Postepy Dermatologii I Alergologii最新文献

{"title":"The association between metabolic syndrome and vitiligo: a systematic review.","authors":"Aleksandra Białczyk, Barbara Kamińska, Rafał Czajkowski","doi":"10.5114/ada.2025.149438","DOIUrl":"10.5114/ada.2025.149438","url":null,"abstract":"<p><p>Vitiligo is a chronic autoimmune disorder linked to systemic inflammation, oxidative stress, and metabolic dysregulation, including metabolic syndrome (MetS). This review examines the shared mechanisms underlying vitiligo and MetS, highlighting oxidative stress, pro-inflammatory cytokines, and lipid dysregulation as central contributors. A systematic analysis of 23 studies found association between vitiligo and MetS, though variations exist based on the disease type, severity, and duration. Emerging therapies, such as statins and thiazolidinediones demonstrate potential for managing vitiligo and its metabolic risks by targeting oxidative and inflammatory pathways. While animal and <i>in vitro</i> studies show promise, clinical outcomes are inconsistent, with safety concerns limiting systemic treatments.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"134-142"},"PeriodicalIF":1.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baumann Skin Type Questionnaire (BSTQ): creation and validation of the Polish language version - part two.","authors":"Justyna Martyna Brzozowska","doi":"10.5114/ada.2025.149555","DOIUrl":"https://doi.org/10.5114/ada.2025.149555","url":null,"abstract":"<p><strong>Introduction: </strong>Skin type assessment is important because it is a guidance for specialists and consumers to select and recommend the most appropriate skin care products and protocols. One easy-to-administer instrument used for skin type classification is the Baumann Skin Type Questionnaire.</p><p><strong>Aim: </strong>Translation and validation of the Polish version of the Baumann Skin Type Questionnaire (BSTQ) - pigmented or non-pigmented and wrinkled or tight skin.</p><p><strong>Material and methods: </strong>Both forward and backward translation of the English version of the BSTQ was performed. The study was conducted on 103 individuals. The respondents completed the questionnaire twice, 1 day after the other. The subjects participated in practical classes of facial care cosmetology which allowed for conducting interviews and skin examinations by a cosmetology expert.</p><p><strong>Results: </strong>The Polish version of the BSTQ demonstrated high test-retest reliability (reproducibility) in the dimension evaluating skin with or without hyperpigmentation as well as wrinkled or tight skin (<i>ICC3</i> = 0.91; <i>ICC3</i> = 0.97, respectively). Moreover, an excellent level of agreement between initial test and retest (pigmented vs. non-pigmented: <i>AC1</i> = 1.00, <i>95% CI</i>:1.00; wrinkled vs. tight: <i>AC1</i> = 0.93, <i>95% CI</i>:0.87-0.99). However, the Polish version of the BSTQ demonstrated a low internal consistency, corroborated by low Guttman's Lambda 6 reliability (pigmented vs. non-pigmented: α_raw = 0.55, α_std = 0.54, <i>G6</i> = 0.63; retest: α_raw = 0.58, α_std = 0.54, <i>G6</i> = 0.63; wrinkled vs. tight: α_raw = 0.33, α_std = 0.25, <i>G6</i> = 0.47; retest: α_raw = 0.36, α_std = 0.33, <i>G6</i> = 0.54).</p><p><strong>Conclusions: </strong>The use of the BSTQ in assessing the skin for hyperpigmentation and age-related changes should be complemented by another diagnostic approach - clinical assessment before starting treatment or anti-aging interventions.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 3","pages":"259-266"},"PeriodicalIF":1.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate in the treatment of atopic dermatitis.","authors":"Roman J Nowicki, Elżbieta Grubska-Suchanek, Aleksandra Wilkowska, Dmitrij F Khvorik, Magdalena Trzeciak","doi":"10.5114/ada.2025.149551","DOIUrl":"https://doi.org/10.5114/ada.2025.149551","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a common inflammatory skin disease. Most cases start in children although some have been reported in adults. Moderate to severe cases of AD not responding to topical treatments may need systemic therapy. Methotrexate may be considered in patients with severe AD who did not achieve the expected improvement after cyclosporine, or who had adverse effects and no possibility of biological treatment with monoclonal antibodies or Janus kinase inhibitors.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 3","pages":"243-247"},"PeriodicalIF":1.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic dermatitis and non-alcoholic fatty liver disease: current state of evidence and possible pathogenetic correlations.","authors":"Marta Dębicka, Aleksandra Bąk, Jerzy Walecki, Irena Walecka","doi":"10.5114/ada.2025.149546","DOIUrl":"10.5114/ada.2025.149546","url":null,"abstract":"<p><p>Relationships between inflammatory diseases and metabolic abnormalities are recently raising much scientific interest. Convincing evidence on the association between atopic dermatitis (AD) and constituents of metabolic syndrome (MS) has already been established. In this article we aim to summarize current data on the link between AD and non-alcoholic fatty liver disease (NAFLD), which is considered a hepatic manifestation of MS. By reviewing animal models, human studies and possible pathogenetic points of contiguity we want to present the current state of knowledge and goals for further investigations. To our best knowledge, this is the first review of this topic so far.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"121-124"},"PeriodicalIF":1.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baumann Skin Type Questionnaire (BSTQ): creation and validation of the Polish language version - part one.","authors":"Justyna Martyna Brzozowska","doi":"10.5114/ada.2025.149544","DOIUrl":"10.5114/ada.2025.149544","url":null,"abstract":"<p><strong>Introduction: </strong>Baumann Skin Type Questionnaire (BSTQ) is a widely used questionnaire, that was designed to determine baseline skin type in dermatology. The self-reported BSTQ, consisting of four parts: oily vs. dry skin, sensitive vs. resistant skin, pigmented vs. non-pigmented skin and wrinkled vs. tight skin, can provide significant guidance for consumers and professionals to select and recommend the most appropriate skin care products and skin care protocols.</p><p><strong>Aim: </strong>Translation and validation of the Polish version of the Baumann Skin Type Questionnaire (BSTQ) - oily vs. dry skin and sensitive vs. resistant skin.</p><p><strong>Material and methods: </strong>Both forward and backward translation of the English version of the BSTQ was performed. The study was conducted on 103 individuals. The respondents completed the questionnaire twice, 1 day after the other. Moreover, the subjects participated in practical classes of facial care cosmetology which allowed for conducting interviews and skin examinations by a cosmetology expert.</p><p><strong>Results: </strong>The Polish version of the BSTQ demonstrated high test-retest reliability (reproducibility) in the dimension assessing oily or dry skin as well as sensitive or resistant skin (<i>ICC3</i> = 0.91; <i>ICC3</i> = 0.96, respectively) and good internal consistency, corroborated by Guttman's Lambda 6 reliability (oily vs. dry: α_raw = 0.75, α_std = 0.74, <i>G6</i> = 0.79; retest: α_raw = 0.77, α_std = 0.77, <i>G6</i> = 0.81; sensitive vs. resistant: α_raw = 0.72, α_std = 0.74, <i>G6</i> = 0.81; retest: α_raw = 0.78, α_std = 0.79, <i>G6</i> = 0.85).</p><p><strong>Conclusions: </strong>The Polish version of the BSTQ (oily vs. dry skin and sensitive vs. resistant skin) showed high reliability, good internal consistency and high accuracy and consistency. It can be used for assessment of oily or dry skin and sensitive or resistant skin.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"190-196"},"PeriodicalIF":1.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of platelet-rich fibrin on repair and healing chronic refractory wounds in rats by regulating Wnt/β-catenin signalling pathway.","authors":"Huasen Huang, Muyi Huang, Xinyuan Wang, Guibin Yin","doi":"10.5114/ada.2025.148762","DOIUrl":"10.5114/ada.2025.148762","url":null,"abstract":"<p><strong>Introduction: </strong>Platelet-rich fibrin is an autologous biomaterial that is rich in platelets and various growth factors, has good biocompatibility, and has significant application potential in tissue repair and regeneration.</p><p><strong>Aim: </strong>To explore the effect of platelet-rich fibrin (PRF) on the repair and healing of chronic refractory wounds in rats by regulating the Wnt/β-catenin (β-catenin) signalling pathway.</p><p><strong>Material and methods: </strong>Full-thickness skin defect open wounds were established on the backs of 50 male SD rats.</p><p><strong>Results: </strong>In comparison with the normal control group, the wound healing rate, CD34-positive cell ratio, and Wnt1, β-catenin, and c-myc protein expression levels of rats in the model group were significantly reduced at each time point; serum TNF-α, IL-1β, IL-6 levels, and GSK-3β protein expression levels were significantly increased. The granulation tissue was severely damaged and infiltrated by a large number of inflammatory cells. The collagen fibres were loosely arranged and unevenly distributed. In comparison with the model group, the wound healing rate, CD34-positive cell ratio, and Wnt1, β-catenin, and c-myc protein expression levels of rats in the PRF group and positive control group at each time point were significantly increased.</p><p><strong>Conclusions: </strong>PRF can promote the repair and healing of chronic refractory wounds in rats by inhibiting ulcer surface inflammation and promoting collagen fibre deposition and angiogenesis. Its mechanism of action may be concerned with the activation of the Wnt/β-catenin signalling pathway.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"175-182"},"PeriodicalIF":1.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors and incidence of hepatitis B, hepatitis C and HIV among syphilis patients in Shanghai, China.","authors":"Juan Wu, Yan Hu, Liyan Ni, Lin Zhu, Wei Zhao, Xin Gu, Rui-Rui Peng, Fu-Quan Long","doi":"10.5114/ada.2025.149083","DOIUrl":"10.5114/ada.2025.149083","url":null,"abstract":"<p><strong>Introduction: </strong>There is great need to screen for HIV, HBV, HBC and syphilis co-infected cases in china because of high prevalance of this disease.</p><p><strong>Aim: </strong>To uncover the risk factors and incidence of hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) among syphilis patients.</p><p><strong>Material and methods: </strong>A total of 5,206 patients with syphilis were enrolled in this retrospective cohort study. The data of clinical and laboratory characteristics of the participants were collected. The correlations between the clinical characteristics and HBV, HCV and HIV co-infection with syphilis were analysed.</p><p><strong>Results: </strong>The prevalence of HBV, HCV and HIV among syphilis patients in our study was 8.4%, 1.8%, and 10.1%, respectively. The median age was significantly lower in the HBV/syphilis co-infected group (47.5 with IQR 36-58 vs. 52 with IQR 36-61), the majority of co-infected individuals were male (251, 57.6% vs. 185, 42.4%). Multivariate logistic regression analysis showed that co-infected with patients co-infected with HCV and combined with gonococcal infection and herpes virus type II infection were independently associated with HBV co-infection in syphilis patients. Multivariate logistic regression analysis found that male gender, age below 30 years, age group of 31-44-years old, co-infection with HSV-2, never married and divorced, and having a RPR titre of ≥ 1 : 32 were independently associated with HIV co-infection.</p><p><strong>Conclusions: </strong>HIV co-infection or homosexuality among syphilis patients had no significant impact on the prevalence of HBV or HCV in the study.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"197-202"},"PeriodicalIF":1.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow mediated skin fluorescence to assess microcirculation in patients with atopic dermatitis.","authors":"Jowita Sroka-Tomaszewska, Marcin Hellmann, Jacek Wolf, Aleksandra Michnowska, Krzysztof Narkiewicz, Magdalena Trzeciak","doi":"10.5114/ada.2025.149085","DOIUrl":"https://doi.org/10.5114/ada.2025.149085","url":null,"abstract":"<p><strong>Introduction: </strong>Atopic dermatitis (AD) is a chronic, inflammatory skin disease with severe itching. Particular attention is dedicated to the coexistence of AD with diseases of the cardiovascular system. Since the earliest manifestation of cardiovascular disease is microvascular endothelium dysfunction, an attempt was made to assess the skin microcirculation.</p><p><strong>Aim: </strong>The work aims to analyse the assessment of skin microcirculation in patients with atopic dermatitis based on changes of nicotinamide adenine dinucleotide (NADH) fluorescence from the epidermis of the forearm measured with the flow mediated skin fluorescence (FMSF) technique.</p><p><strong>Material and methods: </strong>Thirteen patients with AD and eleven healthy individuals participated in the study. Changes in NADH fluorescence were measured by the FMSF technique on the forearm in response to blockage and release of blood flow. Results are presented as a maximum ischemic response (IR_max and IR_index,), hyperaemic response (HR_max and HR_index) or hypoxia sensitivity (HS).</p><p><strong>Results: </strong>The analysed FMSF parameters: IR_max, IR_index, HR_max and HR_index, HS were not significantly lower in AD patients compared with the control group. There was no association between disease severity and NADH fluorescence.</p><p><strong>Conclusions: </strong>The association of AD with cardiovascular disease is multifactorial. The basis of these connections is still being investigated. Microvascular endothelial dysfunction may be one but not the only mechanism responsible for the increased cardiovascular risk in patients with AD.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 3","pages":"298-305"},"PeriodicalIF":1.4,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic ulceration as a late manifestation of tropical disease.","authors":"Justyna Janocha-Litwin, Jakub Marczuk, Jolanta Węgłowska, Krzysztof Simon","doi":"10.5114/ada.2025.148234","DOIUrl":"https://doi.org/10.5114/ada.2025.148234","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 3","pages":"325-327"},"PeriodicalIF":1.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective, randomised comparative study to evaluate safety, tolerability, and efficacy of topical minocycline gel 4% plus oral isotretinoin against oral isotretinoin only in Indian patients with moderate-to-severe acne vulgaris.","authors":"Abhishek De, Saswati Halder, Dhiraj Dhoot, Ashwin Balasubramanian, Hanmant Barkate","doi":"10.5114/ada.2024.146870","DOIUrl":"10.5114/ada.2024.146870","url":null,"abstract":"<p><strong>Introduction: </strong>The concurrent use of tetracyclines and isotretinoin in acne treatment can cause pseudotumor cerebri (PTC). However, topical minocycline (4%) was significantly less systemically absorbed.</p><p><strong>Aim: </strong>To assess the efficacy and safety of a combination of topical minocycline gel 4% with oral isotretinoin compared to isotretinoin alone in the treatment of acne vulgaris in the Indian population.</p><p><strong>Material and methods: </strong>This prospective, randomised, comparative study included 60 patients aged ≥ 12 years with acne. Two groups were formed: the Mino-Iso group applied minocycline gel 4% and took 20 mg isotretinoin capsules in the evening, whereas the Iso group took only 20 mg isotretinoin capsules in the evening. The study duration was 12 weeks.</p><p><strong>Results: </strong>At week 12, the Mino-Iso group showed a significantly greater reduction in inflammatory lesions (-88.5%) than the Iso group (-67.42%) (<i>p</i> < 0.05). The investigator's global assessment (IGA) treatment score was statistically lower and success significantly higher in the Mino-Iso group (<i>p</i> < 0.05 and <i>p</i> = 0.03, respectively). Adverse events (AEs) were reported in 6 and 4 patients in the Mino-Iso and Iso groups, respectively (<i>p</i> = 0.73), all of which were mild in nature and resolved during the study.</p><p><strong>Conclusions: </strong>The combination of topical gel 4% and oral isotretinoin 20 mg capsule significantly reduced inflammatory lesions, improved IGA scores, and had a higher success rate at week 12 than isotretinoin alone, with similar tolerability. Therefore, this combination can be considered a preferable treatment option for moderate-to-severe acne.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"164-170"},"PeriodicalIF":1.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}