Progress in Biophysics & Molecular Biology最新文献_第7页

Family Constellation therapy: A nascent approach for working with non-local consciousness in a therapeutic container 家庭星座疗法：在治疗容器中与非局部意识合作的新方法。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-12-03 DOI: 10.1016/j.pbiomolbio.2023.11.008

Dan Cohen PhD Psychology

{"title":"Family Constellation therapy: A nascent approach for working with non-local consciousness in a therapeutic container","authors":"Dan Cohen PhD Psychology","doi":"10.1016/j.pbiomolbio.2023.11.008","DOIUrl":"10.1016/j.pbiomolbio.2023.11.008","url":null,"abstract":"<div><p>Family Constellations are an emerging therapeutic approach for working with local and non-local consciousness. First developed by German psychoanalyst Bert Hellinger, and now practiced by thousands of licensed and un-licensed facilitators globally, Family Constellations are a transpersonal and systemically oriented therapeutic process. Their aim is to address a focus client's emotional, behavioral, relational, or somatic issues by uncovering and resolving transgenerational entanglements within their family system. The author expands on the proposal of symbiogenesis as a mediator of local and non-local consciousness to query whether applying the Observer Effect to inherited trauma may influence epigenetic marks. An expanded perspective on consciousness, life, death, and quantum fields may provide a more comprehensive framework to address therapeutic interventions for common emotional and behavioral disorders. Innovative features of Family Constellations are its phenomenological orientation, reference to family system entanglements, and potential for symptom relief through cellular mediation of ancestral memory. Family Constellations utilize techniques called representative perception and tuning-in to identify and release ancestral traumas. These are akin to remote viewing and mediumship. While the scientific basis for Family Constellations is speculative, the text references research on the quantum theory of consciousness, mediumship and remote viewing as potential supporting evidence. Four case studies are presented.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"186 ","pages":"Pages 33-38"},"PeriodicalIF":3.8,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0079610723001013/pdfft?md5=5a1f88a8c252602818059feb356d3c4f&pid=1-s2.0-S0079610723001013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An insight to the recent advancements in detection of Mycobacterium tuberculosis using biosensors: A systematic review 洞察利用生物传感器检测结核分枝杆菌的最新进展：系统综述。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-12-03 DOI: 10.1016/j.pbiomolbio.2023.10.003

Mansi Chaturvedi , Monika Patel , Archana Tiwari , Neeraj Dwivedi , D.P. Mondal , Avanish Kumar Srivastava , Chetna Dhand

{"title":"An insight to the recent advancements in detection of Mycobacterium tuberculosis using biosensors: A systematic review","authors":"Mansi Chaturvedi , Monika Patel , Archana Tiwari , Neeraj Dwivedi , D.P. Mondal , Avanish Kumar Srivastava , Chetna Dhand","doi":"10.1016/j.pbiomolbio.2023.10.003","DOIUrl":"10.1016/j.pbiomolbio.2023.10.003","url":null,"abstract":"<div><p>Since ancient times, Tuberculosis (TB) has been a severe invasive illness that has been prevalent for thousands of years and is also known as “consumption” or phthisis. TB is the most common chronic lung bacterial illness in the world, killing over 2 million people each year, caused by <span><em>Mycobacterium tuberculosis</em></span> (MTB). As per the reports of WHO, in spite of technology advancements, the average rate of decline in global TB infections from 2000-2018 was only 1.6% per year, and the worldwide reduction in TB deaths was only 11%. In addition, COVID-19 pandemic has reversed years of global progress in tackling TB with fewer diagnosed cases. The majority of undiagnosed patients of TB are found in low- and middle-income countries where the GeneXpert MTB/RIF assay and sputum smear microscopy have been approved by the WHO as reference procedures for quickly detecting TB. Biosensors, like other cutting-edge technologies, have piqued researchers' interest since they offer a quick and accurate way to identify MTB. Modern integrated technologies allow for the rapid, low-cost, and highly precise detection of analytes in extremely little amounts of sample by biosensors. Here in this review, we outlined the severity of tuberculosis (TB) and the most recent developments in the biosensors sector, as well as their various kinds and benefits for TB detection. The review also emphasizes how widespread TB is and how it needs accurate diagnosis and effective treatment.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"186 ","pages":"Pages 14-27"},"PeriodicalIF":3.8,"publicationDate":"2023-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138489055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How can Phycobilisome, the unique light harvesting system in certain algae working highly efficiently: The connection in between structures and functions 藻胆体，某些藻类中独特的光收集系统是如何高效工作的:结构和功能之间的联系。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-11-28 DOI: 10.1016/j.pbiomolbio.2023.11.005

Runze Liu , Zhang-He Zhen , Wenjun Li , Baosheng Ge , Song Qin

{"title":"How can Phycobilisome, the unique light harvesting system in certain algae working highly efficiently: The connection in between structures and functions","authors":"Runze Liu , Zhang-He Zhen , Wenjun Li , Baosheng Ge , Song Qin","doi":"10.1016/j.pbiomolbio.2023.11.005","DOIUrl":"10.1016/j.pbiomolbio.2023.11.005","url":null,"abstract":"<div><p>Algae, which are ubiquitous in ecosystems, have evolved a variety of light-harvesting complexes to better adapt to diverse habitats. Phycobilisomes/phycobiliproteins, unique to cyanobacteria<span><span>, red algae, and certain </span>cryptomonads<span>, compensate for the lack of chlorophyll absorption, allowing algae to capture and efficiently transfer light energy in aquatic environments. With the advancement of microscopy and spectroscopy, the structure and energy transfer processes of increasingly complex phycobilisomes have been elucidated, providing us with a vivid portrait of the dynamic adaptation of their structures to the light environment in which algae thrive: 1) Cyanobacteria living on the surface of the water use short, small phycobilisomes to absorb red-orange light and reduce the damage from blue-violet light via multiple methods; 2) Large red algae inhabiting the depths of the ocean have evolved long and dense phycobilisomes containing phycoerythrin<span> to capture the feeble blue-green light; 3) In far-red light environments such as caves, algae use special allophycocyanin cores to optimally utilize the far-red light; 4) When the environment shifts, algae can adjust the length, composition and density of their rods to better adapt; 5) By carefully designing the position of the pigments, phycobilisomes can transfer light energy to the reaction center with nearly 100% efficiency via three energy transfer processes.</span></span></span></p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"186 ","pages":"Pages 39-52"},"PeriodicalIF":3.8,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cold snapshots of DNA repair: Cryo-EM structures of DNA-PKcs and NHEJ machinery DNA修复的冷快照:DNA- pkcs和NHEJ机制的低温电镜结构。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-11-28 DOI: 10.1016/j.pbiomolbio.2023.11.007

Himani Amin , Sayma Zahid , Chloe Hall , Amanda K. Chaplin

{"title":"Cold snapshots of DNA repair: Cryo-EM structures of DNA-PKcs and NHEJ machinery","authors":"Himani Amin , Sayma Zahid , Chloe Hall , Amanda K. Chaplin","doi":"10.1016/j.pbiomolbio.2023.11.007","DOIUrl":"10.1016/j.pbiomolbio.2023.11.007","url":null,"abstract":"<div><p>The proteins and protein assemblies involved in DNA repair have been the focus of a multitude of structural studies for the past few decades. Historically, the structures of these protein complexes have been resolved by X-ray crystallography. However, more recently with the advancements in cryo-electron microscopy (cryo-EM) ranging from optimising the methodology for sample preparation to the development of improved electron detectors, the focus has shifted from X-ray crystallography to cryo-EM. This methodological transition has allowed for the structural determination of larger, more complex protein assemblies involved in DNA repair pathways and has subsequently led to a deeper understanding of the mechanisms utilised by these fascinating molecular machines. Here, we review some of the key structural advancements that have been gained in the study of non-homologous end joining (NHEJ) by the use of cryo-EM, with a focus on assemblies composed of DNA-PKcs and Ku70/80 (Ku) and the various methodologies utilised to obtain these structures.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"186 ","pages":"Pages 1-13"},"PeriodicalIF":3.8,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0079610723001001/pdfft?md5=82993d4cb25614e14dc6c19e75a17d9e&pid=1-s2.0-S0079610723001001-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cells and sounds 细胞和声音。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-11-23 DOI: 10.1016/j.pbiomolbio.2023.11.004

Michael Spitzer

引用次数: 0

Shannon's (informational) dissipation as the major engine leading to living dynamic and the origin of self. 香农(信息)耗散作为生命动力和自我起源的主要引擎。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-11-13 DOI: 10.1016/j.pbiomolbio.2023.11.003

Salvatore Chirumbolo, Antonio Vella

引用次数: 0

Growth or death? Control of cell destiny by mTOR and autophagy pathways 成长还是死亡？mTOR和自噬途径对细胞命运的控制。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-11-08 DOI: 10.1016/j.pbiomolbio.2023.10.002

Mahmoud I. Khalil , Mohamad M. Ali , Jasmine Holail , Marwa Houssein

{"title":"Growth or death? Control of cell destiny by mTOR and autophagy pathways","authors":"Mahmoud I. Khalil , Mohamad M. Ali , Jasmine Holail , Marwa Houssein","doi":"10.1016/j.pbiomolbio.2023.10.002","DOIUrl":"10.1016/j.pbiomolbio.2023.10.002","url":null,"abstract":"<div><p><span>One of the central regulators of cell growth, proliferation, and metabolism is the mammalian target of rapamycin<span><span>, mTOR, which exists in two structurally and functionally different complexes: mTORC1 and mTORC2; unlike m TORC2, mTORC1 is activated in response to the sufficiency of nutrients and is inhibited by rapamycin. mTOR complexes have critical roles not only in protein synthesis<span>, gene transcription regulation, proliferation, tumor metabolism, but also in the regulation of the programmed cell death mechanisms such as autophagy and apoptosis. Autophagy is a conserved catabolic mechanism in which damaged molecules are recycled in response to nutrient starvation. Emerging evidence indicates that the mTOR </span></span>signaling pathway<span> is frequently activated in tumors. In addition, dysregulation of autophagy was associated with the development of a variety of human diseases, such as cancer and aging. Since mTOR can inhibit the induction of the autophagic process from the early stages of autophagosome formation to the late stage of </span></span></span>lysosome degradation, the use of mTOR inhibitors to regulate autophagy could be considered a potential therapeutic option. The present review sheds light on the mTOR and autophagy signaling pathways and the mechanisms of regulation of mTOR-autophagy.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"185 ","pages":"Pages 39-55"},"PeriodicalIF":3.8,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72016183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How an emergent cosmology of a nonlocally unified, meaningfully in-formed and holographically manifested Universe can underpin and frame the biological embodiment of quantum entanglement 一个非局部统一、有意义地形成和全息显示的宇宙的新兴宇宙学如何支撑和构建量子纠缠的生物学体现。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-10-21 DOI: 10.1016/j.pbiomolbio.2023.10.001

Jude Currivan

{"title":"How an emergent cosmology of a nonlocally unified, meaningfully in-formed and holographically manifested Universe can underpin and frame the biological embodiment of quantum entanglement","authors":"Jude Currivan","doi":"10.1016/j.pbiomolbio.2023.10.001","DOIUrl":"10.1016/j.pbiomolbio.2023.10.001","url":null,"abstract":"<div><p>With a Nobel Prize for Physics widely viewed as only given for ‘settled’ science, the award then essentially accepts the validity of universal nonlocality. Other key discoveries and insights in recent years are also progressively pointing to the appearance of our Universe, its energy-matter and space-time, as not being foundational but emerging from deeper, discarnate realms of causation. as digitized and meaningful, in-formation, its manifestation pixelated at the so-named Planck scale of existence. Extending from studies of black holes to the entire Universe, a growing number of cosmologists have also developed the so-named holographic principle, to model the four-dimensional appearance of our Universe (three dimensions of space and one of time) as a holographic projection of its two- dimensional boundary. In framing the emergent cosmology of a nonlocally unified, meaningfully in-formed and holographically manifested Universe, an expansion of the three universal Laws of Thermodynamics to three Laws of Information, or Infodynamics also points the way to reconciling Quantum Theory<span> that describes energy-matter and Relativity Theory that describes space-time and offers too an understanding of how the lifecycle of our Universe flows from its first moment until its last. Treating gravity as an emergent consequence of the in-formational and holographic structure of space- time and describing it as the consequence of the intropy associated with the positions in space-time of massive bodies, also points to the findings of the loss of phenotype identity in zero gravity and the role between gravity and cellular identity and the emergence of symbiogenesis.</span></p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"185 ","pages":"Pages 33-36"},"PeriodicalIF":3.8,"publicationDate":"2023-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49694035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational approaches for modeling and structural design of biological systems: A comprehensive review 生物系统建模和结构设计的计算方法：综述。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-10-09 DOI: 10.1016/j.pbiomolbio.2023.08.002

Ekambaram Gayathiri , Palanisamy Prakash , Priya Kumaravel , Jayanthi Jayaprakash , Manikkavalli Gurunathan Ragunathan , Sharmila Sankar , Saravanan Pandiaraj , Natesan Thirumalaivasan , Muthu Thiruvengadam , Rajakumar Govindasamy

{"title":"Computational approaches for modeling and structural design of biological systems: A comprehensive review","authors":"Ekambaram Gayathiri , Palanisamy Prakash , Priya Kumaravel , Jayanthi Jayaprakash , Manikkavalli Gurunathan Ragunathan , Sharmila Sankar , Saravanan Pandiaraj , Natesan Thirumalaivasan , Muthu Thiruvengadam , Rajakumar Govindasamy","doi":"10.1016/j.pbiomolbio.2023.08.002","DOIUrl":"10.1016/j.pbiomolbio.2023.08.002","url":null,"abstract":"<div><p>The convergence of biology and computational science has ushered in a revolutionary era, revolutionizing our understanding of biological systems and providing novel solutions to global problems. The field of genetic engineering has facilitated the manipulation of genetic codes, thus providing opportunities for the advancement of innovative disease therapies and environmental enhancements. The emergence of bio-molecular simulation represents a significant advancement in this particular field, as it offers the ability to gain microscopic insights into molecular-level biological processes<span> over extended periods. Biomolecular simulation plays a crucial role in advancing our comprehension of organismal mechanisms by establishing connections between molecular structures, interactions, and biological functions. The field of computational biology has demonstrated its significance in deciphering intricate biological enigmas through the utilization of mathematical models and algorithms. The process of decoding the human genome has resulted in the advancement of therapies for a wide range of genetic disorders, while the simulation of biological systems contributes to the identification of novel pharmaceutical compounds. The potential of biomolecular simulation and computational biology is vast and limitless. As the exploration of the underlying principles that govern living organisms progresses, the potential impact of this understanding on cancer treatment, environmental restoration, and other domains is anticipated to be transformative. This review examines the notable advancements achieved in the field of computational biology, emphasizing its potential to revolutionize the comprehension and enhancement of biological systems.</span></p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"185 ","pages":"Pages 17-32"},"PeriodicalIF":3.8,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41220333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress of mechanosensitive mechanism on breast cancer 乳腺癌症机械敏感性机制的最新进展。

IF 3.8 3区生物学

Progress in Biophysics & Molecular Biology Pub Date : 2023-10-02 DOI: 10.1016/j.pbiomolbio.2023.09.003

Xiao-Xia Chai , Jie Liu , Tong-Yao Yu , Ge Zhang , Wen-Jun Sun , Yan Zhou , Li Ren , Hui-Ling Cao , Da-Chuan Yin , Chen-Yan Zhang

{"title":"Recent progress of mechanosensitive mechanism on breast cancer","authors":"Xiao-Xia Chai , Jie Liu , Tong-Yao Yu , Ge Zhang , Wen-Jun Sun , Yan Zhou , Li Ren , Hui-Ling Cao , Da-Chuan Yin , Chen-Yan Zhang","doi":"10.1016/j.pbiomolbio.2023.09.003","DOIUrl":"10.1016/j.pbiomolbio.2023.09.003","url":null,"abstract":"<div><p><span><span><span>The mechanical environment is important for tumorigenesis and progression. Tumor cells can sense mechanical signals by mechanosensitive receptors, and these mechanical signals can be converted to biochemical signals to regulate cell behaviors, such as cell differentiation, proliferation, migration, apoptosis, and drug resistance. Here, we summarized the effects of the mechanical microenvironment on breast cancer cell activity, and </span>mechanotransduction mechanism from cellular microenvironment to cell membrane, and finally to the nucleus, and also relative mechanosensitive proteins, ion channels, and </span>signaling pathways were elaborated, therefore the mechanical signal could be transduced to biochemical or molecular signal. Meanwhile, the mechanical models commonly used for biomechanics study </span><em>in vitro</em> and some quantitative descriptions were listed. It provided an essential theoretical basis for the occurrence and development of mechanosensitive breast cancer, and also some potential drug targets were proposed to treat such disease.</p></div>","PeriodicalId":54554,"journal":{"name":"Progress in Biophysics & Molecular Biology","volume":"185 ","pages":"Pages 1-16"},"PeriodicalIF":3.8,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0