局部应用莫匹罗星软膏和夫西地酸治疗细菌性皮肤疾病。

IF 1.4 4区 医学 Q3 ALLERGY
Postepy Dermatologii I Alergologii Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI:10.5114/ada.2024.145185
Junyi Xie, Min Li, Su Yang, Qing Dong
{"title":"局部应用莫匹罗星软膏和夫西地酸治疗细菌性皮肤疾病。","authors":"Junyi Xie, Min Li, Su Yang, Qing Dong","doi":"10.5114/ada.2024.145185","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Bacterial skin diseases have strong virulence to penetrate deep into the skin.</p><p><strong>Aim: </strong>To evaluate the therapeutic effects of 2% mupirocin ointment and 2% fusidic acid cream on bacterial skin diseases and their safety.</p><p><strong>Material and methods: </strong>One-hundred patients with bacterial skin diseases treated from May 2021 to May 2024 were randomly divided into a control group and a treatment group (<i>n</i> = 50) and they were given 2% mupirocin ointment and 2% fusidic acid cream, respectively. The skin injury areas, eczema area and severity index (EASI) scores, therapeutic effects and adverse reactions were compared before and after two courses of medication. The antibacterial activities of these two drugs against <i>Staphylococcus epidermidis</i> and <i>Propionibacterium acnes</i> were detected by the agar diffusion method.</p><p><strong>Results: </strong>After treatment, the EASI and itching scores of both groups significantly decreased compared with those before treatment (<i>t</i> = 30.804, 19.018, <i>p</i> < 0.001; <i>t</i> = 24.594, 12.680, <i>p</i> < 0.001), and the treatment group had significantly lower scores than those of the control group (<i>p</i> < 0.05). The overall effective rate of the treatment group (96.00%) was higher than that of the control group (90.00%) (<i>p</i> > 0.05), and the distribution of therapeutic effects of the treatment group was significantly better (<i>p</i> < 0.05). The two groups had similar incidence rates of adverse reactions (χ<sup>2</sup> = 1.0147, <i>p</i> = 0.3074) that were remitted without additional therapy. Both mupirocin ointment and fusidic acid cream had clear inhibition zones for <i>S. epidermidis</i>, with similar diameters (31.69 ±7.12 mm vs. 31.78 ±6.54 mm, <i>t</i> = 0.0949, <i>p</i> = 0.9245). However, only fusidic acid cream had an obvious inhibition zone for <i>P. acnes</i> on reinforced Brucella agar plate.</p><p><strong>Conclusions: </strong>The therapeutic effects of fusidic acid cream on bacterial skin diseases were superior to those of mupirocin ointment.</p>","PeriodicalId":54595,"journal":{"name":"Postepy Dermatologii I Alergologii","volume":"42 1","pages":"42-46"},"PeriodicalIF":1.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921914/pdf/","citationCount":"0","resultStr":"{\"title\":\"Topical administration of mupirocin ointment and fusidic acid in bacterial infection-induced skin diseases.\",\"authors\":\"Junyi Xie, Min Li, Su Yang, Qing Dong\",\"doi\":\"10.5114/ada.2024.145185\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Bacterial skin diseases have strong virulence to penetrate deep into the skin.</p><p><strong>Aim: </strong>To evaluate the therapeutic effects of 2% mupirocin ointment and 2% fusidic acid cream on bacterial skin diseases and their safety.</p><p><strong>Material and methods: </strong>One-hundred patients with bacterial skin diseases treated from May 2021 to May 2024 were randomly divided into a control group and a treatment group (<i>n</i> = 50) and they were given 2% mupirocin ointment and 2% fusidic acid cream, respectively. The skin injury areas, eczema area and severity index (EASI) scores, therapeutic effects and adverse reactions were compared before and after two courses of medication. The antibacterial activities of these two drugs against <i>Staphylococcus epidermidis</i> and <i>Propionibacterium acnes</i> were detected by the agar diffusion method.</p><p><strong>Results: </strong>After treatment, the EASI and itching scores of both groups significantly decreased compared with those before treatment (<i>t</i> = 30.804, 19.018, <i>p</i> < 0.001; <i>t</i> = 24.594, 12.680, <i>p</i> < 0.001), and the treatment group had significantly lower scores than those of the control group (<i>p</i> < 0.05). The overall effective rate of the treatment group (96.00%) was higher than that of the control group (90.00%) (<i>p</i> > 0.05), and the distribution of therapeutic effects of the treatment group was significantly better (<i>p</i> < 0.05). The two groups had similar incidence rates of adverse reactions (χ<sup>2</sup> = 1.0147, <i>p</i> = 0.3074) that were remitted without additional therapy. Both mupirocin ointment and fusidic acid cream had clear inhibition zones for <i>S. epidermidis</i>, with similar diameters (31.69 ±7.12 mm vs. 31.78 ±6.54 mm, <i>t</i> = 0.0949, <i>p</i> = 0.9245). However, only fusidic acid cream had an obvious inhibition zone for <i>P. acnes</i> on reinforced Brucella agar plate.</p><p><strong>Conclusions: </strong>The therapeutic effects of fusidic acid cream on bacterial skin diseases were superior to those of mupirocin ointment.</p>\",\"PeriodicalId\":54595,\"journal\":{\"name\":\"Postepy Dermatologii I Alergologii\",\"volume\":\"42 1\",\"pages\":\"42-46\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921914/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Postepy Dermatologii I Alergologii\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5114/ada.2024.145185\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Postepy Dermatologii I Alergologii","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5114/ada.2024.145185","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ALLERGY","Score":null,"Total":0}
引用次数: 0

摘要

细菌性皮肤病毒力强,能深入皮肤。目的:评价2%莫匹罗星软膏和2%夫西地酸乳膏治疗细菌性皮肤病的疗效及安全性。材料与方法:选取2021年5月~ 2024年5月收治的细菌性皮肤病患者100例,随机分为对照组和治疗组各50例,分别给予2%莫匹罗星软膏和2%夫西地酸乳膏。比较两疗程治疗前后皮肤损伤面积、湿疹面积及严重程度指数(EASI)评分、治疗效果及不良反应。采用琼脂扩散法检测两种药物对表皮葡萄球菌和痤疮丙酸杆菌的抑菌活性。结果:治疗后,两组患者的EASI和瘙痒评分均较治疗前显著降低(t = 30.804, 19.018, p < 0.001;T = 24.594, 12.680, p < 0.001),治疗组得分显著低于对照组(p < 0.05)。治疗组总有效率(96.00%)高于对照组(90.00%)(p < 0.05),治疗组疗效分布明显优于对照组(p < 0.05)。两组患者不良反应发生率相近(χ2 = 1.0147, p = 0.3074),且不良反应均得到缓解。莫匹罗星软膏和夫西地酸乳膏对表皮葡萄球菌均有明显的抑制区,直径相近(31.69±7.12 mm vs. 31.78±6.54 mm, t = 0.0949, p = 0.9245)。在强化布鲁氏菌琼脂平板上,只有福西地酸乳膏对痤疮假单胞菌有明显的抑菌带。结论:夫西地酸乳膏治疗细菌性皮肤病的疗效优于莫匹罗星软膏。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Topical administration of mupirocin ointment and fusidic acid in bacterial infection-induced skin diseases.

Introduction: Bacterial skin diseases have strong virulence to penetrate deep into the skin.

Aim: To evaluate the therapeutic effects of 2% mupirocin ointment and 2% fusidic acid cream on bacterial skin diseases and their safety.

Material and methods: One-hundred patients with bacterial skin diseases treated from May 2021 to May 2024 were randomly divided into a control group and a treatment group (n = 50) and they were given 2% mupirocin ointment and 2% fusidic acid cream, respectively. The skin injury areas, eczema area and severity index (EASI) scores, therapeutic effects and adverse reactions were compared before and after two courses of medication. The antibacterial activities of these two drugs against Staphylococcus epidermidis and Propionibacterium acnes were detected by the agar diffusion method.

Results: After treatment, the EASI and itching scores of both groups significantly decreased compared with those before treatment (t = 30.804, 19.018, p < 0.001; t = 24.594, 12.680, p < 0.001), and the treatment group had significantly lower scores than those of the control group (p < 0.05). The overall effective rate of the treatment group (96.00%) was higher than that of the control group (90.00%) (p > 0.05), and the distribution of therapeutic effects of the treatment group was significantly better (p < 0.05). The two groups had similar incidence rates of adverse reactions (χ2 = 1.0147, p = 0.3074) that were remitted without additional therapy. Both mupirocin ointment and fusidic acid cream had clear inhibition zones for S. epidermidis, with similar diameters (31.69 ±7.12 mm vs. 31.78 ±6.54 mm, t = 0.0949, p = 0.9245). However, only fusidic acid cream had an obvious inhibition zone for P. acnes on reinforced Brucella agar plate.

Conclusions: The therapeutic effects of fusidic acid cream on bacterial skin diseases were superior to those of mupirocin ointment.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
2.60
自引率
7.10%
发文量
107
审稿时长
6-12 weeks
期刊介绍: Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii is a bimonthly aimed at allergologists and dermatologists.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信