Relationship between cigarette smoking and chronic spontaneous urticaria. Is there a difference in neutrophil-lymphocyte ratio?

IF 1.4 4区 医学 Q3 ALLERGY
Postepy Dermatologii I Alergologii Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI:10.5114/ada.2024.143640
Łukasz Moos, Weronika Chodak, Magdalena Czyczerska, Karolina Garbino, Oktawia Gleba, Bartosz Śnietka, Zenon Brzoza
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Abstract

Introduction: Chronic spontaneous urticaria (CSU) is defined as the appearance of itchy wheals and/or angioedema for at least 6 weeks. Cigarette smoking is one of the world's most common addictions. It is a cause of serious diseases such as renal cancer or thromboembolic incidents. Nevertheless, some studies show that nicotine might have a protective effect on various autoimmune diseases. The neutrophil-lymphocyte ratio (NLR) is a good marker of inflammation.

Aim: To check the prevalence of smokers in our CSU patients and to assess their profile of NLR as a marker of inflammation.

Material and methods: 68 adult patients were included (52 females, and 16 males). The average age of respondents was 52. All of the patients were diagnosed with CSU. The group was divided by gender and smoking. The Mann-Whitney U test (Statistica ver.13) was used.

Results: 73.5% of the respondents were non-smokers, and the remaining 26.5% were smokers. In the female group, irrespective of smoking, statistically significant different levels of neutrophils (NEU), lymphocytes (LYM), and neutrophil-lymphocyte ratio (NLR) were found compared to males. No statistical difference was found between smokers and non-smokers regarding the level of inflammatory factors. Compared to males, females had significantly different levels of LYM in the group of non-smokers and NEU in the group of smokers.

Conclusions: Our study does not support claims that smoking has a protective effect on CSU. Significant differences in NEU, LYM, and NLR need to be further investigated.

吸烟与慢性自发性荨麻疹的关系。中性粒细胞与淋巴细胞的比例有差异吗?
慢性自发性荨麻疹(CSU)定义为出现痒疹和/或血管性水肿至少6周。吸烟是世界上最常见的上瘾之一。它是肾癌或血栓栓塞事件等严重疾病的原因。然而,一些研究表明,尼古丁可能对各种自身免疫性疾病有保护作用。中性粒细胞与淋巴细胞比值(NLR)是炎症的良好标志。目的:检查我们的CSU患者中吸烟者的患病率,并评估其NLR作为炎症标志物的概况。材料与方法:纳入68例成人患者,其中女性52例,男性16例。受访者的平均年龄为52岁。所有患者均被诊断为CSU。该小组按性别和吸烟情况进行了划分。采用Mann-Whitney U检验(Statistica ver.13)。结果:73.5%的受访者为非吸烟者,其余26.5%为吸烟者。在女性组中,无论是否吸烟,中性粒细胞(NEU)、淋巴细胞(LYM)和中性粒细胞-淋巴细胞比率(NLR)水平与男性相比均有统计学上的显著差异。在炎症因子水平方面,吸烟者和非吸烟者之间没有统计学差异。与男性相比,女性不吸烟组的LYM和吸烟组的NEU水平有显著差异。结论:我们的研究不支持吸烟对CSU有保护作用的说法。NEU、LYM和NLR的显著差异有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
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