The effect of house dust mite sensitization on skin dermis thickness in children with allergic respiratory diseases.

IF 1.4 4区 医学 Q3 ALLERGY
Postepy Dermatologii I Alergologii Pub Date : 2025-02-01 Epub Date: 2025-02-20 DOI:10.5114/ada.2025.147855
Uğur Altaş, Sevinç Taşar, Nurbanu Başdoğan, Halil Alkaya, Seda Çevik, Zeynep M Altaş, Mehmet Yaşar Özkars
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引用次数: 0

Abstract

Introduction: An impaired skin barrier has been reported in allergic diseases.

Aim: In this study, we aimed to evaluate dermis thickness in children with house dust allergy without skin symptoms.

Material and methods: This cross-sectional study included children aged 4-18 years with asthma and/or allergic rhinitis. Participants were divided into three groups: healthy controls (n = 50), patients sensitized to house dust mites (n = 60), and patients with negative house dust mite tests (n = 48). The thickness of the dermis layers of the skin was measured at the cubital fossa using an ultrasound.

Results: The median age and gender distribution were similar across the house dust mite-positive and -negative groups and the healthy control group. There was no significant difference between the groups in terms of dermis thickness (p = 0.053). Absolute eosinophils and eosinophil percentage were significantly negatively correlated with dermis (p < 0.05). There was no significant correlation between total IgE, house dust mite specific IgE and skin test values and skin thickness (p > 0.05).

Conclusions: The findings of this study highlight the impact of house dust mite sensitization on skin thickness, offering potential contributions to the management and treatment strategies of allergic diseases.

屋尘螨致敏对过敏性呼吸道疾病患儿皮肤真皮层厚度的影响。
导言:据报道,过敏性疾病会导致皮肤屏障受损:目的:本研究旨在评估无皮肤症状的屋尘过敏儿童的真皮厚度:这项横断面研究包括 4-18 岁患有哮喘和/或过敏性鼻炎的儿童。参与者分为三组:健康对照组(50 人)、对屋尘螨过敏的患者(60 人)和屋尘螨检测呈阴性的患者(48 人)。在肘窝处使用超声波测量皮肤真皮层的厚度:结果:屋尘螨阳性组、阴性组和健康对照组的年龄和性别分布中位数相似。组间真皮厚度无明显差异(p = 0.053)。嗜酸性粒细胞绝对值和嗜酸性粒细胞百分比与真皮呈显著负相关(p < 0.05)。总 IgE、屋尘螨特异性 IgE 和皮试值与皮肤厚度之间无明显相关性(p > 0.05):本研究的结果凸显了屋尘螨致敏对皮肤厚度的影响,为过敏性疾病的管理和治疗策略提供了潜在的帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
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