甲氨蝶呤治疗特应性皮炎。

IF 1.4 4区医学 Q3 ALLERGY

Postepy Dermatologii I Alergologii Pub Date : 2025-04-15 eCollection Date: 2025-06-01 DOI:10.5114/ada.2025.149551

Roman J Nowicki, Elżbieta Grubska-Suchanek, Aleksandra Wilkowska, Dmitrij F Khvorik, Magdalena Trzeciak

{"title":"甲氨蝶呤治疗特应性皮炎。","authors":"Roman J Nowicki, Elżbieta Grubska-Suchanek, Aleksandra Wilkowska, Dmitrij F Khvorik, Magdalena Trzeciak","doi":"10.5114/ada.2025.149551","DOIUrl":null,"url":null,"abstract":"Atopic dermatitis (AD) is a common inflammatory skin disease. Most cases start in children although some have been reported in adults. Moderate to severe cases of AD not responding to topical treatments may need systemic therapy. Methotrexate may be considered in patients with severe AD who did not achieve the expected improvement after cyclosporine, or who had adverse effects and no possibility of biological treatment with monoclonal antibodies or Janus kinase inhibitors.","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 3","pages":"243-247"},"PeriodicalIF":1.4000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262029/pdf/","citationCount":"0","resultStr":"{\"title\":\"Methotrexate in the treatment of atopic dermatitis.\",\"authors\":\"Roman J Nowicki, Elżbieta Grubska-Suchanek, Aleksandra Wilkowska, Dmitrij F Khvorik, Magdalena Trzeciak\",\"doi\":\"10.5114/ada.2025.149551\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Atopic dermatitis (AD) is a common inflammatory skin disease. Most cases start in children although some have been reported in adults. Moderate to severe cases of AD not responding to topical treatments may need systemic therapy. Methotrexate may be considered in patients with severe AD who did not achieve the expected improvement after cyclosporine, or who had adverse effects and no possibility of biological treatment with monoclonal antibodies or Janus kinase inhibitors.\",\"PeriodicalId\":54595,\"journal\":{\"name\":\"Postepy Dermatologii I Alergologii\",\"volume\":\"42 3\",\"pages\":\"243-247\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262029/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Postepy Dermatologii I Alergologii\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/ada.2025.149551\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Postepy Dermatologii I Alergologii","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/ada.2025.149551","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}

引用次数: 0

摘要

特应性皮炎（AD）是一种常见的炎症性皮肤病。大多数病例始于儿童，尽管也有一些报告发生在成人身上。局部治疗无效的中度至重度AD病例可能需要全身治疗。重度AD患者在环孢素治疗后未达到预期改善，或出现不良反应且无法用单克隆抗体或Janus激酶抑制剂进行生物治疗时，可考虑使用甲氨蝶呤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Methotrexate in the treatment of atopic dermatitis.

Atopic dermatitis (AD) is a common inflammatory skin disease. Most cases start in children although some have been reported in adults. Moderate to severe cases of AD not responding to topical treatments may need systemic therapy. Methotrexate may be considered in patients with severe AD who did not achieve the expected improvement after cyclosporine, or who had adverse effects and no possibility of biological treatment with monoclonal antibodies or Janus kinase inhibitors.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊