Postepy Dermatologii I Alergologii最新文献

{"title":"Rapid response to ixekizumab in a patient with erythrodermic psoriasis and drug-induced cirrhosis.","authors":"Delin Ran, Na Wang, Jing Liu, Peng Qu, Baoqi Yang","doi":"10.5114/ada.2025.149667","DOIUrl":"10.5114/ada.2025.149667","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"210-212"},"PeriodicalIF":1.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between metabolic syndrome and vitiligo: a systematic review.","authors":"Aleksandra Białczyk, Barbara Kamińska, Rafał Czajkowski","doi":"10.5114/ada.2025.149438","DOIUrl":"10.5114/ada.2025.149438","url":null,"abstract":"<p><p>Vitiligo is a chronic autoimmune disorder linked to systemic inflammation, oxidative stress, and metabolic dysregulation, including metabolic syndrome (MetS). This review examines the shared mechanisms underlying vitiligo and MetS, highlighting oxidative stress, pro-inflammatory cytokines, and lipid dysregulation as central contributors. A systematic analysis of 23 studies found association between vitiligo and MetS, though variations exist based on the disease type, severity, and duration. Emerging therapies, such as statins and thiazolidinediones demonstrate potential for managing vitiligo and its metabolic risks by targeting oxidative and inflammatory pathways. While animal and <i>in vitro</i> studies show promise, clinical outcomes are inconsistent, with safety concerns limiting systemic treatments.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"134-142"},"PeriodicalIF":1.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic dermatitis and non-alcoholic fatty liver disease: current state of evidence and possible pathogenetic correlations.","authors":"Marta Dębicka, Aleksandra Bąk, Jerzy Walecki, Irena Walecka","doi":"10.5114/ada.2025.149546","DOIUrl":"10.5114/ada.2025.149546","url":null,"abstract":"<p><p>Relationships between inflammatory diseases and metabolic abnormalities are recently raising much scientific interest. Convincing evidence on the association between atopic dermatitis (AD) and constituents of metabolic syndrome (MS) has already been established. In this article we aim to summarize current data on the link between AD and non-alcoholic fatty liver disease (NAFLD), which is considered a hepatic manifestation of MS. By reviewing animal models, human studies and possible pathogenetic points of contiguity we want to present the current state of knowledge and goals for further investigations. To our best knowledge, this is the first review of this topic so far.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"121-124"},"PeriodicalIF":1.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baumann Skin Type Questionnaire (BSTQ): creation and validation of the Polish language version - part one.","authors":"Justyna Martyna Brzozowska","doi":"10.5114/ada.2025.149544","DOIUrl":"10.5114/ada.2025.149544","url":null,"abstract":"<p><strong>Introduction: </strong>Baumann Skin Type Questionnaire (BSTQ) is a widely used questionnaire, that was designed to determine baseline skin type in dermatology. The self-reported BSTQ, consisting of four parts: oily vs. dry skin, sensitive vs. resistant skin, pigmented vs. non-pigmented skin and wrinkled vs. tight skin, can provide significant guidance for consumers and professionals to select and recommend the most appropriate skin care products and skin care protocols.</p><p><strong>Aim: </strong>Translation and validation of the Polish version of the Baumann Skin Type Questionnaire (BSTQ) - oily vs. dry skin and sensitive vs. resistant skin.</p><p><strong>Material and methods: </strong>Both forward and backward translation of the English version of the BSTQ was performed. The study was conducted on 103 individuals. The respondents completed the questionnaire twice, 1 day after the other. Moreover, the subjects participated in practical classes of facial care cosmetology which allowed for conducting interviews and skin examinations by a cosmetology expert.</p><p><strong>Results: </strong>The Polish version of the BSTQ demonstrated high test-retest reliability (reproducibility) in the dimension assessing oily or dry skin as well as sensitive or resistant skin (<i>ICC3</i> = 0.91; <i>ICC3</i> = 0.96, respectively) and good internal consistency, corroborated by Guttman's Lambda 6 reliability (oily vs. dry: α_raw = 0.75, α_std = 0.74, <i>G6</i> = 0.79; retest: α_raw = 0.77, α_std = 0.77, <i>G6</i> = 0.81; sensitive vs. resistant: α_raw = 0.72, α_std = 0.74, <i>G6</i> = 0.81; retest: α_raw = 0.78, α_std = 0.79, <i>G6</i> = 0.85).</p><p><strong>Conclusions: </strong>The Polish version of the BSTQ (oily vs. dry skin and sensitive vs. resistant skin) showed high reliability, good internal consistency and high accuracy and consistency. It can be used for assessment of oily or dry skin and sensitive or resistant skin.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"190-196"},"PeriodicalIF":1.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of platelet-rich fibrin on repair and healing chronic refractory wounds in rats by regulating Wnt/β-catenin signalling pathway.","authors":"Huasen Huang, Muyi Huang, Xinyuan Wang, Guibin Yin","doi":"10.5114/ada.2025.148762","DOIUrl":"10.5114/ada.2025.148762","url":null,"abstract":"<p><strong>Introduction: </strong>Platelet-rich fibrin is an autologous biomaterial that is rich in platelets and various growth factors, has good biocompatibility, and has significant application potential in tissue repair and regeneration.</p><p><strong>Aim: </strong>To explore the effect of platelet-rich fibrin (PRF) on the repair and healing of chronic refractory wounds in rats by regulating the Wnt/β-catenin (β-catenin) signalling pathway.</p><p><strong>Material and methods: </strong>Full-thickness skin defect open wounds were established on the backs of 50 male SD rats.</p><p><strong>Results: </strong>In comparison with the normal control group, the wound healing rate, CD34-positive cell ratio, and Wnt1, β-catenin, and c-myc protein expression levels of rats in the model group were significantly reduced at each time point; serum TNF-α, IL-1β, IL-6 levels, and GSK-3β protein expression levels were significantly increased. The granulation tissue was severely damaged and infiltrated by a large number of inflammatory cells. The collagen fibres were loosely arranged and unevenly distributed. In comparison with the model group, the wound healing rate, CD34-positive cell ratio, and Wnt1, β-catenin, and c-myc protein expression levels of rats in the PRF group and positive control group at each time point were significantly increased.</p><p><strong>Conclusions: </strong>PRF can promote the repair and healing of chronic refractory wounds in rats by inhibiting ulcer surface inflammation and promoting collagen fibre deposition and angiogenesis. Its mechanism of action may be concerned with the activation of the Wnt/β-catenin signalling pathway.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"175-182"},"PeriodicalIF":1.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and incidence of hepatitis B, hepatitis C and HIV among syphilis patients in Shanghai, China.","authors":"Juan Wu, Yan Hu, Liyan Ni, Lin Zhu, Wei Zhao, Xin Gu, Rui-Rui Peng, Fu-Quan Long","doi":"10.5114/ada.2025.149083","DOIUrl":"10.5114/ada.2025.149083","url":null,"abstract":"<p><strong>Introduction: </strong>There is great need to screen for HIV, HBV, HBC and syphilis co-infected cases in china because of high prevalance of this disease.</p><p><strong>Aim: </strong>To uncover the risk factors and incidence of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) among syphilis patients.</p><p><strong>Material and methods: </strong>A total of 5,206 patients with syphilis were enrolled in this retrospective cohort study. The data of clinical and laboratory characteristics of the participants were collected. The correlations between the clinical characteristics and HBV, HCV and HIV co-infection with syphilis were analysed.</p><p><strong>Results: </strong>The prevalence of HBV, HCV and HIV among syphilis patients in our study was 8.4%, 1.8%, and 10.1%, respectively. The median age was significantly lower in the HBV/syphilis co-infected group (47.5 with IQR 36-58 vs. 52 with IQR 36-61), the majority of co-infected individuals were male (251, 57.6% vs. 185, 42.4%). Multivariate logistic regression analysis showed that co-infected with patients co-infected with HCV and combined with gonococcal infection and herpes virus type II infection were independently associated with HBV co-infection in syphilis patients. Multivariate logistic regression analysis found that male gender, age below 30 years, age group of 31-44-years old, co-infection with HSV-2, never married and divorced, and having a RPR titre of ≥ 1 : 32 were independently associated with HIV co-infection.</p><p><strong>Conclusions: </strong>HIV co-infection or homosexuality among syphilis patients had no significant impact on the prevalence of HBV or HCV in the study.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"197-202"},"PeriodicalIF":1.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective, randomised comparative study to evaluate safety, tolerability, and efficacy of topical minocycline gel 4% plus oral isotretinoin against oral isotretinoin only in Indian patients with moderate-to-severe acne vulgaris.","authors":"Abhishek De, Saswati Halder, Dhiraj Dhoot, Ashwin Balasubramanian, Hanmant Barkate","doi":"10.5114/ada.2024.146870","DOIUrl":"10.5114/ada.2024.146870","url":null,"abstract":"<p><strong>Introduction: </strong>The concurrent use of tetracyclines and isotretinoin in acne treatment can cause pseudotumor cerebri (PTC). However, topical minocycline (4%) was significantly less systemically absorbed.</p><p><strong>Aim: </strong>To assess the efficacy and safety of a combination of topical minocycline gel 4% with oral isotretinoin compared to isotretinoin alone in the treatment of acne vulgaris in the Indian population.</p><p><strong>Material and methods: </strong>This prospective, randomised, comparative study included 60 patients aged ≥ 12 years with acne. Two groups were formed: the Mino-Iso group applied minocycline gel 4% and took 20 mg isotretinoin capsules in the evening, whereas the Iso group took only 20 mg isotretinoin capsules in the evening. The study duration was 12 weeks.</p><p><strong>Results: </strong>At week 12, the Mino-Iso group showed a significantly greater reduction in inflammatory lesions (-88.5%) than the Iso group (-67.42%) (<i>p</i> < 0.05). The investigator's global assessment (IGA) treatment score was statistically lower and success significantly higher in the Mino-Iso group (<i>p</i> < 0.05 and <i>p</i> = 0.03, respectively). Adverse events (AEs) were reported in 6 and 4 patients in the Mino-Iso and Iso groups, respectively (<i>p</i> = 0.73), all of which were mild in nature and resolved during the study.</p><p><strong>Conclusions: </strong>The combination of topical gel 4% and oral isotretinoin 20 mg capsule significantly reduced inflammatory lesions, improved IGA scores, and had a higher success rate at week 12 than isotretinoin alone, with similar tolerability. Therefore, this combination can be considered a preferable treatment option for moderate-to-severe acne.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"164-170"},"PeriodicalIF":1.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alopecia areata - Quality of Life Questionnaire - formation and validation of the Polish version.","authors":"Agnieszka Otlewska-Szpotowicz, Wojciech Baran, Aleksandra Batycka-Baran","doi":"10.5114/ada.2024.146222","DOIUrl":"10.5114/ada.2024.146222","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is an autoimmune disorder causing non-scarring hair loss. AA impacts individuals' quality of life (QoL), affecting emotional wellbeing, self-esteem, and social interactions, and is associated with mental health issues like depression and anxiety. There is a lack of adequate, validated, disease-specific questionnaires to evaluate the quality of life in Polish-speaking patients with AA.</p><p><strong>Aim: </strong>Formation and validation of the Polish version of the Alopecia Areata Quality of Life questionnaire (AA-QLI).</p><p><strong>Material and methods: </strong>The original English version of the questionnaire was translated into Polish using a forward and backward translation process according to international standards. The validation was conducted on 21 patients suffering from AA, who completed the questionnaire twice with a 5-day interval. To assess internal consistency of the questionnaire the Cronbach α coefficient was used. The reliability of the Polish version of the questionnaire was evaluated using the intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>The Polish version of the AA-QLI questionnaire demonstrated good internal consistency with Cronbach α coefficient of 0.86 for the first completion of the questionnaire. The ICC of 0.93 indicated very good reproducibility of this questionnaire.</p><p><strong>Conclusions: </strong>The Polish version of the AA-QLI questionnaire showed high internal consistency and reliability, making it a suitable tool for assessing the health-related quality of life in Polish-speaking AA patients.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"83-88"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Demodex</i> mites among solid organ transplant recipients: a cross-sectional study.","authors":"Adriana Marquardt-Feszler, Jakub Ruszkowski, Karolina Cekała, Maria Alicja Dêbska-Ślizień, Beata Imko-Walczuk","doi":"10.5114/ada.2024.145198","DOIUrl":"10.5114/ada.2024.145198","url":null,"abstract":"<p><strong>Introduction: </strong><i>Demodex</i> mites (DM) are pathogenic parasites that in some people cause demodicosis. It is widely discussed which groups of patients are more prone to develop the disease.</p><p><strong>Aim: </strong>To evaluate the prevalence of DM in a population of solid organ transplant recipients (SOTRs) in comparison to immunocompetent controls.</p><p><strong>Material and methods: </strong>A total of 225 SOTRs were tested for DM by 2 methods: microscopic evaluation of scrapings of the face and by dermoscopic examination of the face. Additionally, a group of 95 patients, who do not have any immunosuppression history, were asked to volunteer as controls. Every patient in study group was examined for face symptoms and had his medical history reviewed.</p><p><strong>Results: </strong>The prevalence of positive <i>Demodex</i> test was not significantly different among SOTRs comparing to controls (21 positive results among SOTRs (9.3%) vs. 6 positive controls (6.3%), (<i>p</i> = 0.38)), but there was a numerically higher rate in SOTRs population. Patients treated with tacrolimus had a higher odds ratio of a positive <i>Demodex</i> test when compared to those treated with cyclosporine A (<i>p</i> = 0.046). Skin symptoms were characterized by relatively high negative predictive values (91.0-93.7%). Itch had the best balance between sensitivity and specificity, whereas exfoliation had the highest diagnostic accuracy.</p><p><strong>Conclusions: </strong>In our study, demodicosis does not occur more often among SOTRs than in the general population. Notably, itch and exfoliation are symptoms of the greatest diagnostic value in demodicosis diagnosis. Patients receiving tacrolimus had a higher prevalence of a positive <i>Demodex</i> test when compared to those treated with cyclosporine A.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"89-95"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psoriatic itch from the patients' perspective: a cross-sectional study.","authors":"Magdalena M Kotewicz, Piotr K Krajewski, Andrzej K Jaworek, Jacek C Szepietowski","doi":"10.5114/ada.2024.143787","DOIUrl":"10.5114/ada.2024.143787","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic inflammatory skin disease that affects mental health and is often associated with itch.</p><p><strong>Aim: </strong>To investigate the influence of itch on the symptoms of anxiety, depression, quality of life, and stigmatization in psoriasis patients.</p><p><strong>Material and methods: </strong>The studied group included 106 adults with psoriasis (34% females; mean age: 42.1 ±13.0 years). Disease severity was evaluated using the Psoriasis Area and Severity Index (PASI). The itch intensity was assessed by a numerical rating scale (NRS) and 4-Item Itch Questionnaire (4-IIQ). Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) questionnaires were utilized to estimate the severity of depression and anxiety, respectively, and so was the Hospital Anxiety and Depression Scale (HADS). Quality of life (QoL) was evaluated using the Dermatology Life Quality Index (DLQI), while stigmatization was studied by the 6-Item Stigmatization Scale (6-ISS).</p><p><strong>Results: </strong>Psoriasis patients with itch scored significantly higher (<i>p</i> = 0.037) in HADS total score and DLQI (<i>p</i> < 0.001) than those without itch. Itch NRS correlated significantly with the HADS total score (<i>p</i> = 0.027), GAD-7 (<i>p</i> = 0.008), PHQ-9 (<i>p</i> = 0.008), and DLQI (<i>p</i> = 0.001).</p><p><strong>Conclusions: </strong>Itch significantly impacts the quality of life and well-being of patients with psoriasis.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"21-27"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}