Postepy Dermatologii I Alergologii最新文献

{"title":"Evaluation of the efficacy of microneedling without and with minoxidil 5% and autologous platelet-rich plasma for androgenetic alopecia in men.","authors":"Szymon Leonik, Michał Smoczok, Beata Bergler-Czop","doi":"10.5114/ada.2024.143496","DOIUrl":"10.5114/ada.2024.143496","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenetic alopecia is the most common form of non-cicatricial hair loss in men. The condition also affects young adults and can cause significant psychological distress. In addition to widely accepted methods, clinicians have at their disposal a number of therapies for which there are no established treatment algorithms.</p><p><strong>Methods: </strong>The study was conducted on a selected group of 92 men aged between 20 and 50 years. The patients were divided into three groups, each with a different therapeutic algorithm: group A - three microneedling treatments 1 month apart, group B - three microneedling treatments 1 month apart and daily topical application of 5% minoxidil, group C - three platelet-rich plasma treatments 1 month apart.</p><p><strong>Results: </strong>Each group showed an increase in mean hair number and density. However, only group C demonstrated a statistically significant increase in hair shaft thickness.</p><p><strong>Conclusions: </strong>Currently, there is no clear consensus in the literature regarding algorithms for microneedling and platelet-rich plasma treatment of the scalp. For the study, we selected a minimum effective algorithm that yielded satisfactory results.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"505-514"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of psoriasis disease with physical activity and exercise: systematic review and meta-analysis.","authors":"Hao Zhu, Qiang Sun, Hyunsoo Choi, Yang Li, Wei Zhang","doi":"10.5114/ada.2024.143424","DOIUrl":"10.5114/ada.2024.143424","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis (Pso) is an inflammatory autoimmune skin disease. High BMI, and elevated body fat and body weight is associated with risk of Pso development. People with Pso have lower physical activity than people without Pso, so they are at higher risk for comorbidities and underlying disease. Exercise has been shown to improve disease outcomes and inflammation in people with psoriasis.</p><p><strong>Aim: </strong>Meta-analysis study to investigate the physical activity in psoriasis patients.</p><p><strong>Methods: </strong>We designed this study according to the Systematic Reviews and Meta-Analyses (PRISMA) statement. The ISI, Scopus, PubMed, Cochrane Library, and Google Scholar have been used to search articles up to the end of May 2024.</p><p><strong>Results: </strong>A total of 1319 articles were extracted from the databases, and 7 articles were selected for analysis. High-intensity exercise levels were significantly lower in Pso patients than in healthy people (RR = 0.75; 95% CI: 0.60-0.93; <i>p</i> = 0.010). But there was no significant difference between the 2 groups regarding moderate-intensity exercise (RR = 0.80; 95% CI: 0.57-1.12; <i>p</i> = 0.20) and low-intensity exercise (RR = 1.42; 95% CI: 0.36-5.60; <i>p</i> = 0.62). Also, the number of metabolic equivalent task (MET) minutes in the Pso group was significantly lower than in healthy controls (SMD = -0.71; 95% CI: -0.86-0.56; <i>p</i> < 000001). Finally, the post-exercise PASI score decreased significantly in psoriatic patients (SMD = 3.98; 95% CI: 0.48-7.48; <i>p</i> = 0.03).</p><p><strong>Conclusions: </strong>High-intensity physical activity is significantly lower in Pso patients than in healthy people, MET in the Pso group was significantly lower than in healthy controls, and the post-exercise PASI score decreased significantly in psoriatic patients, which means physical activity intervention can be suggested as a therapeutic method for Pso patients.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"450-455"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult-onset atopic dermatitis induced by vedolizumab: a case series.","authors":"Eleonora Nucera, Sara Urbani, Arianna Aruanno, Franco Scaldaferri, Dario D'Urso, Clara De Simone","doi":"10.5114/ada.2024.144405","DOIUrl":"10.5114/ada.2024.144405","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"542-544"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between Fc epsilon receptor-1α and β (<i>FCER1A</i> and <i>FCER1B</i>) gene polymorphisms in patients with chronic urticaria using omalizumab.","authors":"Hulya Savas, Hatice Uce Ozkol, Gokhan Gorgisen, Halil Özkol, Can Ates, Ahmet Metin, İlknur Yorgun Özdemir","doi":"10.5114/ada.2024.142285","DOIUrl":"https://doi.org/10.5114/ada.2024.142285","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic urticaria requires well-defined treatment strategies in order to achieve a maximum treatment response and maintain the quality of life. Since 2014, omalizumab has been used in chronic urticaria. However, many studies showed that some patients are resistant to omalizumab.</p><p><strong>Aim: </strong>To determine the effects of single nucleotide changes in the <i>FCER1A</i> and <i>FCER1B</i> genes, which are thought to be related to resistance mechanisms, in our population of patients who have not responded to omalizumab treatment.</p><p><strong>Material and methods: </strong>We included 100 patients with chronic urticaria who were treated with omalizumab and 50 healthy individuals. Frequently observed gene polymorphisms, FCER1A (rs2251746) and FCER1B (rs569108), were examined in peripheral blood samples. The regions of rs2251746 and rs569108 gene polymorphisms were amplified using fluorescently labelled probes through real-time polymerase chain reaction (PCR). The analysis was performed bioinformatically via the SNP genotype profiling program.</p><p><strong>Results: </strong>There was no statistically significant relationship between <i>FCER1A</i> (rs2251746) and <i>FCER1B</i> (rs569108) gene polymorphisms in patients and their clinical, demographic characteristics, and the resistance to treatment (<i>p</i> > 0.05). In our study, the mean patient age was found to be higher in the CT group (44.71 ±12.5 years) compared to the TT group (37.34 ±11.5 years) only in the rs2251746 polymorphism (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>In our study, there was no significant relationship between <i>FCER1A</i> and <i>FCER1B</i> gene polymorphisms and resistance to omalizumab therapy. Further, multicentre, large-scale studies are needed to support our results.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"357-363"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased expression of psoriasin (S100A7) and interleukin 17 (IL-17) in lesional skin in lichen planopilaris.","authors":"Agnieszka Otlewska-Szpotowicz, Wojciech Baran, Zdzisław Woźniak, Jacek Szepietowski, Aleksandra Batycka-Baran","doi":"10.5114/ada.2024.142179","DOIUrl":"https://doi.org/10.5114/ada.2024.142179","url":null,"abstract":"<p><strong>Introduction: </strong>Lichen planopilaris (LPP) is an inflammatory, primary scarring alopecia, however its pathogenesis is not completely elucidated. S100A7 is a multifunctional, antimicrobial protein with proinflammatory properties. Interleukin-17 (IL-17) is implicated in the development of various autoimmune skin diseases.</p><p><strong>Aim: </strong>To determine the tissue expression of S100A7, S100A4 and IL-17 in LPP.</p><p><strong>Material and methods: </strong>The immunohistochemical analysis was performed on biopsy specimens obtained from individuals with histologically confirmed lichen planopilaris (<i>n</i> = 23), alopecia areata (AA) (<i>n</i> = 11), and healthy controls (<i>n</i> = 14). The expression was evaluated using Zeiss Axio Imager A2 light microscope.</p><p><strong>Results: </strong>The number of cells showing S100A7 expression was significantly higher in LPP lesional skin compared to AA lesional skin (<i>p</i> = 0.0002) and normal skin of healthy controls (<i>p</i> < 0.0001). The number of cells showing IL-17 expression was significantly higher in LPP lesional skin compared to normal skin of healthy controls (<i>p</i> < 0.0001) and the number of cells showing IL-17 expression was significantly higher in AA lesional skin compared to normal skin of healthy controls (<i>p</i> < 0.0001). The number of cells showing IL-17 expression was not significantly different in LPP lesional skin and in AA lesional skin (<i>p</i> > 0.05). The number of cells showing S100A4 expression was not significantly different in LPP lesional skin, AA lesional skin and in normal skin of healthy controls.</p><p><strong>Conclusions: </strong>The results of our study suggest the possible role of S100A7 and IL-17 in the pathogenesis of LPP.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"364-371"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health-related quality of life in subjects with hidradenitis suppurativa suffering from periodontitis.","authors":"Barbara Paśnik-Chwalik, Beata Jastrząb-Miśkiewicz, Piotr K Krajewski, Łukasz Matusiak, Tomasz Konopka, Jacek C Szepietowski","doi":"10.5114/ada.2024.141614","DOIUrl":"https://doi.org/10.5114/ada.2024.141614","url":null,"abstract":"<p><strong>Introduction: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory disorder affecting the pilosebaceous unit in intertriginous body areas, and recent research suggests an association with periodontitis.</p><p><strong>Aim: </strong>To assess oral health-related quality of life (OHRQoL) in patients with HS diagnosed additionally with periodontitis and to compare it to patients with periodontitis alone.</p><p><strong>Material and methods: </strong>The study involved 55 HS patients, with 25 in the HS + P group (both HS and periodontitis) and matched controls in the periodontitis-only group (P group). Outcomes were assessed using the Oral Health Impact Profile (OHIP-14) questionnaire.</p><p><strong>Results: </strong>No significant difference was observed in the mean OHIP-14 total score between the HS + P group and the P group. Patients with HS + P were less likely to undergo the dental evaluation and floss their teeth less frequently compared to the P group.</p><p><strong>Conclusions: </strong>The findings reveal that the coexistence of HS in patients with periodontitis does not significantly influence OHRQoL. Lower dental evaluation frequency and less frequent flossing in HS+P patients suggest reduced attention to oral health practices.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"395-399"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatophagoides pteronyssinus proteins and their role in the diagnostics and management of house dust mite allergy: exploring allergenic components.","authors":"Magdalena Choina, Krzysztof Kowal, Ewa Markut-Miotła, Emilia Majsiak","doi":"10.5114/ada.2024.142390","DOIUrl":"https://doi.org/10.5114/ada.2024.142390","url":null,"abstract":"<p><p>Component-resolved diagnostics enables the detection of allergen-specific immunoglobulins E (asIgE) to house dust mite (HDM) proteins, which may help clinicians to face the difficulties in diagnostics of HDM allergy. Currently, almost 40 proteins of <i>Dermatophagoides</i> species, that are able to bind asIgE, have been identified, and this number will certainly increase. The association between sensitisation to particular molecules and allergy symptoms is extensively studied. This investigation enables us to identify HDM molecules that promote respiratory, skin, or food allergies, and it could help us predict the possible course of allergic diseases. The individual repertoire of asIgE improves our understanding of immunological response, which underlies allergy symptoms, and helps to form individual therapeutic regimens. This review provides clinicians with information on <i>Dermatophagoides pteronyssinus</i> proteins available in commercial arrays, and their role in the diagnostics and management of HDM allergy.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"339-349"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of gut microbiome alterations in plaque psoriasis patients compared to healthy individuals.","authors":"Karina Polak, Tomasz Muszyński, Aleksandra Frątczak, Fanni Meznerics, András Bánvölgyi, Norbert Kiss, Bartosz Miziołek, Beata Bergler-Czop","doi":"10.5114/ada.2024.142394","DOIUrl":"https://doi.org/10.5114/ada.2024.142394","url":null,"abstract":"<p><strong>Introduction: </strong>Many studies have shown significant alterations in the gut microbiome of patients with psoriasis compared to healthy controls.</p><p><strong>Aim: </strong>The primary objective of the current research was to explore the impact of gut microbiome composition on the progression and severity of plaque psoriasis.</p><p><strong>Material and methods: </strong>A total of 20 patients with moderate-to-severe psoriasis and 20 healthy individuals were recruited and provided a stool sample to assess the gut microbiome. After the samples were prepared according to the NGS library preparation workflow, they were sequenced using the Illumina platform and the report was generated that underwent statistical analysis.</p><p><strong>Results: </strong>The microbiome profiles of psoriasis patients exhibited significant differences compared to healthy controls as evidenced by the statistical analysis of various bacterial genera, with the median abundance significantly lower in psoriasis patients compared to healthy controls (<i>p</i> = 0.033). The analysis of the Firmicutes-to-Bacteroidetes ratio, a commonly evaluated marker of dysbiosis, did not reach statistical significance (<i>p</i> = 0.239). However, there was a noticeable trend towards a higher median ratio in psoriasis patients compared to healthy controls. The ratio did not show significant associations with PASI or BSA but trends towards significance with DLQI (<i>B</i> = -12.11, <i>p</i> = 0.095).</p><p><strong>Conclusions: </strong>Overall, the above findings underscore the importance of the gut microbiome in psoriasis and suggest that modulation of specific bacterial genera, especially that with significant differences, could be a potential strategy for therapeutic intervention. Targeting these depleted genera through microbiome-based interventions, such as probiotic supplementation or faecal microbiota transplantation, could potentially help to restore gut homeostasis and alleviate the inflammatory burden in psoriasis.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"378-387"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of serum inflammatory factors in predicting treatment response in patients with vitiligo and concomitant Hashimoto's thyroiditis.","authors":"Xuwen Yin, Lei Shi, Heng Li, Jianwen Long","doi":"10.5114/ada.2024.142287","DOIUrl":"https://doi.org/10.5114/ada.2024.142287","url":null,"abstract":"<p><strong>Introduction: </strong>Vitiligo (VL) is associated with several autoimmune diseases, especially Hashimoto's thyroiditis, VL and concomitant Hashimoto's thyroiditis (HT) up to 34% in VL.</p><p><strong>Aim: </strong>To assess the predictive value of serum inflammatory factors in guiding treatment response among patients with concurrent VL and concomitant HT.</p><p><strong>Material and methods: </strong>This retrospective study enrolled 67 cases of VL and concomitant HT, and the patients according to treatment outcomes were divided into the unsatisfied group and the satisfied group. The serum thyroid parameters, autoimmune markers, and inflammatory factor levels were analysed and the correlation analysis of serum inflammatory factors was made.</p><p><strong>Results: </strong>The study analysis of serum thyroid parameters showed elevated levels of thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroperoxidase (TPO), and thyroglobulin (Tg) (<i>p</i> < 0.05) in the group with unsatisfactory treatment response. Patients in the unsatisfied group exhibited elevated inflammatory factor levels of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10) (<i>p</i> < 0.05) compared to their counterparts in the satisfied group. Correlation analysis showed that the levels of the above inflammatory factors were significantly negatively correlated with the treatment response.</p><p><strong>Conclusions: </strong>CRP, TNF-α, IL-6, IL-8, IL-10 showed the strongest correlation with VL and concomitant HT, and serum inflammatory factors levels can predict treatment response in patients with VL and concomitant HT.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"372-377"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidradenitis suppurativa: a new therapeutic approach for an old disease.","authors":"Marta Billewicz, Joanna Wojtania, Anna Woźniacka","doi":"10.5114/ada.2024.142185","DOIUrl":"https://doi.org/10.5114/ada.2024.142185","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterised by recurrent painful nodules, abscesses, fistulas and scarring. The primary distinguishing factor in the complex, yet still not fully understood, pathogenesis is an inflammation occurring within the hair follicle, followed by an immune response leading to further development of the skin lesions seen in HS. The treatment of patients with HS is very difficult due to the complexity of the lesions and the frequent tendency to recurrence, which also has a negative impact on the psychological state of patients and directly translates into a reduced quality of life. This review article addresses the pathogenesis, clinical presentation of HS and, in particular, explores the new therapeutic options available.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"350-356"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}