Postepy Dermatologii I Alergologii最新文献

{"title":"Interleukins 30 and 27 in psoriasis and inflammation.","authors":"Marianna Majchrzycka, Joanna Wegner, Zygmunt Adamski, Dorota Jenerowicz","doi":"10.5114/ada.2025.147548","DOIUrl":"10.5114/ada.2025.147548","url":null,"abstract":"<p><p>This review explores the roles of interleukin-30 (IL-30) and interleukin-27 (IL-27) in inflammation and autoimmune diseases, with a focus on psoriasis. The two coexisting cytokines should be analysed in conjunction as their actions are antagonistic <i>in vivo</i>. While IL-27 exhibits diverse anti-inflammatory mechanisms, the understanding of IL-30's functions remains limited. Studies suggest that IL-27 may play a role in regulating psoriasis, but findings are inconsistent. IL-30 shows promise in mitigating psoriatic lesions and suppressing inflammatory responses. However, research on IL-30's involvement in autoimmune diseases presents conflicting results. This article provides a literature review on the complex correlations between cytokines, their role in the pathogenesis of psoriasis, inflammation, carcinogenesis, and autoimmune diseases, and provides a detailed picture of the interplay between IL-27 and IL-30 to uncover novel therapeutic targets for psoriasis and other autoimmune conditions.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"1-4"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical administration of mupirocin ointment and fusidic acid in bacterial infection-induced skin diseases.","authors":"Junyi Xie, Min Li, Su Yang, Qing Dong","doi":"10.5114/ada.2024.145185","DOIUrl":"10.5114/ada.2024.145185","url":null,"abstract":"<p><strong>Introduction: </strong>Bacterial skin diseases have strong virulence to penetrate deep into the skin.</p><p><strong>Aim: </strong>To evaluate the therapeutic effects of 2% mupirocin ointment and 2% fusidic acid cream on bacterial skin diseases and their safety.</p><p><strong>Material and methods: </strong>One-hundred patients with bacterial skin diseases treated from May 2021 to May 2024 were randomly divided into a control group and a treatment group (<i>n</i> = 50) and they were given 2% mupirocin ointment and 2% fusidic acid cream, respectively. The skin injury areas, eczema area and severity index (EASI) scores, therapeutic effects and adverse reactions were compared before and after two courses of medication. The antibacterial activities of these two drugs against <i>Staphylococcus epidermidis</i> and <i>Propionibacterium acnes</i> were detected by the agar diffusion method.</p><p><strong>Results: </strong>After treatment, the EASI and itching scores of both groups significantly decreased compared with those before treatment (<i>t</i> = 30.804, 19.018, <i>p</i> < 0.001; <i>t</i> = 24.594, 12.680, <i>p</i> < 0.001), and the treatment group had significantly lower scores than those of the control group (<i>p</i> < 0.05). The overall effective rate of the treatment group (96.00%) was higher than that of the control group (90.00%) (<i>p</i> > 0.05), and the distribution of therapeutic effects of the treatment group was significantly better (<i>p</i> < 0.05). The two groups had similar incidence rates of adverse reactions (χ² = 1.0147, <i>p</i> = 0.3074) that were remitted without additional therapy. Both mupirocin ointment and fusidic acid cream had clear inhibition zones for <i>S. epidermidis</i>, with similar diameters (31.69 ±7.12 mm vs. 31.78 ±6.54 mm, <i>t</i> = 0.0949, <i>p</i> = 0.9245). However, only fusidic acid cream had an obvious inhibition zone for <i>P. acnes</i> on reinforced Brucella agar plate.</p><p><strong>Conclusions: </strong>The therapeutic effects of fusidic acid cream on bacterial skin diseases were superior to those of mupirocin ointment.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"42-46"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dialogue between programmed cell death and psoriasis.","authors":"Jun Tian, Lei Zhang, Li Yang","doi":"10.5114/ada.2024.147195","DOIUrl":"10.5114/ada.2024.147195","url":null,"abstract":"<p><p>Psoriasis is a chronic inflammatory skin condition, associated with both physical and psychological burden. The aetiology of psoriasis is not fully understood. Physiologically programmed cell death (PCD) pathways are crucial for maintaining organismal homeostasis. Several investigations have highlighted the link between dysregulated PCD and the initiation of psoriasis. This review aims to outline various forms of programmed cell death pathways, encompassing the psoriasis distinctive features, triggers, implications in psoriasis pathogenesis, and therapeutic opportunities. It aspires to offer a comprehensive exploration of the role of programmed cell death in the context of psoriasis, providing a rational framework for further investigation and potential therapeutic interventions.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"13-20"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can social media encourage young Polish adults to visit a dermatologist? An original study.","authors":"Zuzanna Pawlus, Aleksandra Spyra, Karina Polak, Bartosz Miziołek, Beata Bergler-Czop","doi":"10.5114/ada.2025.147554","DOIUrl":"10.5114/ada.2025.147554","url":null,"abstract":"<p><strong>Introduction: </strong>Social media (SM) play an important role in contemporary world, influencing all areas of life, including dermatology, as people are often obtaining medical knowledge from content-sharing platforms on the Internet.</p><p><strong>Aim: </strong>The objective of this study was to evaluate if Polish adults aged 18-35 follow dermatological news on SM, which platforms and contents they find the most interesting and to assess if SM content can encourage them to visit a healthcare professional.</p><p><strong>Material and methods: </strong>Online questionnaires were distributed from January to March 2024 among young adult people from Poland. The collected data were analysed using descriptive and analytical statistics.</p><p><strong>Results: </strong>44% of respondents confirmed that SM content prompted them to visit a dermatologist. The most popular platform was Instagram. The main reason for visiting a specialist was the desire to improve the appearance of one's skin. In 34% of the cases, the dermatological examination revealed skin disease. According to 92% of respondents, SM can have a positive impact on the willingness to visit a dermatologist.</p><p><strong>Conclusions: </strong>81% of young Polish adults read dermatology-related content on SM. The main areas of interest were skincare and skin diseases. Almost half of the respondents were encouraged by SM to visit a dermatologist, with 56% consistency of diagnosis made by a healthcare professional and SM user.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"68-74"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of bacterial skin infections and difference analysis in T lymphocytes and inflammatory factors.","authors":"Xiaobo Qin, Dongdong Cheng, Qian Wang","doi":"10.5114/ada.2024.145284","DOIUrl":"10.5114/ada.2024.145284","url":null,"abstract":"<p><strong>Introduction: </strong>Postpartum women have relatively weaker bodies and may experience trauma during childbirth, providing opportunities for bacterial invasion. Therefore, there is indeed a certain risk of developing acute bacterial skin infections after childbirth. Postpartum acute bacterial skin infection can cause local or systemic symptoms, affect breastfeeding, and exacerbate the psychological and economic burden on patients.</p><p><strong>Aim: </strong>This study aimed to analyse pathogen resistance in patients with acute postpartum bacterial skin infections and the differences of T lymphocytes and inflammatory factors.</p><p><strong>Material and methods: </strong>In this case control study, a total of 100 patients with acute postpartum bacterial skin infections were selected as the experimental group. Another 100 healthy parturients were selected as the controls. The peripheral blood samples of the two groups were collected to detect the distribution of T lymphocyte subsets. The levels of inflammatory factors were detected. Separation and identification of pathogenic bacteria and drug sensitive test were performed in the experimental subjects.</p><p><strong>Results: </strong>The pathogens and drug resistance: Gram-positive bacteria such as Staphylococcus aureus and β-haemolytic Streptococcus were highly resistant to penicillin, erythromycin, clindamycin, and tetracycline, but sensitive to linezolid and vancomycin. Escherichia coli, Pseudomonas aeruginosa and other Gram-negative bacteria were highly resistant to amoxicillin, ampicillin, aztreonam, ceftriaxone, cefazolin, ciprofloxacin, and sensitive to imipenem. CD4+ and CD4+/CD8+ were markedly higher, and Th17/Treg was markedly lower in the controls compared to the experimental subjects (<i>p</i> < 0.05). IL-4, IL-10, and hs-CRP in the experimental subjects were higher compared to the controls (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Staphylococcus aureus and Escherichia coli are the most common drug-resistant pathogens in patients with acute postpartum bacterial skin infections. The immune system plays an important regulatory role in the process of infection. T lymphocytes and inflammatory factors are differentially expressed in the process of infection.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"47-53"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of genetic and environmental factors in childhood asthma and allergic rhinitis patients.","authors":"Xin Wang, Lanxin Zhao, Songyi Gao, Honghong Hou, Wenjing Zhao","doi":"10.5114/ada.2024.146183","DOIUrl":"10.5114/ada.2024.146183","url":null,"abstract":"<p><strong>Introduction: </strong>Asthma and allergic rhinitis are common respiratory diseases in children, with complex aetiologies involving genetic and environmental factors.</p><p><strong>Aim: </strong>This work was to identify the genetic and environmental risk factors' prevalence in asthma and allergic rhinitis in paediatric patients.</p><p><strong>Material and methods: </strong>A cross-sectional study was conducted among 120 paediatric patients with asthma and allergic rhinitis. Univariate analysis was used to examine the associations between various factors, including age, weight status, personal history of allergies, CD14 polymorphisms, and environmental exposures.</p><p><strong>Results: </strong>The study included 120 paediatric patients (65 males, 55 females; mean age: 6.4 ±3.5 years) with asthma and allergic rhinitis. The results showed significant associations between asthma and allergic rhinitis and several factors, including age (c² = 34.48, <i>p</i> < 0.001), weight status (c² = 63.1, <i>p</i> < 0.001), personal history of allergies (c² = 54.1, <i>p</i> < 0.001), and CD14 polymorphisms (-159C/T, -550C/T, and 2758A/G) (c² = 23.5, <i>p</i> < 0.001; c² = 20.63, <i>p</i> < 0.001; c² = 24.5, <i>p</i> < 0.001, respectively). Environmental factors, including paternal and maternal education levels, parental history of asthma and allergies, caesarean section delivery, home renovation history, exposure to pets, household dust, pollen, plush toys, cold air exposure, long-term family smoking, number of cars near the residence, outdoor activities, winter gas heating, and natural gas use, were also significantly more prevalent in our patients.</p><p><strong>Conclusions: </strong>This study highlights the importance of both genetic and environmental factors in the development of childhood asthma and AR. The identification of specific genetic polymorphisms and environmental risk factors can provide information about the development of personalized prevention and treatment strategies for these diseases.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"143-149"},"PeriodicalIF":1.4,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between allergic asthma and cerebrovascular accident: allergic asthma can increase recurrence of stroke.","authors":"Shi Jinghua, Zhao Gaonian, Jiang Su","doi":"10.5114/ada.2024.145458","DOIUrl":"10.5114/ada.2024.145458","url":null,"abstract":"<p><strong>Introduction: </strong>Adult asthma as inflammatory-based disease can be an independent risk factor for stroke.</p><p><strong>Aim: </strong>To evaluate the relationship between adult asthma and cerebrovascular accident.</p><p><strong>Material and methods: </strong>120 patients (asthma stroke, asthma non-stroke, and non-asthma stroke groups) who were matched for age and gender were included in this prospective cohort study to observe pulmonary function changes and recurrence rate of stroke among asthmatic patients during 6-month follow-up after first even after first even stroke.</p><p><strong>Results: </strong>In the asthma stroke group, post stroke forced vital capacity (FVC) (3.04 ±0.13 vs. 2.58 ±0.15, <i>p =</i> 0.006), forced expiratory volume in 1 s (FEV1) (2.68 ±0.15 vs. 2.01 ±0.12, <i>p =</i> 0.02), FEV1/FVC (0.88 ±0.03 vs. 0.77 ±0.02, <i>p =</i> 0.001), maximal inspiratory pressure (MIP) (74.05 ±5.36 vs. 56.57 ±3.83, <i>p =</i> 0.001), maximal expiratory pressure (MEP) (88.30 ±3.65 vs. 71.42 ±3.98, <i>p =</i> 0.001) and 6-minute walk test (6MWT) (446.32 ±47.56 vs. 338.62 ±28.85, <i>p =</i> 0.001) were significantly decreased in comparison to before stroke. Also, stroke recurrence was 32.5% in the asthma stroke group and 12.5% in the non-asthma stroke group, which was significantly higher in the asthma stroke group (<i>p =</i> 0.001). Comparison of pulmonary function showed that all FVC (2.58 ±0.15 vs. 3.36 ±0.14, <i>p =</i> 0.001), FEV1 (2.01 ±0.12 vs. 2.73 ±0.16, <i>p =</i> 0.001), FEV1/FVC (0.77 ±0.02 vs. 0.81 ±0.03, <i>p =</i> 0.001), MIP (56.57 ±3.83 vs. 70.62 ±2.77, <i>p =</i> 0.001), MEP (71.42 ±3.98 vs. 85.97 ±2.31, <i>p =</i> 0.001) and 6MWT (338.62 ±28.85 vs. 385.67 ±29.82, <i>p =</i> 0.001) in the asthma stroke group were significantly decreased in comparison to the non-asthma stroke group.</p><p><strong>Conclusions: </strong>FVC, FEV1, FEV1/FVC, MIP, MEP and 6MWT were significantly decreased in allergic asthma patients after stroke, also adult asthma can increase the risk of recurrence of risk of stroke in asthmatic stroke patients.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 2","pages":"150-155"},"PeriodicalIF":1.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144303645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between cigarette smoking and chronic spontaneous urticaria. Is there a difference in neutrophil-lymphocyte ratio?","authors":"Łukasz Moos, Weronika Chodak, Magdalena Czyczerska, Karolina Garbino, Oktawia Gleba, Bartosz Śnietka, Zenon Brzoza","doi":"10.5114/ada.2024.143640","DOIUrl":"10.5114/ada.2024.143640","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic spontaneous urticaria (CSU) is defined as the appearance of itchy wheals and/or angioedema for at least 6 weeks. Cigarette smoking is one of the world's most common addictions. It is a cause of serious diseases such as renal cancer or thromboembolic incidents. Nevertheless, some studies show that nicotine might have a protective effect on various autoimmune diseases. The neutrophil-lymphocyte ratio (NLR) is a good marker of inflammation.</p><p><strong>Aim: </strong>To check the prevalence of smokers in our CSU patients and to assess their profile of NLR as a marker of inflammation.</p><p><strong>Material and methods: </strong>68 adult patients were included (52 females, and 16 males). The average age of respondents was 52. All of the patients were diagnosed with CSU. The group was divided by gender and smoking. The Mann-Whitney U test (Statistica ver.13) was used.</p><p><strong>Results: </strong>73.5% of the respondents were non-smokers, and the remaining 26.5% were smokers. In the female group, irrespective of smoking, statistically significant different levels of neutrophils (NEU), lymphocytes (LYM), and neutrophil-lymphocyte ratio (NLR) were found compared to males. No statistical difference was found between smokers and non-smokers regarding the level of inflammatory factors. Compared to males, females had significantly different levels of LYM in the group of non-smokers and NEU in the group of smokers.</p><p><strong>Conclusions: </strong>Our study does not support claims that smoking has a protective effect on CSU. Significant differences in NEU, LYM, and NLR need to be further investigated.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 6","pages":"617-621"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alexithymia in people with tattoos.","authors":"Justyna Putek, Jacek C Szepietowski","doi":"10.5114/ada.2024.142593","DOIUrl":"10.5114/ada.2024.142593","url":null,"abstract":"<p><strong>Introduction: </strong>Tattoos are a form of body modifications. Alexithymia is a complex personality structure that includes emotional and cognitive deficits such as difficulty in recognizing and describing feelings.</p><p><strong>Aim: </strong>To assess the prevalence of alexithymia among tattooed individuals. Moreover, we aimed to check if the type of tattoo is related to alexithymia.</p><p><strong>Material and methods: </strong>This was a cross-sectional survey, conducted on 403 individuals from Poland. 200 of them had tattoos and were assigned to the study group, and 203 of them had no tattoos and were assigned to the control group.</p><p><strong>Results: </strong>Most respondents (24%) had one tattoo. Most tattoos (29.8%) were situated on forearms and palms, had a plant motif (21.8%) and were done to express personality of the respondents (20.7%). In the research group 80 (19.9%) respondents were classified as alexithymic ones. Out of them, 47 (11.7%) individuals had tattoos and 33 (8.9%) belonged to the non-tattooed group. 35 (17.5%) respondents with non-verbal tattoos were screened as alexithymic while 12 (6%) individuals with verbal, personal tattoos were classified as alexithymic ones (<i>p</i> < 0.05). Twenty-two (11%) respondents who did their tattoos for psychological reasons and 25 (12.5%) individuals who did their tattoos for aesthetic reasons were classified as alexithymic (NS).</p><p><strong>Conclusions: </strong>Subjects with tattoos should be regarded as a group with increased prevalence of alexithymia. Individuals with non-verbal tattoos had a higher tendency to be screened as alexithymic as alexithymic ones. Motivation for getting the tattoo does not seem to have a significant impact on the prevalence of alexithymia.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 6","pages":"584-589"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antihistamine-refractory chronic urticaria patients who used biological agent treatment in terms of cardiovascular risk.","authors":"Efe E Kaşıkçı, Melih Özışık, Papatya Bayrak Değirmenci","doi":"10.5114/ada.2024.145572","DOIUrl":"10.5114/ada.2024.145572","url":null,"abstract":"<p><strong>Introduction: </strong>The idea that chronic inflammatory processes may play a role in the etiopathogenesis of both treatment - refractory chronic spontaneous urticaria and cardiovascular diseases is an important research topic.</p><p><strong>Aim: </strong>Within the scope of this research, we aimed to elucidate a new perspective on the follow-up of chronic urticaria patients by evaluating the 10-year cardiovascular risk and metabolic syndrome in resistant chronic spontaneous urticaria patients who were unresponsive to maximum antihistamine treatment.</p><p><strong>Material and methods: </strong>A total of 170 individuals who applied to our institution's Health Science University, Tepecik Education and Research Hospital, allergy and immunology outpatient clinic have been analysed in this retrospective case-control study. Metabolic syndrome was calculated according to the National Cholesterol Education Program -- Adult Treatment Panel III, and the cardiovascular risk was calculated according to the Framingham Heart Study of the National Heart, Lung and Blood Institute.</p><p><strong>Results: </strong>The study included 85 patients diagnosed with chronic spontaneous urticaria (CSU) alongside 85 control subjects. Comparative analysis between the CSU patient group and the control group revealed substantial differences in terms of gender distribution, smoking habits, metabolic syndrome prevalence, waist circumference measurements, body mass index (BMI), hypertension incidence, and levels of C-reactive protein (CRP) (<i>p</i> < 0.05). However, factors such as patient age, fasting blood glucose, diabetes status, triglyceride (TAG), high density lipoprotein (HDL), low density lipoprotein (LDL), and the percentage risk of cardiovascular events over 10 years were not found to influence CSU (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Regarding the outcomes of this study, the presence of hypertension, obesity, waist circumference and C-reactive protein values associated with metabolic syndrome should be followed for antihistamine-refractory CSU. Early diagnosis and treatment of metabolic syndrome and its components in these patients may play a role in preventing potential complications. No significant increase in the 10-year cardiovascular risk was observed.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 6","pages":"610-616"},"PeriodicalIF":1.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}