisting of sequential applications of peels, mesopeptide cocktails, and microneedling at 2-week intervals. Between sessions, participants applied a serum containing ferulic acid and adhered to photoprotective measures. Assessments included photographic documentation, videodermoscopic examinations, skin pH assessments, transepidermal water loss (TEWL) measurements, and sebum quantification.</p><p><strong>Results: </strong>A general post-treatment improvement was observed in all participants, with 15 out of 20 individuals reporting lifting effects, wrinkle reduction, and enhanced skin tone. Additionally, reductions in hyperpigmentation, erythema, and skin flaccidity were noted. The mean pH measured on the cheek before treatment was 6.18 ±0.41, after 2 weeks: 5.95 ±0.47, after 4 weeks: 5.63 ±0.34, and after 6 weeks: 5.48 ±0.49. These differences were statistically significant (<i>p</i> < 0.05). Furthermore, a significant decrease in TEWL was observed after treatment (12.91 vs. 9.46 g/h/m²; <i>p</i> = 0.0008).</p><p><strong>Conclusions: </strong>The described three-step therapeutic regimen demonstrated excellent tolerability and safety. The observed improvements in nearly all measured skin parameters underscore the efficacy of this comprehensive approach to skin rejuvenation.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"387-392"},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of different dosing regimens of isotretinoin for acne vulgaris: a systematic review.","authors":"Linmei Lin, Wanqi Lin, Yi Zheng, Huimin Cai","doi":"10.5114/ada.2025.153322","DOIUrl":"10.5114/ada.2025.153322","url":null,"abstract":"<p><p>This systematic review aimed to examine the effectiveness and safety of different isotretinoin dosing regimens for treating acne vulgaris. Isotretinoin is known as a potent treatment for moderate to severe acne, but its use is associated with dose-dependent side effects. This review aims to evaluate the comparative effectiveness of various dosing strategies, including high-dose, low-dose, and intermittent regimens. A comprehensive search of electronic databases was conducted, and 15 randomized controlled trials were included in the final analysis. The findings indicate that low-dose and intermittent dosing regimens offer comparable efficacy to high-dose regimens while minimizing adverse effects such as mucocutaneous reactions, including cheilitis and xerosis. The results highlight the potential for personalized isotretinoin therapy, which can reduce the severity of side effects while maintaining clinical effectiveness. Further research is needed to assess long-term outcomes, including relapse rates and the safety profile of these dosing regimens over extended periods. Clinicians should consider individual patient characteristics when selecting isotretinoin dosing strategies to balance therapeutic efficacy and tolerability.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"346-353"},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of skin microbiome with interleukin-23 in patients with plaque psoriasis.","authors":"Hanan Hassan Sabry, Zainab Sami Noor, Rasha Abdel Hameed Elsayed, Nader Nasr Nazmy","doi":"10.5114/ada.2025.153336","DOIUrl":"10.5114/ada.2025.153336","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic autoimmune disease influenced by immune dysregulation and microbiome alterations. The IL-23/Th17 axis is central to its pathogenesis, promoting inflammation and keratinocyte hyperproliferation. Skin microbiome dysbiosis has been implicated in disease onset, but its relationship with IL-23 requires further exploration.</p><p><strong>Aim: </strong>This study aimed to investigate variations in the skin microbiome between psoriatic patients and healthy controls, and examine the correlation of IL-23 serum levels and genetic polymorphisms with psoriasis presence and severity.</p><p><strong>Material and methods: </strong>This case-control study included 40 patients with plaque psoriasis and 40 healthy controls. Clinical data, including Psoriasis Area and Severity Index (PASI) scores, were collected. Skin microbiome analysis was performed using culture methods, serum IL-23 levels were measured by ELISA, and genetic analysis of the IL-23 rs2201841 polymorphism was conducted using PCR-RFLP.</p><p><strong>Results: </strong>Psoriasis patients exhibited higher fungal growth (75% vs. 17.5%, <i>p</i> < 0.001) and mixed bacterial-fungal infections (55% vs. 15%, <i>p</i> < 0.001). Serum IL-23 levels were significantly lower in patients (157.2 ±214.8 pg/ml vs. 252.7 ±308.2 pg/ml, <i>p</i> < 0.001) and negatively correlated with PASI scores (<i>r</i> = -0.866, <i>p</i> < 0.001). The IL-23 rs2201841 SNP showed no significant association with psoriasis. Fungal growth (OR = 3.61, <i>p</i> = 0.002) and reduced IL-23 levels (OR = 0.996, <i>p</i> = 0.039) independently predicted disease susceptibility.</p><p><strong>Conclusions: </strong>Alterations in the skin microbiome and reduced IL-23 levels are associated with psoriasis. These findings suggest fungal infections and IL-23 as potential biomarkers for disease diagnosis and monitoring.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 4","pages":"361-372"},"PeriodicalIF":1.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12458058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of immune system-related genes on the development of atopic dermatitis.","authors":"Dominika Cieśla, Tomasz Nowak","doi":"10.5114/ada.2025.152114","DOIUrl":"10.5114/ada.2025.152114","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a disease with a complex genetic background, in which only the predisposition to atopy is inherited. Genetic, environmental, and psychosomatic factors contribute to the development of this allergic inflammatory disease. The patient's age and population affiliation also play a significant role. Gene groups associated with AD are primarily: genes responsible for the epidermal barrier, interaction with the environment and related to the immune response. In turn, polymorphisms in these genes can affect the severity of atopic dermatitis through mechanisms such as excessive stimulation of the immune system or increased synthesis of immunoglobulin E (IgE). Among the genes related to the immune system that play an important role in the development of atopic dermatitis, we can distinguish: Chitinase-3-like protein 1 (<i>CHI3L1</i>), <i>FcεRI</i> (Fc epsilon RI, ligand-binding subunit of the high-affinity IgE receptor), toll-like receptors (<i>TLRs</i>), and cytokine encoding genes.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 3","pages":"232-242"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}