Serofast state after syphilis treatment: implications and recommendations for clinical practice. Narrative review.

IF 1.4 4区医学 Q3 ALLERGY

Postepy Dermatologii I Alergologii Pub Date : 2025-01-31 eCollection Date: 2025-06-01 DOI:10.5114/ada.2024.147332

Martyna Kiołbasa, Konrad Kaminiów, Maciej Pastuszczak

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Abstract

Introduction: Serofast state is defined as an insufficient decrease in the non-treponemal reaction titre after 6-12 months for early syphilis or after 12-24 months for late syphilis counting from the recommended treatment, with the simultaneous resolution of the infection symptoms.

Aim: The aim of this article was to review the current understanding of the serofast state. Additionally, data on recommended diagnostic and therapeutic approaches for patients with serofast state were presented.

Methods: In order to review the current understanding in the field of serofast syphilis, the PubMed database was searched.

Results: The available literature relating to serofast syphilis is mainly concerned with predictive factors of the serofast state.

Conclusions: Understanding the predictive factors of the serofast state and its pathomechanism is crucial. This knowledge enables early identification of patients who, following treatment, may require increased clinical supervision and a slightly altered therapeutic management plan.

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梅毒治疗后血清稳定状态：临床实践的意义和建议。叙述审查。

简介：血清稳定状态定义为推荐治疗后，早期梅毒患者在6-12个月或晚期梅毒患者在12-24个月后非螺旋体反应滴度未充分降低，感染症状同时消退。目的：本文的目的是回顾目前对血清快速状态的理解。此外，还介绍了推荐的血清快速状态患者诊断和治疗方法的数据。方法：检索PubMed数据库，回顾目前对血清快速梅毒的认识。结果：现有的关于血清稳定梅毒的文献主要关注血清稳定状态的预测因素。结论：了解血清快速状态的预测因素及其病理机制至关重要。这些知识使早期识别患者，在治疗后，可能需要增加临床监督和稍微改变治疗管理计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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