Postepy Dermatologii I Alergologii最新文献

{"title":"LED-emitted blue light improves quality of life and reduces fatigue after COVID-19 infection.","authors":"Daniel Nolberczak, Aleksandra Lesiak, Rafał Czajkowski, Igor Aleksander Bednarski, Joanna Narbutt","doi":"10.5114/ada.2024.144522","DOIUrl":"10.5114/ada.2024.144522","url":null,"abstract":"<p><strong>Introduction: </strong>Despite multiple clinical presentations of long COVID, the most common symptom encountered by the patients is fatigue which significantly impacts daily functioning and quality of life. There are, however, multiple unanswered questions regarding the treatment of fatigue among long COVID patients. Several studies highlighted that repetitive exposure to blue light may alleviate the fatigue in different groups of patients but the studies on the efficacy of blue light therapy in treatment of fatigue in long COVID patients are lacking.</p><p><strong>Aim: </strong>To evaluate the effects of blue light therapy in treatment of fatigue among COVID-19 survivors.</p><p><strong>Material and methods: </strong>The study comprised of 43 adults who underwent COVID-19 infection with a subjective feeling of fatigue 4 weeks after the infection. All participants underwent 10 full-body blue light irradiation for 15 min a day for 5 consecutive days each week. All participants were assessed using the Fatigue Severity Scale (FSS), Short Form 36 Vitality Subscale (SF-36) and Dermatology Life Quality Index (DLQI). Serum samples were taken to measure the levels of tryptophan, kynurenine, kynurenic acid, quinolinic acid and serotonin before and after irradiation.</p><p><strong>Results: </strong>Irradiation with blue light resulted in a significant decrease in FSS and DLQI as well as in an increase in SF-36 and serum levels of tryptophan, kynurenine and serotonin.</p><p><strong>Conclusions: </strong>Our study shows that blue light therapy could be used as adjunctive treatment of fatigue and provide an opportunity for further scientific inquiries.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"515-520"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pruritus prevalence and characteristics in Care and Treatment Facility and Geriatric Outpatient Clinic patients: a cross-sectional study using a standardized pruritus questionnaires.","authors":"Paula Mazan, Aleksandra Lesiak, Małgorzata Skibińska, Monika Rynkowska-Kidawa, Igor Bednarski, Dorota Sobolewska-Sztychny, Marcin Noweta, Joanna Narbutt","doi":"10.5114/ada.2024.144478","DOIUrl":"10.5114/ada.2024.144478","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic pruritus is one of the most common symptoms in geriatric patients. Pathogenesis of pruritus is multifactorial.</p><p><strong>Aim: </strong>To evaluate the prevalence and characteristics of pruritus in geriatric patients and to characterise pruritus and explore its possible underlying causes.</p><p><strong>Material and methods: </strong>The study included 132 patients of 65 years of age or older. The intensity of itch was assessed by Visual Analogue Scale (VAS) and Numerical Rating Scale (NRS), xerosis was assessed by overall skin dryness scale (ODS). Patients were asked to complete the 10-Item Pruritus Severity Scale (10-PSS).</p><p><strong>Results: </strong>Patients with pruritus had significantly higher glucose levels and incidence of xerosis compared to those without pruritus. Patients with anaemia had significantly higher 10-PSS scores than those without. A high correlation was found between 10-PSS, NRS and VAS scales. The incidence of pruritus was significantly higher in patients using antihypertensives, antidiabetics and/or statins compared to those who did not use these medications.</p><p><strong>Conclusions: </strong>One of the most common causes of pruritus is xerosis. It is essential to provide appropriate education to patients and caregivers on the use of emollients. Therefore, the development of recommendations would be desirable. Many drugs commonly used in elderly patients may be responsible for pruritus. An in-depth investigation is necessary as pruritus may be the only symptom or it may precede the appearance of typical skin lesions in the course of certain dermatoses for many months.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"463-472"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study between fractional microneedling radiofrequency with systemic isotretinoin and fractional microneedling alone in the treatment of rosacea.","authors":"Anwar Issa Hasan, Kholod A Ali, Tuqa Mohammed Latif","doi":"10.5114/ada.2024.142597","DOIUrl":"10.5114/ada.2024.142597","url":null,"abstract":"<p><strong>Introduction: </strong>Rosacea is a chronic inflammatory disease presenting with facial flushing, non-transient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. The pathogenesis of rosacea is not fully understood, but immune dysfunction, Demodex infection, neurovascular dysregulation, and exposure to ultraviolet radiation represent contributing factors.</p><p><strong>Aim: </strong>To evaluate and compare effectiveness of fractional micro-needling radiofrequency with systemic isotretinoin and micro-needling alone in the treatment of rosacea.</p><p><strong>Material and methods: </strong>A cross-sectional comparative study between fractional microneedling radiofrequency with systemic isotretinoin and micro-needling alone in the treatment of rosacea was carried out in a private outpatient clinic and Al-Yarmouk teaching hospital from January 2022 to June 2023. Group A comprised 25 patients treated with systemic isotretinoin (10 mg/day) for 6 weeks and fractional microneedling radiofrequency for 16 weeks. Patients received a session every 2 weeks during the first 2 months of treatment then one session per month. Group B comprised 25 patients treated with fractional microneedling radiofrequency for 16 weeks. The patients received a session every 2 weeks during the first 2 months of treatment then one session per month. Measurement of baseline serum lipid profile, complete blood count, and liver enzyme levels was done to all patients receiving isotretinoin. All patients in both groups were instructed to use sunscreen and emollients. Follow-up of all patients was carried out for 3 months after treatment. Patients were assessment according to the Grade system of rosacea, patient satisfaction, and relapse rate. Relapse rate: no relapse (0), relapse (1). Patient satisfaction: poor (0), fair (1), and good (2).</p><p><strong>Results: </strong>There was no significant difference in the mean severity score for rosacea between group A and group B, before, after 8 weeks, and after 16 weeks. Patients in group A showed higher good satisfaction (72%) than group B (32%). During the follow-up period the relapse rate was higher in group B (32%) than in group A (16%), the percentage reduction (response rate) of the mean of severity score was 41.37% after 8 weeks and 91.37% after 16 weeks in group A, and 34.48% after 8 weeks and 82.75% after 16 weeks in group B.</p><p><strong>Conclusions: </strong>Fractional microneedling radiofrequency is a safe and effective method in the treatment of rosacea, and so it can be used when there are contraindications to other lines of therapy, when patients are resistant to long-term oral therapy, and when patients (including pregnant women) choose not to take oral or topical drugs.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"495-499"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic cigarettes in dermatology: a systematic review of the literature.","authors":"Paulina Rutecka, Dawid Wolak, Karina Polak, Bartosz Miziołek, Beata Bergler-Czop","doi":"10.5114/ada.2024.144520","DOIUrl":"10.5114/ada.2024.144520","url":null,"abstract":"<p><strong>Introduction: </strong>Electronic cigarettes (e-cigarettes) have been gaining worldwide popularity for several years now, making vaping a major alternative to regular tobacco smoking.</p><p><strong>Aim: </strong>There is still a lack of data on the occurrence of dermatological diseases due to e-cigarettes, so the research was performed.</p><p><strong>Methods: </strong>A systematic review of the literature was performed in Embase and Medline databases. The search included EMTREE and MESH approaches and was conducted according to the PRISMA guidelines.</p><p><strong>Results: </strong>Electronic cigarettes were identified both as an initiating and aggravating factor in several dermatological diseases. Vaping resulted in impaired wound healing and thermal injuries in the healthy skin.</p><p><strong>Conclusions: </strong>Electronic cigarettes have been reported to contribute to the development of various skin diseases and be a source of thermal injury. Lack of data and poor compliance concerning reporting the side effects of vaping make this topic an important issue to monitor.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"446-449"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the expression of Bcl-2 and Ki-67 prognostic markers and apoptotic index with biological behaviour in aggressive and non-aggressive non-melanoma eyelid skin cancer.","authors":"Zuzana Prídavková, Lukáš Plank, Peter Žiak, Juraj Halička, Karolína Benca-Kapitánová, Rastislav Vida, Vladimír Bartoš","doi":"10.5114/ada.2024.144402","DOIUrl":"10.5114/ada.2024.144402","url":null,"abstract":"<p><strong>Introduction: </strong>Prognostic biomarkers facilitate the identification of high-risk tumours.</p><p><strong>Aim: </strong>To evaluate the association of Bcl-2 protein and Ki-67 antigen expression and the apoptotic index with biological behaviour of non-melanoma eyelid tumours.</p><p><strong>Material and methods: </strong>Combined analysis of retrospective and prospective study of data from two centres over a period from 2008 to 2023 on histologically confirmed malignant non-melanoma eyelid tumours without any age limitation. Selected prognostic markers related to the aggressive or non-aggressive tumour types were evaluated.</p><p><strong>Results: </strong>The study cohort included 68 patients with 70 non-melanoma eyelid tumours (<i>n</i> = 70). The basal cell carcinoma was the most frequently present type (97.1%). The median age was 68 years. A tumour size > 5 mm correlates to the aggressive type (<i>p</i> = 0.047). Resection margins < 2 mm were in 33.9%, without any connection to the recurrence rate (<i>p</i> = 0.076). The average value of Bcl-2 expression in non-aggressive types was 82.65% (<i>p</i> < 0.001). The value of Ki-67 expression in patients with non-aggressive tumours was 35.49% (<i>p</i> = 0.068). Non-aggressive tumours most frequently exhibited the apoptotic index of Grade I (<i>p</i> = 0.535). No Grade III case was observed in the aggressive types. In 2 cases, the orbital exenteration was carried out (0.03%). In 1 case biological therapy was administered. HDR brachytherapy was applied in 6 cases. A recurrence of the disease was observed in 4 (0.06%) cases.</p><p><strong>Conclusions: </strong>New information on cancer biomarkers in non-melanoma eyelid skin carcinoma contributes to choosing a correct therapy with achieving good aesthetic results and a good survival rate.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"456-462"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficacy of microneedling without and with minoxidil 5% and autologous platelet-rich plasma for androgenetic alopecia in men.","authors":"Szymon Leonik, Michał Smoczok, Beata Bergler-Czop","doi":"10.5114/ada.2024.143496","DOIUrl":"10.5114/ada.2024.143496","url":null,"abstract":"<p><strong>Introduction: </strong>Androgenetic alopecia is the most common form of non-cicatricial hair loss in men. The condition also affects young adults and can cause significant psychological distress. In addition to widely accepted methods, clinicians have at their disposal a number of therapies for which there are no established treatment algorithms.</p><p><strong>Methods: </strong>The study was conducted on a selected group of 92 men aged between 20 and 50 years. The patients were divided into three groups, each with a different therapeutic algorithm: group A - three microneedling treatments 1 month apart, group B - three microneedling treatments 1 month apart and daily topical application of 5% minoxidil, group C - three platelet-rich plasma treatments 1 month apart.</p><p><strong>Results: </strong>Each group showed an increase in mean hair number and density. However, only group C demonstrated a statistically significant increase in hair shaft thickness.</p><p><strong>Conclusions: </strong>Currently, there is no clear consensus in the literature regarding algorithms for microneedling and platelet-rich plasma treatment of the scalp. For the study, we selected a minimum effective algorithm that yielded satisfactory results.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"505-514"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of psoriasis disease with physical activity and exercise: systematic review and meta-analysis.","authors":"Hao Zhu, Qiang Sun, Hyunsoo Choi, Yang Li, Wei Zhang","doi":"10.5114/ada.2024.143424","DOIUrl":"10.5114/ada.2024.143424","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis (Pso) is an inflammatory autoimmune skin disease. High BMI, and elevated body fat and body weight is associated with risk of Pso development. People with Pso have lower physical activity than people without Pso, so they are at higher risk for comorbidities and underlying disease. Exercise has been shown to improve disease outcomes and inflammation in people with psoriasis.</p><p><strong>Aim: </strong>Meta-analysis study to investigate the physical activity in psoriasis patients.</p><p><strong>Methods: </strong>We designed this study according to the Systematic Reviews and Meta-Analyses (PRISMA) statement. The ISI, Scopus, PubMed, Cochrane Library, and Google Scholar have been used to search articles up to the end of May 2024.</p><p><strong>Results: </strong>A total of 1319 articles were extracted from the databases, and 7 articles were selected for analysis. High-intensity exercise levels were significantly lower in Pso patients than in healthy people (RR = 0.75; 95% CI: 0.60-0.93; <i>p</i> = 0.010). But there was no significant difference between the 2 groups regarding moderate-intensity exercise (RR = 0.80; 95% CI: 0.57-1.12; <i>p</i> = 0.20) and low-intensity exercise (RR = 1.42; 95% CI: 0.36-5.60; <i>p</i> = 0.62). Also, the number of metabolic equivalent task (MET) minutes in the Pso group was significantly lower than in healthy controls (SMD = -0.71; 95% CI: -0.86-0.56; <i>p</i> < 000001). Finally, the post-exercise PASI score decreased significantly in psoriatic patients (SMD = 3.98; 95% CI: 0.48-7.48; <i>p</i> = 0.03).</p><p><strong>Conclusions: </strong>High-intensity physical activity is significantly lower in Pso patients than in healthy people, MET in the Pso group was significantly lower than in healthy controls, and the post-exercise PASI score decreased significantly in psoriatic patients, which means physical activity intervention can be suggested as a therapeutic method for Pso patients.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"450-455"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult-onset atopic dermatitis induced by vedolizumab: a case series.","authors":"Eleonora Nucera, Sara Urbani, Arianna Aruanno, Franco Scaldaferri, Dario D'Urso, Clara De Simone","doi":"10.5114/ada.2024.144405","DOIUrl":"10.5114/ada.2024.144405","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 5","pages":"542-544"},"PeriodicalIF":1.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between Fc epsilon receptor-1α and β (<i>FCER1A</i> and <i>FCER1B</i>) gene polymorphisms in patients with chronic urticaria using omalizumab.","authors":"Hulya Savas, Hatice Uce Ozkol, Gokhan Gorgisen, Halil Özkol, Can Ates, Ahmet Metin, İlknur Yorgun Özdemir","doi":"10.5114/ada.2024.142285","DOIUrl":"https://doi.org/10.5114/ada.2024.142285","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic urticaria requires well-defined treatment strategies in order to achieve a maximum treatment response and maintain the quality of life. Since 2014, omalizumab has been used in chronic urticaria. However, many studies showed that some patients are resistant to omalizumab.</p><p><strong>Aim: </strong>To determine the effects of single nucleotide changes in the <i>FCER1A</i> and <i>FCER1B</i> genes, which are thought to be related to resistance mechanisms, in our population of patients who have not responded to omalizumab treatment.</p><p><strong>Material and methods: </strong>We included 100 patients with chronic urticaria who were treated with omalizumab and 50 healthy individuals. Frequently observed gene polymorphisms, FCER1A (rs2251746) and FCER1B (rs569108), were examined in peripheral blood samples. The regions of rs2251746 and rs569108 gene polymorphisms were amplified using fluorescently labelled probes through real-time polymerase chain reaction (PCR). The analysis was performed bioinformatically via the SNP genotype profiling program.</p><p><strong>Results: </strong>There was no statistically significant relationship between <i>FCER1A</i> (rs2251746) and <i>FCER1B</i> (rs569108) gene polymorphisms in patients and their clinical, demographic characteristics, and the resistance to treatment (<i>p</i> > 0.05). In our study, the mean patient age was found to be higher in the CT group (44.71 ±12.5 years) compared to the TT group (37.34 ±11.5 years) only in the rs2251746 polymorphism (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>In our study, there was no significant relationship between <i>FCER1A</i> and <i>FCER1B</i> gene polymorphisms and resistance to omalizumab therapy. Further, multicentre, large-scale studies are needed to support our results.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"357-363"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased expression of psoriasin (S100A7) and interleukin 17 (IL-17) in lesional skin in lichen planopilaris.","authors":"Agnieszka Otlewska-Szpotowicz, Wojciech Baran, Zdzisław Woźniak, Jacek Szepietowski, Aleksandra Batycka-Baran","doi":"10.5114/ada.2024.142179","DOIUrl":"https://doi.org/10.5114/ada.2024.142179","url":null,"abstract":"<p><strong>Introduction: </strong>Lichen planopilaris (LPP) is an inflammatory, primary scarring alopecia, however its pathogenesis is not completely elucidated. S100A7 is a multifunctional, antimicrobial protein with proinflammatory properties. Interleukin-17 (IL-17) is implicated in the development of various autoimmune skin diseases.</p><p><strong>Aim: </strong>To determine the tissue expression of S100A7, S100A4 and IL-17 in LPP.</p><p><strong>Material and methods: </strong>The immunohistochemical analysis was performed on biopsy specimens obtained from individuals with histologically confirmed lichen planopilaris (<i>n</i> = 23), alopecia areata (AA) (<i>n</i> = 11), and healthy controls (<i>n</i> = 14). The expression was evaluated using Zeiss Axio Imager A2 light microscope.</p><p><strong>Results: </strong>The number of cells showing S100A7 expression was significantly higher in LPP lesional skin compared to AA lesional skin (<i>p</i> = 0.0002) and normal skin of healthy controls (<i>p</i> < 0.0001). The number of cells showing IL-17 expression was significantly higher in LPP lesional skin compared to normal skin of healthy controls (<i>p</i> < 0.0001) and the number of cells showing IL-17 expression was significantly higher in AA lesional skin compared to normal skin of healthy controls (<i>p</i> < 0.0001). The number of cells showing IL-17 expression was not significantly different in LPP lesional skin and in AA lesional skin (<i>p</i> > 0.05). The number of cells showing S100A4 expression was not significantly different in LPP lesional skin, AA lesional skin and in normal skin of healthy controls.</p><p><strong>Conclusions: </strong>The results of our study suggest the possible role of S100A7 and IL-17 in the pathogenesis of LPP.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"41 4","pages":"364-371"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11404093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}