Postepy Dermatologii I Alergologii最新文献

{"title":"B-ultrasound or CT-guided 3D-printing individualized non-coplanar template brachytherapy for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.","authors":"Pengbing Han, Fengju Li, Yanping Zhang, Liying Gao, Guiqiong Zhang, Qing Guo, Yuxia Zhu, Qun Su","doi":"10.5114/ada.2024.136252","DOIUrl":"10.5114/ada.2024.136252","url":null,"abstract":"<p><strong>Introduction: </strong>It is worth to explore a more effective treatment method to minimize the damage for patients during the treatment process.</p><p><strong>Aim: </strong>To explore the method, feasibility and efficacy of B-ultrasound or computed tomography (CT)-guided 3D printing individualized non-coplanar template brachytherapy in the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.</p><p><strong>Material and methods: </strong>Ten patients with locally uncontrolled recurrent head and neck squamous cell carcinoma who were treated in our department from August 2021 to February 2023 were collected and treated by 3D printing individualized non-coplanar template brachytherapy under the guidance of B-ultrasound or CT, using the 192Ir high-dose rate afterloading treatment machine of NUCLETRON Technologies GmbH. The radiation source was 192Ir, with a diameter of 0.5 mm, a length of 3.5 mm, a total dose of 10-24 Gy, 5-8 Gy/time, once a week.</p><p><strong>Results: </strong>According to the efficacy evaluation criteria, CT scan was performed after 1-6 months, followed up for 24 months, including CR 40% (4/10), PR 50% (5/10), NC 10% (5/10), PD 0 (0). The total effective rate of CR + PR was 90% (9/10), the 6-month local control rate was 90%, the 12-month local control rate was 80%, the 18-month local control rate was 70%, and the 24-month local control rate was 70%. The overall survival rate at 24 months was 100%.</p><p><strong>Conclusions: </strong>Safe and effective interpolation is used to guide the 3D printing of a single non-coplanar template with B-ultrasound or CT in the radiotherapy of local and uncontrolled recurrent head and neck squamous cell carcinoma. According to the guidance of B-ultrasound or CT, the 3D printing individualized non-coplanar template has an obvious healing effect especially in the brachytherapy, and can also protect the functional organs well, with less side effects and fewer complications. Therefore, this method is the most effective for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical relevance of cluster analysis in phenotyping allergic rhinitis in the paediatric population of the Kuyavian-Pomeranian voivodeship, Poland.","authors":"Agnieszka Kowalczyk, Aneta Krogulska","doi":"10.5114/ada.2023.135676","DOIUrl":"10.5114/ada.2023.135676","url":null,"abstract":"<p><strong>Introduction: </strong>Allergic rhinitis (AR) is the most common allergic disease in the world, and additionally, its prevalence is successively increasing. Children with AR constitute a heterogeneous group of patients differing both in the course of AR and in the frequency of asthma coexistence. It is possible to identify children with AR at risk of a more severe course of the disease by analysing the potential family, environmental and clinical factors related to the development of the disease; the findings will help identify patients with a higher risk of developing asthma in the future, and who will benefit the most from early allergen-specific immunotherapy.</p><p><strong>Aim: </strong>Evaluation of clinical relevance of cluster analysis in phenotyping AR based on an analysis of selected clinical and environmental factors.</p><p><strong>Material and methods: </strong>The study sample was 80 children (7-17 y.o.) with AR, including 28 children with associated asthma. The effects of AR symptoms on the patients daily functioning, skin prick tests (Allergopharma), allergen-specific IgE for airborne allergens (Biocheck GmbH), total cholesterol, cholesterol high-density lipoprotein (HDL), cholesterol low-density lipoprotein (LDL), triglyceride levels in the blood (ARCHITECTcSystem), FeNO and nNO concentrations (HypAir FeNO Medisoft) and results of methacholine challenge test (Lungtest 1000Ispa) were analysed.</p><p><strong>Results: </strong>Four clusters of patients with AR were extracted, differing in the incidence and severity of AR symptoms and the coincidence of asthma. Most of the children from cluster 1 (<i>n</i> = 24; 85.71%) and cluster 2 (<i>n</i> = 15; 78.95%) had persistent AR, while most of the children from cluster 3 (<i>n</i> = 11; 73.33%) and cluster 4 (<i>n</i> = 14; 77.78%) had intermittent AR. The co-occurrence of asthma was significantly higher in cluster 1 than in other clusters (<i>p</i> = 0.0002). Children in clusters 3 and 4 reported a lower impact of AR symptoms on daily functioning (<i>p</i> = 0.0153). Children in cluster 1 had significantly more often an abnormally high total cholesterol level (<i>p</i> = 0.033) and in cluster 4 significantly more often abnormally high triglyceride levels (<i>p</i> = 0.009) were observed. Patients in cluster 2 were significantly less likely to have abnormal high LDL levels (<i>p</i> = 0.015).</p><p><strong>Conclusions: </strong>Children with AR from the Kuyavian-Pomeranian voivodeship differing in the course of AR, the frequency of coexistence of asthma, and occurrence of lipid parameter abnormalities.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the effectiveness of biological medications in the treatment for psoriasis depend on the moment of starting therapy? A preliminary study.","authors":"Michał Niedźwiedź, Marcin Noweta, Joanna Narbutt, Witold Owczarek, Magdalena Ciążyńska, Agnieszka Czerwińska, Janusz Krzyścin, Aleksandra Lesiak, Małgorzata Skibińska","doi":"10.5114/ada.2024.135917","DOIUrl":"10.5114/ada.2024.135917","url":null,"abstract":"<p><strong>Introduction: </strong>It is well known that biological medications acting on selected elements of the immune response are highly effective in psoriasis treatment. It is a common perception that psoriasis is a seasonal disorder with improvement in warmer months, however it has not been unequivocally confirmed. It is not known whether the time of year of starting systematic therapy for psoriasis influences treatment outcomes.</p><p><strong>Material and methods: </strong>Changes in psoriasis severity scores during treatment with biologics were investigated. The scores were recorded for 62 patients with moderate to severe psoriasis at the beginning, after 1, 4 and 7 months of the therapy. Patients were divided into two groups: those beginning the treatment in the cold period of the year (November-March) and in the warm period (May-September). The seasonal groups were also divided into subgroups according to the type of biologics used: interleukin inhibitors and tumor necrosis factor α (TNF-α) inhibitors. Results of the treatment were analysed using standard statistical tests of differences between samples.</p><p><strong>Results: </strong>After 1 and 4 months of the therapy, better efficacy of interleukin inhibitors was found in patients starting treatment in summer. The course of psoriasis improvement in patients taking TNF-α inhibitors resulted in consistent improvement regardless of the season. The outcome of the treatment after 7 months was similar for both seasonal groups and types of biologics used.</p><p><strong>Conclusions: </strong>Our understanding of the effectiveness of the treatments depending on the time of the year combined with the type of biologics used, may further improve results of the therapy.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10962378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear IgA dermatosis secondary to treatment with piperacillin-tazobactam in a nonagenarian patient.","authors":"Vanesa García-Paz, Carolina Gómez-Farińas, Soledad Sánchez-Sánchez, Andrea Otero-Alonso, Clara Carballas-Vázquez, Leticia Vila-Sexto","doi":"10.5114/ada.2023.133817","DOIUrl":"10.5114/ada.2023.133817","url":null,"abstract":"","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of excessive short-acting β₂-agonist use and asthma exacerbations: a retrospective analysis of a Polish prescription database.","authors":"Maciej Kupczyk, Wojciech Barg, Grażyna Bochenek, Grzegorz Brożek, Piotr D Browiecki, Dorota Brzostek, Andrzej D Browski, Rafał Dobek, Radosław Gawlik, Aleksandra Kucharczyk, Izabela Kupryś-Lipińska, Agnieszka Mastalerz-Migas, Marek L Kowalski","doi":"10.5114/ada.2023.133454","DOIUrl":"10.5114/ada.2023.133454","url":null,"abstract":"<p><strong>Introduction: </strong>Despite being linked to unfavourable outcomes, short-acting β₂-agonists (SABAs) are still overused by a substantial proportion of patients with asthma.</p><p><strong>Aim: </strong>To analyse the prevalence and predictors of SABA overuse and exacerbations in patients with asthma in a nationwide database of prescription purchase records.</p><p><strong>Material and methods: </strong>The prevalence of excessive SABA use (≥ 12 canisters) and overuse (≥ 3 canisters) was analysed among patients aged 18-64 years who purchased asthma medications in 2018. Predictors of excessive SABA use and SABA overuse were examined by quasi-Poisson regression. Negative binomial regression was used to study the association of excessive SABA use or overuse to the risk of asthma exacerbation defined as a prescription for oral corticosteroids.</p><p><strong>Results: </strong>Of 91,763 patients with asthma, 42,189 (46%) were SABA users (mean age, 47 years; 58% female). Among them, 34% purchased ≥ 3 SABA canisters, and 6% purchased ≥ 12 canisters. The risk (risk ratio, 95% CI) of excessive SABA use was lower in patients with concomitant prescriptions for inhaled corticosteroids (0.41, 0.34-0.48) or inhaled corticosteroids and long-acting β₂-agonists (0.52, 0.47-0.56), women (0.63, 0.58-0.68), and those in secondary care (0.60, 0.44-0.66); older age was associated with a higher risk of excessive SABA use (1.06, 1.03-1.10). Excessive SABA use was the strongest predictor of asthma exacerbations among all patients (3.24, 2.84-3.70) and in those with ≥ 1 exacerbation (1.60, 1.50-1.71).</p><p><strong>Conclusions: </strong>Excessive SABA use is highly prevalent in asthma management, is associated with lack of prescriptions for inhaled corticosteroids, and substantially increases the exacerbation risk.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Affective temperament, depressive symptoms and interleukins in patients with psoriasis.","authors":"Luiza Marek-Józefowicz, Marcin Jaracz, Alina Borkowska","doi":"10.5114/ada.2023.134192","DOIUrl":"https://doi.org/10.5114/ada.2023.134192","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.5114/ada.2021.104289.].</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of peripheral lung function measurements in paediatric asthma control assessment: a pilot study.","authors":"Maria Wawszczak, Marek Kulus, Joanna Peradzyńska","doi":"10.5114/ada.2023.133831","DOIUrl":"10.5114/ada.2023.133831","url":null,"abstract":"<p><strong>Introduction: </strong>Recent studies have indicated the significance of the peripheral airways in asthma control. Methods estimating airway resistance, air trapping, and ventilation inhomogeneity are useful for assessing this area of the lung and have proven utility in the evaluation of asthma; however, it is unclear which method is most effective at characterising uncontrolled asthma.</p><p><strong>Aim: </strong>To evaluate the diagnostic accuracy of various peripheral airway function measurements in the assessment of asthma control in children.</p><p><strong>Material and methods: </strong>Children with controlled (<i>n</i> = 35) and uncontrolled (<i>n</i> = 29) asthma performed a sequence of pulmonary function tests (i.e. spirometry, body plethysmography, oscillometry, nitrogen washout test, and exhaled nitric oxide). The diagnostic accuracy of each peripheral airway measure was evaluated by an area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Most peripheral airway parameters were significantly increased in children with uncontrolled asthma compared with children with controlled asthma. The measures with the highest diagnostic accuracy for asthma control were lung clearance index (LCI) (AUC = 0.76), with high specificity (0.97) and modest sensitivity (0.46), acinar ventilation heterogeneity (Sacin) (AUC = 0.73), with high sensitivity (0.85) and modest specificity (0.54), and resonance frequency (Fres) (AUC= 0.74), with perfect specificity (1.0) but low sensitivity (0.38).</p><p><strong>Conclusions: </strong>LCI, Sacin and Fres had the highest discriminative capacity for distinguishing children with controlled and uncontrolled asthma among all evaluated peripheral airways measures. Discrepancies in the performance (i.e. sensitivity and specificity) of each parameter suggest that a combination may be most effective in determining asthma control status.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between body mass index <i>z</i>-score and acne severity in adolescents: a prospective analysis.","authors":"Bahar Öztelcan Gündüz, Hatice Ataş","doi":"10.5114/ada.2023.133468","DOIUrl":"10.5114/ada.2023.133468","url":null,"abstract":"<p><strong>Introduction: </strong>Acne vulgaris is a prevalent skin disorder influenced by a variety of factors, including a high body mass index (BMI) and obesity.</p><p><strong>Aim: </strong>To investigate the association between BMI <i>z</i>-scores and acne severity in boys and girls aged 10-18 years.</p><p><strong>Material and methods: </strong>A 72-patient prospective analysis was performed, in which patient weight, height, body mass index (BMI), body mass index <i>z</i> score (BMI <i>z</i>-score), percentiles, and demographic information were collected, and acne severity was categorized as mild or moderate/severe.</p><p><strong>Results: </strong>The results indicated that patients with moderate/severe acne were significantly older and had higher weight, height, BMI, and BMI <i>z</i>-scores than those with mild acne (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>The findings suggest that higher BMI <i>z</i>-scores are linked to increased acne severity. These results emphasize the importance of addressing weight-related risk factors for the prevention and treatment of acne vulgaris. The early detection and management of weight-related conditions can play a crucial role in improving the overall well-being of individuals with acne, considering its negative impact on mental health and social functioning.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of upadacitinib for the treatment of moderate-to-severe atopic dermatitis: a meta-analysis of randomized clinical trials.","authors":"Linxi Zeng, Sen Feng, Lulu Yao, Bin Wang, Guoqiang Zhang","doi":"10.5114/ada.2023.133959","DOIUrl":"10.5114/ada.2023.133959","url":null,"abstract":"<p><strong>Introduction: </strong>Recent studies have confirmed the possibility of using upadacitinib for treating atopic dermatitis (AD). However, there is no meta-analysis to summarize and quantify the efficacy and safety of the drug, especially for adolescents with AD.</p><p><strong>Aim: </strong>To evaluate the overall efficacy and safety of upadacitinib in adults and adolescents with AD.</p><p><strong>Material and methods: </strong>We developed this systematic review and meta-analysis according to PRISMA guidelines. Risk-of-bias assessment tool, RoB2 (revised version 2019) was used for quality assessment.</p><p><strong>Results: </strong>Four RCTs were enrolled in the analysis, 3 of which on both adults and adolescents, while the other on adults only. For either adults or adolescents, the group treated with upadacitinib all had better performance than controls: EASI-75 (adults): RR = 4.68, 95% CI: 4.09, 5.35; NRS4 (adults): RR = 4.07, 95% CI: 3.15, 5.25; EASI-75 (adolescents): RR = 4.16, 95% CI: 2.70, 6.42; NRS4 (adolescents): RR = 4.52, 95% CI: 2.49, 8.21. Furthermore, upadacitinib 30 mg was more effective than 15 mg. For serious AEs, upper respiratory tract infection and headache, there was no significant difference between the upadacitinib group and controls. However, the treatment of upadacitinib may increase the risk of nasopharyngitis, increase blood creatine phosphokinase and cause acne.</p><p><strong>Conclusions: </strong>Upadacitinib seems to be a promising drug for AD. More long-term and larger-sized randomized clinical trials are required to further assess the safety and efficacy of upadacitinib for AD.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum sRAGE levels in children with atopic dermatitis: a prospective study.","authors":"Hatice Eke-Gungor, Bilal Sagiroglu, Zehra Nur Can-Coskun, Derya Kocer, Çiğdem Karakukcu","doi":"10.5114/ada.2023.133585","DOIUrl":"10.5114/ada.2023.133585","url":null,"abstract":"<p><strong>Introduction: </strong>Atopic dermatitis (AD) is chronic inflammatory skin disorder. The receptor for advanced glycation end products (RAGE) plays a role in inflammatory reactions. The soluble form of RAGE (sRAGE) acts as a decoy to inhibit interactions of RAGE.</p><p><strong>Aim: </strong>To determine serum sRAGE levels in children with AD.</p><p><strong>Material and methods: </strong>AD diagnosis was made according to Hanifin and Rajka criteria. Disease severity was scored by the scoring atopic dermatitis (SCORAD) index. Skin prick testing (SPT), total immunoglobulin E (Ig E) and eosinophil counts were analysed. The sRAGE levels were determined using ELISA technique.</p><p><strong>Results: </strong>The children, aged 0.4 to 2.0 years with AD (<i>n</i> = 65) were investigated in two groups according to the presence (AD+/Atopy+ [<i>n</i> = 40]) or absence (AD+/Atopy- [<i>n</i> = 25]) of SPT positivity. The comparisons were made with a healthy control group matched for age and sex. The medians (interquartile range) of sRAGE levels in patient and control groups were 8.43 (1.04-18.37) and 14.09 (6.35-28.64), respectively (<i>p</i> < 0.001). The medians (interquartile range) of sRAGE levels in AD+/Atopy+, AD+/Atopy- and control groups were 8.5 (3.1-17.27), 7.75 (1.04-18.37) and 14.09 (6.35-28.64), respectively (<i>p</i> = 0.004). Correlation analysis failed to reach significance with the disease severity sRAGE levels, total IgE levels and eosinophil counts.</p><p><strong>Conclusions: </strong>To our knowledge, this is the first study investigating the association of sRAGE levels with AD and disease severity in childhood. Serum sRAGE levels are decreased in AD but not correlated with disease severity. sRAGE levels may be important in the AD disease process.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}