Postepy Dermatologii I Alergologii最新文献

{"title":"Clinical curative effect and quality of life evaluation of dupilumab in treating children with atopic dermatitis and its effect on IgE levels, eosinophil count, Th2 cytokines (IL-4 and IL-13), and thymus and activation-regulated chemokine.","authors":"Yougang Ren, Zhongxiao Wu, Mouzhe Yang, Haitao Lou","doi":"10.5114/ada.2024.146176","DOIUrl":"10.5114/ada.2024.146176","url":null,"abstract":"<p><strong>Introduction: </strong>Atopic dermatitis (AD) is a common chronic skin inflammatory disease. The traditional treatment shows limited effect and side effects. Dupilumab is a monoclonal antibody immunotherapy targeting IL-4 and IL-13, which may become a new direction for treating AD.</p><p><strong>Aim: </strong>This study was to explore the clinical curative effect of dupilumab in the treatment of children with AD, and its influence on the quality of life (QoL) of children.</p><p><strong>Material and methods: </strong>54 children with AD, who were treated in the outpatient and inpatient departments of the hospital from August 2023 to July 2024, were included in this study. These children were treated with dupilumab, and their clinical curative effect as well as QoL were evaluated through relevant scales as well as the IgE, eosinophil counts, and Th2 cytokine levels.</p><p><strong>Results: </strong>After treatment, Eczema Area and Severity Index (EASI) score was 8.8 ±4.5, Scoring Atopic Dermatitis (SCORAD) score was 15.1 ±8.4, and itching Numeric Rating Scale (NRS) score was 1.1 ±0.7. Compared with those before treatment, the scores of 25.4 ±6.2, 38.6 ±10.3, and 6.9 ±2.2 were highly decreased with differences being statistically significant (<i>p</i> < 0.05). Only 3 cases had an Investigator's Global Assessment (IGA) ≥ 3, which was greatly reduced than that before treatment (<i>p</i> < 0.05). 5 cases had the adverse reaction of conjunctivitis after treatment, Patient-Oriented Eczema Measure (POEM) score was 4.8 ±1.6, and Dermatology Life Quality Index (DLQI) was scored as 3.3 ±1.8. These were observably lower than those before the patients were treated, exhibiting significant differences (<i>p</i> < 0.05). There were significant reductions in IgE levels, eosinophil count, Th2 cytokines (IL-4 and IL-13), and thymus and activation-regulated chemokine (TARC) after treatment (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Dupilumab could effectively treat children with AD and improve their QoL, so it had a clinical application value.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"62-67"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical predictors of biochemical hyperandrogenemia and its relation to treatment resistance in women with acne.","authors":"Cemile Tuğba Altunel, Semih Tatlıcan","doi":"10.5114/ada.2024.144480","DOIUrl":"10.5114/ada.2024.144480","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of biochemical hyperandrogenemia (BHA) in female acne varies across studies. While certain phenotypic features may suggest hormonal evaluation, clinical predictors of BHA are unclear. Furthermore, the predictors of treatment outcome remain inconclusive, and despite common belief, no strong evidence links BHA to treatment resistance.</p><p><strong>Aim: </strong>To identify determinants of BHA and treatment response in female acne.</p><p><strong>Material and methods: </strong>Female acne patients who underwent hormonal tests (androstenedione, DHEAS04, E2, FSH, LH, free testosterone, prolactin, SHBG, TSH, total testosterone, and 17-OHP) from January 2020 to September 2022 were analysed for associations of clinical parameters with BHA, PCOS, and treatment resistance.</p><p><strong>Results: </strong>Among 86 females (mean age: 24, range: 14-41), acne categories were as follows: persistent (46.5%), adult-onset (26.7%), recurrent (19.8%), and adolescent (7%). Clinical and BHA rates were 65.1% and 70.9%, respectively. The most common elevated hormones were 17-OHP (65%) and androstenedione (40%). Hirsutism and truncal acne were associated with BHA. High DHEAS04 and menstrual irregularity were linked to the persistent category, and 17-OHP elevation was related to a chronic course. PCOS prevalence (17.4%) was associated with high DHEAS04, Free Androgen Index, TT, low E2, and hirsutism. Persistent/recurrent acne and hirsutism were associated with treatment failure.</p><p><strong>Conclusions: </strong>The persistent course and prolonged duration of acne in females, combined with hirsutism and truncal location, are associated with BHA. Patients without androgenic signs may have BHA, and PCOS diagnosis can be established through appropriate referral. Treatment response does not correlate with hormone levels; however, prolonged duration/persistent course and hirsutism predict poorer outcomes.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"54-61"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic evolution of acute to chronic radiation dermatitis in head and neck cancer patients undergoing radiochemotherapy: a study of two cases.","authors":"Aleksandra Pilśniak, Grażyna Kamińska-Winciorek, Anastazja Szlauer-Stefańska, Tomasz Rutkowski, Krzysztof Składowski","doi":"10.5114/ada.2025.147546","DOIUrl":"10.5114/ada.2025.147546","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"110-113"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attack frequency and associated factors in hereditary angioedema patients: a single-centre experience.","authors":"Makbule Seda Bayrak Durmaz, Nurgul Sevimli","doi":"10.5114/ada.2024.144488","DOIUrl":"10.5114/ada.2024.144488","url":null,"abstract":"<p><strong>Introduction: </strong>Hereditary angioedema (HAE) significantly affects patients' quality of life due to its life-threatening potential and the unpredictability of attacks.</p><p><strong>Aim: </strong>To determine strategic goals to reduce the frequency of attacks and improve the quality of life by evaluating the attack triggers, attack management strategies, and medication use attitudes of HAE patients treated in our clinic.</p><p><strong>Material and methods: </strong>Patients who were followed up in our clinic with a diagnosis of HAE in 2022-2023 were included in the study. Patient data were obtained by retrospective scanning of file records.</p><p><strong>Results: </strong>The analysis included 23 HAE patients with an average age of 34.7 years, predominantly female (60.9%). In the patients' family history, there was a high prevalence of HAE (95.7%) and HAE-related death (73.9%). The median duration of HAE diagnostic delay was 9 years (0-50). A significant positive correlation was found between patient age and the duration of diagnostic delay (<i>r</i> = 0.575; <i>p</i> = 0.004). The majority of patients were aware of acute attack triggers and contraindicated medications (91.3%, 70%, respectively). Gastrointestinal, facial, and limb symptoms were common, with emotional stress identified as the leading trigger. The median monthly attack frequency was 6 (1-10), with nearly half experiencing more frequent episodes. Response times to on-demand treatment for icatibant were less than 30 min in 52.2% of patients. Despite experiencing frequent attacks, many patients exhibited pharmacophobia, leading to reluctance towards second-line long-term prophylactic (LTP) therapy.</p><p><strong>Conclusions: </strong>The high frequency of attacks in our patients was related to the lack of use of LTP agents and personal life stress. Despite severe attacks and a family history of HAE-related deaths, pharmacophobia to LTP was common, with pharmacophobia resulting from side effects of second-line LTP agents. Our findings highlight the need for our patients to have access to psychosocial support programs and first-line LTP agents.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"75-82"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycosis fungoides unveiled following dupilumab treatment in a patient with a history of atopic dermatitis. Usefulness of HFUS in monitoring skin features. A review with a case report.","authors":"Hanna Cisoń, Wiktor Cisoń, Barbara Białynicka-Birula, Marianna Suseł, Rafał Białynicki-Birula, Jacek C Szepietowski","doi":"10.5114/ada.2024.143463","DOIUrl":"10.5114/ada.2024.143463","url":null,"abstract":"<p><p>Dupilumab has revolutionized atopic dermatitis (AD) treatment, but concerns arise about its potential link to cutaneous T-cell lymphomas (CTCL). This review explores CTCL occurrence post-dupilumab therapy in AD and its potential therapeutic effects. A case study of a 76-year-old patient with severe AD treated with dupilumab, developing erythroderma revealing mycosis fungoides (MF), underscores the need to understand associated mechanisms and risk factors for safe dupilumab use. This case also highlights the utility of the high-frequency ultrasound in monitoring cutaneous manifestations in patients with MF.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"5-12"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-operative anaphylaxis after functional endoscopic sinus surgery (FESS): an unusual eosinophilic granulomatosis with polyangiitis (EGPA) presentation.","authors":"David Longhino, Angela Rizzi, Arianna Aruanno, Eleonora Nucera","doi":"10.5114/ada.2024.147336","DOIUrl":"10.5114/ada.2024.147336","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"117-118"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic spontaneous urticaria linked with autoimmune atrophic gastritis in a paediatric patient.","authors":"Sarka Kacerova, Jiri Bufka, Lenka Vankova, Vaclava Gutova, Ondrej Daum, Jan Schwarz","doi":"10.5114/ada.2025.147591","DOIUrl":"10.5114/ada.2025.147591","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"114-116"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of caspase-1 in coronary artery lesions in Kawasaki disease and its mechanism of action on vascular smooth muscle cells.","authors":"Yang Yang, Daqing Sun, Rui Ma, Mei Lv, Weikai Wang","doi":"10.5114/ada.2024.145459","DOIUrl":"10.5114/ada.2024.145459","url":null,"abstract":"<p><strong>Introduction: </strong>Kawasaki disease (KD) is a highly common vascular inflammation in children, with coronary artery lesion (CAL) being one of its most common complications and a key factor for adverse prognosis.</p><p><strong>Aim: </strong>In this study, we observed the clinical significance of caspase-1 in KD and CAL, and found that caspase-1 was elevated in KD and showed an excellent diagnostic value.</p><p><strong>Material and methods: </strong>A prospective analysis was conducted on 67 children with acute KD admitted to our hospital from August 2022 to April 2023 (research group) and 67 healthy outpatient children during the same period (control group). The differences in caspase-1 expression levels between the two study groups were compared, and the diagnostic value of caspase-1 for KD was analyzed using the receiver operating characteristic (ROC) curve. Subsequently, the correlation between caspase-1 and inflammatory factors in the study groups was observed and the diagnostic value of caspase-1 for CAL was analyzed. Subsequently, human coronary artery smooth muscle cells (HCASMCs) were purchased, and caspase-1 aberrant expression vectors were transfected into HCASMCs to detect the proliferation and apoptosis ability of the cells.</p><p><strong>Results: </strong>Caspase-1 of the research group was higher than that of the control group, and the sensitivity and specificity of caspase-1 for diagnosing the occurrence of KD were 50.75% and 89.55%, respectively (<i>p</i> < 0.05). Pearson correlation coefficients showed a positive correlation between both caspase-1 and inflammatory factors in the research group (<i>p</i> < 0.05). In addition, caspase-1 showed an excellent diagnostic effect on the occurrence of CAL. In <i>in vitro</i> assays, elevated caspase-1 expression was seen to promote aberrant proliferation and inhibit apoptosis in HCASMCs (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Caspase-1 is elevated in KD and shows an excellent diagnostic value for both KD and the occurrence of CAL in KD patients, possibly through promoting the abnormal proliferation of HCASMCs.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"96-104"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TCA chemical peel as facial anti-aging therapy for postmenopausal women: a randomised clinical study.","authors":"Laura Piejko, Małgorzata Glenc-Ambroży, Jan Juszczyk, Joanna Czajkowska, Monika Bugdol, Mikołaj Łanocha, Beata Bergler-Czop, Anna Polak","doi":"10.5114/ada.2024.144161","DOIUrl":"10.5114/ada.2024.144161","url":null,"abstract":"<p><strong>Introduction: </strong>A randomised controlled clinical trial involving a novel trichloroacetic acid (TCA) peel was performed. The experimental group, the placebo group, the staff administering treatments, the persons evaluating intervention results, and the statistical analyst were all blinded.</p><p><strong>Aim: </strong>To assess the efficacy of a novel TCA peel containing urea peroxide 5%, coenzyme Q10 5%, and kojic acid 10% as anti-aging skin therapy for postmenopausal women.</p><p><strong>Material and methods: </strong>Forty-six postmenopausal women at a mean age of 60.63 ±2.6 years were equally and randomly divided into an experimental group (EG; <i>n</i> = 23) and a control group (CG; <i>n</i> = 23), which received facial skin treatments with a TCA peel and a placebo solution, respectively. Treatment sessions were performed once weekly for 4 consecutive weeks. Between the sessions, the participants were required to apply the same post-peel cream in the morning and evening. Skin-aging parameters - hydration, elasticity, and sebum levels - were measured using the MC 750 B2 (Courage + Khazaka electronic GmbH, Cologne, Germany), wrinkle appearance was assessed based on photographs taken with the Fujifilm XT-1 camera, and the Wrinkle Severity Rating Scale and skin aesthetic improvement was rated using the Patient's Aesthetic Improvement Scale and the Global Aesthetic Improvement Scale. All assessments were carried out pre- and post-intervention and at months 1 and 3 of follow-up.</p><p><strong>Results: </strong>Skin hydration and participants' satisfaction with treatment results measured post-treatment and at month 3 of follow-up were greater in the EG than in the CG.</p><p><strong>Conclusions: </strong>The TCA chemical peel improved facial skin hydration in postmenopausal women, but not skin elasticity. The results of the treatments were rated by the participants as satisfying.Trial Registration no: ISRCTN41899475; doi.org/10.1186/ISRCTN41899475.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"28-41"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases.","authors":"Uğur Altaş, Sevinç Taşar, Nurbanu Başdoğan, Halil Alkaya, Seda Çevik, Zeynep M Altaş, Mehmet Yaşar Özkars","doi":"10.5114/ada.2025.147855","DOIUrl":"10.5114/ada.2025.147855","url":null,"abstract":"<p><strong>Introduction: </strong>An impaired skin barrier has been reported in allergic diseases.</p><p><strong>Aim: </strong>In this study, we aimed to evaluate dermis thickness in children with house dust allergy without skin symptoms.</p><p><strong>Material and methods: </strong>This cross-sectional study included children aged 4-18 years with asthma and/or allergic rhinitis. Participants were divided into three groups: healthy controls (<i>n</i> = 50), patients sensitized to house dust mites (<i>n</i> = 60), and patients with negative house dust mite tests (<i>n</i> = 48). The thickness of the dermis layers of the skin was measured at the cubital fossa using an ultrasound.</p><p><strong>Results: </strong>The median age and gender distribution were similar across the house dust mite-positive and -negative groups and the healthy control group. There was no significant difference between the groups in terms of dermis thickness (<i>p</i> = 0.053). Absolute eosinophils and eosinophil percentage were significantly negatively correlated with dermis (<i>p</i> < 0.05). There was no significant correlation between total IgE, house dust mite specific IgE and skin test values and skin thickness (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The findings of this study highlight the impact of house dust mite sensitization on skin thickness, offering potential contributions to the management and treatment strategies of allergic diseases.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"105-109"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}