Progress in Biophysics & Molecular Biology最新文献_第7页

Measurement methods, influencing factors and applications of intercellular receptor-ligand binding kinetics in diseases 细胞间受体-配体结合动力学在疾病中的测量方法、影响因素和应用。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-01 Epub Date: 2024-11-02 DOI: 10.1016/j.pbiomolbio.2024.11.001

Qian Wu, Liangchao Li, Yuyan Zhang, Xiaozhi Ming, Nianjie Feng

{"title":"Measurement methods, influencing factors and applications of intercellular receptor-ligand binding kinetics in diseases","authors":"Qian Wu, Liangchao Li, Yuyan Zhang, Xiaozhi Ming, Nianjie Feng","doi":"10.1016/j.pbiomolbio.2024.11.001","DOIUrl":"10.1016/j.pbiomolbio.2024.11.001","url":null,"abstract":"<div><div>Receptor-ligand binding on contacting cells dictates the extent of transmembrane signaling through membrane receptors during cell communication, influencing both the physiological and pathological activities of cells. This process is integral to fundamental biological mechanisms including signal transduction, cancer metastasis, immune responses, and inflammatory cascades, all of which are profoundly influenced by the cell microenvironment. This article provides an overview of the kinetic theory of receptor-ligand binding and examines methods for measuring this interaction, along with their respective advantages and disadvantages. Furthermore, it comprehensively explores the factors that impact receptor-ligand binding, encompassing protein-membrane interactions, the bioelectric microenvironment, auxiliary factors, hydrogen bond strength, pH levels, cis and trans interactions between ligands and receptors. The application of receptor-ligand binding kinetics in various diseases such as immunity, cancer, and inflammation are also discussed. Additionally, the investigation into how functional substances alter receptor-ligand binding dynamics within specific cellular microenvironments presents a promising new approach to treating related diseases.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 43-54"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A physical perspective on lithium therapy 从物理角度看锂疗法

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1016/j.pbiomolbio.2024.11.002

Dana Kamp

{"title":"A physical perspective on lithium therapy","authors":"Dana Kamp","doi":"10.1016/j.pbiomolbio.2024.11.002","DOIUrl":"10.1016/j.pbiomolbio.2024.11.002","url":null,"abstract":"<div><div>Lithium salts have strong medical properties in neurological disorders such as bipolar disorder and lithium-responsive headaches. They have recently gathered attention due to their potential preventive effect in viral infections. Though the therapeutic effect of lithium was documented by Cade in the late 1940s, its underlying mechanism of action is still disputed. Acute lithium exposure has an activating effect on excitable organic tissue and organisms, and is highly toxic. Lithium exposure is associated with a strong metabolic response in the organism, with large changes in phospholipid and cholesterol expression. Opposite to acute exposure, this metabolic response alleviates excessive cellular activity. The presence of lithium ions strongly affects lipid conformation and membrane phase unlike other alkali ions, with consequences for membrane permeability, buffer property and excitability. This review investigates how lithium ions affect lipid membrane composition and function, and how lithium response might in fact be the body’s attempt to counteract the physical presence of lithium ions at cell level. Ideas for further research in microbiology and drug development are discussed.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 55-74"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the current status and future prospects of the bone remodeling process: Biological and mathematical perspectives 回顾骨重塑过程的现状和未来前景：生物学和数学视角。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-01 Epub Date: 2024-10-17 DOI: 10.1016/j.pbiomolbio.2024.10.001

Mehran Bahrami , Hanieh Khonakdar , Armaghan Moghaddam , Saba Nemati Mahand , Poorya Esmaili Bambizi , Benjamin Kruppke , Hossein Ali Khonakdar

{"title":"A review of the current status and future prospects of the bone remodeling process: Biological and mathematical perspectives","authors":"Mehran Bahrami , Hanieh Khonakdar , Armaghan Moghaddam , Saba Nemati Mahand , Poorya Esmaili Bambizi , Benjamin Kruppke , Hossein Ali Khonakdar","doi":"10.1016/j.pbiomolbio.2024.10.001","DOIUrl":"10.1016/j.pbiomolbio.2024.10.001","url":null,"abstract":"<div><div>This review dives into the complex dynamics of bone remodeling, combining biological insights with mathematical perspectives to better understand this fundamental aspect of skeletal health. Bone, being a crucial part of our body, constantly renews itself, and with the growing number of individuals facing bone-related issues, research in this field is vital. In this review, we categorized and classified most common mathematical models used to simulate the mechanical behavior of bone under different loading and health conditions, shedding light on the evolving landscape of bone biology. While current models have effectively captured the essence of healthy bone remodeling, the ever-expanding knowledge in bone biology suggests an update in mathematical methods. Knowing the role of the skeleton in whole-body physiology, and looking at the recent discoveries about activities of bone cells emphasize the urgency of refining our mathematical descriptions of the bone remodeling process. The underexplored impact of bone diseases like osteoporosis, Paget's disease, or breast cancer on bone remodeling also points to the need for intensified research into diverse disease types and their unique effects on bone health. By reviewing a range of bone remodeling models, we show the necessity for tailor-made mathematical models to decipher their roots and enhance patient treatment strategies. Collaboration among scientists from various domains is pivotal to surmount these challenges, ensuring improved accuracy and applicability of mathematical models. Ultimately, this effort aims to deepen our understanding of bone remodeling processes and their broader implications for diverse health conditions.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 16-33"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

m6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies 骨肉瘤中的 m6A 甲基化调节因子和 ncRNA：潜在的治疗策略

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1016/j.pbiomolbio.2024.10.003

Ce Shi , Lei Chen , Kui Huang , Guanghui Yang , Tingting Shi , Jinshuang Li , Hongbing Zheng

{"title":"m6A methylation regulators and ncRNAs in osteosarcoma: Potential therapeutic strategies","authors":"Ce Shi , Lei Chen , Kui Huang , Guanghui Yang , Tingting Shi , Jinshuang Li , Hongbing Zheng","doi":"10.1016/j.pbiomolbio.2024.10.003","DOIUrl":"10.1016/j.pbiomolbio.2024.10.003","url":null,"abstract":"<div><div>Osteosarcoma (OS) represents the primary form of bone cancer observed in paediatric and adolescent populations. Nearly 10%–15% of patients have metastases at diagnosis, and the 5-year survival rate was less than 20%. Although numerous investigators have offered significant efforts, the survival rates for patients with OS have remained almost unchanged over the past three decades. The most pervasive and abundant modification of internal transcripts in eukaryotic messenger RNAs (mRNAs) is N6-methyladenosine (m6A), and it is regulated by m6A methylation regulators. A number of recent studies have demonstrated that m6A modifications can regulate the biological activities of tumour cells and are intimately linked with cancer development, prognosis, drug resistance, and therapy. N6-methyladenosine modification of Non-coding RNA (ncRNA) has likewise shown a broad potential in gene regulation and tumor biology. Epigenetic changes induced by mRNAs and ncRNAs methylation are important for a better understanding of OS development and targeted drug development. Therefore, this paper summarises the biological functions of m6A-modified regulators in osteosarcoma and the role of mutual regulation between m6A and ncRNAs in osteosarcoma. Furthermore, the potential clinical applications of m6A modifications in OS are presented for consideration. It provides new directions for the future research and clinical treatment strategies of osteosarcoma.</div></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"194 ","pages":"Pages 34-42"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting long non-coding RNA H19 as a therapeutic strategy for liver disease 将长非编码 RNA H19 作为肝病治疗策略的靶点

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI: 10.1016/j.pbiomolbio.2024.09.005

Yulan Shi , Fenghua Qu , Shiyun Zeng , Xinchen Wang , Yuting Liu , Qirui Zhang , Ding Yuan , Chengfu Yuan

引用次数: 0

Biological evolution is dead in the water of Darwin's warm little pond 生物进化在达尔文温暖的小池塘里已经死了。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-01 Epub Date: 2024-08-15 DOI: 10.1016/j.pbiomolbio.2024.08.003

Olen R. Brown , David A. Hullender

{"title":"Biological evolution is dead in the water of Darwin's warm little pond","authors":"Olen R. Brown , David A. Hullender","doi":"10.1016/j.pbiomolbio.2024.08.003","DOIUrl":"10.1016/j.pbiomolbio.2024.08.003","url":null,"abstract":"<div><p>The origin of life and its evolution are generally taught as occurring by abiogenesis and gene-centric neo-Darwinism. Significant biological evolutionary changes are preserved and given direction (descent with modification) by Darwin's (Spencer's) natural selection by survival of the fittest. Only survival of the fittest (adapted/broadened) is available to provide a ‘naturalistic’ direction to prefer one outcome/reaction over another for abiogenesis. Thus, assembly of first life must reach some threshold (the first minimal cell) before ‘survival of the fittest’ (the only naturalistic explanation available) can function as Darwin proposed for biological change. We propose the novel concept that the requirement for co-origination of vitamins with enzymes is a fundamental, but overlooked, problem that survival of the fittest (even broadly redefined beyond Darwin) cannot reasonably overcome. We support this conclusion with probability calculations. We focus on the stage of evolution involving the transition from non-life to the first, minimal living cell. We show that co-origination of required biochemical processes makes the origin of life probabilistically absurdly improbable even when all assumptions are chosen to unreasonably favor evolutionary theories.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"193 ","pages":"Pages 1-6"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR-based electrochemical biosensors for animal health: Recent advances 基于 CRISPR 的动物健康电化学生物传感器：最新进展。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI: 10.1016/j.pbiomolbio.2024.09.001

Anil Gattani , Sanju Mandal , Aditya Agrawal , Pragati Patel , Anand Kumar Jain , Purnima Singh , Akshay Garg , Aditya Mishra

{"title":"CRISPR-based electrochemical biosensors for animal health: Recent advances","authors":"Anil Gattani , Sanju Mandal , Aditya Agrawal , Pragati Patel , Anand Kumar Jain , Purnima Singh , Akshay Garg , Aditya Mishra","doi":"10.1016/j.pbiomolbio.2024.09.001","DOIUrl":"10.1016/j.pbiomolbio.2024.09.001","url":null,"abstract":"<div><p>Animal diseases are a major concern to animal welfare, human health and the global economy. Early detection, prevention and control of these animal diseases are crucial to ensure sustainability of livestock sector, to reduce farm losses and protecting public health. Points of care (POC) devices are small, portable instruments that provide rapid results thus reduce the risk of disease transmission and enable early intervention. CRISPR based diagnostics offer more accurate and efficient solution for monitoring animal health due to their quick response, can detect very low level of pathogenic organism or disease markers and specificity. These diagnostics are particularly useful in the in area with limited resources or access to common diagnostic methods, especially in developing countries. The ability of electrochemical sensors to detect accurately very low analyte concentration makes them suitable for POC diagnostics and field application. CRISPR base electrochemical biosensors show great potential in revolutionizing disease detection and diagnosis including animal health. However, challenges, such as achieving selectivity and sensitivity, need to be addressed to enhance the competitiveness of these biosensors. Currently, most CRISPR based bioassay research focuses on nucleic acid target detection, but researchers exploring to monitor small organic/inorganic non-nucleic acid molecules like toxins and proteins. Emerging diagnostics would be centered on CRISPR-Cas system will offer great potential as an accurate, specific and effective means to identify microorganism, virus, toxins, small molecules, peptides and nucleic acid related to various animal health disorders particularly when integrated into electrochemical biosensing platform.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"193 ","pages":"Pages 7-18"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on the effects and mechanisms of magnetic field on neurodegenerative diseases 磁场对神经退行性疾病的影响和机制的研究进展

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-01 Epub Date: 2024-09-12 DOI: 10.1016/j.pbiomolbio.2024.09.004

Shuxian Ding , Jinhua Li , Yanwen Fang , Xingjie Zhuo , Lili Gu , Xinyue Zhang , Yuanxiao Yang , Min Wei , Zhongcai Liao , Qin Li

{"title":"Research progress on the effects and mechanisms of magnetic field on neurodegenerative diseases","authors":"Shuxian Ding , Jinhua Li , Yanwen Fang , Xingjie Zhuo , Lili Gu , Xinyue Zhang , Yuanxiao Yang , Min Wei , Zhongcai Liao , Qin Li","doi":"10.1016/j.pbiomolbio.2024.09.004","DOIUrl":"10.1016/j.pbiomolbio.2024.09.004","url":null,"abstract":"<div><p>With the progress of modern science and technology, magnetic therapy technology develops rapidly, and many types of magnetic therapy methods continue to emerge, making magnetic therapy one of the main techniques of physiotherapy. With the continuous development of magnetic field research and clinical applications, magnetic therapy, as a non-invasive brain stimulation therapy technology, has attracted much attention due to its potential in the treatment of motor dysfunction, cognitive impairment and speech disorders in patients with neurodegenerative diseases. However, the role of magnetic fields in the prognosis and treatment of neurodegenerative diseases and their mechanisms remain largely unexplored. In this paper, the therapeutic effect and neuroprotective mechanism of the magnetic field on neurodegenerative diseases are reviewed, and the new magnetic therapy techniques are also summarized. Although the neuroprotective mechanism of magnetic field cannot be fully elaborated, it is helpful to promote the application of magnetic field in neurodegenerative diseases and provide a new theoretical basis for the related magnetic field research in the later period.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"193 ","pages":"Pages 35-45"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142240833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytochrome P450 monooxygenase systems: Diversity and plasticity for adaptive stress response 细胞色素 P450 单氧化酶系统：适应性应激反应的多样性和可塑性。

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1016/j.pbiomolbio.2024.09.003

Innokenty M. Mokhosoev , Dmitry V. Astakhov , Alexander A. Terentiev , Nurbubu T. Moldogazieva

{"title":"Cytochrome P450 monooxygenase systems: Diversity and plasticity for adaptive stress response","authors":"Innokenty M. Mokhosoev , Dmitry V. Astakhov , Alexander A. Terentiev , Nurbubu T. Moldogazieva","doi":"10.1016/j.pbiomolbio.2024.09.003","DOIUrl":"10.1016/j.pbiomolbio.2024.09.003","url":null,"abstract":"<div><p>Superfamily of cytochromes P450 (CYPs) is composed of heme-thiolate-containing monooxygenase enzymes, which play crucial roles in the biosynthesis, bioactivation, and detoxification of a variety of organic compounds, both endogenic and exogenic. Majority of CYP monooxygenase systems are multi-component and contain various redox partners, cofactors and auxiliary proteins, which contribute to their diversity in both prokaryotes and eukaryotes. Recent progress in bioinformatics and computational biology approaches make it possible to undertake whole-genome and phylogenetic analyses of CYPomes of a variety of organisms. Considerable variations in sequences within and between CYP families and high similarity in secondary and tertiary structures between all CYPs along with dramatic conformational changes in secondary structure elements of a substrate binding site during catalysis have been reported. This provides structural plasticity and substrate promiscuity, which underlie functional diversity of CYPs. Gene duplication and mutation events underlie CYP evolutionary diversity and emergence of novel selectable functions, which provide the involvement of CYPs in high adaptability to changing environmental conditions and dietary restrictions. In our review, we discuss the recent advancements and challenges in the elucidating the evolutionary origin and mechanisms underlying the CYP monooxygenase system diversity and plasticity. Our review is in the view of hypothesis that diversity of CYP monooxygenase systems is translated into the broad metabolic profiles, and this has been acquired during the long evolutionary time to provide structural plasticity leading to high adaptative capabilities to environmental stress conditions.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"193 ","pages":"Pages 19-34"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142156663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From straight to curved: A historical perspective of DNA shape 从直线到曲线：DNA 形状的历史视角

IF 3.2 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2024-11-01 Epub Date: 2024-09-10 DOI: 10.1016/j.pbiomolbio.2024.09.002

Jean Lucas Benvenuti , Pedro Lenz Casa , Fernanda Pessi de Abreu , Gustavo Sganzerla Martinez , Scheila de Avila e Silva

{"title":"From straight to curved: A historical perspective of DNA shape","authors":"Jean Lucas Benvenuti , Pedro Lenz Casa , Fernanda Pessi de Abreu , Gustavo Sganzerla Martinez , Scheila de Avila e Silva","doi":"10.1016/j.pbiomolbio.2024.09.002","DOIUrl":"10.1016/j.pbiomolbio.2024.09.002","url":null,"abstract":"<div><p>DNA is the macromolecule responsible for storing the genetic information of a cell and it has intrinsic properties such as deformability, stability and curvature. DNA Curvature plays an important role in gene transcription and, consequently, in the subsequent production of proteins, a fundamental process of cells. With recent advances in bioinformatics and theoretical biology, it became possible to analyze and understand the involvement of DNA Curvature as a discriminatory characteristic of gene-promoting regions. These regions act as sites where RNAp (ribonucleic acid-polymerase) binds to initiate transcription. This review aims to describe the formation of Curvature, as well as highlight its importance in predicting promoters. Furthermore, this article provides the potential of DNA Curvature as a distinguishing feature for promoter prediction tools, as well as outlining the calculation procedures that have been described by other researchers. This work may support further studies directed towards the enhancement of promoter prediction software.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"193 ","pages":"Pages 46-54"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0